Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID	6416
Gene name	Mitogen-activated protein kinase kinase 4
Gene symbol	MAP2K4
Synonyms (NCBI Gene)	JNKKJNKK1MAPKK4MEK4MKK4PRKMK4SAPKK-1SAPKK1SEK1SERK1SKK1
Chromosome	17
Chromosome location	17p12
Summary	This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, different

616

Show/Hide all (616)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019756	hsa-miR-375	Microarray	20215506
MIRT028937	hsa-miR-26b-5p	Microarray	19088304
MIRT023483	hsa-miR-15b-5p	CLASH	23622248
MIRT053655	hsa-miR-145-5p	Microarray	22942087
MIRT053698	hsa-miR-188-5p	Microarray	22942087
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assayWestern blot	24556602
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assayWestern blot	24556602
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assayWestern blot	24556602
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assayWestern blot	24556602
MIRT437965	hsa-miR-92a-3p	qRT-PCRLuciferase reporter assayWestern blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCRLuciferase reporter assayWestern blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCRLuciferase reporter assayWestern blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCRLuciferase reporter assayWestern blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCRLuciferase reporter assayWestern blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCRLuciferase reporter assayWestern blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCRLuciferase reporter assayWestern blot	24705900
MIRT437965	hsa-miR-92a-3p	qRT-PCRLuciferase reporter assayWestern blot	24705900
MIRT556342	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT556341	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT437965	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT556340	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT556339	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT030360	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT556338	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT556337	hsa-miR-548ab	PAR-CLIP	21572407
MIRT556336	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT556335	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT556334	hsa-miR-548ak	PAR-CLIP	21572407
MIRT556333	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT556332	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT556331	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT556330	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT556329	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT556328	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT556327	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT556326	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT556325	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT556324	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT556323	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT556322	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT556321	hsa-miR-548i	PAR-CLIP	21572407
