GRIK1 (glutamate ionotropic receptor kainate type subunit 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 2897
• Gene name: Glutamate ionotropic receptor kainate type subunit 1
• Gene symbol: GRIK1
• Synonyms (NCBI Gene): EAA3, EEA3, GLR5, GLUR5, GluK1, gluR-5
• Chromosome: 21
• Chromosome location: 21q21.3
• Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are com

miRNA Show/Hide all (6)

miRTarBase ID	miRNA	Experiments	Reference
MIRT2006745	hsa-miR-377	CLIP-seq
MIRT2006746	hsa-miR-4742-3p	CLIP-seq
MIRT2006747	hsa-miR-499-3p	CLIP-seq
MIRT2006748	hsa-miR-499a-3p	CLIP-seq
MIRT2006749	hsa-miR-630	CLIP-seq
MIRT2006750	hsa-miR-664	CLIP-seq

Gene ontology (GO) Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004970	Function	Glutamate-gated receptor activity	IDA	8589992, 8730589
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8260617
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0007215	Process	Glutamate receptor signaling pathway	TAS	8260617
GO:0007268	Process	Chemical synaptic transmission	TAS	10580501
GO:0007399	Process	Nervous system development	TAS	8260617
GO:0007417	Process	Central nervous system development	TAS	10580501
GO:0015276	Function	Ligand-gated monoatomic ion channel activity	IEA
GO:0015277	Function	Kainate selective glutamate receptor activity	IBA
GO:0015277	Function	Kainate selective glutamate receptor activity	IDA	9335499
GO:0015277	Function	Kainate selective glutamate receptor activity	IEA
GO:0015277	Function	Kainate selective glutamate receptor activity	TAS	10580501
GO:0016020	Component	Membrane	IEA
GO:0019722	Process	Calcium-mediated signaling	IEA
GO:0022849	Function	Glutamate-gated calcium ion channel activity	ISS
GO:0032983	Component	Kainate selective glutamate receptor complex	IBA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0035235	Process	Ionotropic glutamate receptor signaling pathway	IEA
GO:0035249	Process	Synaptic transmission, glutamatergic	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0042734	Component	Presynaptic membrane	IBA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IBA
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	TAS	9335499
GO:0060078	Process	Regulation of postsynaptic membrane potential	IEA
GO:0098839	Component	Postsynaptic density membrane	IBA
GO:1904315	Function	Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA

Other IDs

• MIM: 138245
• HGNC: 4579
• e!Ensembl: ENSG00000171189

Protein

• UniProt ID: P39086
• Protein name: Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5)
• Protein function: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervo
• PDB: 2ZNS , 2ZNT , 2ZNU , 3FUZ , 3FV1 , 3FV2 , 3FVG , 3FVK , 3FVN , 3FVO , 4MF3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00060	Lig_chan	575 → 846	Ligand-gated ion channel	Family
  PF01094	ANF_receptor	53 → 399	Receptor family ligand binding region	Family
  PF10613	Lig_chan-Glu_bd	447 → 561	Ligated ion channel L-glutamate- and glycine-binding site	Domain

• Sequence:

  MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKF
  AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ
  SICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDS
  TGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEIL
  KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSME
  RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRF
  MNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGI
  WNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCL
  DLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK
  VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT
  PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL
  IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM
  WAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG
  VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFI
  VLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECG
  KLIREERGIRKQSSVHTV

• Sequence length: 918

Pathways

KEGG Pathway	Reactome Pathway
Neuroactive ligand-receptor interaction	Activation of Na-permeable kainate receptors
Glutamatergic synapse	Activation of Ca-permeable Kainate Receptor

