Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
ALZHEIMER DISEASE	MONDO_0004975	APP	Causal	33589840 34099642 34493870 35379992 35851147 37198259 37985413	GWAS catalog	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
		GRN	Causal	35379992 37198259 37985413	GWAS catalog	Neutrophil degranulation
		MAPT	Causal	34743297	GWAS catalog	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
		AARS2	Unknown	30514930	GWAS catalog	Aminoacyl-tRNA biosynthesis
		ABAT	Unknown	35851147	GWAS catalog	Alanine, aspartate and glutamate metabolism Valine, leucine and isoleucine degradation beta-Alanine metabolism +5 more
		ABCA1	Unknown	21116278 26993346 30805717 35379992 37198259 37985413	GWAS catalog	ABC transporters Efferocytosis Fat digestion and absorption +6 more
		ABCA6	Unknown	39998322	GWAS catalog	ABC transporters ABC transporters in lipid homeostasis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
		ABCA7	Unknown	21460840 21460841 23571587 24162737 30617256 31473137 33074286 33589840 34493870 34743297 35379992 35589863 35770850 37198259 37985413 39129223 39537608 40676597	GWAS catalog	ABC transporters ABC transporters in lipid homeostasis
		ABCA8	Unknown	26830138	GWAS catalog	ABC transporters ABC-family proteins mediated transport
		ABCB9	Unknown	34743297	GWAS catalog	ABC transporters Lysosome ABC-family proteins mediated transport
		ABCD2	Unknown	35589863	GWAS catalog	ABC transporters Peroxisome ABC transporters in lipid homeostasis +1 more
		ABCF3	Unknown	37198259	GWAS catalog	—
		ABCG8	Unknown	35851147	GWAS catalog	ABC transporters Fat digestion and absorption Bile secretion +5 more
		ABHD1	Unknown	39998322	GWAS catalog	—
		ABHD12	Unknown	35589863	GWAS catalog	Arachidonate production from DAG
		ABHD17A	Unknown	39998322	GWAS catalog	—
		ABI3	Unknown	35379992 35851147 37985413 39129223	GWAS catalog	—
		ABRAXAS2	Unknown	39998322	GWAS catalog	Metalloprotease DUBs
		ABT1	Unknown	35589863	GWAS catalog	—
		ACBD5	Unknown	39998322	GWAS catalog	Peroxisomal lipid metabolism Class I peroxisomal membrane protein import
		ACE	Unknown	33541420 33589840 35589863 35851147 37198259	GWAS catalog	Renin-angiotensin system Renin secretion Chagas disease +4 more
		ACER1	Unknown	39998322	GWAS catalog	Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway +1 more
		ACER3	Unknown	33074286	GWAS catalog	Sphingolipid metabolism Metabolic pathways Sphingolipid de novo biosynthesis
		ACKR2	Unknown	25340798	GWAS catalog	Chemokine receptors bind chemokines
		ACMSD	Unknown	33541420	GWAS catalog	Tryptophan metabolism Metabolic pathways
		ACOX1	Unknown	39998322	GWAS catalog	Fatty acid degradation beta-Alanine metabolism alpha-Linolenic acid metabolism +13 more
		ACP7	Unknown	39998322	GWAS catalog	—
		ACSL6	Unknown	25778476	GWAS catalog	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +7 more
		ACTB	Unknown	39998322	GWAS catalog	ATP-dependent chromatin remodeling Rap1 signaling pathway Phagosome +54 more
		ACTL6B	Unknown	39998322	GWAS catalog	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ACTN4	Unknown	39537608	GWAS catalog	Focal adhesion Adherens junction Tight junction +7 more
		ACTR3C	Unknown	39998322	GWAS catalog	Endocytosis Tight junction Fc gamma R-mediated phagocytosis +6 more
		ADAD2	Unknown	38184787	GWAS catalog	—
		ADAM10	Unknown	30617256 30820047 33541420 33589840 39537608	GWAS catalog	Efferocytosis Alzheimer disease Epithelial cell signaling in Helicobacter pylori infection +10 more
		ADAM17	Unknown	35379992 37198259 39998322	GWAS catalog	Efferocytosis Notch signaling pathway TNF signaling pathway +10 more
		ADAMTS1	Unknown	30820047 33589840 35379992 37198259 37985413	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS18	Unknown	35851147	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS2	Unknown	40708016	GWAS catalog	Collagen biosynthesis and modifying enzymes Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS20	Unknown	24162737 30820047	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS4	Unknown	30617256 33541420 35589863 37198259 39537608	GWAS catalog	Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADARB1	Unknown	39998322	GWAS catalog	C6 deamination of adenosine Formation of editosomes by ADAR proteins