MIRT556320	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT556319	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT556318	hsa-miR-548w	PAR-CLIP	21572407
MIRT556317	hsa-miR-548y	PAR-CLIP	21572407
MIRT556316	hsa-miR-559	PAR-CLIP	21572407
MIRT556315	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT556314	hsa-miR-3614-5p	PAR-CLIP	21572407
MIRT556313	hsa-miR-5193	PAR-CLIP	21572407
MIRT556312	hsa-miR-660-3p	PAR-CLIP	21572407
MIRT556311	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT556310	hsa-miR-3185	PAR-CLIP	21572407
MIRT556309	hsa-miR-4691-5p	PAR-CLIP	21572407
MIRT556308	hsa-miR-6792-3p	PAR-CLIP	21572407
MIRT556307	hsa-miR-6749-3p	PAR-CLIP	21572407
MIRT556306	hsa-miR-7703	PAR-CLIP	21572407
MIRT556305	hsa-miR-4325	PAR-CLIP	21572407
MIRT556304	hsa-miR-7855-5p	PAR-CLIP	21572407
MIRT556303	hsa-miR-6818-3p	PAR-CLIP	21572407
MIRT473860	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT473859	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT473858	hsa-miR-4534	PAR-CLIP	23592263
MIRT473857	hsa-miR-8082	PAR-CLIP	23592263
MIRT473856	hsa-miR-3134	PAR-CLIP	23592263
MIRT473855	hsa-miR-4261	PAR-CLIP	23592263
MIRT473854	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT473853	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT473852	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT473851	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT030360	hsa-miR-25-3p	Western blot	27353001
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assayqRT-PCRWestern blot	27594411
MIRT054442	hsa-miR-27a-3p	Luciferase reporter assayqRT-PCRWestern blot	27594411
MIRT736251	hsa-miR-200a-3p	Luciferase reporter assayWestern blottingqRT-PCRFlow cytometryImmunocytochemistry (ICC)	32016794
MIRT737290	hsa-miR-512-3p	Luciferase reporter assayWestern blottingImmunohistochemistry (IHC)qRT-PCR	32850377
MIRT556342	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT556341	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT437965	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT556340	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT556339	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT030360	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT556338	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT556337	hsa-miR-548ab	PAR-CLIP	21572407
MIRT556336	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT556335	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT556334	hsa-miR-548ak	PAR-CLIP	21572407
MIRT556333	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT556332	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT556331	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT556330	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT556329	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT556328	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT556327	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT556326	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT556325	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT556324	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT556323	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT556322	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT556321	hsa-miR-548i	PAR-CLIP	21572407
