PLCL2 (phospholipase C like 2)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 23228
• Gene name: Phospholipase C like 2
• Gene symbol: PLCL2
• Synonyms (NCBI Gene): PLCE2
• Chromosome: 3
• Chromosome location: 3p24.3

miRNA Show/Hide all (34)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025184	hsa-miR-181a-5p	Microarray	17612493
MIRT2595190	hsa-miR-1910	CLIP-seq
MIRT2595191	hsa-miR-1912	CLIP-seq
MIRT2595192	hsa-miR-25	CLIP-seq
MIRT2595193	hsa-miR-3128	CLIP-seq
MIRT2595194	hsa-miR-3157-5p	CLIP-seq
MIRT2595195	hsa-miR-32	CLIP-seq
MIRT2595196	hsa-miR-363	CLIP-seq
MIRT2595197	hsa-miR-367	CLIP-seq
MIRT2595198	hsa-miR-4270	CLIP-seq
MIRT2595199	hsa-miR-4279	CLIP-seq
MIRT2595200	hsa-miR-4300	CLIP-seq
MIRT2595201	hsa-miR-4304	CLIP-seq
MIRT2595202	hsa-miR-4441	CLIP-seq
MIRT2595203	hsa-miR-4522	CLIP-seq
MIRT2595204	hsa-miR-455-3p	CLIP-seq
MIRT2595205	hsa-miR-4691-3p	CLIP-seq
MIRT2595206	hsa-miR-4715-3p	CLIP-seq
MIRT2595207	hsa-miR-4720-5p	CLIP-seq
MIRT2595208	hsa-miR-4799-3p	CLIP-seq
MIRT2595209	hsa-miR-515-5p	CLIP-seq
MIRT2595210	hsa-miR-760	CLIP-seq
MIRT2595211	hsa-miR-920	CLIP-seq
MIRT2595212	hsa-miR-92a	CLIP-seq
MIRT2595213	hsa-miR-92b	CLIP-seq
MIRT2595190	hsa-miR-1910	CLIP-seq
MIRT2595194	hsa-miR-3157-5p	CLIP-seq
MIRT2595198	hsa-miR-4270	CLIP-seq
MIRT2595200	hsa-miR-4300	CLIP-seq
MIRT2595201	hsa-miR-4304	CLIP-seq
MIRT2595202	hsa-miR-4441	CLIP-seq
MIRT2595204	hsa-miR-455-3p	CLIP-seq
MIRT2595205	hsa-miR-4691-3p	CLIP-seq
MIRT2595211	hsa-miR-920	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002322	Process	B cell proliferation involved in immune response	IEA
GO:0002337	Process	B-1a B cell differentiation	IEA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IBA
GO:0004435	Function	Phosphatidylinositol-4,5-bisphosphate phospholipase C activity	IEA
GO:0005515	Function	Protein binding	IPI	15231748, 28514442, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007214	Process	Gamma-aminobutyric acid signaling pathway	IBA
GO:0007214	Process	Gamma-aminobutyric acid signaling pathway	IEA
GO:0008081	Function	Phosphoric diester hydrolase activity	IEA
GO:0032228	Process	Regulation of synaptic transmission, GABAergic	IBA
GO:0032228	Process	Regulation of synaptic transmission, GABAergic	IEA
GO:0032228	Process	Regulation of synaptic transmission, GABAergic	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0046488	Process	Phosphatidylinositol metabolic process	IBA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA
GO:0050811	Function	GABA receptor binding	IDA	16754670
GO:0050811	Function	GABA receptor binding	IEA
GO:0050859	Process	Negative regulation of B cell receptor signaling pathway	IEA
GO:0051209	Process	Release of sequestered calcium ion into cytosol	IBA
GO:0070679	Function	Inositol 1,4,5 trisphosphate binding	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	26706316

