FLRT2 (fibronectin leucine rich transmembrane protein 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 23768
• Gene name: Fibronectin leucine rich transmembrane protein 2
• Gene symbol: FLRT2
• Synonyms (NCBI Gene): -
• Chromosome: 14
• Chromosome location: 14q31.3
• Summary: This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consist

miRNA Show/Hide all (201)

miRTarBase ID	miRNA	Experiments	Reference
MIRT998967	hsa-miR-105	CLIP-seq
MIRT998968	hsa-miR-1229	CLIP-seq
MIRT998969	hsa-miR-125a-5p	CLIP-seq
MIRT998970	hsa-miR-125b	CLIP-seq
MIRT998971	hsa-miR-147	CLIP-seq
MIRT998972	hsa-miR-181a	CLIP-seq
MIRT998973	hsa-miR-181b	CLIP-seq
MIRT998974	hsa-miR-181c	CLIP-seq
MIRT998975	hsa-miR-181d	CLIP-seq
MIRT998976	hsa-miR-202	CLIP-seq
MIRT998977	hsa-miR-221	CLIP-seq
MIRT998978	hsa-miR-222	CLIP-seq
MIRT998979	hsa-miR-224	CLIP-seq
MIRT998980	hsa-miR-3175	CLIP-seq
MIRT998981	hsa-miR-3177-5p	CLIP-seq
MIRT998982	hsa-miR-33a	CLIP-seq
MIRT998983	hsa-miR-33b	CLIP-seq
MIRT998984	hsa-miR-365	CLIP-seq
MIRT998985	hsa-miR-3689d	CLIP-seq
MIRT998986	hsa-miR-3944-5p	CLIP-seq
MIRT998987	hsa-miR-4262	CLIP-seq
MIRT998988	hsa-miR-4269	CLIP-seq
MIRT998989	hsa-miR-4271	CLIP-seq
MIRT998990	hsa-miR-4281	CLIP-seq
MIRT998991	hsa-miR-4289	CLIP-seq
MIRT998992	hsa-miR-4307	CLIP-seq
MIRT998993	hsa-miR-4319	CLIP-seq
MIRT998994	hsa-miR-4463	CLIP-seq
MIRT998995	hsa-miR-4464	CLIP-seq
MIRT998996	hsa-miR-4494	CLIP-seq
MIRT998997	hsa-miR-4514	CLIP-seq
MIRT998998	hsa-miR-4642	CLIP-seq
MIRT998999	hsa-miR-4672	CLIP-seq
MIRT999000	hsa-miR-4685-5p	CLIP-seq
MIRT999001	hsa-miR-4692	CLIP-seq
MIRT999002	hsa-miR-4709-3p	CLIP-seq
MIRT999003	hsa-miR-4711-5p	CLIP-seq
MIRT999004	hsa-miR-4720-5p	CLIP-seq
MIRT999005	hsa-miR-4725-3p	CLIP-seq
MIRT999006	hsa-miR-4732-3p	CLIP-seq
MIRT999007	hsa-miR-4738-3p	CLIP-seq
MIRT999008	hsa-miR-4742-5p	CLIP-seq
MIRT999009	hsa-miR-4748	CLIP-seq
MIRT999010	hsa-miR-4749-3p	CLIP-seq
MIRT999011	hsa-miR-4775	CLIP-seq
MIRT999012	hsa-miR-4799-3p	CLIP-seq
MIRT999013	hsa-miR-499a-5p	CLIP-seq
MIRT999014	hsa-miR-514	CLIP-seq
MIRT999015	hsa-miR-514b-3p	CLIP-seq
MIRT999016	hsa-miR-520d-5p	CLIP-seq
MIRT999017	hsa-miR-524-5p	CLIP-seq
MIRT999018	hsa-miR-548v	CLIP-seq
MIRT999019	hsa-miR-587	CLIP-seq
MIRT999020	hsa-miR-590-3p	CLIP-seq
MIRT999021	hsa-miR-599	CLIP-seq
MIRT999022	hsa-miR-616	CLIP-seq
MIRT999023	hsa-miR-648	CLIP-seq
MIRT999024	hsa-miR-670	CLIP-seq
MIRT1556399	hsa-miR-4724-5p	CLIP-seq
MIRT1996019	hsa-miR-1323	CLIP-seq
MIRT998971	hsa-miR-147	CLIP-seq
MIRT998972	hsa-miR-181a	CLIP-seq
MIRT998973	hsa-miR-181b	CLIP-seq
MIRT998974	hsa-miR-181c	CLIP-seq
MIRT998975	hsa-miR-181d	CLIP-seq
MIRT998979	hsa-miR-224	CLIP-seq
MIRT1996020	hsa-miR-3129-3p	CLIP-seq
MIRT1996021	hsa-miR-3160-5p	CLIP-seq
MIRT998987	hsa-miR-4262	CLIP-seq
MIRT998991	hsa-miR-4289	CLIP-seq
MIRT1996022	hsa-miR-4291	CLIP-seq
MIRT998992	hsa-miR-4307	CLIP-seq
MIRT1996023	hsa-miR-4446-5p	CLIP-seq
MIRT1996024	hsa-miR-4699-5p	CLIP-seq
MIRT999010	hsa-miR-4749-3p	CLIP-seq
MIRT999011	hsa-miR-4775	CLIP-seq
MIRT1996025	hsa-miR-499-3p	CLIP-seq
MIRT1996026	hsa-miR-499a-3p	CLIP-seq
MIRT1996027	hsa-miR-545	CLIP-seq
MIRT1996028	hsa-miR-548a-3p	CLIP-seq
MIRT1996029	hsa-miR-548c-3p	CLIP-seq
MIRT1996030	hsa-miR-548e	CLIP-seq
MIRT1996031	hsa-miR-548f	CLIP-seq
MIRT1996032	hsa-miR-548o	CLIP-seq
MIRT1996033	hsa-miR-548p	CLIP-seq
MIRT1996034	hsa-miR-548q	CLIP-seq
MIRT999019	hsa-miR-587	CLIP-seq
MIRT999021	hsa-miR-599	CLIP-seq
MIRT999022	hsa-miR-616	CLIP-seq
MIRT1996035	hsa-miR-642b	CLIP-seq
MIRT1996036	hsa-miR-944	CLIP-seq
MIRT2230088	hsa-miR-1266	CLIP-seq
MIRT998971	hsa-miR-147	CLIP-seq
MIRT2230089	hsa-miR-2277-3p	CLIP-seq
MIRT2230090	hsa-miR-3120-3p	CLIP-seq