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (22)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	38184787	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	23453885, 34446935	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	23453885	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	23453885	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	17903305	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	17903305	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EOSINOPHILIC ESOPHAGITIS	—	GWAS catalog	36400179	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEPATOCELLULAR CARCINOMA	—	GWAS catalog	22807686	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	34062886	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	34062886	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	34062886, 40829600	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	23453885	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OCULAR HYPERTENSION	—	GWAS catalog	36222912	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEONECROSIS	—	GWAS catalog	26265699	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIODONTITIS	—	GWAS catalog	24024966	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	23453885	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	30019117	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEIZURES	—	CTD	12080343	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	34062886	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	26089329	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	34446935	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	33667223	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (46)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	8419920		★☆☆☆☆ Found in Text Mining only
Amyotrophic Lateral Sclerosis, Familial	Amyotrophic lateral sclerosis	BEFREE	8419920, 8464923		★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	BEFREE	29104074		★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety Disorder	BEFREE	29104074		★☆☆☆☆ Found in Text Mining only
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	36323684	Associate	★☆☆☆☆ Found in Text Mining only
Auditory Perceptual Disorders	Auditory perceptual disorder	Pubtator	36323684	Associate	★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	36068227	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autistic Disorder	Autism	Pubtator	20034085	Associate	★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	20034085		★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	17299517		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	LHGDN	17698324		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	19086053		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar disorder	Pubtator	27063557	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Neoplasms	Breast neoplasm	Pubtator	19047151	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	22807686	Associate	★☆☆☆☆ Found in Text Mining only
Clonic Seizures	Clonic Seizures	CTD_human_DG	12080343		★☆☆☆☆ Found in Text Mining only
Complex partial seizures	Seizure	CTD_human_DG	12080343		★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	19893199, 8464923		★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down syndrome	Pubtator	19893199, 22931243	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	12409614, 29988380		★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	9848088		★☆☆☆☆ Found in Text Mining only
Epileptic drop attack	Hypotonic seizures	CTD_human_DG	12080343		★☆☆☆☆ Found in Text Mining only
Fragile X Syndrome	Fragile X Syndrome	BEFREE	23560306, 27411166		★☆☆☆☆ Found in Text Mining only
Generalized seizures	Seizure	CTD_human_DG	12080343		★☆☆☆☆ Found in Text Mining only
Hemimegalencephaly	Hemimegalencephaly	Pubtator	15571509	Associate	★☆☆☆☆ Found in Text Mining only
Hepatitis B	Hepatitis b	Pubtator	22807686	Associate	★☆☆☆☆ Found in Text Mining only
Hyperkinesis	Hyperkinesia	Pubtator	36323684	Associate	★☆☆☆☆ Found in Text Mining only
Idiopathic generalized epilepsy	Epilepsy	BEFREE	11920863, 9259378		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	19893199	Associate	★☆☆☆☆ Found in Text Mining only
Jacksonian Seizure	Jacksonian Seizure	CTD_human_DG	12080343		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	GWASCAT_DG	22807686		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	GWASDB_DG	22807686		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	26255971		★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	BEFREE	30770891		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	22111545		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	28489853	Associate	★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	35086395	Associate	★☆☆☆☆ Found in Text Mining only
Primary biliary cirrhosis	Biliary Cirrhosis	GWASDB_DG	23000144		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	11702055, 14969737, 15886719, 22730074, 7719702		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	11702055, 15886719		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	LHGDN	17698324		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Seizures	Seizures	Pubtator	32233732	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Single Seizure	Seizure	CTD_human_DG	12080343		★☆☆☆☆ Found in Text Mining only
SPHEROCYTOSIS, TYPE 1 (disorder)	Spherocytosis	BEFREE	9848088		★☆☆☆☆ Found in Text Mining only
Tonic - clonic seizures	Seizure	CTD_human_DG	12080343		★☆☆☆☆ Found in Text Mining only
Visual seizure	Seizure	CTD_human_DG	12080343		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

BACH1 3 shared diseasesEosinophilia, Ocular hypertension, Osteonecrosis 3 shared evidence sourcesGWAS catalog (Eosinophilia), GWAS catalog (Ocular hypertension), GWAS catalog (Osteonecrosis) Related via 3 shared diseases including Eosinophilia, Ocular hypertension — evidence mostly GWAS catalog. MEAK7 2 shared diseasesEosinophilia, Upper aerodigestive tract neoplasm 2 shared evidence sourcesGWAS catalog (Eosinophilia), GWAS catalog (Upper aerodigestive tract neoplasm) Related via 2 shared diseases including Eosinophilia, Upper aerodigestive tract neoplasm — evidence mostly GWAS catalog. GRIK2 3 shared pathwaysGlutamatergic synapse, Activation of Ca-permeable Kainate Receptor, Activation of Na-permeable kainate receptors Related via 3 shared pathways including Glutamatergic synapse, Activation of Ca-permeable Kainate Receptor. NKAIN3 2 shared diseasesPeriodontitis, Upper aerodigestive tract neoplasm 2 shared evidence sourcesGWAS catalog (Periodontitis), GWAS catalog (Upper aerodigestive tract neoplasm) Related via 2 shared diseases including Periodontitis, Upper aerodigestive tract neoplasm — evidence mostly GWAS catalog. MT3 2 shared diseasesEosinophilia, Seizures 2 shared evidence sourcesGWAS catalog (Eosinophilia), CTD (Seizures) Related via 2 shared diseases including Eosinophilia, Seizures — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
BACH1	3	["Eosinophilia","Ocular hypertension","Osteonecrosis"]	0	[]	3	["GWAS catalog (Eosinophilia)","GWAS catalog (Ocular hypertension)","GWAS catalog (Osteonecrosis)"]
MEAK7	2	["Eosinophilia","Upper aerodigestive tract neoplasm"]	0	[]	2	["GWAS catalog (Eosinophilia)","GWAS catalog (Upper aerodigestive tract neoplasm)"]
GRIK2	0	[]	3	["Glutamatergic synapse","Activation of Ca-permeable Kainate Receptor","Activation of Na-permeable kainate receptors"]	0	[]
NKAIN3	2	["Periodontitis","Upper aerodigestive tract neoplasm"]	0	[]	2	["GWAS catalog (Periodontitis)","GWAS catalog (Upper aerodigestive tract neoplasm)"]
MT3	2	["Eosinophilia","Seizures"]	0	[]	2	["GWAS catalog (Eosinophilia)","CTD (Seizures)"]

Diseases Linked via Similar Genes

Central nervous system cancer Linked via 2 of 5 related genesMEAK7, GRIK2 Color vision deficiency Linked via 2 of 5 related genesMEAK7, GRIK2 Glioma Linked via 2 of 5 related genesMEAK7, GRIK2 Breast neoplasms Linked via 2 of 5 related genesGRIK2, MT3 Non-small-cell lung carcinoma Linked via 2 of 5 related genesGRIK2, MT3

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Central nervous system cancer	2	["MEAK7","GRIK2"]
Color vision deficiency	2	["MEAK7","GRIK2"]
Glioma	2	["MEAK7","GRIK2"]
Breast neoplasms	2	["GRIK2","MT3"]
Non-small-cell lung carcinoma	2	["GRIK2","MT3"]