Other IDs

• MIM: 614276
• HGNC: 9064
• e!Ensembl: ENSG00000154822

Protein

• UniProt ID: Q9UPR0
• Protein name: Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2)
• Protein function: May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	754 → 862	C2 domain	Domain
  PF00387	PI-PLC-Y	618 → 732	Phosphatidylinositol-specific phospholipase C, Y domain	Family
  PF00388	PI-PLC-X	428 → 571	Phosphatidylinositol-specific phospholipase C, X domain	Family
  PF09279	EF-hand_like	334 → 419	Phosphoinositide-specific phospholipase C, efhand-like	Domain
  PF16457	PH_12	135 → 251	Pleckstrin homology domain	Domain

• Sequence:

  MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCS
  LGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKK
  TVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD
  SEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVAN
  IWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN
  PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDT
  KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE
  HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN
  EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLG
  DKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKEN
  MEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANEN
  PGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQ
  NGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVD
  PYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDE
  FIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGK
  KSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCM
  LAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADA
  VYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNE
  TLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE

• Sequence length: 1127

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (30)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ANXIETY DISORDER	—	GWAS catalog	39294497	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	32296059	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	34446935, 35764056	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	35764056	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BILIARY LIVER CIRRHOSIS	—	GWAS catalog	21399635, 26394269, 34033851	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	29059683, 32424353	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	29059683, 32424353	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANNABIS DEPENDENCE	—	GWAS catalog	37156939, 37985822	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	39046104	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DUODENAL ULCER	—	GWAS catalog	38036781	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC ULCER	—	GWAS catalog	38036781	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	29942085, 30643256, 37464041	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDER	—	GWAS catalog	29942085	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	21833088, 26920376	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	24916648	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	29255261, 29942085, 30595370, 30643256, 32231276	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	36376028	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PEPTIC ULCER DISEASE	—	GWAS catalog	38036781	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER	—	GWAS catalog	38637617	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY BILIARY CIRRHOSIS	—	GWAS catalog	21399635, 26394269, 34033851	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	25939698, 33385400, 39885523	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS VULGARIS	—	GWAS catalog	26626624	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	24390342, 30423114, 33310728, 36333501, 40262193	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	21822266, 26198764, 31374203, 35396580	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	30019117	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	34446935	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	33385400	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (23)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Arthritis Psoriatic	Psoriatic arthritis	Pubtator	22328738	Associate	★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	22328738, 36973646	Associate	★☆☆☆☆ Found in Text Mining only
Arthritis, Psoriatic	Psoriatic Arthritis	BEFREE	22328738		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	24916648	Associate	★☆☆☆☆ Found in Text Mining only
