Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

← Back to all clusters

Cluster 2

57 diseases · 145 shared-gene connections
57 Diseases
9,677 Unique genes
0.073 Avg. similarity score
Major depressive disorder Most-connected disease (19 links)
Log in to save this analysis

Save This Analysis

Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.
Major depressive disorder Schizophrenia Diabetes mellitus type 2 Metabolic syndrome Bipolar disorder Attention deficit hyperactivity disorder

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Major depressive disorder 19 17 1,960
Schizophrenia 17 12 2,541
Diabetes mellitus type 2 17 9 3,080
Metabolic syndrome 13 11 1,303
Bipolar disorder 13 9 1,220
Attention deficit hyperactivity disorder 11 10 1,105
Alzheimer disease 10 8 2,218
Insomnia 10 8 1,079
Obesity 9 8 1,194
Parkinson disease 9 8 529
Substance abuse 9 8 516
Scoliosis 9 7 1,033
Color vision deficiency 8 8 966
Osteoarthritis 8 8 730
Dementia 8 7 590
Anxiety disorder 7 7 146
Mood disorder 7 7 298
Neurotic disorder 7 7 435
Post-traumatic stress disorder 7 7 203
Depression 6 6 279
Autism 6 4 1,463
Bipolar depression 5 5 105
Oligodendroglioma 5 5 559
Cannabis abuse 4 4 116
Gastroesophageal reflux disease 4 4 279
Irritable bowel syndrome 4 4 134
Ear disorder 4 1 2
retinitis pigmentosa 18 4 1 1
Oculocerebrodental syndrome 4 0 1
Panic disorder 3 3 34
Willis-ekbom disease 3 3 191
3-methylcrotonyl-coa carboxylase deficiency 3 1 2
Birk-aharoni syndrome 3 0 2
opsismodysplasia 3 0 1
Gout 2 2 819
Pemphigus foliaceus 2 2 1
Alopecia-neurological defects-endocrinopathy syndrome 2 1 1
Craniolenticulosutural dysplasia 2 1 1
Partial deletion of short arm of chromosome 3 2 1 1
SNUPN-related muscular dystrophy with or without multi-system involvement 2 1 1
inherited interstitial lung disease 2 1 1
Auroneurodental syndrome 2 0 2
Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder 1 1 1
Congenital lactase deficiency 1 1 1
Developmental delay with language and ocular abnormalities 1 1 2
Diabetes deafness developmental delay and short stature syndrome 1 1 1
Patellar tendinitis 1 1 2
Sedoheptulokinase deficiency 1 1 1
Deafness, y-linked 1 0 1
Glyoxalase ii deficiency 1 0 1
Phosphoribosylaminoimidazole carboxylase deficiency 1 0 1
Vacuolar neuromyopathy 1 0 1
Vibratory urticaria 1 0 1
Warsaw breakage syndrome 1 0 1
hydroxyprolinemia 1 0 1
pterin-4 alpha-carbinolamine dehydratase 1 deficiency 1 0 1
siddiqi syndrome 1 0 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
FOXP2 21 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Autism and 17 more
BDNF 20 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar depression and 16 more
DCC 19 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Autism and 15 more
NCAM1 19 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Autism, Bipolar depression and 15 more
PDE4B 19 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Autism and 15 more
RBFOX1 19 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 15 more
LSAMP 18 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Cannabis abuse and 14 more
MAD1L1 18 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Autism and 14 more
SORCS3 18 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Autism and 14 more
TCF4 18 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 14 more
CNTNAP2 17 / 57 Alzheimer disease, Autism, Bipolar disorder, Dementia and 13 more
SLC39A8 17 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 13 more
CACNA1C 16 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Autism, Bipolar depression and 12 more
CADM2 16 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 12 more
CSMD1 16 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 12 more
DRD2 16 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 12 more
ERBB4 16 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Color vision deficiency and 12 more
IGSF11 16 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Cannabis abuse and 12 more
