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Gene Gene information from NCBI Gene database.
Entrez ID 119391
Gene name Glutathione S-transferase omega 2
Gene symbol GSTO2
Synonyms (NCBI Gene)
GSTO 2-2bA127L20.1
Chromosome 10
Chromosome location 10q25.1
Summary The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq,
miRNA miRNA information provided by mirtarbase database.
70 Show/Hide all (70)
miRTarBase ID miRNA Experiments Reference
MIRT681099 hsa-miR-4712-3p HITS-CLIP 23706177
MIRT681098 hsa-miR-218-2-3p HITS-CLIP 23706177
MIRT681097 hsa-miR-3158-5p HITS-CLIP 23706177
MIRT681096 hsa-miR-1184 HITS-CLIP 23706177
MIRT681095 hsa-miR-1205 HITS-CLIP 23706177
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23 Show/Hide all (23)
GO ID Ontology Definition Evidence Reference
GO:0004364 Function Glutathione transferase activity IBA
GO:0004364 Function Glutathione transferase activity IEA
GO:0005515 Function Protein binding IPI 25416956, 25910212, 31515488, 32296183
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612314 23064 ENSG00000065621
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H4Y5
Protein name Glutathione S-transferase omega-2 (GSTO-2) (EC 2.5.1.18) (Glutathione S-transferase omega 2-2) (GSTO 2-2) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2)
Protein function Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsoni
PDB 3Q18 , 3Q19 , 3QAG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13410 GST_C_2 108 → 206 Domain
PF13417 GST_N_3 26 → 101 Glutathione S-transferase, N-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate. Strongest expression in the testis. {ECO:0000269|PubMed:12618591}.
Sequence
Sequence length 243
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Glutathione metabolism Glutathione conjugation
Metabolism of xenobiotics by cytochrome P450 Vitamin C (ascorbate) metabolism
Drug metabolism - cytochrome P450  
Drug metabolism - other enzymes  
Metabolic pathways  
Platinum drug resistance  
Pathways in cancer  
Chemical carcinogenesis - DNA adducts  
Chemical carcinogenesis - receptor activation  
Chemical carcinogenesis - reactive oxygen species  
Hepatocellular carcinoma  
Fluid shear stress and atherosclerosis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (7)
Phenotype Name Clinical Significance Source Reference Evidence Score
ALZHEIMERS DISEASE — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER — GWAS catalog 39358599
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (66)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 15040808, 15985314 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyotrophic lateral sclerosis 1 Amyotrophic lateral sclerosis Pubtator 34311603 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 20374258, 22040239, 24471578
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Asthma Asthma Pubtator 24471578 Associate
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Bladder Neoplasm Bladder Neoplasm BEFREE 22306368
★★★★★
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm CTD_human_DG 22306368
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 19859803, 20210239, 23376175, 25300926, 26993125, 28670895
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 25835968, 25892883, 27221910 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma of bladder Bladder carcinoma BEFREE 22306368, 25716313
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 30224590 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only