Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
DEPRESSION, POSTPARTUM	C0221074	HP1BP3	Unknown	—	Disgenet	—
		HTR1A	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		MTHFR	Unknown	—	Disgenet	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		OPRM1	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Estrogen signaling pathway +6 more
		PER2	Unknown	—	Disgenet	Circadian rhythm Circadian entrainment Transcriptional misregulation in cancer +1 more
		SLC6A4	Unknown	—	Disgenet	Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft
		TPH1	Unknown	—	Disgenet	Tryptophan metabolism Folate biosynthesis Metabolic pathways +3 more
		TTC9B	Unknown	—	Disgenet	—
DEPRESSIVE DISORDER	C0011581 MESH:D003866 MONDO:0002050 MONDO_0002050	A2M	Unknown	—	Disgenet	Complement and coagulation cascades Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation +3 more
		AANAT	Unknown	—	Disgenet	Tryptophan metabolism Metabolic pathways Serotonin and melatonin biosynthesis
		ABCB1	Unknown	—	Disgenet	ABC transporters Bile secretion MicroRNAs in cancer +2 more
		ACE	Unknown	—	Disgenet	Renin-angiotensin system Renin secretion Chagas disease +4 more
		ACSL4	Unknown	15108178	CTD	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +8 more
		ADCY5	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +66 more
		ADCY7	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +58 more
		ADCY8	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		ADCYAP1	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment +5 more
		ADORA2A	Unknown	26860412	CTD	Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway +8 more
		ADRA2A	Unknown	—	Disgenet	cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		ADRB1	Unknown	—	Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +12 more
		AGT	Unknown	—	Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +18 more
		AKT1	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ALB	Unknown	9029664	CTD	Thyroid hormone synthesis Platelet degranulation Recycling of bile acids and salts +7 more
		ALG8	Unknown	—	Disgenet	N-Glycan biosynthesis Metabolic pathways Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein +1 more
		ALK	Unknown	—	Disgenet	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		ANKK1	Unknown	—	Disgenet	—
		APAF1	Unknown	—	Disgenet, GenCC	Platinum drug resistance p53 signaling pathway Apoptosis +24 more
		APP	Unknown	—	Disgenet	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
		APRT	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Nucleotide metabolism +2 more
		AQP4	Unknown	—	Disgenet	Vasopressin-regulated water reabsorption Bile secretion Vasopressin regulates renal water homeostasis via Aquaporins +1 more
		AR	Unknown	—	Disgenet	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARHGEF10	Unknown	—	Disgenet	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARRB2	Unknown	—	Disgenet	MAPK signaling pathway Chemokine signaling pathway Endocytosis +21 more
		ARTN	Unknown	—	Disgenet	MAPK signaling pathway PI3K-Akt signaling pathway RAF/MAP kinase cascade +1 more
		ASMT	Unknown	—	Disgenet	Tryptophan metabolism Metabolic pathways Serotonin and melatonin biosynthesis
		ATF3	Unknown	—	Disgenet	Response of EIF2AK1 (HRI) to heme deficiency
		ATF4	Unknown	—	Disgenet	MAPK signaling pathway cGMP-PKG signaling pathway Mitophagy - animal +41 more
		ATP1A3	Unknown	—	Disgenet	cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction +18 more
		ATP2A2	Unknown	—	Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +16 more
		ATXN3	Unknown	—	Disgenet	Protein processing in endoplasmic reticulum Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases +2 more
		BAG1	Unknown	—	Disgenet	Protein processing in endoplasmic reticulum Regulation of HSF1-mediated heat shock response
		BCL2	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +46 more
		BDNF	Unknown	16330021 21945287	CTD, Disgenet	MAPK signaling pathway Ras signaling pathway cAMP signaling pathway +9 more
		BICC1	Unknown	—	Disgenet	—
		BMAL1	Unknown	—	Disgenet	—
		BMP1	Unknown	34985809	GWAS catalog	Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation +2 more
		BRCA1	Unknown	—	Disgenet	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRINP1	Unknown	34985809	GWAS catalog	—
		CACNA1C	Unknown	—	Disgenet	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +34 more
		CADM1	Unknown	22113448	CTD	Cell adhesion molecules Adherens junctions interactions Nectin/Necl trans heterodimerization
		HTR1A	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		MTHFR	Unknown	17074966	CTD, Disgenet	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		OPRM1	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Estrogen signaling pathway +6 more
		PER2	Unknown	—	Disgenet	Circadian rhythm Circadian entrainment Transcriptional misregulation in cancer +1 more
		SLC6A4	Unknown	12898347 18458677 18686203 21843009	CTD, Disgenet	Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft
		TPH1	Unknown	—	Disgenet	Tryptophan metabolism Folate biosynthesis Metabolic pathways +3 more
DEPRESSIVE DISORDER, MAJOR	MESH:D003865	CACNA1C	Unknown	28696432	CTD	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +34 more
DEPRESSIVE DISORDER, MAJOR	MESH:D003865	SLC6A4	Unknown	16055263	CTD	Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft
DEPRESSIVE DISORDER, TREATMENT-RESISTANT	C2063866	SLC6A4	Unknown	—	Disgenet	Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft
MAJOR DEPRESSION, SINGLE EPISODE	C0024517	CACNA1C	Unknown	—	Disgenet	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +34 more
		HTR1A	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		SLC6A4	Unknown	—	Disgenet	Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft
		TPH1	Unknown	—	Disgenet	Tryptophan metabolism Folate biosynthesis Metabolic pathways +3 more
MAJOR DEPRESSIVE DISORDER	C1269683 MONDO_0002009	ABCB1	Unknown	—	Disgenet	ABC transporters Bile secretion MicroRNAs in cancer +2 more