MAPT 16 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Autism and 12 more
NRXN1 16 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 12 more
SOX5 16 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 12 more
ARHGAP15 15 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Autism and 11 more
BRINP1 15 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Bipolar disorder, Color vision deficiency and 11 more
DLG2 15 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Dementia and 11 more
GRM8 15 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Autism and 11 more
HTR1A 15 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Autism and 11 more
NTM 15 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Color vision deficiency and 11 more
NTRK2 15 / 57 Alzheimer disease, Anxiety disorder, Autism, Bipolar depression and 11 more
PTPRD 15 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Cannabis abuse, Dementia and 11 more
RELN 15 / 57 Alzheimer disease, Autism, Bipolar depression, Bipolar disorder and 11 more
SDK1 15 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Autism and 11 more
TENM4 15 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar depression and 11 more
ANK3 14 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar depression and 10 more
ASTN2 14 / 57 Attention deficit hyperactivity disorder, Autism, Bipolar disorder, Diabetes mellitus type 2 and 10 more
AUTS2 14 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 10 more
COMT 14 / 57 Attention deficit hyperactivity disorder, Autism, Bipolar depression, Bipolar disorder and 10 more
FHIT 14 / 57 Attention deficit hyperactivity disorder, Autism, Bipolar disorder, Color vision deficiency and 10 more
NPAS3 14 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 10 more
NRXN3 14 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 10 more
PLCL2 14 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Autism, Cannabis abuse and 10 more
RUNX1T1 14 / 57 Attention deficit hyperactivity disorder, Autism, Bipolar disorder, Cannabis abuse and 10 more
TLR4 14 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Diabetes mellitus type 2 and 10 more
TRPS1 14 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Color vision deficiency, Dementia and 10 more
VRK2 14 / 57 Attention deficit hyperactivity disorder, Autism, Bipolar disorder, Cannabis abuse and 10 more
AKAP6 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 9 more
APOE 13 / 57 Alzheimer disease, Anxiety disorder, Bipolar disorder, Dementia and 9 more
CDH13 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Color vision deficiency and 9 more
CELF4 13 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Color vision deficiency and 9 more
ERCC4 13 / 57 Attention deficit hyperactivity disorder, Autism, Bipolar disorder, Color vision deficiency and 9 more
GRIK2 13 / 57 Alzheimer disease, Autism, Bipolar depression, Bipolar disorder and 9 more
IMMP2L 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 9 more
LRFN5 13 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 9 more
MACROD2 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 9 more
METTL15 13 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 9 more
NEGR1 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 9 more
NKAIN2 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Color vision deficiency and 9 more
NLGN1 13 / 57 Attention deficit hyperactivity disorder, Autism, Bipolar disorder, Diabetes mellitus type 2 and 9 more
NYAP2 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Dementia, Diabetes mellitus type 2 and 9 more
PCDH15 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Color vision deficiency and 9 more
PTPRN2 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Dementia and 9 more
RARB 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 9 more
RERE 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 9 more
SEMA6D 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Cannabis abuse and 9 more
