Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	NR1H3	Causal	—	Disgenet	PPAR signaling pathway Efferocytosis Insulin resistance +12 more
		TNFRSF1A	Causal	19525953 24076602 21833088 27386562 31604244 40262193	CTD, Disgenet, GWAS catalog	MAPK signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +39 more
		A2M	Unknown	—	Disgenet	Complement and coagulation cascades Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation +3 more
		ABT1	Unknown	37377963	GWAS catalog	—
		ACSF3	Unknown	31604244	GWAS catalog	Fatty acid biosynthesis Valine, leucine and isoleucine degradation Metabolic pathways +2 more
		ADAMTSL1	Unknown	19010793	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADCY3	Unknown	31604244	GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		AFF1	Unknown	31604244	GWAS catalog	Transcriptional misregulation in cancer
		AGAP2	Unknown	21833088	GWAS catalog	FoxO signaling pathway Endocytosis
		AGBL2	Unknown	24076602	GWAS catalog	—
		AGER	Unknown	—	Disgenet	Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications +7 more
		AGPAT1	Unknown	37377963	GWAS catalog	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways +4 more
		AHI1	Unknown	21833088 24076602 40262193	GWAS catalog	Anchoring of the basal body to the plasma membrane
		AIM2	Unknown	31068361	CTD, Disgenet	NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway The AIM2 inflammasome
		AKAP13	Unknown	31604244	GWAS catalog	Parathyroid hormone synthesis, secretion and action Human cytomegalovirus infection NRAGE signals death through JNK +2 more
		ALDH1L1	Unknown	31604244	GWAS catalog	One carbon pool by folate Metabolic pathways Metabolism of folate and pterines
		ALPK2	Unknown	21833088 26920376 31604244	GWAS catalog	—
		ANKFN1	Unknown	39024449	GWAS catalog	—
		ANKRD55	Unknown	24076602 27386562 31604244 37377963 40262193	GWAS catalog	—
		APOA4	Unknown	31604244	GWAS catalog	Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism +1 more
		APOC2	Unknown	—	Disgenet	Cholesterol metabolism Chylomicron assembly Chylomicron remodeling +3 more
		APOE	Unknown	15048896	CTD, Disgenet	Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 +10 more
		ARHGAP26	Unknown	31604244	GWAS catalog	Rho GTPase cycle
		ARHGAP27	Unknown	31604244	GWAS catalog	Rho GTPase cycle
		ARHGEF10	Unknown	23412934	GWAS catalog	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF3	Unknown	26920376 31604244	GWAS catalog	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARL11	Unknown	23412934	GWAS catalog	—
		ASAP1	Unknown	19525955	GWAS catalog	Endocytosis Fc gamma R-mediated phagocytosis VxPx cargo-targeting to cilium
		ASAP2	Unknown	19010793	GWAS catalog	Endocytosis Fc gamma R-mediated phagocytosis
		ATF1	Unknown	31604244	GWAS catalog	Aldosterone synthesis and secretion Transcriptional misregulation in cancer CREB phosphorylation +1 more
		ATF6B	Unknown	37377963	GWAS catalog	cGMP-PKG signaling pathway Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway +22 more
		ATP6	Unknown	—	Disgenet	Oxidative phosphorylation Metabolic pathways Thermogenesis +10 more
		ATP8	Unknown	—	Disgenet	Oxidative phosphorylation Metabolic pathways Thermogenesis +10 more
		ATXN1	Unknown	31604244	GWAS catalog	Notch signaling pathway Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		ATXN2	Unknown	31604244	GWAS catalog	Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		AXDND1	Unknown	19010793	GWAS catalog	—
		BACH2	Unknown	21833088 24076602 31604244 40262193	GWAS catalog	—
		BAK1	Unknown	26920376	GWAS catalog	Platinum drug resistance Protein processing in endoplasmic reticulum Apoptosis +32 more
		BATF	Unknown	21833088 24076602 31407831 31604244 40262193	GWAS catalog	PD-L1 expression and PD-1 checkpoint pathway in cancer Interleukin-4 and Interleukin-13 signaling
		BATF3	Unknown	31604244	GWAS catalog	PD-L1 expression and PD-1 checkpoint pathway in cancer
		BBX	Unknown	33296963	GWAS catalog	—
		BCAS1	Unknown	31604244	GWAS catalog	—
		BCHE	Unknown	20122907	CTD, Disgenet	Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin
		BCL2	Unknown	31604244	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +46 more
		BCL2L14	Unknown	31604244	GWAS catalog	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
		BICD1	Unknown	19010793	GWAS catalog	Viral life cycle - HIV-1 COPI-independent Golgi-to-ER retrograde traffic
		BMAL1	Unknown	33296963	GWAS catalog	—
		BOD1L2	Unknown	19010793	GWAS catalog	—
		BORCS8-MEF2B	Unknown	31604244	GWAS catalog	cGMP-PKG signaling pathway Apelin signaling pathway Myogenesis
		HLA-DRB1	Unknown	19525955 20598377 23472185 25911099	CTD, Disgenet, GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
MULTIPLE SCLEROSIS, RELAPSING-REMITTING	C0751967 MESH:D020529	APOE	Unknown	15096402 34624384	CTD, Disgenet	Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 +10 more
MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO	MONDO:0007462PS126200	HLA-DRB1	Causal	14657362 11101853	ClinVar	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO, 5	MONDO:0013893	TNFRSF1A	Unknown	—	ClinVar	MAPK signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +39 more

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Multiple sclerosis

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