CAMK2B (calcium/calmodulin dependent protein kinase II beta)

Gene

• Entrez ID: 816
• Gene name: Calcium/calmodulin dependent protein kinase II beta
• Gene symbol: CAMK2B
• Synonyms (NCBI Gene): CAM2, CAMK2, CAMKB, CaMKIIbeta, MRD54
• Chromosome: 7
• Chromosome location: 7p13
• Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, t

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1554385102	C>T	Likely-pathogenic, uncertain-significance	Splice donor variant
rs1554385111	T>C	Pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs1554385203	T>A	Pathogenic	Coding sequence variant, missense variant
rs1554385305	C>T	Pathogenic	Splice acceptor variant
rs1554386687	C>T	Pathogenic	Coding sequence variant, missense variant
rs1554387293	G>A	Pathogenic	Coding sequence variant, missense variant
rs1554389088	G>A	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs1554402092	C>T	Pathogenic	5 prime UTR variant, coding sequence variant, missense variant
rs1554434435	G>A	Pathogenic, likely-pathogenic	5 prime UTR variant, coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045124	hsa-miR-186-5p	CLASH	23622248
MIRT860136	hsa-miR-1228	CLIP-seq
MIRT860137	hsa-miR-129-3p	CLIP-seq
MIRT860138	hsa-miR-129-5p	CLIP-seq
MIRT860139	hsa-miR-147	CLIP-seq
MIRT860140	hsa-miR-3065-3p	CLIP-seq
MIRT860141	hsa-miR-3127-5p	CLIP-seq
MIRT860142	hsa-miR-3151	CLIP-seq
MIRT860143	hsa-miR-3202	CLIP-seq
MIRT860144	hsa-miR-3591-3p	CLIP-seq
MIRT860145	hsa-miR-3616-3p	CLIP-seq
MIRT860146	hsa-miR-3650	CLIP-seq
MIRT860147	hsa-miR-3911	CLIP-seq
MIRT860148	hsa-miR-3944-3p	CLIP-seq
MIRT860149	hsa-miR-4291	CLIP-seq
MIRT860150	hsa-miR-4436b-3p	CLIP-seq
MIRT860151	hsa-miR-4447	CLIP-seq
MIRT860152	hsa-miR-4450	CLIP-seq
MIRT860153	hsa-miR-4455	CLIP-seq
MIRT860154	hsa-miR-4472	CLIP-seq
MIRT860155	hsa-miR-4476	CLIP-seq
MIRT860156	hsa-miR-4655-5p	CLIP-seq
MIRT860157	hsa-miR-4687-5p	CLIP-seq
MIRT860158	hsa-miR-4690-3p	CLIP-seq
MIRT860159	hsa-miR-4695-5p	CLIP-seq
MIRT860160	hsa-miR-4731-5p	CLIP-seq
MIRT860161	hsa-miR-4747-5p	CLIP-seq
MIRT860162	hsa-miR-4775	CLIP-seq
MIRT860163	hsa-miR-488	CLIP-seq
MIRT860164	hsa-miR-491-5p	CLIP-seq
MIRT860165	hsa-miR-495	CLIP-seq
MIRT860166	hsa-miR-564	CLIP-seq
MIRT860167	hsa-miR-590-3p	CLIP-seq
MIRT860168	hsa-miR-609	CLIP-seq
MIRT860169	hsa-miR-644	CLIP-seq
MIRT860170	hsa-miR-765	CLIP-seq
MIRT860171	hsa-miR-1307	CLIP-seq
MIRT860172	hsa-miR-1323	CLIP-seq
MIRT860173	hsa-miR-3136-3p	CLIP-seq
MIRT860174	hsa-miR-3154	CLIP-seq
MIRT860175	hsa-miR-320e	CLIP-seq
MIRT860176	hsa-miR-3919	CLIP-seq
MIRT860177	hsa-miR-423-3p	CLIP-seq
MIRT860178	hsa-miR-4285	CLIP-seq
MIRT860179	hsa-miR-4475	CLIP-seq
MIRT860158	hsa-miR-4690-3p	CLIP-seq
MIRT860180	hsa-miR-512-3p	CLIP-seq
MIRT860181	hsa-miR-548o	CLIP-seq
MIRT860182	hsa-miR-593	CLIP-seq
MIRT860183	hsa-miR-626	CLIP-seq
MIRT860184	hsa-miR-922	CLIP-seq
MIRT860185	hsa-miR-1184	CLIP-seq
MIRT860186	hsa-miR-1205	CLIP-seq