SGCZ 13 / 57 Attention deficit hyperactivity disorder, Autism, Color vision deficiency, Diabetes mellitus type 2 and 9 more
TENM2 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 9 more
THSD7A 13 / 57 Alzheimer disease, Anxiety disorder, Bipolar depression, Bipolar disorder and 9 more
TMEM106B 13 / 57 Alzheimer disease, Anxiety disorder, Bipolar disorder, Dementia and 9 more
ZBTB20 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 9 more
ZNF804A 13 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 9 more
ASB3 12 / 57 Alzheimer disease, Color vision deficiency, Dementia, Diabetes mellitus type 2 and 8 more
BANK1 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 8 more
C6ORF118 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Color vision deficiency and 8 more
CAMK1D 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Color vision deficiency and 8 more
CARMIL1 12 / 57 Autism, Bipolar disorder, Color vision deficiency, Gastroesophageal reflux disease and 8 more
CTTNBP2 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 8 more
EFNA5 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 8 more
ESR1 12 / 57 Alzheimer disease, Anxiety disorder, Attention deficit hyperactivity disorder, Bipolar disorder and 8 more
FSTL5 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar depression and 8 more
GLIS3 12 / 57 Alzheimer disease, Color vision deficiency, Dementia, Diabetes mellitus type 2 and 8 more
GRIA1 12 / 57 Alzheimer disease, Autism, Bipolar disorder, Diabetes mellitus type 2 and 8 more
GRIK3 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 8 more
H2BC4 12 / 57 Alzheimer disease, Autism, Bipolar disorder, Diabetes mellitus type 2 and 8 more
HTR2A 12 / 57 Autism, Bipolar depression, Bipolar disorder, Color vision deficiency and 8 more
IGSF9B 12 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 8 more
LINGO2 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Bipolar disorder, Color vision deficiency and 8 more
MAGI2 12 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Bipolar disorder, Cannabis abuse and 8 more
MDGA2 12 / 57 Attention deficit hyperactivity disorder, Color vision deficiency, Diabetes mellitus type 2, Insomnia and 8 more
NAALADL2 12 / 57 Alzheimer disease, Autism, Bipolar disorder, Color vision deficiency and 8 more
NALF1 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 8 more
NCOA5 12 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 8 more
NT5C2 12 / 57 Attention deficit hyperactivity disorder, Autism, Bipolar disorder, Cannabis abuse and 8 more
OLFM1 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Color vision deficiency, Dementia and 8 more
PCDH9 12 / 57 Autism, Dementia, Diabetes mellitus type 2, Gastroesophageal reflux disease and 8 more
PCLO 12 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 8 more
PLCL1 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar disorder and 8 more
PRKN 12 / 57 Alzheimer disease, Autism, Color vision deficiency, Dementia and 8 more
RIMS1 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Bipolar depression and 8 more
SLC6A4 12 / 57 Anxiety disorder, Attention deficit hyperactivity disorder, Autism, Bipolar depression and 8 more
SNX29 12 / 57 Alzheimer disease, Attention deficit hyperactivity disorder, Autism, Color vision deficiency and 8 more
TCF7L2 12 / 57 Alzheimer disease, Autism, Bipolar disorder, Color vision deficiency and 8 more
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

None of these pathways reaches significance (all FDR q ≥ 0.05). They’re the best candidates found, but treat them as weak evidence for why this cluster groups together.
Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Unblocking of NMDA receptors, glutamate binding and activation
DLG2, GRIA1, GRIN2B, GRIN2C, CALM1, ACTN2, CAMK2G, GRIA4, GRIN2A, DLG4, CAMK2A, CAMK2B
 Reactome 22 / 22 1.2× 8.60e-3 6.27e-2
Type I diabetes mellitus
HLA-C, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DRB5, ICA1, PTPRN2, FAS, IL1A, IL1B, IL2, INS