MIRT556320	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT556319	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT556318	hsa-miR-548w	PAR-CLIP	21572407
MIRT556317	hsa-miR-548y	PAR-CLIP	21572407
MIRT556316	hsa-miR-559	PAR-CLIP	21572407
MIRT556315	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT556314	hsa-miR-3614-5p	PAR-CLIP	21572407
MIRT556313	hsa-miR-5193	PAR-CLIP	21572407
MIRT556312	hsa-miR-660-3p	PAR-CLIP	21572407
MIRT556311	hsa-miR-3121-5p	PAR-CLIP	21572407
MIRT556310	hsa-miR-3185	PAR-CLIP	21572407
MIRT556309	hsa-miR-4691-5p	PAR-CLIP	21572407
MIRT556308	hsa-miR-6792-3p	PAR-CLIP	21572407
MIRT556307	hsa-miR-6749-3p	PAR-CLIP	21572407
MIRT556306	hsa-miR-7703	PAR-CLIP	21572407
MIRT556305	hsa-miR-4325	PAR-CLIP	21572407
MIRT556304	hsa-miR-7855-5p	PAR-CLIP	21572407
MIRT556303	hsa-miR-6818-3p	PAR-CLIP	21572407
MIRT473860	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT473859	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT473858	hsa-miR-4534	PAR-CLIP	23592263
MIRT473857	hsa-miR-8082	PAR-CLIP	23592263
MIRT473856	hsa-miR-3134	PAR-CLIP	23592263
MIRT473855	hsa-miR-4261	PAR-CLIP	23592263
MIRT473854	hsa-miR-542-3p	PAR-CLIP	23592263
MIRT473853	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT473852	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT473851	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT1128003	hsa-miR-1231	CLIP-seq
MIRT1128004	hsa-miR-1255a	CLIP-seq
MIRT1128005	hsa-miR-1255b	CLIP-seq
MIRT1128006	hsa-miR-125a-3p	CLIP-seq
MIRT1128007	hsa-miR-1266	CLIP-seq
MIRT1128008	hsa-miR-1273c	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128010	hsa-miR-1284	CLIP-seq
MIRT1128011	hsa-miR-1285	CLIP-seq
MIRT1128012	hsa-miR-129-3p	CLIP-seq
MIRT1128013	hsa-miR-134	CLIP-seq
MIRT1128014	hsa-miR-137	CLIP-seq
MIRT1128015	hsa-miR-140-3p	CLIP-seq
MIRT1128016	hsa-miR-15a	CLIP-seq
MIRT1128017	hsa-miR-15b	CLIP-seq
MIRT1128018	hsa-miR-16	CLIP-seq
MIRT1128019	hsa-miR-195	CLIP-seq
MIRT1128020	hsa-miR-1972	CLIP-seq
MIRT1128021	hsa-miR-2115	CLIP-seq
MIRT1128022	hsa-miR-2276	CLIP-seq
MIRT1128023	hsa-miR-2278	CLIP-seq
MIRT1128024	hsa-miR-25	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT1128027	hsa-miR-3065-5p	CLIP-seq
MIRT1128028	hsa-miR-3118	CLIP-seq
MIRT1128029	hsa-miR-3164	CLIP-seq
MIRT1128030	hsa-miR-3171	CLIP-seq
MIRT1128031	hsa-miR-3183	CLIP-seq
MIRT1128032	hsa-miR-3187-5p	CLIP-seq
MIRT1128033	hsa-miR-32	CLIP-seq
MIRT1128034	hsa-miR-3202	CLIP-seq
MIRT1128035	hsa-miR-34b	CLIP-seq
MIRT1128036	hsa-miR-3591-3p	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT1128038	hsa-miR-3611	CLIP-seq
MIRT1128039	hsa-miR-3622a-3p	CLIP-seq
MIRT1128040	hsa-miR-3622b-3p	CLIP-seq
MIRT1128041	hsa-miR-363	CLIP-seq
MIRT1128042	hsa-miR-3664-3p	CLIP-seq
MIRT1128043	hsa-miR-3665	CLIP-seq
MIRT1128044	hsa-miR-367	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT1128046	hsa-miR-369-3p	CLIP-seq
MIRT1128047	hsa-miR-374a	CLIP-seq
MIRT1128048	hsa-miR-374b	CLIP-seq
MIRT1128049	hsa-miR-378g	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT1128051	hsa-miR-3977	CLIP-seq
