Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
BORDERLINE SCHIZOPHRENIA	C0036343	AGER	Unknown	—	Disgenet	Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications +7 more
CHRONIC SCHIZOPHRENIA	C0221765	ACE	Unknown	—	Disgenet	Renin-angiotensin system Renin secretion Chagas disease +4 more
		ASAH1	Unknown	—	Disgenet	Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway +3 more
		CHGB	Unknown	—	Disgenet	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
		HSPA9	Unknown	—	Disgenet	RNA degradation Tuberculosis Regulation of HSF1-mediated heat shock response +1 more
		IGF2BP2	Unknown	—	Disgenet	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IL2RG	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Endocytosis +17 more
		LEP	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +7 more
		MLC1	Unknown	—	Disgenet	—
		SP1	Unknown	—	Disgenet	Endocrine resistance Mitophagy - animal TGF-beta signaling pathway +18 more
EARLY ONSET SCHIZOPHRENIA	C1656427	DNMT3B	Unknown	—	Disgenet	Cysteine and methionine metabolism Metabolic pathways MicroRNAs in cancer +2 more
		NDUFS1	Unknown	—	Disgenet	Oxidative phosphorylation Metabolic pathways Thermogenesis +12 more
		SOX10	Unknown	—	Disgenet	EGR2 and SOX10-mediated initiation of Schwann cell myelination
LATENT SCHIZOPHRENIA	C0023105	AGER	Unknown	—	Disgenet	Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications +7 more
PARANOID SCHIZOPHRENIA	C0036349	ALDH3B1	Unknown	—	Disgenet	Glycolysis / Gluconeogenesis Histidine metabolism Tyrosine metabolism +7 more
		CALR	Unknown	—	Disgenet	Protein processing in endoplasmic reticulum Phagosome Efferocytosis +14 more
		CCKAR	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +4 more
		DPYSL2	Unknown	—	Disgenet	Axon guidance CRMPs in Sema3A signaling Recycling pathway of L1
		HLA-A	Unknown	—	Disgenet	Endocytosis Phagosome Cellular senescence +25 more
		HLA-DRB4	Unknown	—	Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HSPA1A	Unknown	—	Disgenet	Spliceosome MAPK signaling pathway Protein processing in endoplasmic reticulum +16 more
		IFNG	Unknown	—	Disgenet	Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway +33 more
		IL2	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway +21 more
		KCNN3	Unknown	—	Disgenet	Insulin secretion GnRH secretion Ca2+ activated K+ channels
		NTRK2	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		PAX6	Unknown	—	Disgenet	Signaling pathways regulating pluripotency of stem cells Maturity onset diabetes of the young Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) +1 more
		TNFRSF1B	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor TNF signaling pathway +9 more
		TPH2	Unknown	—	Disgenet	Tryptophan metabolism Folate biosynthesis Metabolic pathways +2 more
		YWHAZ	Unknown	—	Disgenet	Cell cycle Oocyte meiosis PI3K-Akt signaling pathway +15 more
PSEUDONEUROTIC SCHIZOPHRENIAS	C0033823	AGER	Unknown	—	Disgenet	Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications +7 more
PSEUDOPSYCHOPATHIC SCHIZOPHRENIA	C0033836	AGER	Unknown	—	Disgenet	Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications +7 more
SCHIZOPHRENIA	C0036341 MONDO:0005090 HP:0100753 MESH:D012559 MONDO_0005090	ABCA13	Causal	19944402 23910238 27712136 29486958 48999322 49435281	Disgenet, GWAS catalog	ABC transporters Neutrophil degranulation
		MC4R	Causal	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +2 more
		MTHFR	Causal	16641680 17074966 18583979 33907183	CTD, ClinVar, Disgenet, GWAS catalog	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		PHIP	Causal	—	Disgenet	—
		SETD1A	Causal	—	Disgenet	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		A1BG	Unknown	25821032	CTD, Disgenet	Platelet degranulation Neutrophil degranulation
		ABCA1	Unknown	—	Disgenet	ABC transporters Efferocytosis Fat digestion and absorption +6 more
		ABCA2	Unknown	—	Disgenet, GenCC	ABC transporters Lysosome ABC transporters in lipid homeostasis
		ABCA6	Unknown	34099189	GWAS catalog	ABC transporters ABC transporters in lipid homeostasis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
		ABCB1	Unknown	26198764 32606422 35396580 39753749	Disgenet, GWAS catalog	ABC transporters Bile secretion MicroRNAs in cancer +2 more