 KEGG 41 / 44 1.2× 1.87e-2 9.88e-2
Uptake and function of anthrax toxins
ANTXR1, MAP2K3, CALM1, FURIN, MAP2K1, ANTXR2, CALM2, MAP2K4, CALM3, MAP2K2, MAP2K7, MAP2K6
 Reactome 13 / 13 1.2× 6.02e-2 1.89e-1
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
CYP8B1, PTGES3, TBXAS1, AKR1C3, CBR1, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, HPGDS, PTGDS
 Reactome 12 / 12 1.2× 7.48e-2 2.12e-1
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
CHRNA2, CHRNA6, CHRNA7, CHRNB2, CHRNA5, CHRNA4, CHRNA3, CHRNB3, CHRNA1, CHRFAM7A, CHRNA9, CHRNB4
 Reactome 12 / 12 1.2× 7.48e-2 2.12e-1
Activation of Ca-permeable Kainate Receptor
GRIK1, GRIK2, GRIK3, CALM1, GRIK4, DLG4, CALM2, DLG3, GRIK5, CALM3, NCALD, DLG1
 Reactome 12 / 12 1.2× 7.48e-2 2.12e-1
Drug metabolism - cytochrome P450
ADH5, CYP1A2, CYP2D6, GSTM3, GSTO1, GSTO2, GSTP1, GSTT1, MAOA, MAOB, UGT1A10, UGT1A8
 KEGG 64 / 73 1.1× 7.72e-2 2.15e-1
cGMP effects
PDE10A, PDE1A, PDE9A, PRKG1, PDE11A, IRAG1, ITPR1, PDE5A, PDE2A, PDE1B, PRKG2
 Reactome 11 / 11 1.2× 9.28e-2 2.38e-1
Signaling by ERBB4
EGFR, ERBB3, ERBB4, HBEGF, EREG, NRG3, NRG2, EGF, NRG1, BTC, NRG4
 Reactome 11 / 11 1.2× 9.28e-2 2.38e-1
Tryptophan catabolism
SLC3A2, SLC7A5, TDO2, IDO2, IDO1, AADAT, KMO, HAAO, SLC36A4, KYAT1, KYNU
 Reactome 11 / 11 1.2× 9.28e-2 2.38e-1
Signaling by activated point mutants of FGFR1
FGF8, FGFR1, FGF17, FGF20, FGF9, FGF2, FGF5, FGF1, FGF23, FGF6, FGF4
 Reactome 11 / 11 1.2× 9.28e-2 2.38e-1
Maturity onset diabetes of the young
HNF1B, HNF4G, RFX6, INS, HNF4A, PAX4, PAX6, GCK, HNF1A, FOXA2, HHEX, IAPP
 KEGG 24 / 26 1.1× 9.50e-2 2.41e-1
Downstream signaling of activated FGFR1
FGF10, FLRT2, FGF3, FGF8, FGFR1, FGF17, FGF20, FGF9, FGF2, KL, FGF5, FLRT1
 Reactome 17 / 18 1.2× 1.09e-1 2.60e-1
PI3K events in ERBB4 signaling
ERBB4, HBEGF, PIK3R1, EREG, NRG3, NRG2, NRG1, BTC, NRG4, PIK3CA
 Reactome 10 / 10 1.2× 1.15e-1 2.68e-1
Cocaine addiction
GRIN2B, GRIN2C, GRIN3B, GRM3, BDNF, CDK5, CDK5R1, MAOA, MAOB, DRD2, SLC6A3, CREB5
 KEGG 43 / 49 1.1× 1.35e-1 2.92e-1

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
nervous system development
ACTL6B, AGRN, APBA1, APOB, ARHGEF2, ARID1A, ARID1B, ATOH7, ATXN10, BARHL2, BORCS5, BPNT1
 GO:0007399 450 / 631 1.4× 2.17e-24 6.21e-21 ✓ sig.
positive regulation of transcription by RNA polymerase II
ACTN4, AGRN, APP, ARHGEF2, ATF7, ATOH7, AUTS2, BARHL2, BAZ1B, BCAS3, BCL11A, BCL3
 GO:0045944 781 / 1,208 1.2× 7.04e-21 1.29e-17 ✓ sig.
modulation of chemical synaptic transmission
ADCY8, BSN, BTBD9, CACNA1A, CAMKV, DLGAP2, EIF4EBP2, GRIA1, GRIK1, GRIK2, GRIK3, GRIN3B
 GO:0050804 106 / 121 1.7× 4.66e-17 4.80e-14 ✓ sig.
chemical synaptic transmission
APBA1, APP, BSN, CACNA1A, CACNA1E, CACNA1G, CACNB2, CHRM3, CHRNA6, CHRNE, DLG2, DOC2A
 GO:0007268 182 / 236 1.5× 6.12e-16 5.01e-13 ✓ sig.
response to hypoxia
ABAT, ADAM17, BMP2, BNIP3, CD24, DPP4, ERCC2, HSPG2, PAK1, PLOD1, PRKAA1, TGFB2
 GO:0001666 141 / 176 1.5× 4.29e-15 3.01e-12 ✓ sig.
axon guidance
ALCAM, B3GNT2, CDH4, DAG1, DCC, DLX5, DRAXIN, DSCAM, EFNA5, EMB, EPHA4, EPHA5
 GO:0007411 149 / 192 1.5× 1.05e-13 5.77e-11 ✓ sig.
positive regulation of DNA-templated transcription
DYRK1B, ABT1, ACTB, ACTL6B, AGT, APOE, ARID1A, ARID1B, ATF7IP, BCL3, BMP2, CAMK4
 GO:0045893 501 / 778 1.2× 2.77e-13 1.43e-10 ✓ sig.
response to xenobiotic stimulus
ABAT, ABCA1, ABCG8, ADAM17, ADCYAP1R1, ADRA1A, BCAR3, BLOC1S3, COL18A1, CPS1, DUSP6, GABRG3
 GO:0009410 184 / 248 1.4× 2.84e-13 1.46e-10 ✓ sig.
cell population proliferation
ALDH1A2, CCDC85C, CD2AP, CEBPA, CNTNAP2, CRK, DAPL1, DLX5, EGFR, ELAVL1, ERCC1, ESRRB
 GO:0008283 191 / 263 1.4× 2.91e-12 1.21e-9 ✓ sig.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
AGT, APP, CASS4, CCR7, EFNA5, EGFR, ERBB3, ERBB4, F2R, F2RL1, FERMT2, FGFR3
 GO:0051897 162 / 217 1.4× 3.13e-12 1.29e-9 ✓ sig.
xenobiotic metabolic process
CYP1A2, CYP2F1, RORA, SLC28A3, SMOX, BCHE, CYP2D6, CYP46A1, GSTO2, GSTP1, CYP2J2, HNF4A
 GO:0006805 98 / 120 1.6× 7.56e-12 2.85e-9 ✓ sig.