MIRT1128052	hsa-miR-424	CLIP-seq
MIRT1128053	hsa-miR-4256	CLIP-seq
MIRT1128054	hsa-miR-4271	CLIP-seq
MIRT1128055	hsa-miR-431	CLIP-seq
MIRT1128056	hsa-miR-4452	CLIP-seq
MIRT1128057	hsa-miR-4486	CLIP-seq
MIRT1128058	hsa-miR-4501	CLIP-seq
MIRT1128059	hsa-miR-4502	CLIP-seq
MIRT1128060	hsa-miR-4518	CLIP-seq
MIRT1128061	hsa-miR-4524	CLIP-seq
MIRT1128062	hsa-miR-4642	CLIP-seq
MIRT1128063	hsa-miR-4649-5p	CLIP-seq
MIRT1128064	hsa-miR-4650-5p	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT740154	hsa-miR-4678	CLIP-seq
MIRT1128066	hsa-miR-4690-3p	CLIP-seq
MIRT1128067	hsa-miR-4690-5p	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT1128068	hsa-miR-4717-3p	CLIP-seq
MIRT1128069	hsa-miR-4723-3p	CLIP-seq
MIRT1128070	hsa-miR-4725-3p	CLIP-seq
MIRT1128071	hsa-miR-4747-5p	CLIP-seq
MIRT1128072	hsa-miR-4764-5p	CLIP-seq
MIRT1128073	hsa-miR-4772-3p	CLIP-seq
MIRT1128074	hsa-miR-4777-5p	CLIP-seq
MIRT1128075	hsa-miR-4789-5p	CLIP-seq
MIRT1128076	hsa-miR-497	CLIP-seq
MIRT1128077	hsa-miR-503	CLIP-seq
MIRT1128078	hsa-miR-505	CLIP-seq
MIRT1128079	hsa-miR-5095	CLIP-seq
MIRT1128080	hsa-miR-513a-5p	CLIP-seq
MIRT1128081	hsa-miR-516a-3p	CLIP-seq
MIRT1128082	hsa-miR-518d-5p	CLIP-seq
MIRT1128083	hsa-miR-519b-5p	CLIP-seq
MIRT1128084	hsa-miR-519c-5p	CLIP-seq
MIRT1128085	hsa-miR-520c-5p	CLIP-seq
MIRT1128086	hsa-miR-526a	CLIP-seq
MIRT1128087	hsa-miR-544	CLIP-seq
MIRT1128088	hsa-miR-612	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT1128089	hsa-miR-646	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT1128091	hsa-miR-758	CLIP-seq
MIRT1128092	hsa-miR-92a	CLIP-seq
MIRT1128093	hsa-miR-92b	CLIP-seq
MIRT1556631	hsa-miR-1302	CLIP-seq
MIRT1556632	hsa-miR-22	CLIP-seq
MIRT1556633	hsa-miR-221	CLIP-seq
MIRT1556634	hsa-miR-222	CLIP-seq
MIRT1556635	hsa-miR-3122	CLIP-seq
MIRT1556636	hsa-miR-3649	CLIP-seq
MIRT1556637	hsa-miR-382	CLIP-seq
MIRT1556638	hsa-miR-3913-5p	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT1556639	hsa-miR-4298	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT1556640	hsa-miR-548v	CLIP-seq
MIRT2036387	hsa-miR-1227	CLIP-seq
MIRT2036388	hsa-miR-1229	CLIP-seq
MIRT1128007	hsa-miR-1266	CLIP-seq
MIRT1128008	hsa-miR-1273c	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128012	hsa-miR-129-3p	CLIP-seq
MIRT1128015	hsa-miR-140-3p	CLIP-seq
MIRT2036389	hsa-miR-145	CLIP-seq
MIRT2036390	hsa-miR-150	CLIP-seq
MIRT1128020	hsa-miR-1972	CLIP-seq
MIRT1128021	hsa-miR-2115	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT2036391	hsa-miR-299-3p	CLIP-seq
MIRT2036392	hsa-miR-3120-3p	CLIP-seq
MIRT2036393	hsa-miR-3150b-3p	CLIP-seq
MIRT1128031	hsa-miR-3183	CLIP-seq
MIRT1128034	hsa-miR-3202	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT1128039	hsa-miR-3622a-3p	CLIP-seq
MIRT1128040	hsa-miR-3622b-3p	CLIP-seq
MIRT2036394	hsa-miR-3647-3p	CLIP-seq
MIRT1128042	hsa-miR-3664-3p	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT2036395	hsa-miR-3942-5p	CLIP-seq
MIRT1128051	hsa-miR-3977	CLIP-seq
MIRT2036396	hsa-miR-4251	CLIP-seq
MIRT2036397	hsa-miR-4267	CLIP-seq
MIRT1128054	hsa-miR-4271	CLIP-seq
MIRT1128055	hsa-miR-431	CLIP-seq
MIRT2036398	hsa-miR-4329	CLIP-seq