MIRT2230091	hsa-miR-3150a-5p	CLIP-seq
MIRT2230092	hsa-miR-3150b-5p	CLIP-seq
MIRT998981	hsa-miR-3177-5p	CLIP-seq
MIRT2230093	hsa-miR-3660	CLIP-seq
MIRT2230094	hsa-miR-3919	CLIP-seq
MIRT2230095	hsa-miR-421	CLIP-seq
MIRT2230096	hsa-miR-4256	CLIP-seq
MIRT2230097	hsa-miR-4270	CLIP-seq
MIRT2230098	hsa-miR-4441	CLIP-seq
MIRT2230099	hsa-miR-4518	CLIP-seq
MIRT2230100	hsa-miR-4526	CLIP-seq
MIRT2230101	hsa-miR-4709-5p	CLIP-seq
MIRT2230102	hsa-miR-4731-3p	CLIP-seq
MIRT2230103	hsa-miR-4756-3p	CLIP-seq
MIRT2230104	hsa-miR-4761-5p	CLIP-seq
MIRT2230105	hsa-miR-4796-3p	CLIP-seq
MIRT2230106	hsa-miR-4801	CLIP-seq
MIRT2230107	hsa-miR-520g	CLIP-seq
MIRT2230108	hsa-miR-520h	CLIP-seq
MIRT1996027	hsa-miR-545	CLIP-seq
MIRT1996028	hsa-miR-548a-3p	CLIP-seq
MIRT1996030	hsa-miR-548e	CLIP-seq
MIRT1996031	hsa-miR-548f	CLIP-seq
MIRT999021	hsa-miR-599	CLIP-seq
MIRT2533921	hsa-miR-1265	CLIP-seq
MIRT2533922	hsa-miR-1273g	CLIP-seq
MIRT2533923	hsa-miR-127-5p	CLIP-seq
MIRT2533924	hsa-miR-129-5p	CLIP-seq
MIRT2533925	hsa-miR-1305	CLIP-seq
MIRT2533926	hsa-miR-140-5p	CLIP-seq
MIRT998972	hsa-miR-181a	CLIP-seq
MIRT998973	hsa-miR-181b	CLIP-seq
MIRT998974	hsa-miR-181c	CLIP-seq
MIRT998975	hsa-miR-181d	CLIP-seq
MIRT2533927	hsa-miR-182	CLIP-seq
MIRT2533928	hsa-miR-2054	CLIP-seq
MIRT2230090	hsa-miR-3120-3p	CLIP-seq
MIRT2533929	hsa-miR-3148	CLIP-seq
MIRT2533930	hsa-miR-3152-5p	CLIP-seq
MIRT2533931	hsa-miR-3185	CLIP-seq
MIRT2533932	hsa-miR-3200-3p	CLIP-seq
MIRT2533933	hsa-miR-325	CLIP-seq
MIRT2533934	hsa-miR-340	CLIP-seq
MIRT2533935	hsa-miR-34b	CLIP-seq
MIRT2533936	hsa-miR-3614-5p	CLIP-seq
MIRT2533937	hsa-miR-3646	CLIP-seq
MIRT2533938	hsa-miR-3662	CLIP-seq
MIRT2533939	hsa-miR-3667-5p	CLIP-seq
MIRT2533940	hsa-miR-3682-5p	CLIP-seq
MIRT2533941	hsa-miR-370	CLIP-seq
MIRT2533942	hsa-miR-3713	CLIP-seq
MIRT2230094	hsa-miR-3919	CLIP-seq
MIRT2533943	hsa-miR-411	CLIP-seq
MIRT2533944	hsa-miR-412	CLIP-seq
MIRT2230095	hsa-miR-421	CLIP-seq
MIRT998987	hsa-miR-4262	CLIP-seq
MIRT2533945	hsa-miR-4297	CLIP-seq
MIRT2533946	hsa-miR-4521	CLIP-seq
MIRT2533947	hsa-miR-4528	CLIP-seq
MIRT2230101	hsa-miR-4709-5p	CLIP-seq
MIRT2230103	hsa-miR-4756-3p	CLIP-seq
MIRT2533948	hsa-miR-4774-3p	CLIP-seq
MIRT2230105	hsa-miR-4796-3p	CLIP-seq
MIRT2533949	hsa-miR-498	CLIP-seq
MIRT2230107	hsa-miR-520g	CLIP-seq
MIRT2230108	hsa-miR-520h	CLIP-seq
MIRT2533950	hsa-miR-532-5p	CLIP-seq
MIRT1996027	hsa-miR-545	CLIP-seq
MIRT1996029	hsa-miR-548c-3p	CLIP-seq
MIRT2533951	hsa-miR-563	CLIP-seq
MIRT2533952	hsa-miR-600	CLIP-seq
MIRT2533953	hsa-miR-603	CLIP-seq
MIRT998967	hsa-miR-105	CLIP-seq
MIRT2533921	hsa-miR-1265	CLIP-seq
MIRT2533923	hsa-miR-127-5p	CLIP-seq
MIRT998972	hsa-miR-181a	CLIP-seq
MIRT998973	hsa-miR-181b	CLIP-seq
MIRT998974	hsa-miR-181c	CLIP-seq
MIRT998975	hsa-miR-181d	CLIP-seq
MIRT2533927	hsa-miR-182	CLIP-seq
MIRT2533928	hsa-miR-2054	CLIP-seq
MIRT2533931	hsa-miR-3185	CLIP-seq
MIRT2533932	hsa-miR-3200-3p	CLIP-seq
MIRT2533933	hsa-miR-325	CLIP-seq
MIRT2533934	hsa-miR-340	CLIP-seq
MIRT2533936	hsa-miR-3614-5p	CLIP-seq
MIRT2533937	hsa-miR-3646	CLIP-seq
MIRT998984	hsa-miR-365	CLIP-seq
MIRT2533938	hsa-miR-3662	CLIP-seq
MIRT2533939	hsa-miR-3667-5p	CLIP-seq
MIRT2533941	hsa-miR-370	CLIP-seq
MIRT2230094	hsa-miR-3919	CLIP-seq
MIRT2533943	hsa-miR-411	CLIP-seq
MIRT2533944	hsa-miR-412	CLIP-seq
MIRT998987	hsa-miR-4262	CLIP-seq
MIRT998991	hsa-miR-4289	CLIP-seq
MIRT2533945	hsa-miR-4297	CLIP-seq
MIRT2533947	hsa-miR-4528	CLIP-seq
MIRT999000	hsa-miR-4685-5p	CLIP-seq
MIRT999010	hsa-miR-4749-3p	CLIP-seq
MIRT2230103	hsa-miR-4756-3p	CLIP-seq
MIRT999016	hsa-miR-520d-5p	CLIP-seq
MIRT999017	hsa-miR-524-5p	CLIP-seq
MIRT2533950	hsa-miR-532-5p	CLIP-seq
MIRT2533952	hsa-miR-600	CLIP-seq
MIRT2533953	hsa-miR-603	CLIP-seq