social behavior
CNTNAP2, DSCAM, EIF4EBP2, MKKS, NEGR1, NLGN4X, NRXN1, NRXN2, NRXN3, RPTOR, SEPTIN5, SHANK2
 GO:0035176 54 / 58 1.8× 8.62e-12 3.21e-9 ✓ sig.
positive regulation of MAPK cascade
ADRA1A, ADRA1B, ADRA1D, APP, AVPI1, BANK1, BCAR3, BMP2, CDON, EGFR, ERBB3, ERBB4
 GO:0043410 165 / 224 1.4× 1.30e-11 4.67e-9 ✓ sig.
neuron migration
ABI3, AUTS2, BARHL2, CELSR1, CRK, DAB1, DCC, DISC1, GFRA3, MARK2, MEF2C, NEO1
 GO:0001764 105 / 132 1.5× 3.08e-11 9.96e-9 ✓ sig.
regulation of postsynaptic membrane potential
CHRNA2, CHRNA6, CHRNE, GABBR1, GABRA2, GABRA4, GABRG3, GRIA1, GRIK1, GRIK3, GRIN3B, HCN1
 GO:0060078 54 / 59 1.8× 5.02e-11 1.55e-8 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Diabetes mellitus type 2 Metabolic syndrome 0.386 1,222 < 1e-300 < 1e-300 ✓ sig.
Attention deficit hyperactivity disorder Substance abuse 0.378 445 < 1e-300 < 1e-300 ✓ sig.
Bipolar disorder Major depressive disorder 0.293 720 < 1e-300 < 1e-300 ✓ sig.
Bipolar disorder Schizophrenia 0.249 751 1.24e-309 1.51e-306 ✓ sig.
Major depressive disorder Schizophrenia 0.252 905 1.92e-248 1.36e-245 ✓ sig.
Attention deficit hyperactivity disorder Autism 0.241 499 2.00e-238 1.33e-235 ✓ sig.
Depression Major depressive disorder 0.123 245 4.04e-184 1.19e-181 ✓ sig.
Major depressive disorder Mood disorder 0.119 241 2.23e-163 5.18e-161 ✓ sig.
Attention deficit hyperactivity disorder Schizophrenia 0.179 553 2.31e-161 5.14e-159 ✓ sig.
Autism Schizophrenia 0.194 652 2.32e-159 4.96e-157 ✓ sig.
Attention deficit hyperactivity disorder Major depressive disorder 0.183 474 3.77e-152 7.55e-150 ✓ sig.
Major depressive disorder Neurotic disorder 0.126 268 3.73e-132 6.23e-130 ✓ sig.
Alzheimer disease Dementia 0.134 333 8.54e-132 1.41e-129 ✓ sig.
Attention deficit hyperactivity disorder Bipolar disorder 0.177 350 1.74e-130 2.86e-128 ✓ sig.
Autism Major depressive disorder 0.174 507 7.08e-118 1.08e-115 ✓ sig.
Autism Bipolar disorder 0.169 388 1.31e-117 1.99e-115 ✓ sig.
Bipolar depression Bipolar disorder 0.083 102 1.32e-109 1.86e-107 ✓ sig.
Alzheimer disease Gastroesophageal reflux disease 0.082 189 1.57e-93 1.58e-91 ✓ sig.
Bipolar disorder Mood disorder 0.110 151 3.75e-87 3.42e-85 ✓ sig.
Attention deficit hyperactivity disorder Metabolic syndrome 0.142 299 2.43e-82 2.09e-80 ✓ sig.
Diabetes mellitus type 2 Schizophrenia 0.186 882 2.65e-82 2.27e-80 ✓ sig.
Insomnia Major depressive disorder 0.134 360 1.38e-75 1.11e-73 ✓ sig.
Attention deficit hyperactivity disorder Insomnia 0.134 258 5.86e-74 4.63e-72 ✓ sig.
Metabolic syndrome Schizophrenia 0.138 466 1.27e-70 9.72e-69 ✓ sig.
Insomnia Metabolic syndrome 0.127 268 2.02e-64 1.41e-62 ✓ sig.
Diabetes mellitus type 2 Obesity 0.127 482 4.61e-64 3.20e-62 ✓ sig.
Insomnia Schizophrenia 0.122 395 2.68e-62 1.80e-60 ✓ sig.