MIRT2036399	hsa-miR-4491	CLIP-seq
MIRT1128060	hsa-miR-4518	CLIP-seq
MIRT2036400	hsa-miR-452	CLIP-seq
MIRT2036401	hsa-miR-4639-3p	CLIP-seq
MIRT1128062	hsa-miR-4642	CLIP-seq
MIRT1128064	hsa-miR-4650-5p	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT2036402	hsa-miR-4657	CLIP-seq
MIRT2036403	hsa-miR-4676-3p	CLIP-seq
MIRT2036404	hsa-miR-4681	CLIP-seq
MIRT1128066	hsa-miR-4690-3p	CLIP-seq
MIRT2036405	hsa-miR-4703-5p	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT2036406	hsa-miR-4713-5p	CLIP-seq
MIRT2036407	hsa-miR-4714-5p	CLIP-seq
MIRT1128069	hsa-miR-4723-3p	CLIP-seq
MIRT1128070	hsa-miR-4725-3p	CLIP-seq
MIRT1128071	hsa-miR-4747-5p	CLIP-seq
MIRT2036408	hsa-miR-4784	CLIP-seq
MIRT1128081	hsa-miR-516a-3p	CLIP-seq
MIRT2036409	hsa-miR-532-3p	CLIP-seq
MIRT2036410	hsa-miR-548h	CLIP-seq
MIRT2036411	hsa-miR-548j	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT2036412	hsa-miR-668	CLIP-seq
MIRT2036413	hsa-miR-887	CLIP-seq
MIRT2036414	hsa-miR-892a	CLIP-seq
MIRT2036415	hsa-miR-942	CLIP-seq
MIRT2036416	hsa-miR-943	CLIP-seq
MIRT2266617	hsa-miR-1205	CLIP-seq
MIRT2036387	hsa-miR-1227	CLIP-seq
MIRT1128003	hsa-miR-1231	CLIP-seq
MIRT2266618	hsa-miR-124	CLIP-seq
MIRT2266619	hsa-miR-127-3p	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128010	hsa-miR-1284	CLIP-seq
MIRT1128011	hsa-miR-1285	CLIP-seq
MIRT2266620	hsa-miR-136	CLIP-seq
MIRT2266621	hsa-miR-141	CLIP-seq
MIRT2036389	hsa-miR-145	CLIP-seq
MIRT2266622	hsa-miR-200a	CLIP-seq
MIRT2266623	hsa-miR-204	CLIP-seq
MIRT2266624	hsa-miR-211	CLIP-seq
MIRT1128024	hsa-miR-25	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT2266625	hsa-miR-29a	CLIP-seq
MIRT2266626	hsa-miR-29b	CLIP-seq
MIRT2266627	hsa-miR-29c	CLIP-seq
MIRT2266628	hsa-miR-3065-3p	CLIP-seq
MIRT1128027	hsa-miR-3065-5p	CLIP-seq
MIRT2036392	hsa-miR-3120-3p	CLIP-seq
MIRT2036393	hsa-miR-3150b-3p	CLIP-seq
MIRT2266629	hsa-miR-3161	CLIP-seq
MIRT1128032	hsa-miR-3187-5p	CLIP-seq
MIRT1128033	hsa-miR-32	CLIP-seq
MIRT1128035	hsa-miR-34b	CLIP-seq
MIRT1128036	hsa-miR-3591-3p	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT1128038	hsa-miR-3611	CLIP-seq
MIRT2266630	hsa-miR-3619-3p	CLIP-seq
MIRT1128041	hsa-miR-363	CLIP-seq
MIRT2266631	hsa-miR-3660	CLIP-seq
MIRT2266632	hsa-miR-3661	CLIP-seq
MIRT2266633	hsa-miR-3663-5p	CLIP-seq
MIRT1128044	hsa-miR-367	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT2266634	hsa-miR-3690	CLIP-seq
MIRT2266635	hsa-miR-3692	CLIP-seq
MIRT1128049	hsa-miR-378g	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT2036395	hsa-miR-3942-5p	CLIP-seq
MIRT2266636	hsa-miR-409-3p	CLIP-seq
MIRT2036396	hsa-miR-4251	CLIP-seq
MIRT2266637	hsa-miR-4254	CLIP-seq
MIRT1128053	hsa-miR-4256	CLIP-seq
MIRT2266638	hsa-miR-4287	CLIP-seq
MIRT2036398	hsa-miR-4329	CLIP-seq
MIRT2266639	hsa-miR-433	CLIP-seq
MIRT2266640	hsa-miR-4469	CLIP-seq
MIRT1128057	hsa-miR-4486	CLIP-seq
MIRT2266641	hsa-miR-4520a-3p	CLIP-seq
MIRT2266642	hsa-miR-4526	CLIP-seq
MIRT2266643	hsa-miR-4638-3p	CLIP-seq
MIRT2036401	hsa-miR-4639-3p	CLIP-seq
MIRT1128062	hsa-miR-4642	CLIP-seq
MIRT1128063	hsa-miR-4649-5p	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT740154	hsa-miR-4678	CLIP-seq