MIRT860187	hsa-miR-3158-5p	CLIP-seq
MIRT860188	hsa-miR-3166	CLIP-seq
MIRT860189	hsa-miR-3663-5p	CLIP-seq
MIRT860190	hsa-miR-4269	CLIP-seq
MIRT860191	hsa-miR-4733-3p	CLIP-seq
MIRT860192	hsa-miR-4771	CLIP-seq
MIRT860193	hsa-miR-544	CLIP-seq
MIRT860138	hsa-miR-129-5p	CLIP-seq
MIRT1922653	hsa-miR-579	CLIP-seq
MIRT1955260	hsa-miR-624	CLIP-seq
MIRT860145	hsa-miR-3616-3p	CLIP-seq
MIRT860148	hsa-miR-3944-3p	CLIP-seq
MIRT860150	hsa-miR-4436b-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003779	Function	Actin binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004683	Function	Calcium/calmodulin-dependent protein kinase activity	IBA
GO:0004683	Function	Calcium/calmodulin-dependent protein kinase activity	IDA	31930741
GO:0004683	Function	Calcium/calmodulin-dependent protein kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	20668654, 25416956, 26871637, 27173435, 29426014, 32296183, 32707033, 33961781
GO:0005516	Function	Calmodulin binding	IBA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005954	Component	Calcium- and calmodulin-dependent protein kinase complex	IDA	20668654
GO:0005954	Component	Calcium- and calmodulin-dependent protein kinase complex	IEA
GO:0006468	Process	Protein phosphorylation	TAS	9060999
GO:0007165	Process	Signal transduction	TAS	9060999
GO:0007399	Process	Nervous system development	IEA
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0014069	Component	Postsynaptic density	IBA
GO:0014733	Process	Regulation of skeletal muscle adaptation	TAS	15294044
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016529	Component	Sarcoplasmic reticulum	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030666	Component	Endocytic vesicle membrane	IEA
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0033017	Component	Sarcoplasmic reticulum membrane	IEA
GO:0042802	Function	Identical protein binding	IPI	20668654, 25416956
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	20668654
GO:0043005	Component	Neuron projection	IBA
GO:0045202	Component	Synapse	IEA
GO:0046777	Process	Protein autophosphorylation	IDA	18817731
GO:0048168	Process	Regulation of neuronal synaptic plasticity	IBA
GO:0048169	Process	Regulation of long-term neuronal synaptic plasticity	TAS	18817731
GO:0051823	Process	Regulation of synapse structural plasticity	TAS	18817731
GO:0051924	Process	Regulation of calcium ion transport	TAS	15294044
GO:0060291	Process	Long-term synaptic potentiation	IEA
GO:0060291	Process	Long-term synaptic potentiation	TAS	20668654
GO:0060998	Process	Regulation of dendritic spine development	TAS	18817731
GO:0061003	Process	Positive regulation of dendritic spine morphogenesis	ISS
GO:0090129	Process	Positive regulation of synapse maturation	ISS
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1903076	Process	Regulation of protein localization to plasma membrane	IBA
GO:2001222	Process	Regulation of neuron migration	IMP	29100089

