Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	9542
Gene name	Neuregulin 2
Gene symbol	NRG2
Synonyms (NCBI Gene)	DON1HRG2NTAK
Chromosome	5
Chromosome location	5q31.2
Summary	This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of

166 Show/Hide all (166)

miRTarBase ID	miRNA	Experiments	Reference
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612709	hsa-miR-8485	HITS-CLIP	23824327
MIRT612708	hsa-miR-4654	HITS-CLIP	23824327
MIRT612707	hsa-miR-4769-5p	HITS-CLIP	23824327
MIRT612706	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT612705	hsa-miR-5089-5p	HITS-CLIP	23824327
MIRT1193915	hsa-miR-1252	CLIP-seq
MIRT1193916	hsa-miR-1253	CLIP-seq
MIRT1193917	hsa-miR-1908	CLIP-seq
MIRT1193918	hsa-miR-3178	CLIP-seq
MIRT1193919	hsa-miR-3184	CLIP-seq
MIRT1193920	hsa-miR-3960	CLIP-seq
MIRT1193921	hsa-miR-423-5p	CLIP-seq
MIRT1193922	hsa-miR-4479	CLIP-seq
MIRT1193923	hsa-miR-4694-5p	CLIP-seq
MIRT1193924	hsa-miR-522	CLIP-seq
MIRT1193925	hsa-miR-658	CLIP-seq
MIRT1193926	hsa-miR-663	CLIP-seq
MIRT1193927	hsa-miR-744	CLIP-seq
MIRT2284813	hsa-miR-766	CLIP-seq

15 Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005102	Function	Signaling receptor binding	TAS
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	TAS	9168115
GO:0007399	Process	Nervous system development	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0038130	Process	ERBB4 signaling pathway	IBA
GO:0048513	Process	Animal organ development	IBA

MIM	HGNC	e!Ensembl
603818	7998	ENSG00000158458

O14511

Protein name

Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]

Protein function

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerizatio

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02158	Neuregulin	430 → 831	Neuregulin intracellular region	Disordered
PF07679	I-set	238 → 328	Immunoglobulin I-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Restricted to the cerebellum in the adult.

Sequence

MRQVCCSALPPPPLEKGRCSSYSDSSSSSSERSSSSSSSSSESGSSSRSSSNNSSISRPA
APPEPRPQQQPQPRSPAARRAAARSRAAAAGGMRRDPAPGFSMLLFGVSLACYSPSLKSV
QDQAYKAPVVVEGKVQGLVPAGGSSSNSTREPPASGRVALVKVLDKWPLRSGGLQREQVI
SVGSCVPLERNQRYIFFLEPTEQPLVFKTAFAPLDTNGKNLKKEVGKILCTDCATRPKLK
KMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNK
VKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCY
YIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKRVLTITGICVALLVVG
IVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPA
TDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLS
SVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPA
RLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGP
GPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECA
PPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDD
ADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPP
PRAKQDSAPL

Sequence length

850

Interactions

View interactions

KEGG Pathway	Reactome Pathway
EGFR tyrosine kinase inhibitor resistance	Signaling by ERBB2
ErbB signaling pathway	Signaling by ERBB4
Amyotrophic lateral sclerosis	SHC1 events in ERBB2 signaling
	PI3K events in ERBB4 signaling
	SHC1 events in ERBB4 signaling
	PIP3 activates AKT signaling
	GRB7 events in ERBB2 signaling
	Downregulation of ERBB2:ERBB3 signaling
	GRB2 events in ERBB2 signaling
	PI3K events in ERBB2 signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	RAF/MAP kinase cascade
	ERBB2 Regulates Cell Motility
	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
	ERBB2 Activates PTK6 Signaling
	Downregulation of ERBB2 signaling
	Signaling by ERBB2 KD Mutants
	Signaling by ERBB2 TMD/JMD mutants

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (7)
ASTROCYTOMA	—	GWAS catalog	36810956	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism spectrum disorder	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Conflicting classifications of pathogenicity	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DISABILITY	—	Disgenet, GenCC Disgenet, GenCC	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	35396580	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Conflicting classifications of pathogenicity	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (20)
Breast Neoplasms	Breast neoplasm	Pubtator	17962208, 23912956, 33176622	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Charcot-Marie-Tooth Disease	Charcot-Marie-Tooth Disease	BEFREE	10369162		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	BEFREE	17563728		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	Pubtator	17563728	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma 1 Open Angle A	Glaucoma	Pubtator	17563728	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma, Open-Angle	Glaucoma	LHGDN	17563728		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	34054873	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	34054873, 34284546	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington disease	Pubtator	33049985	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	28722770		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	17962208		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30637711		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30123134		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	17962208		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	BEFREE	28322273, 31838721		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	35677537	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30637711		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	32264916	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	28322273		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30123134		★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
NRG1	[]	20	["EGFR tyrosine kinase inhibitor resistance","ErbB signaling pathway","PIP3 activates AKT signaling","Downregulation of ERBB2:ERBB3 signaling","RAF\/MAP kinase cascade","Downregulation of ERBB2 signaling","Signaling by ERBB2","Signaling by ERBB4","SHC1 events in ERBB2 signaling","PI3K events in ERBB4 signaling","SHC1 events in ERBB4 signaling","GRB2 events in ERBB2 signaling"]	[]
NRG3	[]	17	["ErbB signaling pathway","PIP3 activates AKT signaling","RAF\/MAP kinase cascade","Downregulation of ERBB2 signaling","Signaling by ERBB2","Signaling by ERBB4","SHC1 events in ERBB2 signaling","PI3K events in ERBB4 signaling","SHC1 events in ERBB4 signaling","GRB2 events in ERBB2 signaling","PI3K events in ERBB2 signaling","Constitutive Signaling by Aberrant PI3K in Cancer"]	[]
NRG4	[]	17	["ErbB signaling pathway","PIP3 activates AKT signaling","RAF\/MAP kinase cascade","Downregulation of ERBB2 signaling","Signaling by ERBB2","Signaling by ERBB4","SHC1 events in ERBB2 signaling","PI3K events in ERBB4 signaling","SHC1 events in ERBB4 signaling","GRB2 events in ERBB2 signaling","PI3K events in ERBB2 signaling","Constitutive Signaling by Aberrant PI3K in Cancer"]	[]
ERBB3	[]	17	["EGFR tyrosine kinase inhibitor resistance","ErbB signaling pathway","PIP3 activates AKT signaling","Downregulation of ERBB2:ERBB3 signaling","RAF\/MAP kinase cascade","Downregulation of ERBB2 signaling","Signaling by ERBB2","Signaling by ERBB4","SHC1 events in ERBB2 signaling","PI3K events in ERBB2 signaling","Constitutive Signaling by Aberrant PI3K in Cancer","ERBB2 Regulates Cell Motility"]	[]
ERBB4	[]	17	["ErbB signaling pathway","PIP3 activates AKT signaling","RAF\/MAP kinase cascade","Downregulation of ERBB2 signaling","Signaling by ERBB2","Signaling by ERBB4","SHC1 events in ERBB2 signaling","PI3K events in ERBB4 signaling","SHC1 events in ERBB4 signaling","GRB2 events in ERBB2 signaling","PI3K events in ERBB2 signaling","Constitutive Signaling by Aberrant PI3K in Cancer"]	[]

NRG2 (neuregulin 2)

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