MIRT2266644	hsa-miR-4685-3p	CLIP-seq
MIRT2036405	hsa-miR-4703-5p	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT2266645	hsa-miR-4712-5p	CLIP-seq
MIRT2036406	hsa-miR-4713-5p	CLIP-seq
MIRT2036407	hsa-miR-4714-5p	CLIP-seq
MIRT1128068	hsa-miR-4717-3p	CLIP-seq
MIRT2266646	hsa-miR-4738-3p	CLIP-seq
MIRT2266647	hsa-miR-4742-5p	CLIP-seq
MIRT2266648	hsa-miR-4771	CLIP-seq
MIRT2266649	hsa-miR-4775	CLIP-seq
MIRT2266650	hsa-miR-4776-5p	CLIP-seq
MIRT2036408	hsa-miR-4784	CLIP-seq
MIRT1128075	hsa-miR-4789-5p	CLIP-seq
MIRT2266651	hsa-miR-487b	CLIP-seq
MIRT1128078	hsa-miR-505	CLIP-seq
MIRT2266652	hsa-miR-506	CLIP-seq
MIRT2266653	hsa-miR-5096	CLIP-seq
MIRT1128080	hsa-miR-513a-5p	CLIP-seq
MIRT2036410	hsa-miR-548h	CLIP-seq
MIRT2036411	hsa-miR-548j	CLIP-seq
MIRT2266654	hsa-miR-590-3p	CLIP-seq
MIRT1128088	hsa-miR-612	CLIP-seq
MIRT2266655	hsa-miR-617	CLIP-seq
MIRT2266656	hsa-miR-619	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT2266657	hsa-miR-631	CLIP-seq
MIRT2266658	hsa-miR-634	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT2036412	hsa-miR-668	CLIP-seq
MIRT1128091	hsa-miR-758	CLIP-seq
MIRT2266659	hsa-miR-767-5p	CLIP-seq
MIRT2266660	hsa-miR-770-5p	CLIP-seq
MIRT2036413	hsa-miR-887	CLIP-seq
MIRT2036414	hsa-miR-892a	CLIP-seq
MIRT1128092	hsa-miR-92a	CLIP-seq
MIRT1128093	hsa-miR-92b	CLIP-seq
MIRT2036387	hsa-miR-1227	CLIP-seq
MIRT2036392	hsa-miR-3120-3p	CLIP-seq
MIRT2036393	hsa-miR-3150b-3p	CLIP-seq
MIRT2390550	hsa-miR-3174	CLIP-seq
MIRT2390551	hsa-miR-339-5p	CLIP-seq
MIRT2390552	hsa-miR-3606	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT2390553	hsa-miR-3682-5p	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT2036395	hsa-miR-3942-5p	CLIP-seq
MIRT2036396	hsa-miR-4251	CLIP-seq
MIRT2266638	hsa-miR-4287	CLIP-seq
MIRT2036398	hsa-miR-4329	CLIP-seq
MIRT2390554	hsa-miR-4424	CLIP-seq
MIRT2266640	hsa-miR-4469	CLIP-seq
MIRT2036401	hsa-miR-4639-3p	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT2266644	hsa-miR-4685-3p	CLIP-seq
MIRT2036405	hsa-miR-4703-5p	CLIP-seq
MIRT2036406	hsa-miR-4713-5p	CLIP-seq
MIRT2036407	hsa-miR-4714-5p	CLIP-seq
MIRT2036408	hsa-miR-4784	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT2036412	hsa-miR-668	CLIP-seq
MIRT2390555	hsa-miR-921	CLIP-seq
MIRT740154	hsa-miR-4678	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128010	hsa-miR-1284	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT1128038	hsa-miR-3611	CLIP-seq
MIRT2438485	hsa-miR-4704-5p	CLIP-seq
MIRT1128075	hsa-miR-4789-5p	CLIP-seq
MIRT2266653	hsa-miR-5096	CLIP-seq
MIRT1128080	hsa-miR-513a-5p	CLIP-seq
MIRT1128091	hsa-miR-758	CLIP-seq
MIRT2453656	hsa-miR-1321	CLIP-seq
MIRT2453657	hsa-miR-148a	CLIP-seq
MIRT2453658	hsa-miR-148b	CLIP-seq
MIRT2453659	hsa-miR-152	CLIP-seq
MIRT2453660	hsa-miR-3136-3p	CLIP-seq
MIRT2453661	hsa-miR-4270	CLIP-seq
MIRT2453662	hsa-miR-4276	CLIP-seq
MIRT2453663	hsa-miR-4441	CLIP-seq
MIRT2453664	hsa-miR-4739	CLIP-seq
MIRT2453665	hsa-miR-4755-3p	CLIP-seq
MIRT2453666	hsa-miR-4756-5p	CLIP-seq
MIRT2453656	hsa-miR-1321	CLIP-seq
MIRT2453657	hsa-miR-148a	CLIP-seq
MIRT2453658	hsa-miR-148b	CLIP-seq
MIRT2453659	hsa-miR-152	CLIP-seq
MIRT2453660	hsa-miR-3136-3p	CLIP-seq