Major depressive disorder Obesity 0.128 359 6.21e-62 4.15e-60 ✓ sig.
Bipolar disorder Depression 0.089 123 6.31e-62 4.20e-60 ✓ sig.
Cannabis abuse Substance abuse 0.109 62 8.53e-61 5.56e-59 ✓ sig.
Diabetes mellitus type 2 Major depressive disorder 0.155 678 7.59e-60 4.92e-58 ✓ sig.
Major depressive disorder Substance abuse 0.092 209 8.41e-59 5.34e-57 ✓ sig.
Diabetes mellitus type 2 Insomnia 0.118 438 1.09e-58 6.93e-57 ✓ sig.
Insomnia Neurotic disorder 0.101 139 3.56e-56 2.16e-54 ✓ sig.
Metabolic syndrome Obesity 0.120 268 1.01e-54 6.00e-53 ✓ sig.
Depression Mood disorder 0.129 66 1.74e-53 1.03e-51 ✓ sig.
Obesity Schizophrenia 0.121 402 3.19e-52 1.83e-50 ✓ sig.
Alzheimer disease Schizophrenia 0.151 624 4.24e-51 2.39e-49 ✓ sig.
Insomnia Substance abuse 0.100 145 8.92e-51 5.00e-49 ✓ sig.
Attention deficit hyperactivity disorder Neurotic disorder 0.095 134 9.15e-51 5.12e-49 ✓ sig.
Metabolic syndrome Substance abuse 0.094 157 5.38e-49 2.91e-47 ✓ sig.
Mood disorder Neurotic disorder 0.109 72 6.27e-47 3.23e-45 ✓ sig.
Bipolar disorder Obesity 0.109 238 6.84e-44 3.33e-42 ✓ sig.
Diabetes mellitus type 2 Gout 0.091 324 3.56e-40 1.59e-38 ✓ sig.
Neurotic disorder Post-traumatic stress disorder 0.096 56 6.95e-40 3.06e-38 ✓ sig.
Anxiety disorder Mood disorder 0.107 43 3.40e-39 1.46e-37 ✓ sig.
Gout Metabolic syndrome 0.097 188 4.53e-39 1.95e-37 ✓ sig.
Alzheimer disease Diabetes mellitus type 2 0.147 681 6.26e-39 2.68e-37 ✓ sig.
Alzheimer disease Major depressive disorder 0.129 477 2.09e-36 8.43e-35 ✓ sig.
Bipolar depression Mood disorder 0.098 36 1.29e-35 5.05e-34 ✓ sig.
Color vision deficiency Scoliosis 0.095 173 1.17e-34 4.40e-33 ✓ sig.
Diabetes mellitus type 2 Osteoarthritis 0.080 282 8.67e-33 3.07e-31 ✓ sig.
Post-traumatic stress disorder Substance abuse 0.079 53 1.35e-32 4.77e-31 ✓ sig.
Color vision deficiency Major depressive disorder 0.095 254 3.40e-32 1.18e-30 ✓ sig.
Attention deficit hyperactivity disorder Scoliosis 0.094 183 4.01e-32 1.39e-30 ✓ sig.
Major depressive disorder Scoliosis 0.098 266 4.05e-32 1.40e-30 ✓ sig.
Insomnia Willis-ekbom disease 0.057 68 6.50e-31 2.15e-29 ✓ sig.
Alzheimer disease Metabolic syndrome 0.105 335 1.53e-29 4.85e-28 ✓ sig.
Gastroesophageal reflux disease Post-traumatic stress disorder 0.085 38 8.58e-28 2.55e-26 ✓ sig.
Dementia Major depressive disorder 0.072 171 8.27e-27 2.36e-25 ✓ sig.
Irritable bowel syndrome Neurotic disorder 0.069 37 1.32e-26 3.75e-25 ✓ sig.
Anxiety disorder Neurotic disorder 0.070 38 2.92e-26 8.02e-25 ✓ sig.
Color vision deficiency Schizophrenia 0.088 285 1.32e-25 3.52e-24 ✓ sig.
Mood disorder Post-traumatic stress disorder 0.080 37 1.34e-25 3.57e-24 ✓ sig.
Bipolar depression Depression 0.078 28 3.06e-25 8.00e-24 ✓ sig.
Metabolic syndrome Willis-ekbom disease 0.047 67 3.25e-25 8.46e-24 ✓ sig.
Schizophrenia Scoliosis 0.091 297 1.10e-24 2.79e-23 ✓ sig.
