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Gene Gene information from NCBI Gene database.
Entrez ID 1398
Gene name CRK proto-oncogene, adaptor protein
Gene symbol CRK
Synonyms (NCBI Gene)
CRKIIp38
Chromosome 17
Chromosome location 17p13.3
Summary This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytop
miRNA miRNA information provided by mirtarbase database.
1023 Show/Hide all (1023)
miRTarBase ID miRNA Experiments Reference
MIRT002993 hsa-miR-126-3p Luciferase reporter assay 18602365
MIRT002993 hsa-miR-126-3p Luciferase reporter assayWestern blot 18602365
MIRT002993 hsa-miR-126-3p qRT-PCR 18602365
MIRT002993 hsa-miR-126-3p Review 19935707
MIRT002993 hsa-miR-126-3p Luciferase reporter assay 18602365
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
94 Show/Hide all (94)
GO ID Ontology Definition Evidence Reference
GO:0001764 Process Neuron migration IEA
GO:0001784 Function Phosphotyrosine residue binding IEA
GO:0001784 Function Phosphotyrosine residue binding IPI 20624904
GO:0001878 Process Response to yeast IEA
GO:0002685 Process Regulation of leukocyte migration IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
164762 2362 ENSG00000167193
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P46108
Protein name Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Protein function Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. ; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates atta
PDB 1JU5 , 2DVJ , 2EYV , 2EYW , 2EYX , 2EYY , 2EYZ , 2MS4 , 5UL6 , 6ATV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00017 SH2 13 → 104 SH2 domain Domain
PF00018 SH3_1 138 → 184 SH3 domain Domain
PF07653 SH3_2 239 → 294 Variant SH3 domain Domain
Sequence
Sequence length 304
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
MAPK signaling pathway ARMS-mediated activation
ErbB signaling pathway Downstream signal transduction
Rap1 signaling pathway Regulation of actin dynamics for phagocytic cup formation
Chemokine signaling pathway p130Cas linkage to MAPK signaling for integrins
Efferocytosis VEGFA-VEGFR2 Pathway
Focal adhesion PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Fc gamma R-mediated phagocytosis MET activates RAP1 and RAC1
Neurotrophin signaling pathway MET receptor recycling
Regulation of actin cytoskeleton Regulation of signaling by CBL
Insulin signaling pathway FCGR3A-mediated phagocytosis
Growth hormone synthesis, secretion and action  
Bacterial invasion of epithelial cells  
Shigellosis  
Yersinia infection  
Human cytomegalovirus infection  
Human immunodeficiency virus 1 infection  
Pathways in cancer  
MicroRNAs in cancer  
Renal cell carcinoma  
Chronic myeloid leukemia  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (7)
Phenotype Name Clinical Significance Source Reference Evidence Score
ALZHEIMER DISEASE — GWAS catalog 39998322
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION — GWAS catalog 30061737, 35872910, 36653681, 39537608
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE — GWAS catalog 37156999
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSION — GWAS catalog 37947095
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE — GWAS catalog 37156999
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (363)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acanthosis Nigricans Acanthosis Nigricans BEFREE 22585574
★★★★★
★☆☆☆☆
Found in Text Mining only
Actinic keratosis Actinic keratosis BEFREE 29298652
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 29349553, 29484391, 29890468, 30718368, 31432106
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 11585739, 24356912, 27775076, 30879017
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 12970743, 21164364, 21858220, 22415779, 28900489, 30321617, 30827261, 30879017
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 15969750, 17078869
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenocortical carcinoma Adrenocortical carcinoma BEFREE 28114280
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenoleukodystrophy Adrenoleukodystrophy BEFREE 30298517
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 22302101, 22855790
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 17950728
★★★★★
★☆☆☆☆
Found in Text Mining only