MIRT2453661	hsa-miR-4270	CLIP-seq
MIRT2453662	hsa-miR-4276	CLIP-seq
MIRT2453663	hsa-miR-4441	CLIP-seq
MIRT2453664	hsa-miR-4739	CLIP-seq
MIRT2453665	hsa-miR-4755-3p	CLIP-seq
MIRT2453666	hsa-miR-4756-5p	CLIP-seq
MIRT2566278	hsa-miR-1200	CLIP-seq
MIRT2036387	hsa-miR-1227	CLIP-seq
MIRT1128003	hsa-miR-1231	CLIP-seq
MIRT2266618	hsa-miR-124	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128010	hsa-miR-1284	CLIP-seq
MIRT2566279	hsa-miR-135a	CLIP-seq
MIRT2566280	hsa-miR-135b	CLIP-seq
MIRT1128014	hsa-miR-137	CLIP-seq
MIRT2266621	hsa-miR-141	CLIP-seq
MIRT2036389	hsa-miR-145	CLIP-seq
MIRT2266622	hsa-miR-200a	CLIP-seq
MIRT1556632	hsa-miR-22	CLIP-seq
MIRT2566281	hsa-miR-2277-3p	CLIP-seq
MIRT1128023	hsa-miR-2278	CLIP-seq
MIRT1128024	hsa-miR-25	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT2566282	hsa-miR-3117-3p	CLIP-seq
MIRT2036392	hsa-miR-3120-3p	CLIP-seq
MIRT2566283	hsa-miR-3133	CLIP-seq
MIRT2036393	hsa-miR-3150b-3p	CLIP-seq
MIRT2566284	hsa-miR-3166	CLIP-seq
MIRT2566285	hsa-miR-3169	CLIP-seq
MIRT1128033	hsa-miR-32	CLIP-seq
MIRT1128036	hsa-miR-3591-3p	CLIP-seq
MIRT2566286	hsa-miR-3605-5p	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT1128038	hsa-miR-3611	CLIP-seq
MIRT1128039	hsa-miR-3622a-3p	CLIP-seq
MIRT1128040	hsa-miR-3622b-3p	CLIP-seq
MIRT1128041	hsa-miR-363	CLIP-seq
MIRT1128044	hsa-miR-367	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT2566287	hsa-miR-3714	CLIP-seq
MIRT2566288	hsa-miR-376c	CLIP-seq
MIRT2566289	hsa-miR-3908	CLIP-seq
MIRT2566290	hsa-miR-3910	CLIP-seq
MIRT2566291	hsa-miR-3919	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT2566292	hsa-miR-3942-3p	CLIP-seq
MIRT2036395	hsa-miR-3942-5p	CLIP-seq
MIRT2036396	hsa-miR-4251	CLIP-seq
MIRT2566293	hsa-miR-4324	CLIP-seq
MIRT2036398	hsa-miR-4329	CLIP-seq
MIRT2566294	hsa-miR-4421	CLIP-seq
MIRT2566295	hsa-miR-4428	CLIP-seq
MIRT2566296	hsa-miR-4433	CLIP-seq
MIRT2566297	hsa-miR-4490	CLIP-seq
MIRT2566298	hsa-miR-4515	CLIP-seq
MIRT2036401	hsa-miR-4639-3p	CLIP-seq
MIRT1128062	hsa-miR-4642	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT740154	hsa-miR-4678	CLIP-seq
MIRT2036405	hsa-miR-4703-5p	CLIP-seq
MIRT2438485	hsa-miR-4704-5p	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT2566299	hsa-miR-4707-5p	CLIP-seq
MIRT2266645	hsa-miR-4712-5p	CLIP-seq
MIRT2036407	hsa-miR-4714-5p	CLIP-seq
MIRT1128068	hsa-miR-4717-3p	CLIP-seq
MIRT1128071	hsa-miR-4747-5p	CLIP-seq
MIRT2566300	hsa-miR-4759	CLIP-seq
MIRT2566301	hsa-miR-4773	CLIP-seq
MIRT2566302	hsa-miR-4778-5p	CLIP-seq
MIRT2036408	hsa-miR-4784	CLIP-seq
MIRT1128075	hsa-miR-4789-5p	CLIP-seq
MIRT2566303	hsa-miR-4802-5p	CLIP-seq
MIRT2266652	hsa-miR-506	CLIP-seq
MIRT2266653	hsa-miR-5096	CLIP-seq
MIRT1128080	hsa-miR-513a-5p	CLIP-seq
MIRT2566304	hsa-miR-526b	CLIP-seq
MIRT2566305	hsa-miR-544b	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT2566306	hsa-miR-627	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT2036412	hsa-miR-668	CLIP-seq
MIRT1128091	hsa-miR-758	CLIP-seq
MIRT2566307	hsa-miR-765	CLIP-seq
MIRT2266660	hsa-miR-770-5p	CLIP-seq
MIRT2036414	hsa-miR-892a	CLIP-seq
MIRT2566308	hsa-miR-922	CLIP-seq
MIRT2566309	hsa-miR-924	CLIP-seq
