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Gene Gene information from NCBI Gene database.
Entrez ID 1399
Gene name CRK like proto-oncogene, adaptor protein
Gene symbol CRKL
Synonyms (NCBI Gene)
-
Chromosome 22
Chromosome location 22q11.21
Summary This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kin
miRNA miRNA information provided by mirtarbase database.
1577 Show/Hide all (1577)
miRTarBase ID miRNA Experiments Reference
MIRT004697 hsa-miR-107 FlowImmunoblotMicroarrayqRT-PCR 19688090
MIRT006177 hsa-miR-15a-5p Luciferase reporter assayMicroarrayNorthern blotqRT-PCRWestern blot 21880628
MIRT006177 hsa-miR-15a-5p Luciferase reporter assayMicroarrayNorthern blotqRT-PCRWestern blot 21880628
MIRT006177 hsa-miR-15a-5p Luciferase reporter assayMicroarrayNorthern blotqRT-PCRWestern blot 21880628
MIRT006177 hsa-miR-15a-5p Luciferase reporter assayMicroarrayNorthern blotqRT-PCRWestern blot 21880628
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
84 Show/Hide all (84)
GO ID Ontology Definition Evidence Reference
GO:0001558 Process Regulation of cell growth IEA
GO:0001568 Process Blood vessel development IEA
GO:0001655 Process Urogenital system development IEA
GO:0001764 Process Neuron migration IEA
GO:0001783 Process B cell apoptotic process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602007 2363 ENSG00000099942
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P46109
Protein name Crk-like protein
Protein function May mediate the transduction of intracellular signals.
PDB 2BZX , 2BZY , 2DBK , 2EO3 , 2LQN , 2LQW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00017 SH2 14 → 88 SH2 domain Domain
PF00018 SH3_1 129 → 175 SH3 domain Domain
PF07653 SH3_2 239 → 294 Variant SH3 domain Domain
Sequence
MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH
YIINSLPNRRFKIGDQEFDHLPALLEFY
KIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT
AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK
LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA
KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIF
DPQNPD
ENE
Sequence length 303
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
MAPK signaling pathway Frs2-mediated activation
ErbB signaling pathway Downstream signal transduction
Rap1 signaling pathway MET activates RAP1 and RAC1
Chemokine signaling pathway MET receptor recycling
Efferocytosis Erythropoietin activates RAS
Focal adhesion Regulation of signaling by CBL
Fc gamma R-mediated phagocytosis  
Neurotrophin signaling pathway  
Regulation of actin cytoskeleton  
Insulin signaling pathway  
Growth hormone synthesis, secretion and action  
Bacterial invasion of epithelial cells  
Shigellosis  
Yersinia infection  
Human cytomegalovirus infection  
Human immunodeficiency virus 1 infection  
Pathways in cancer  
MicroRNAs in cancer  
Renal cell carcinoma  
Chronic myeloid leukemia  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (6)
Phenotype Name Clinical Significance Source Reference Evidence Score
CONGENITAL HEART DISEASE — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CRKL-related disorder Likely benign; Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIGEORGE SYNDROME — CTD, Disgenet
CTD, Disgenet
16399080
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DISTAL 22Q11.2 MICRODELETION SYNDROME — Disgenet, Orphanet
Disgenet, Orphanet
—
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Melanoma Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (130)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
22q11 Deletion Syndrome 22q11 deletion syndrome Pubtator 22586683 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
22q11 Deletion Syndrome 22q11 deletion syndrome BEFREE 9730608
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 7521685
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 22211192, 22586683, 27078848
★★★★★
★☆☆☆☆
Found in Text Mining only
Ankyloglossia Ankyloglossia HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 28558797
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm Aortic Aneurysm HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Valve Insufficiency Aortic Valve Insufficiency BEFREE 20688158
★★★★★
★☆☆☆☆
Found in Text Mining only
Aortic Valve Insufficiency Aortic Valve Insufficiency HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Arachnodactyly Arachnodactyly HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only