		ABCB4	Unknown	—	Disgenet	ABC transporters Bile secretion PPARA activates gene expression +2 more
		ABCC10	Unknown	26198764 28540026	GWAS catalog	ABC transporters ABC-family proteins mediated transport
		ABCC8	Unknown	35396580	GWAS catalog	ABC transporters Insulin secretion Type II diabetes mellitus +3 more
		ABCD1	Unknown	20889312	GWAS catalog	ABC transporters Peroxisome ABC transporters in lipid homeostasis +5 more
		ABCF1	Unknown	30285260	GWAS catalog	ABC-family proteins mediated transport
		ABHD17C	Unknown	35396580	GWAS catalog	—
		ABHD5	Unknown	26198764 28991256 30285260 35396580	GWAS catalog	Regulation of lipolysis in adipocytes
		ABT1	Unknown	36137488	GWAS catalog	—
		ACADS	Unknown	30285260 31835028	GWAS catalog	Fatty acid degradation Valine, leucine and isoleucine degradation beta-Alanine metabolism +7 more
		ACE	Unknown	39753749	Disgenet, GWAS catalog	Renin-angiotensin system Renin secretion Chagas disease +4 more
		ACHE	Unknown	—	Disgenet	Glycerophospholipid metabolism Cholinergic synapse Neurotransmitter clearance +2 more
		AGER	Unknown	—	Disgenet	Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications +7 more
		ALDH3B1	Unknown	—	Disgenet	Glycolysis / Gluconeogenesis Histidine metabolism Tyrosine metabolism +7 more
		ASAH1	Unknown	—	Disgenet	Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway +3 more
		CCKAR	Unknown	—	Disgenet	Calcium signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +4 more
		CHGB	Unknown	—	Disgenet	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
		DNMT3B	Unknown	—	Disgenet	Cysteine and methionine metabolism Metabolic pathways MicroRNAs in cancer +2 more
		DPYSL2	Unknown	—	Disgenet	Axon guidance CRMPs in Sema3A signaling Recycling pathway of L1
		HLA-A	Unknown	—	Disgenet	Endocytosis Phagosome Cellular senescence +25 more
		HSPA1A	Unknown	30285260	Disgenet, GWAS catalog	Spliceosome MAPK signaling pathway Protein processing in endoplasmic reticulum +16 more
		HSPA9	Unknown	32606422 35396580	Disgenet, GWAS catalog	RNA degradation Tuberculosis Regulation of HSF1-mediated heat shock response +1 more
		IFNG	Unknown	—	Disgenet	Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway +33 more
		IGF2BP2	Unknown	36738649	Disgenet, GWAS catalog	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IL2	Unknown	35396580	Disgenet, GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway +21 more
		IL2RG	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Endocytosis +17 more
		KCNN3	Unknown	11326292 24206670 26198764 26537360 35396580	Disgenet, GWAS catalog	Insulin secretion GnRH secretion Ca2+ activated K+ channels
		LEP	Unknown	26198764	Disgenet, GWAS catalog	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +7 more
		MLC1	Unknown	—	Disgenet	—
		NDUFS1	Unknown	—	Disgenet	Oxidative phosphorylation Metabolic pathways Thermogenesis +12 more
		NTRK2	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		PAX6	Unknown	—	Disgenet	Signaling pathways regulating pluripotency of stem cells Maturity onset diabetes of the young Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) +1 more
		PRODH	Unknown	16234811	CTD, Disgenet	Arginine and proline metabolism Metabolic pathways Proline catabolism
		SHANK3	Unknown	31374203 35396580	CTD, Disgenet, GWAS catalog	Glutamatergic synapse
		SOX10	Unknown	—	Disgenet	EGR2 and SOX10-mediated initiation of Schwann cell myelination
		SP1	Unknown	35396580	Disgenet, GWAS catalog	Endocrine resistance Mitophagy - animal TGF-beta signaling pathway +18 more
		TNFRSF1B	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor TNF signaling pathway +9 more
		TPH2	Unknown	—	Disgenet	Tryptophan metabolism Folate biosynthesis Metabolic pathways +2 more
SCHIZOPHRENIA 15	C3151380 MONDO:0013498	SHANK3	Causal	20385823 24124131 26687841 29486958	ClinVar, Disgenet, GWAS catalog	Glutamatergic synapse
SCHIZOPHRENIA 4	C1833247 MONDO:0010943	PRODH	Causal	—	ClinVar, Disgenet	Arginine and proline metabolism Metabolic pathways Proline catabolism
SCHIZOPHRENIA, CATATONIC	C0036344	MLC1	Unknown	—	Disgenet	—
SCHIZOPHRENIA, PARANOID	MESH:D012563	DPYSL2	Unknown	17105906	CTD	Axon guidance CRMPs in Sema3A signaling Recycling pathway of L1

«‹12 3…51 ›»

Schizophrenia

Bookmark This Disease