Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CLASS III OBESITY	C1556381	KSR2	Unknown	—	Disgenet	Ras signaling pathway MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants +4 more
MORBID OBESITY	C0028756 EFO_0001074	ADCY3	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		ADCY9	Unknown	39024449	GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		AGER	Unknown	—	Disgenet	Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications +7 more
		AKAP6	Unknown	39024449	GWAS catalog	—
		AS3MT	Unknown	39024449	GWAS catalog	Chemical carcinogenesis - reactive oxygen species Methylation
		ASTN2	Unknown	39024449	GWAS catalog	—
		BBS4	Unknown	—	Disgenet	BBSome-mediated cargo-targeting to cilium
		BDNF	Unknown	39024449	Disgenet, GWAS catalog	MAPK signaling pathway Ras signaling pathway cAMP signaling pathway +9 more
		CAST	Unknown	39024449	GWAS catalog	Shigellosis Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
		CTNNBL1	Unknown	—	Disgenet	Spliceosome mRNA Splicing - Major Pathway
		DNAH8	Unknown	39024449	GWAS catalog	Motor proteins Amyotrophic lateral sclerosis Huntington disease +1 more
		DNAJB4	Unknown	39024449	GWAS catalog	—
		ETV5	Unknown	39024449	GWAS catalog	Transcriptional misregulation in cancer Prostate cancer
		FAIM2	Unknown	39024449	GWAS catalog	—
		FTO	Unknown	39024449 40465716	GWAS catalog	Reversal of alkylation damage by DNA dioxygenases
		GHRL	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +3 more
		GIPC2	Unknown	39024449	GWAS catalog	—
		GIPR	Unknown	39024449	GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +3 more
		GLP1R	Unknown	39024449	GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +5 more
		KCNMA1	Unknown	—	Disgenet	cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion +4 more
		KSR2	Unknown	—	Disgenet	Ras signaling pathway MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants +4 more
		LEP	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +7 more
		LEPR	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +4 more
		LINGO2	Unknown	39024449	GWAS catalog	—
		MAP2K5	Unknown	39024449	GWAS catalog	MAPK signaling pathway Gap junction Neurotrophin signaling pathway +2 more
		MC4R	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +2 more
		MCHR1	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +3 more
		MCM6	Unknown	39024449	GWAS catalog	DNA replication Cell cycle Activation of ATR in response to replication stress +4 more
		NPY2R	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Peptide ligand-binding receptors G alpha (i) signalling events
		NTRK2	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NYAP2	Unknown	39024449	GWAS catalog	—
		POM121C	Unknown	39024449	GWAS catalog	Nucleocytoplasmic transport Amyotrophic lateral sclerosis
		PPARG	Unknown	39024449	Disgenet, GWAS catalog	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		RAPSN	Unknown	39024449	GWAS catalog	—
		RARB	Unknown	39024449	GWAS catalog	Pathways in cancer Small cell lung cancer Non-small cell lung cancer +3 more
		SEC16B	Unknown	39024449	GWAS catalog	COPII-mediated vesicle transport
		SF3A2	Unknown	39024449	GWAS catalog	Spliceosome mRNA Splicing - Major Pathway
		SH2B1	Unknown	39024449	GWAS catalog	Neurotrophin signaling pathway Prolactin receptor signaling Growth hormone receptor signaling +1 more
		SKIDA1	Unknown	39024449	GWAS catalog	—
		SLC39A8	Unknown	39024449	GWAS catalog	Ferroptosis Alzheimer disease Parkinson disease +1 more
		TCF7L2	Unknown	39024449	GWAS catalog	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TFAP2B	Unknown	39024449	GWAS catalog	Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
		TMEM18	Unknown	39024449	GWAS catalog	—
		UCP3	Unknown	—	Disgenet	The fatty acid cycling model The proton buffering model
		ZRANB3	Unknown	39024449	GWAS catalog	—
OBESITY	C0028754 EFO_0001073 MESH:D009765 601665	BDNF	Causal	23563607 36137488 36187959 39024449	Disgenet, GWAS catalog	MAPK signaling pathway Ras signaling pathway cAMP signaling pathway +9 more
		DDHD2	Causal	—	Disgenet	Synthesis of PA
		DIXDC1	Causal	—	Disgenet	—
		EMC1	Causal	—	Disgenet	—
		ENPP1	Causal	—	CTD, Disgenet	Purine metabolism Pyrimidine metabolism Starch and sucrose metabolism +7 more
		FBXO11	Causal	—	Disgenet	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		LEPR	Causal	17065336 17229951 19913045 20567778 22276206 23563609 24263156 25222487 29743445 30689673 30993381 3519326 35235096 35472412	CTD, Disgenet, GWAS catalog	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +4 more
		MC4R	Causal	17143585 18454148 19079260 19079261 19151714 23251400 22013104 23563607 23563609 30677029	CTD, Disgenet, GWAS catalog	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +2 more
		PPARG	Causal	11089532 28242765 39024449	CTD, Disgenet, GWAS catalog, HPO	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		ADCY3	Unknown	23563607 29311635 30677029 31504550 36187959	CTD, Disgenet, GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		ADCY9	Unknown	23563607 39024449	GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		AKAP6	Unknown	36137488 39024449	GWAS catalog	—