		ACE	Unknown	—	Disgenet	Renin-angiotensin system Renin secretion Chagas disease +4 more
		ADCY5	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +66 more
		ADCY7	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +58 more
		ALG8	Unknown	30219690	GWAS catalog	N-Glycan biosynthesis Metabolic pathways Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein +1 more
		ANKK1	Unknown	30643256 36738649 38177345	GWAS catalog	—
		APAF1	Unknown	—	Disgenet	Platinum drug resistance p53 signaling pathway Apoptosis +24 more
		APRT	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Nucleotide metabolism +2 more
		ARHGEF10	Unknown	34586374	GWAS catalog	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARTN	Unknown	—	Disgenet	MAPK signaling pathway PI3K-Akt signaling pathway RAF/MAP kinase cascade +1 more
		ATP2A2	Unknown	31835028 34924174	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +16 more
		BDNF	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway cAMP signaling pathway +9 more
		BMAL1	Unknown	24528284 33296963	GWAS catalog	—
		BRINP1	Unknown	29942085 30643256 31926635 31969693 34045744 36738649 37106081 37464041 37985818 38177345	GWAS catalog	—
		CACNA1C	Unknown	20351715 23453885 30626913 31835028 31926635 33483693 37464041	Disgenet, GWAS catalog	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +34 more
		CADM1	Unknown	33686288 34734193	GWAS catalog	Cell adhesion molecules Adherens junctions interactions Nectin/Necl trans heterodimerization
		HTR1A	Unknown	29317602	Disgenet, GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		MTHFR	Unknown	34734193	Disgenet, GWAS catalog	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		SLC6A4	Unknown	—	Disgenet	Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft
		TPH1	Unknown	—	Disgenet	Tryptophan metabolism Folate biosynthesis Metabolic pathways +3 more
MENTAL DEPRESSION	C0011570	A2M	Unknown	—	Disgenet	Complement and coagulation cascades Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation +3 more
		AANAT	Unknown	—	Disgenet	Tryptophan metabolism Metabolic pathways Serotonin and melatonin biosynthesis
		ABCB1	Unknown	—	Disgenet	ABC transporters Bile secretion MicroRNAs in cancer +2 more
		ACSL4	Unknown	—	Disgenet	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +8 more
		ADCY5	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +66 more
		ADCY7	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +58 more
		ADCY8	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		ADCYAP1	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment +5 more
		ADORA2A	Unknown	—	Disgenet	Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway +8 more
		ADRA2A	Unknown	—	Disgenet	cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		ADRB1	Unknown	—	Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +12 more
		AGT	Unknown	—	Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +18 more
		AKT1	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ALB	Unknown	—	Disgenet	Thyroid hormone synthesis Platelet degranulation Recycling of bile acids and salts +7 more
		ALK	Unknown	—	Disgenet	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		ANKK1	Unknown	—	Disgenet	—
		APP	Unknown	—	Disgenet	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
		APRT	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Nucleotide metabolism +2 more
		AQP4	Unknown	—	Disgenet	Vasopressin-regulated water reabsorption Bile secretion Vasopressin regulates renal water homeostasis via Aquaporins +1 more
		AR	Unknown	—	Disgenet	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARHGEF10	Unknown	—	Disgenet	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARRB2	Unknown	—	Disgenet	MAPK signaling pathway Chemokine signaling pathway Endocytosis +21 more
		ARTN	Unknown	—	Disgenet	MAPK signaling pathway PI3K-Akt signaling pathway RAF/MAP kinase cascade +1 more
		ASMT	Unknown	—	Disgenet	Tryptophan metabolism Metabolic pathways Serotonin and melatonin biosynthesis
		ATF3	Unknown	—	Disgenet	Response of EIF2AK1 (HRI) to heme deficiency
		ATF4	Unknown	—	Disgenet	MAPK signaling pathway cGMP-PKG signaling pathway Mitophagy - animal +41 more
		ATP1A3	Unknown	—	Disgenet	cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction +18 more
		ATP2A2	Unknown	—	Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +16 more
		ATXN3	Unknown	—	Disgenet	Protein processing in endoplasmic reticulum Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases +2 more
		BAG1	Unknown	—	Disgenet	Protein processing in endoplasmic reticulum Regulation of HSF1-mediated heat shock response
		BDNF	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway cAMP signaling pathway +9 more
		BICC1	Unknown	—	Disgenet	—
		BMAL1	Unknown	—	Disgenet	—
		BRCA1	Unknown	—	Disgenet	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		CACNA1C	Unknown	—	Disgenet	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +34 more
		CADM1	Unknown	—	Disgenet	Cell adhesion molecules Adherens junctions interactions Nectin/Necl trans heterodimerization
		HTR1A	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		MTHFR	Unknown	—	Disgenet	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		OPRM1	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Estrogen signaling pathway +6 more
		PER2	Unknown	—	Disgenet	Circadian rhythm Circadian entrainment Transcriptional misregulation in cancer +1 more
		SLC6A4	Unknown	—	Disgenet	Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft
		TPH1	Unknown	—	Disgenet	Tryptophan metabolism Folate biosynthesis Metabolic pathways +3 more
RECURRENT MAJOR DEPRESSIVE EPISODES	C0154409	CACNA1C	Unknown	—	Disgenet	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +34 more
RECURRENT MAJOR DEPRESSIVE EPISODES	C0154409	SLC6A4	Unknown	—	Disgenet	Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft

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Major depressive disorder

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