Other IDs

• MIM: 607707
• HGNC: 1461
• e!Ensembl: ENSG00000058404

Protein

• UniProt ID: Q13554
• Protein name: Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)
• Protein function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticul
• PDB: 3BHH, 7URW, 7URY, 7URZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	14 → 272	Protein kinase domain	Domain
  PF08332	CaMKII_AD	534 → 661	Calcium/calmodulin dependent protein kinase II association domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. {ECO:0000269|PubMed:16690701}.
• Sequence:

  MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLER
  EARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQI
  LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY
  LSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
  VTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKL
  KGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTK
  NSAAATSPKGTLPPAALEPQTTVIHNPVDGIKESSDSANTTIEDEDAKAPRVPDILSSVR
  RGSGAPEAEGPLPCPSPAPFSPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSP
  ALLGPLSSPSPRISDILNSVRRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIK
  TTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHT
  TILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGA
  PVAPLQ

• Sequence length: 666

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Abnormality of the nervous system	Likely pathogenic; Pathogenic	rs1554389088	RCV001814167	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Intellectual disability	Likely pathogenic; Pathogenic	rs2128963917, rs1554385102, rs1554385111, rs1554385305, rs1554386687, rs1554389088, rs1554402092, rs1554434435, rs2096680726	RCV005622120 RCV000577913 RCV000577892 RCV000577873 RCV000577912 RCV000577890 RCV000577922 RCV000577898 RCV001260651	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Intellectual disability, autosomal dominant 54	Likely pathogenic; Pathogenic	rs2486084284, rs1554385111, rs1554386687, rs1554389088, rs1554402092, rs1554434435, rs1554387293, rs1554385203	RCV003236654 RCV000516162 RCV000516159 RCV000516163 RCV000516161 RCV000516157 RCV000678219 RCV000678220	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Autism spectrum disorder	Uncertain significance; Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL DOMINANT NON-SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet, GWAS catalog, Orphanet Disgenet, GWAS catalog, Orphanet Disgenet, GWAS catalog, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRAIN ANEURYSM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CAMK2B-related disorder	Benign; Likely benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CANNABIS ABUSE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL NEUROLOGIC ANOMALIES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEVELOPMENTAL DISABILITIES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Developmental disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dystonia, early-onset, and/or spastic paraplegia	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLOBAL DEVELOPMENTAL DELAY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary ataxia	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 54	—	Disgenet, HPO Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual disability, autosomal dominant 40	Conflicting classifications of pathogenicity	ClinVar GWAS catalog	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental abnormality	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA, IMPAIRED LANGUAGE, AND DYSMORPHIC FEATURES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHOSES, SUBSTANCE-INDUCED	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of large intestine	Colorectal Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety disorder	Pubtator	33082841	Associate	★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	37597360	Associate	★☆☆☆☆ Found in Text Mining only
Autosomal dominant non-syndromic intellectual disability	Non-Syndromic Intellectual Disability	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Carcinoma	Breast Carcinoma	BEFREE	21871176, 27605043		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21871176, 27605043	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30951563		★☆☆☆☆ Found in Text Mining only
Congenital digestive system anomalies	Congenital Digestive System Anomalies	CLINVAR_DG	29100089		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	35151267	Associate	★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	GWASCAT_DG	23989986		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	30456555		★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	16247765, 29054677		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	40141237	Associate	★☆☆☆☆ Found in Text Mining only
Dyskinetic syndrome	Dyskinetic Syndrome	CLINVAR_DG	29100089		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	35805192	Associate	★☆☆☆☆ Found in Text Mining only
Gastroesophageal reflux disease	Gastroesophageal Reflux Disease	HPO_DG			★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	28062709		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	30816530	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	28062709		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	LHGDN	12496285		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	30816530		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	30816530	Associate	★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	CLINVAR_DG	29100089		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gross motor development delay	Developmental delay	CLINVAR_DG	29100089		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	28232802		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	29100089		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Intellectual Disability	Mental retardation	GENOMICS_ENGLAND_DG	29560374		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Intellectual Disability	Intellectual developmental disorder	Pubtator	37625567	Associate	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Intellectual Disability	Mental retardation	HPO_DG			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Intracranial Aneurysm	Intracranial Aneurysm	GWASCAT_DG	29531279		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21871176, 27605043		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	21871176		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	9060999		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	1469290		★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	16247765, 29054677		★☆☆☆☆ Found in Text Mining only
Mental Retardation Autosomal Recessive 7	Intellectual developmental disorder	Pubtator	37625567	Associate	★☆☆☆☆ Found in Text Mining only
MENTAL RETARDATION, AUTOSOMAL DOMINANT 54	Mental retardation	CLINVAR_DG	29100089		★☆☆☆☆ Found in Text Mining only
MENTAL RETARDATION, AUTOSOMAL DOMINANT 54	Mental retardation	UNIPROT_DG	29100089, 29560374		★☆☆☆☆ Found in Text Mining only
MENTAL RETARDATION, AUTOSOMAL DOMINANT 54	Mental retardation	GENOMICS_ENGLAND_DG			★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome	Metabolic syndrome	Pubtator	37612641	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Metabolic Syndrome X	Metabolic Syndrome	GWASCAT_DG	22399527		★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	GWASDB_DG	22399527		★☆☆☆☆ Found in Text Mining only
Movement Disorders	Movement Disorders	CLINVAR_DG	29100089		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15750623		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	29784083		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	9060999		★☆☆☆☆ Found in Text Mining only
Profound global developmental delay	Developmental Delay	CLINVAR_DG	29100089		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	LHGDN	11042361, 16247765		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	CTD_human_DG	11042361, 20336626		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	BEFREE	16247765		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Severe depression	Mental Depression	BEFREE	16247765		★☆☆☆☆ Found in Text Mining only
Severe intellectual disability	Mental retardation	BEFREE	30184290		★☆☆☆☆ Found in Text Mining only
Sleep Disorders Circadian Rhythm	Sleep disorder	Pubtator	33536559	Associate	★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ventricular arrhythmia	Ventricular arrhythmia	BEFREE	28428622		★☆☆☆☆ Found in Text Mining only