Gene ontology (GO) Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003007	Process	Heart morphogenesis	IEA
GO:0003007	Process	Heart morphogenesis	ISS
GO:0005104	Function	Fibroblast growth factor receptor binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	NAS	10644439
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IEA
GO:0005911	Component	Cell-cell junction	ISS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IEA
GO:0005925	Component	Focal adhesion	IEA
GO:0005925	Component	Focal adhesion	ISS
GO:0007155	Process	Cell adhesion	IEA
GO:0007411	Process	Axon guidance	IEA
GO:0008543	Process	Fibroblast growth factor receptor signaling pathway	IEA
GO:0008543	Process	Fibroblast growth factor receptor signaling pathway	ISS
GO:0016020	Component	Membrane	IEA
GO:0030054	Component	Cell junction	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	NAS	10644439
GO:0031012	Component	Extracellular matrix	NAS	10644439
GO:0042734	Component	Presynaptic membrane	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045499	Function	Chemorepellent activity	IEA
GO:0050919	Process	Negative chemotaxis	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0061343	Process	Cell adhesion involved in heart morphogenesis	IEA
GO:0061343	Process	Cell adhesion involved in heart morphogenesis	ISS
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070161	Component	Anchoring junction	IEA
GO:0071711	Process	Basement membrane organization	IEA
GO:0071711	Process	Basement membrane organization	ISS
GO:0098978	Component	Glutamatergic synapse	IEA
GO:2001222	Process	Regulation of neuron migration	IEA