		ASTN2	Unknown	23251661	GWAS catalog	—
		BBS4	Unknown	—	Disgenet	BBSome-mediated cargo-targeting to cilium
		CAST	Unknown	39024449	GWAS catalog	Shigellosis Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
		DNAH8	Unknown	39024449	GWAS catalog	Motor proteins Amyotrophic lateral sclerosis Huntington disease +1 more
		DNAJB4	Unknown	39024449	GWAS catalog	—
		ETV5	Unknown	23563607 39024449	GWAS catalog	Transcriptional misregulation in cancer Prostate cancer
		FAIM2	Unknown	30677029 31504550 39024449	GWAS catalog	—
		FTO	Unknown	17496892 19079260 19079261 19151714 19918250 21076408 17658951 18159244 19553259 20421936 21544081 21552555 21706003 23563607 23563609 30677029 31504550 31852448 34836030 36137488 39024449 40465716	CTD, Disgenet, GWAS catalog	Reversal of alkylation damage by DNA dioxygenases
		GHRL	Unknown	—	CTD, Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +3 more
		GIPC2	Unknown	39024449	GWAS catalog	—
		GIPR	Unknown	23563607 39024449	Disgenet, GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +3 more
		GLP1R	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +5 more
		KCNMA1	Unknown	21708048 27605626	CTD, Disgenet, GWAS catalog	cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion +4 more
		KSR2	Unknown	—	Disgenet	Ras signaling pathway MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants +4 more
		LEP	Unknown	17517446 18515891 19913045 20122948 24042701 25086370 25551525 25554529 26186301 27071101 28698385 31313498 9202122 9502777 9826672	CTD, Disgenet	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +7 more
		LINGO2	Unknown	23251661 23563607 39024449	GWAS catalog	—
		MAP2K5	Unknown	23563607 39024449	GWAS catalog	MAPK signaling pathway Gap junction Neurotrophin signaling pathway +2 more
		MCM6	Unknown	39024449	GWAS catalog	DNA replication Cell cycle Activation of ATR in response to replication stress +4 more
		NPY2R	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Peptide ligand-binding receptors G alpha (i) signalling events
		NTRK2	Unknown	15494731	CTD, Disgenet	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NYAP2	Unknown	21706003	GWAS catalog	—
		POM121C	Unknown	23251661 39024449	GWAS catalog	Nucleocytoplasmic transport Amyotrophic lateral sclerosis
		RARB	Unknown	19553259 39024449	GWAS catalog	Pathways in cancer Small cell lung cancer Non-small cell lung cancer +3 more
		SEC16B	Unknown	23563607 30677029 31504550 36137488 39024449	GWAS catalog	COPII-mediated vesicle transport
		SF3A2	Unknown	39024449	GWAS catalog	Spliceosome mRNA Splicing - Major Pathway
		SH2B1	Unknown	19079261 23563607 39024449	CTD, Disgenet, GWAS catalog	Neurotrophin signaling pathway Prolactin receptor signaling Growth hormone receptor signaling +1 more
		SLC39A8	Unknown	39024449	GWAS catalog	Ferroptosis Alzheimer disease Parkinson disease +1 more
		TCF7L2	Unknown	39024449	GWAS catalog	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TFAP2B	Unknown	19557161 23563607 31504550 39024449	GWAS catalog	Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
		TMEM18	Unknown	19079261 20421936 23563607 23563609 30677029 31504550 36137488 39024449	CTD, Disgenet, GWAS catalog	—
		UCP3	Unknown	14671178 18177726 24646999 9753710 12588803 14764818 26287746 29311637 29311636 37855273 12165561 11443223 12646665 11487744 10199800 15486053 23869016 11136233 9769326 25163632	CTD, Disgenet	The fatty acid cycling model The proton buffering model
OBESITY DUE TO CONGENITAL LEPTIN DEFICIENCY	66628 MONDO:0013991	LEP	Causal	26567097	ClinVar, GenCC, Orphanet	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +7 more
OBESITY DUE TO LEPTIN RECEPTOR GENE DEFICIENCY	179494 C5191640 MONDO:0013992	LEPR	Causal	17229951 9537324	ClinVar, Disgenet, GenCC, Orphanet	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +4 more
OBESITY DUE TO MELANOCORTIN 4 RECEPTOR DEFICIENCY	71529 C4273958 MONDO:0019115	MC4R	Causal	10903343	Disgenet, GWAS catalog, Orphanet	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +2 more
OBESITY, HYPERPHAGIA, AND DEVELOPMENTAL DELAY	613886 C3151303 MESH:C563938 MONDO:0013483	NTRK2	Causal	—	CTD, ClinVar, Disgenet, GenCC, HPO	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
OBESITY, MORBID	MESH:D009767	ADCY3	Unknown	29311637	CTD	Purine metabolism Metabolic pathways Endocrine resistance +61 more
		BDNF	Unknown	21708048	CTD	MAPK signaling pathway Ras signaling pathway cAMP signaling pathway +9 more
		KCNMA1	Unknown	21708048	CTD	cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion +4 more
		KSR2	Unknown	29273807	CTD	Ras signaling pathway MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants +4 more
		LEP	Unknown	15070752 9500540	CTD	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +7 more
		LEPR	Unknown	9537324	CTD	Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling +4 more
		MC4R	Unknown	29273807 29311635	CTD	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +2 more

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Obesity

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