Attention deficit hyperactivity disorder Color vision deficiency 0.084 160 1.11e-24 2.83e-23 ✓ sig.
Metabolic syndrome Osteoarthritis 0.078 148 1.18e-24 2.99e-23 ✓ sig.
Parkinson disease Schizophrenia 0.063 182 1.26e-24 3.17e-23 ✓ sig.
Color vision deficiency Obesity 0.084 167 4.28e-24 1.05e-22 ✓ sig.
Dementia Obesity 0.073 121 6.31e-24 1.53e-22 ✓ sig.
Gastroesophageal reflux disease Substance abuse 0.067 50 9.36e-23 2.12e-21 ✓ sig.
Anxiety disorder Post-traumatic stress disorder 0.077 25 5.26e-21 1.11e-19 ✓ sig.
Dementia Scoliosis 0.069 105 8.94e-21 1.87e-19 ✓ sig.
Oligodendroglioma Scoliosis 0.068 101 1.67e-20 3.46e-19 ✓ sig.
Color vision deficiency Oligodendroglioma 0.068 97 1.68e-20 3.48e-19 ✓ sig.
Diabetes mellitus type 2 Scoliosis 0.086 326 5.55e-20 1.12e-18 ✓ sig.
Obesity Osteoarthritis 0.072 130 6.22e-20 1.25e-18 ✓ sig.
Anxiety disorder Depression 0.068 27 7.52e-20 1.51e-18 ✓ sig.
Major depressive disorder Parkinson disease 0.060 142 5.08e-19 9.69e-18 ✓ sig.
Color vision deficiency Dementia 0.066 97 8.19e-19 1.55e-17 ✓ sig.
Alzheimer disease Parkinson disease 0.059 153 1.37e-18 2.57e-17 ✓ sig.
Bipolar disorder Parkinson disease 0.063 103 4.43e-18 8.11e-17 ✓ sig.
Substance abuse Willis-ekbom disease 0.054 36 2.06e-17 3.64e-16 ✓ sig.
Major depressive disorder Oligodendroglioma 0.060 143 3.73e-17 6.49e-16 ✓ sig.
Cannabis abuse Post-traumatic stress disorder 0.067 20 4.55e-17 7.88e-16 ✓ sig.
Metabolic syndrome Oligodendroglioma 0.062 108 1.40e-16 2.35e-15 ✓ sig.
Dementia Oligodendroglioma 0.061 66 2.22e-16 3.68e-15 ✓ sig.
Anxiety disorder Cannabis abuse 0.060 15 2.63e-13 3.55e-12 ✓ sig.
Anxiety disorder Bipolar depression 0.059 14 1.11e-12 1.41e-11 ✓ sig.
Irritable bowel syndrome Post-traumatic stress disorder 0.053 17 2.04e-12 2.51e-11 ✓ sig.
Anxiety disorder Panic disorder 0.052 9 2.07e-11 2.33e-10 ✓ sig.
Gastroesophageal reflux disease Irritable bowel syndrome 0.045 18 3.57e-11 3.92e-10 ✓ sig.
Bipolar depression Panic disorder 0.053 7 2.59e-9 2.37e-8 ✓ sig.
Panic disorder Pemphigus foliaceus 0.029 1 2.21e-3 3.10e-3 ✓ sig.
Color vision deficiency Ear disorder 0.002 2 3.93e-3 4.98e-3 ✓ sig.
3-methylcrotonyl-coa carboxylase deficiency Cannabis abuse 0.008 1 1.50e-2 1.66e-2 ✓ sig.
Irritable bowel syndrome Patellar tendinitis 0.007 1 1.73e-2 1.90e-2 ✓ sig.
Alopecia-neurological defects-endocrinopathy syndrome Depression 0.004 1 1.81e-2 1.98e-2 ✓ sig.
Alzheimer disease Developmental delay with language and ocular abnormalities 0.001 2 2.07e-2 2.26e-2 ✓ sig.
Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder Parkinson disease 0.002 1 3.44e-2 3.63e-2 ✓ sig.
Diabetes deafness developmental delay and short stature syndrome Parkinson disease 0.002 1 3.44e-2 3.63e-2 ✓ sig.
inherited interstitial lung disease Parkinson disease 0.002 1 3.44e-2 3.63e-2 ✓ sig.
Parkinson disease Partial deletion of short arm of chromosome 3 0.002 1 3.44e-2 3.63e-2 ✓ sig.