Other IDs

• MIM: 604807
• HGNC: 3761
• e!Ensembl: ENSG00000185070

Protein

• UniProt ID: O43155
• Protein name: Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2)
• Protein function: Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migr
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00041	fn3	423 → 496	Fibronectin type III domain	Domain
  PF01463	LRRCT	336 → 361	Leucine rich repeat C-terminal domain	Family
  PF13855	LRR_8	252 → 311	Leucine rich repeat	Repeat
  PF13855	LRR_8	181 → 242	Leucine rich repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed in pancreas, skeletal muscle, brain, and heart. {ECO:0000269|PubMed:10644439}.
• Sequence:

  MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLG
  IPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENN
  IQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPV
  DLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRN
  SLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLS
  NLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSC
  PTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPP
  ISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSL
  VNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSP
  FLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSIL
  EMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT
  

• Sequence length: 660

Pathways

Reactome Pathway:

Downstream signaling of activated FGFR1

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	35589863	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CATARACT	—	GWAS catalog	32514122	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (14)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Atherosclerosis	Atherosclerosis	Pubtator	37370144	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28325946, 29487336		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28325946, 40644891	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	34689221	Associate	★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	37370144	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	22747982		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28325946, 29487336		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	26890304		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28325946		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28325946		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	26890304		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	26890304, 37960876	Associate	★☆☆☆☆ Found in Text Mining only
Sleep Apnea, Obstructive	Sleep Apnea	BEFREE	24732660		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	30702489	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for FLRT2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to FLRT2.