Biliary cirrhosis	Biliary cirrhosis	GWASCAT_DG	21399635		★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	24977159	Associate	★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	29942085		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mood Disorders	Mood Disorder	GWASCAT_DG	29942085		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	24916648		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial infarction	Pubtator	24916648	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial Infarction	GWASCAT_DG	24916648		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial Infarction	GWASDB_DG	24916648		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Primary biliary cirrhosis	Biliary Cirrhosis	GWASDB_DG	21399635		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Primary biliary cirrhosis	Biliary Cirrhosis	GWASCAT_DG	21399635, 26394269		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis	Psoriasis	GWASCAT_DG	25939698		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Psoriasis vulgaris	Psoriasis vulgaris	GWASCAT_DG	26626624		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Rheumatoid Arthritis	Rheumatoid arthritis	GWASDB_DG	24390342		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Rheumatoid Arthritis	Rheumatoid arthritis	GWASCAT_DG	24390342, 30423114		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	CTD_human_DG	21822266		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	GWASCAT_DG	31374203		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Scleroderma Systemic	Systemic sclerosis	Pubtator	25880423	Associate	★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	25880423		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	36880837	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ST8SIA4 3 shared diseasesAnxiety disorder, Biliary cirrhosis, Biliary cholangitis 3 shared evidence sourcesGWAS catalog (Anxiety disorder), GWAS catalog (Biliary cirrhosis), GWAS catalog (Biliary cholangitis) Related via 3 shared diseases including Anxiety disorder, Biliary cirrhosis — evidence mostly GWAS catalog. IL1RL2 3 shared diseasesBiliary cirrhosis, Peptic ulcer disease, Biliary cholangitis 3 shared evidence sourcesGWAS catalog (Biliary cirrhosis), GWAS catalog (Peptic ulcer disease), GWAS catalog (Biliary cholangitis) Related via 3 shared diseases including Biliary cirrhosis, Peptic ulcer disease — evidence mostly GWAS catalog. CNGA4 3 shared diseasesDuodenal ulcer, Gastric ulcer, Peptic ulcer disease 3 shared evidence sourcesGWAS catalog (Duodenal ulcer), GWAS catalog (Gastric ulcer), GWAS catalog (Peptic ulcer disease) Related via 3 shared diseases including Duodenal ulcer, Gastric ulcer — evidence mostly GWAS catalog. FBXL20 3 shared diseasesBiliary cirrhosis, Peptic ulcer disease, Biliary cholangitis 3 shared evidence sourcesGWAS catalog (Biliary cirrhosis), GWAS catalog (Peptic ulcer disease), GWAS catalog (Biliary cholangitis) Related via 3 shared diseases including Biliary cirrhosis, Peptic ulcer disease — evidence mostly GWAS catalog. RPS6KA4 3 shared diseasesBiliary cirrhosis, Cannabis abuse, Biliary cholangitis 3 shared evidence sourcesGWAS catalog (Biliary cirrhosis), GWAS catalog (Cannabis abuse), GWAS catalog (Biliary cholangitis) Related via 3 shared diseases including Biliary cirrhosis, Cannabis abuse — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ST8SIA4	3	["Anxiety disorder","Biliary cirrhosis","Biliary cholangitis"]	0	[]	3	["GWAS catalog (Anxiety disorder)","GWAS catalog (Biliary cirrhosis)","GWAS catalog (Biliary cholangitis)"]
IL1RL2	3	["Biliary cirrhosis","Peptic ulcer disease","Biliary cholangitis"]	0	[]	3	["GWAS catalog (Biliary cirrhosis)","GWAS catalog (Peptic ulcer disease)","GWAS catalog (Biliary cholangitis)"]
CNGA4	3	["Duodenal ulcer","Gastric ulcer","Peptic ulcer disease"]	0	[]	3	["GWAS catalog (Duodenal ulcer)","GWAS catalog (Gastric ulcer)","GWAS catalog (Peptic ulcer disease)"]
FBXL20	3	["Biliary cirrhosis","Peptic ulcer disease","Biliary cholangitis"]	0	[]	3	["GWAS catalog (Biliary cirrhosis)","GWAS catalog (Peptic ulcer disease)","GWAS catalog (Biliary cholangitis)"]
RPS6KA4	3	["Biliary cirrhosis","Cannabis abuse","Biliary cholangitis"]	0	[]	3	["GWAS catalog (Biliary cirrhosis)","GWAS catalog (Cannabis abuse)","GWAS catalog (Biliary cholangitis)"]

Diseases Linked via Similar Genes

Systemic lupus erythematosus Linked via 3 of 5 related genesST8SIA4, FBXL20, RPS6KA4 Coronary artery disease Linked via 2 of 5 related genesST8SIA4, FBXL20 Crohn disease Linked via 2 of 5 related genesST8SIA4, RPS6KA4 Color vision deficiency Linked via 1 of 5 related genesST8SIA4 Prostate cancer Linked via 1 of 5 related genesST8SIA4

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Systemic lupus erythematosus	3	["ST8SIA4","FBXL20","RPS6KA4"]
Coronary artery disease	2	["ST8SIA4","FBXL20"]
Crohn disease	2	["ST8SIA4","RPS6KA4"]
Color vision deficiency	1	["ST8SIA4"]
Prostate cancer	1	["ST8SIA4"]