Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	1262
Gene name	Cyclic nucleotide gated channel subunit alpha 4
Gene symbol	CNGA4
Synonyms (NCBI Gene)	CNCA2CNG-4CNG4CNG5CNGB2OCNC2OCNCBETAOCNCb
Chromosome	11
Chromosome location	11p15.4
Summary	CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008]

34 Show/Hide all (34)

miRTarBase ID	miRNA	Experiments	Reference
MIRT635306	hsa-miR-4490	HITS-CLIP	23824327
MIRT635305	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT635304	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635303	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT572629	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT572628	hsa-miR-1324	PAR-CLIP	20371350
MIRT572627	hsa-miR-4494	PAR-CLIP	20371350
MIRT572626	hsa-miR-499b-5p	PAR-CLIP	20371350
MIRT572624	hsa-miR-3155a	PAR-CLIP	20371350
MIRT572625	hsa-miR-3155b	PAR-CLIP	20371350
MIRT572623	hsa-miR-484	PAR-CLIP	20371350
MIRT635305	hsa-miR-3177-5p	HITS-CLIP	27418678
MIRT635305	hsa-miR-3177-5p	HITS-CLIP	27418678
MIRT635306	hsa-miR-4490	HITS-CLIP	27418678
MIRT635306	hsa-miR-4490	HITS-CLIP	27418678
MIRT635303	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT635303	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT635304	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT635304	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT635306	hsa-miR-4490	HITS-CLIP	23824327
MIRT635305	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT635304	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT635303	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT572629	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT572628	hsa-miR-1324	PAR-CLIP	20371350
MIRT572627	hsa-miR-4494	PAR-CLIP	20371350
MIRT572626	hsa-miR-499b-5p	PAR-CLIP	20371350
MIRT572624	hsa-miR-3155a	PAR-CLIP	20371350
MIRT572625	hsa-miR-3155b	PAR-CLIP	20371350
MIRT572623	hsa-miR-484	PAR-CLIP	20371350
MIRT899543	hsa-miR-1343	CLIP-seq
MIRT899544	hsa-miR-4450	CLIP-seq
MIRT899545	hsa-miR-4667-5p	CLIP-seq
MIRT899546	hsa-miR-4700-5p	CLIP-seq

31 Show/Hide all (31)

GO ID	Ontology	Definition	Evidence
GO:0000166	Function	Nucleotide binding	IEA
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005221	Function	Intracellularly cyclic nucleotide-activated monoatomic cation channel activity	IEA
GO:0005222	Function	Intracellularly cAMP-activated cation channel activity	IBA
GO:0005223	Function	Intracellularly cGMP-activated cation channel activity	IBA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	ISS
GO:0006814	Process	Sodium ion transport	ISS
GO:0006816	Process	Calcium ion transport	IEA
GO:0006816	Process	Calcium ion transport	ISS
GO:0007606	Process	Sensory perception of chemical stimulus	IBA
GO:0007608	Process	Sensory perception of smell	IEA
GO:0007608	Process	Sensory perception of smell	IEA
GO:0016020	Component	Membrane	IEA
GO:0017071	Component	Intracellular cyclic nucleotide activated cation channel complex	IBA
GO:0030552	Function	CAMP binding	IEA
GO:0030553	Function	CGMP binding	IBA
GO:0030553	Function	CGMP binding	IEA
GO:0030660	Component	Golgi-associated vesicle membrane	TAS
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0042995	Component	Cell projection	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0060170	Component	Ciliary membrane	IEA
GO:0060170	Component	Ciliary membrane	TAS
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0098655	Process	Monoatomic cation transmembrane transport	IBA
GO:0098804	Component	Non-motile cilium membrane	IEA
GO:0098804	Component	Non-motile cilium membrane	ISS

MIM	HGNC	e!Ensembl
609472	2152	ENSG00000132259

Q8IV77

Protein name

Cyclic nucleotide-gated channel alpha-4 (CNG channel alpha-4) (CNGa4) (Olfactory cyclic nucleotide-gated channel subunit 2) (OCNC2)

Protein function

Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00027	cNMP_binding	366 → 457	Cyclic nucleotide-binding domain	Domain
PF00520	Ion_trans	34 → 277	Ion transport protein	Family
PF16526	CLZ	464 → 535	C-terminal leucine zipper domain of cyclic nucleotide-gated channels	Coiled-coil

Sequence

MSQDTKVKTTESSPPAPSKARKLLPVLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPD
LQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGRISSRYVRTWSFFLDLA
SLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVI
HWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPPPAR
EEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLE
RRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEEL
VLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIIN
IKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNKLDV
NAEAAEIALQEATESRLRGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWP
MPEDLAEADDEGEPEEGTSKDEEGRASQEGPPGPE

Sequence length

575

Interactions

View interactions

KEGG Pathway	Reactome Pathway
cAMP signaling pathway	VxPx cargo-targeting to cilium
Olfactory transduction

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DUODENAL ULCER	—	GWAS catalog	37965154, 38036781	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC ULCER	—	GWAS catalog	37965154	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	31527586, 33608531	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PEPTIC ULCER DISEASE	—	GWAS catalog	33608531, 38036781, 39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CNGA4 (cyclic nucleotide gated channel subunit alpha 4)

Bookmark This Gene