Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	51130
Gene name	Ankyrin repeat and SOCS box containing 3
Gene symbol	ASB3
Synonyms (NCBI Gene)	ASB-3
Chromosome	2
Chromosome location	2p16.2
Summary	The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins

94 Show/Hide all (94)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018047	hsa-miR-335-5p	Microarray	18185580
MIRT040170	hsa-miR-615-3p	CLASH	23622248
MIRT036646	hsa-miR-935	CLASH	23622248
MIRT527249	hsa-miR-1285-5p	PAR-CLIP	22012620
MIRT527248	hsa-miR-342-3p	PAR-CLIP	22012620
MIRT728292	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT728291	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT088933	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT088936	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT088934	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT088935	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT088938	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT088933	hsa-miR-30a-5p	HITS-CLIP	27418678
MIRT088936	hsa-miR-30b-5p	HITS-CLIP	27418678
MIRT088934	hsa-miR-30c-5p	HITS-CLIP	27418678
MIRT088935	hsa-miR-30d-5p	HITS-CLIP	27418678
MIRT088938	hsa-miR-30e-5p	HITS-CLIP	27418678
MIRT527249	hsa-miR-1285-5p	PAR-CLIP	22012620
MIRT527248	hsa-miR-342-3p	PAR-CLIP	22012620
MIRT802234	hsa-miR-127-5p	CLIP-seq
MIRT802235	hsa-miR-128	CLIP-seq
MIRT802236	hsa-miR-142-5p	CLIP-seq
MIRT802237	hsa-miR-2116	CLIP-seq
MIRT802238	hsa-miR-27a	CLIP-seq
MIRT802239	hsa-miR-27b	CLIP-seq
MIRT802240	hsa-miR-30a	CLIP-seq
MIRT802241	hsa-miR-30b	CLIP-seq
MIRT802242	hsa-miR-30c	CLIP-seq
MIRT802243	hsa-miR-30d	CLIP-seq
MIRT802244	hsa-miR-30e	CLIP-seq
MIRT802245	hsa-miR-383	CLIP-seq
MIRT802246	hsa-miR-4299	CLIP-seq
MIRT802247	hsa-miR-4496	CLIP-seq
MIRT802248	hsa-miR-4659a-5p	CLIP-seq
MIRT802249	hsa-miR-4659b-5p	CLIP-seq
MIRT802250	hsa-miR-4677-5p	CLIP-seq
MIRT802251	hsa-miR-4716-5p	CLIP-seq
MIRT802252	hsa-miR-4766-3p	CLIP-seq
MIRT802253	hsa-miR-4772-5p	CLIP-seq
MIRT802254	hsa-miR-4803	CLIP-seq
MIRT802255	hsa-miR-499-3p	CLIP-seq
MIRT802256	hsa-miR-499a-3p	CLIP-seq
MIRT802257	hsa-miR-543	CLIP-seq
MIRT802258	hsa-miR-548a-5p	CLIP-seq
MIRT802259	hsa-miR-548ab	CLIP-seq
MIRT802260	hsa-miR-548ak	CLIP-seq
MIRT802261	hsa-miR-548b-5p	CLIP-seq
MIRT802262	hsa-miR-548c-5p	CLIP-seq
MIRT802263	hsa-miR-548d-5p	CLIP-seq
MIRT802264	hsa-miR-548h	CLIP-seq
MIRT802265	hsa-miR-548i	CLIP-seq
MIRT802266	hsa-miR-548j	CLIP-seq
MIRT802267	hsa-miR-548k	CLIP-seq
MIRT802268	hsa-miR-548l	CLIP-seq
MIRT802269	hsa-miR-548p	CLIP-seq
MIRT802270	hsa-miR-548w	CLIP-seq
MIRT802271	hsa-miR-548y	CLIP-seq
MIRT802272	hsa-miR-559	CLIP-seq
MIRT802273	hsa-miR-570	CLIP-seq
MIRT802274	hsa-miR-802	CLIP-seq
MIRT802248	hsa-miR-4659a-5p	CLIP-seq
MIRT802249	hsa-miR-4659b-5p	CLIP-seq
MIRT2480041	hsa-miR-3163	CLIP-seq
MIRT2480042	hsa-miR-3664-5p	CLIP-seq
MIRT2480043	hsa-miR-3919	CLIP-seq
MIRT2480044	hsa-miR-3942-3p	CLIP-seq
MIRT2480045	hsa-miR-4474-3p	CLIP-seq
MIRT2480046	hsa-miR-4668-3p	CLIP-seq
MIRT2480047	hsa-miR-4714-5p	CLIP-seq
MIRT2480048	hsa-miR-4756-3p	CLIP-seq
MIRT2480049	hsa-miR-548ac	CLIP-seq
MIRT2480050	hsa-miR-548ae	CLIP-seq
MIRT2480051	hsa-miR-548aj	CLIP-seq
MIRT2480052	hsa-miR-548am	CLIP-seq
MIRT2480053	hsa-miR-548d-3p	CLIP-seq
MIRT2480054	hsa-miR-548x	CLIP-seq
MIRT2480055	hsa-miR-548z	CLIP-seq
MIRT2480056	hsa-miR-760	CLIP-seq
MIRT2480041	hsa-miR-3163	CLIP-seq
MIRT2480042	hsa-miR-3664-5p	CLIP-seq
MIRT2480043	hsa-miR-3919	CLIP-seq
MIRT2480044	hsa-miR-3942-3p	CLIP-seq
MIRT2480045	hsa-miR-4474-3p	CLIP-seq
MIRT2480046	hsa-miR-4668-3p	CLIP-seq
MIRT2480047	hsa-miR-4714-5p	CLIP-seq
MIRT2480048	hsa-miR-4756-3p	CLIP-seq
MIRT2480049	hsa-miR-548ac	CLIP-seq
MIRT2480050	hsa-miR-548ae	CLIP-seq
MIRT2480051	hsa-miR-548aj	CLIP-seq
MIRT2480052	hsa-miR-548am	CLIP-seq
MIRT2480053	hsa-miR-548d-3p	CLIP-seq
MIRT2480054	hsa-miR-548x	CLIP-seq
MIRT2480055	hsa-miR-548z	CLIP-seq
MIRT2480056	hsa-miR-760	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25814554, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0016567	Process	Protein ubiquitination	IEA
GO:0035556	Process	Intracellular signal transduction	IEA

MIM	HGNC	e!Ensembl
605760	16013	ENSG00000115239

Interactions View interactions

Reactome Pathway
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (26)
ALZHEIMER DISEASE	—	GWAS catalog	35851147, 36543923	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANOREXIA NERVOSA	—	GWAS catalog	31308545, 33686288	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANTI-NEUTROPHIL ANTIBODY ASSOCIATED VASCULITIS	—	GWAS catalog	36530128	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BULIMIA NERVOSA	—	GWAS catalog	23568457	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	37359372	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	36543923	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EATING DISORDER	—	GWAS catalog	31308545	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CANCER	—	GWAS catalog	35121771	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CARCINOMA	—	GWAS catalog	35121771	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	35851147	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GENERALIZED ANXIETY DISORDER	—	GWAS catalog	38063329	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	35835914	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	27770636	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	30104567	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	33686288	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	39349817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	23251661	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	40205036	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	40205036	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	40205036	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC CARCINOMA	—	GWAS catalog	32887889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PREECLAMPSIA	—	GWAS catalog	38714721	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	38839884	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	30019117	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	23041239	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	26818947, 39349817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ASB3 (ankyrin repeat and SOCS box containing 3)

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