		ADARB2	Unknown	39998322	GWAS catalog	—
		ADCK1	Unknown	39998322	GWAS catalog	—
		ADCY8	Unknown	21116278	GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		ADCYAP1R1	Unknown	26830138	GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment +5 more
		ADGRA3	Unknown	39998322	GWAS catalog	—
		ADGRB3	Unknown	35851147	GWAS catalog	—
		ADGRE1	Unknown	40708016	GWAS catalog	Class B/2 (Secretin family receptors)
		ADGRE3	Unknown	39998322	GWAS catalog	Class B/2 (Secretin family receptors) Neutrophil degranulation
		ADGRG4	Unknown	39250132	GWAS catalog	—
ALZHEIMER DISEASE 18	C3810041 MONDO:0014265 OMIM:615590	ADAM10	Unknown	—	CTD, ClinVar, Disgenet	Efferocytosis Alzheimer disease Epithelial cell signaling in Helicobacter pylori infection +10 more
ALZHEIMER DISEASE 9	MESH:C563834 MONDO:0012153	ABCA7	Causal	104220 23029339 24878767 25807283 26101835 26141617 27066581 28447221 29181857 29504051 29782324 30210277 30911827 30917570 30924900 31182772 31381512 31405128 31410005 32317127 32844072	CTD, ClinVar	ABC transporters ABC transporters in lipid homeostasis
ALZHEIMER DISEASE TYPE 1	MONDO:0007088	APP	Causal	—	ClinVar, GenCC	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
ALZHEIMER DISEASE, FAMILIAL, 1	104300 C1863052	APP	Unknown	—	Disgenet, HPO	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
ALZHEIMERS DISEASE	C0002395	ABAT	Unknown	—	Disgenet	Alanine, aspartate and glutamate metabolism Valine, leucine and isoleucine degradation beta-Alanine metabolism +5 more
		ABCA1	Unknown	—	Disgenet	ABC transporters Efferocytosis Fat digestion and absorption +6 more
		ABCA7	Unknown	—	Disgenet	ABC transporters ABC transporters in lipid homeostasis
		ABI3	Unknown	—	Disgenet	—
		ACE	Unknown	—	Disgenet	Renin-angiotensin system Renin secretion Chagas disease +4 more
		ADAM10	Unknown	—	Disgenet	Efferocytosis Alzheimer disease Epithelial cell signaling in Helicobacter pylori infection +10 more
		ADAM17	Unknown	—	Disgenet	Efferocytosis Notch signaling pathway TNF signaling pathway +10 more
		ADAMTS1	Unknown	—	Disgenet	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		APP	Unknown	—	Disgenet	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
		GRN	Unknown	—	Disgenet	Neutrophil degranulation
		MAPT	Unknown	—	Disgenet	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
EARLY-ONSET ALZHEIMERS DISEASE	EFO_0022957	ADAMTS2	Unknown	39023044	GWAS catalog	Collagen biosynthesis and modifying enzymes Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
EARLY-ONSET AUTOSOMAL DOMINANT ALZHEIMER DISEASE	1020 MONDO:0015140	APP	Unknown	20301414	GWAS catalog, Orphanet	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
FAMILIAL ALZHEIMER DISEASE	C0276496	APP	Unknown	—	Disgenet	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
LATE-ONSET ALZHEIMER'S DISEASE	EFO_1001870	ABCA7	Unknown	21460841 23571587 24162737 30617256 34493870 38958117	GWAS catalog	ABC transporters ABC transporters in lipid homeostasis
		ABCA8	Unknown	27770636	GWAS catalog	ABC transporters ABC-family proteins mediated transport
		ABI3	Unknown	28714976	GWAS catalog	—
		ACTR3C	Unknown	27770636	GWAS catalog	Endocytosis Tight junction Fc gamma R-mediated phagocytosis +6 more
		ADAM10	Unknown	30820047	GWAS catalog	Efferocytosis Alzheimer disease Epithelial cell signaling in Helicobacter pylori infection +10 more
		ADAMTS1	Unknown	30820047	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS20	Unknown	24162737 30820047	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		APP	Unknown	34493870	GWAS catalog	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
PRIMARY DEGENERATIVE DEMENTIA OF THE ALZHEIMER TYPE, PRESENILE ONSET	C5779573	APP	Causal	—	Disgenet	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
	C5779573	ABCA7	Unknown	—	Disgenet	ABC transporters ABC transporters in lipid homeostasis

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Alzheimer disease

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