Gene Gene information from NCBI Gene database.
Entrez ID 805
Gene name Calmodulin 2
Gene symbol CALM2
Synonyms (NCBI Gene)
CALMCALML2CAM1CAM3CAMCCAMIICAMIIILQT15PHKDPHKD2caM
Chromosome 2
Chromosome location 2p21
Summary This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role
miRNA miRNA information provided by mirtarbase database.
696
miRTarBase ID miRNA Experiments Reference
MIRT005904 hsa-miR-1-3p qRT-PCR 21169019
MIRT005904 hsa-miR-1-3p Proteomics 18668040
MIRT040483 hsa-miR-598-3p CLASH 23622248
MIRT507911 hsa-miR-130a-3p HITS-CLIP 21572407
MIRT507910 hsa-miR-3666 HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
86
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle IEA
GO:0000922 Component Spindle pole IDA 16760425
GO:0000922 Component Spindle pole IEA
GO:0002027 Process Regulation of heart rate IEA
GO:0002027 Process Regulation of heart rate IMP 23040497
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
114182 1445 ENSG00000143933
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
16
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Cardiovascular phenotype Pathogenic rs398124647 RCV005532578
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Long QT syndrome Pathogenic rs398124647 RCV003318349
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Long QT syndrome 1 Pathogenic; Likely pathogenic rs398124647, rs398124648, rs398124650, rs398124649, rs2103823599, rs2103823638, rs2103823612, rs2103821507, rs730882254, rs2465708816, rs1558693760, rs1573214371, rs1573214163, rs1687164164 RCV000143836
RCV000143837
RCV000143838
RCV000143839
RCV000143840
View all (10 more)
★★★★★
ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Long QT syndrome 15 Pathogenic; Likely pathogenic rs398124647, rs398124648, rs398124650, rs398124649, rs730882254, rs2465707237, rs1553431702, rs1573214371, rs1573214163 RCV000162067
RCV000162068
RCV000162069
RCV000162066
RCV000162070
View all (5 more)
★★★★★
ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ARRHYTHMIAS, CARDIAC CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CALM2-related disorder Uncertain significance; Benign; Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CANNABIS ABUSE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute leukemia Leukemia BEFREE 16956826, 17804713, 18094714, 20007546
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 10637482, 10637483, 16491119, 23831922
★☆☆☆☆
Found in Text Mining only
Acute Megakaryocytic Leukemias Megakaryocytic Leukemia BEFREE 11417476
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 8169749
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 26824338
★☆☆☆☆
Found in Text Mining only
Adenoid Cystic Carcinoma Adenocarcinoma BEFREE 9374166
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 10637482, 16491119
★☆☆☆☆
Found in Text Mining only
Adult Acute Myeloblastic Leukemia Myeloblastic Leukemia BEFREE 10637482
★☆☆☆☆
Found in Text Mining only
Adult onset autosomal dominant leukodystrophy Leukodystrophy BEFREE 19725832
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 31984950 Associate
★☆☆☆☆
Found in Text Mining only