Dementia Sedoheptulokinase deficiency 0.002 1 3.83e-2 4.02e-2 ✓ sig.
Congenital lactase deficiency Osteoarthritis 0.001 1 4.74e-2 4.92e-2 ✓ sig.
Craniolenticulosutural dysplasia Osteoarthritis 0.001 1 4.74e-2 4.92e-2 ✓ sig.
Osteoarthritis Pemphigus foliaceus 0.001 1 4.74e-2 4.92e-2 ✓ sig.
Osteoarthritis retinitis pigmentosa 18 0.001 1 4.74e-2 4.92e-2 ✓ sig.
Osteoarthritis SNUPN-related muscular dystrophy with or without multi-system involvement 0.001 1 4.74e-2 4.92e-2 ✓ sig.
3-methylcrotonyl-coa carboxylase deficiency Substance abuse 0.002 1 6.59e-2 6.74e-2
Partial deletion of short arm of chromosome 3 Scoliosis 0.001 1 6.71e-2 6.86e-2
3-methylcrotonyl-coa carboxylase deficiency Parkinson disease 0.002 1 6.75e-2 6.90e-2
Craniolenticulosutural dysplasia Insomnia 0.001 1 7.01e-2 7.14e-2
Insomnia Oculocerebrodental syndrome 0.001 1 7.01e-2 7.14e-2
Attention deficit hyperactivity disorder retinitis pigmentosa 18 0.001 1 7.18e-2 7.31e-2
Birk-aharoni syndrome Dementia 0.002 1 7.52e-2 7.65e-2
Obesity opsismodysplasia 0.001 1 7.75e-2 7.88e-2
Bipolar disorder inherited interstitial lung disease 0.001 1 7.92e-2 8.04e-2
Bipolar disorder Oculocerebrodental syndrome 0.001 1 7.92e-2 8.04e-2
Bipolar disorder retinitis pigmentosa 18 0.001 1 7.92e-2 8.04e-2
Metabolic syndrome opsismodysplasia 0.001 1 8.46e-2 8.57e-2
Autism Deafness, y-linked 0.001 1 9.50e-2 9.60e-2
Autism retinitis pigmentosa 18 0.001 1 9.50e-2 9.60e-2
Major depressive disorder Vibratory urticaria 0.001 1 1.27e-1 1.28e-1
Ear disorder Scoliosis 0.001 1 1.30e-1 1.31e-1
Alzheimer disease Vacuolar neuromyopathy 0.000 1 1.44e-1 1.45e-1
Bipolar disorder Birk-aharoni syndrome 0.001 1 1.52e-1 1.53e-1
Auroneurodental syndrome Metabolic syndrome 0.001 1 1.62e-1 1.63e-1
Glyoxalase ii deficiency Schizophrenia 0.000 1 1.65e-1 1.66e-1
hydroxyprolinemia Schizophrenia 0.000 1 1.65e-1 1.66e-1
Oculocerebrodental syndrome Schizophrenia 0.000 1 1.65e-1 1.66e-1
Phosphoribosylaminoimidazole carboxylase deficiency Schizophrenia 0.000 1 1.65e-1 1.66e-1
Alopecia-neurological defects-endocrinopathy syndrome Diabetes mellitus type 2 0.000 1 2.00e-1 2.00e-1
Diabetes mellitus type 2 Oculocerebrodental syndrome 0.000 1 2.00e-1 2.00e-1
Diabetes mellitus type 2 opsismodysplasia 0.000 1 2.00e-1 2.00e-1
Diabetes mellitus type 2 pterin-4 alpha-carbinolamine dehydratase 1 deficiency 0.000 1 2.00e-1 2.00e-1
Diabetes mellitus type 2 siddiqi syndrome 0.000 1 2.00e-1 2.00e-1
Diabetes mellitus type 2 SNUPN-related muscular dystrophy with or without multi-system involvement 0.000 1 2.00e-1 2.00e-1
Diabetes mellitus type 2 Warsaw breakage syndrome 0.000 1 2.00e-1 2.00e-1
Birk-aharoni syndrome Major depressive disorder 0.001 1 2.38e-1 2.39e-1
Alzheimer disease Ear disorder 0.000 1 2.67e-1 2.68e-1
Ear disorder Schizophrenia 0.000 1 3.03e-1 3.03e-1
Auroneurodental syndrome Diabetes mellitus type 2 0.000 1 3.60e-1 3.60e-1