MIRT1128092	hsa-miR-92a	CLIP-seq
MIRT1128093	hsa-miR-92b	CLIP-seq
MIRT2036387	hsa-miR-1227	CLIP-seq
MIRT1128003	hsa-miR-1231	CLIP-seq
MIRT1128007	hsa-miR-1266	CLIP-seq
MIRT2684463	hsa-miR-1273e	CLIP-seq
MIRT1128009	hsa-miR-128	CLIP-seq
MIRT1128011	hsa-miR-1285	CLIP-seq
MIRT2566279	hsa-miR-135a	CLIP-seq
MIRT2566280	hsa-miR-135b	CLIP-seq
MIRT1128014	hsa-miR-137	CLIP-seq
MIRT2266621	hsa-miR-141	CLIP-seq
MIRT2036389	hsa-miR-145	CLIP-seq
MIRT2684464	hsa-miR-1825	CLIP-seq
MIRT1128020	hsa-miR-1972	CLIP-seq
MIRT2684465	hsa-miR-199a-5p	CLIP-seq
MIRT2684466	hsa-miR-199b-5p	CLIP-seq
MIRT2266622	hsa-miR-200a	CLIP-seq
MIRT2684467	hsa-miR-218	CLIP-seq
MIRT1556632	hsa-miR-22	CLIP-seq
MIRT2566281	hsa-miR-2277-3p	CLIP-seq
MIRT1128024	hsa-miR-25	CLIP-seq
MIRT1128025	hsa-miR-27a	CLIP-seq
MIRT1128026	hsa-miR-27b	CLIP-seq
MIRT2036392	hsa-miR-3120-3p	CLIP-seq
MIRT2036393	hsa-miR-3150b-3p	CLIP-seq
MIRT1128032	hsa-miR-3187-5p	CLIP-seq
MIRT1128033	hsa-miR-32	CLIP-seq
MIRT1128036	hsa-miR-3591-3p	CLIP-seq
MIRT2566286	hsa-miR-3605-5p	CLIP-seq
MIRT1128037	hsa-miR-3607-3p	CLIP-seq
MIRT1128039	hsa-miR-3622a-3p	CLIP-seq
MIRT1128040	hsa-miR-3622b-3p	CLIP-seq
MIRT1128041	hsa-miR-363	CLIP-seq
MIRT1128042	hsa-miR-3664-3p	CLIP-seq
MIRT1128044	hsa-miR-367	CLIP-seq
MIRT1128045	hsa-miR-3686	CLIP-seq
MIRT2566287	hsa-miR-3714	CLIP-seq
MIRT1128049	hsa-miR-378g	CLIP-seq
MIRT2566289	hsa-miR-3908	CLIP-seq
MIRT2566291	hsa-miR-3919	CLIP-seq
MIRT1128050	hsa-miR-3921	CLIP-seq
MIRT2036395	hsa-miR-3942-5p	CLIP-seq
MIRT2036396	hsa-miR-4251	CLIP-seq
MIRT2684468	hsa-miR-4302	CLIP-seq
MIRT2036398	hsa-miR-4329	CLIP-seq
MIRT2684469	hsa-miR-4422	CLIP-seq
MIRT2566296	hsa-miR-4433	CLIP-seq
MIRT1128057	hsa-miR-4486	CLIP-seq
MIRT1128060	hsa-miR-4518	CLIP-seq
MIRT2036400	hsa-miR-452	CLIP-seq
MIRT2036401	hsa-miR-4639-3p	CLIP-seq
MIRT1128062	hsa-miR-4642	CLIP-seq
MIRT1128063	hsa-miR-4649-5p	CLIP-seq
MIRT1128064	hsa-miR-4650-5p	CLIP-seq
MIRT1128065	hsa-miR-4653-5p	CLIP-seq
MIRT2036403	hsa-miR-4676-3p	CLIP-seq
MIRT740154	hsa-miR-4678	CLIP-seq
MIRT2036405	hsa-miR-4703-5p	CLIP-seq
MIRT740155	hsa-miR-4705	CLIP-seq
MIRT2566299	hsa-miR-4707-5p	CLIP-seq
MIRT2266645	hsa-miR-4712-5p	CLIP-seq
MIRT2036407	hsa-miR-4714-5p	CLIP-seq
MIRT1128068	hsa-miR-4717-3p	CLIP-seq
MIRT2036408	hsa-miR-4784	CLIP-seq
MIRT2566303	hsa-miR-4802-5p	CLIP-seq
MIRT2566304	hsa-miR-526b	CLIP-seq
MIRT1128088	hsa-miR-612	CLIP-seq
MIRT740153	hsa-miR-624	CLIP-seq
MIRT2566306	hsa-miR-627	CLIP-seq
MIRT2684470	hsa-miR-636	CLIP-seq
MIRT2684471	hsa-miR-648	CLIP-seq
MIRT1128090	hsa-miR-659	CLIP-seq
MIRT2036412	hsa-miR-668	CLIP-seq
MIRT2566307	hsa-miR-765	CLIP-seq
MIRT2266660	hsa-miR-770-5p	CLIP-seq
MIRT2036414	hsa-miR-892a	CLIP-seq
MIRT2566308	hsa-miR-922	CLIP-seq
MIRT1128092	hsa-miR-92a	CLIP-seq
MIRT1128093	hsa-miR-92b	CLIP-seq
MIRT2036416	hsa-miR-943	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
HSF2	Repression	11557063

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IBA
GO:0000165	Process	MAPK cascade	IEA
GO:0000165	Process	MAPK cascade	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	7716521
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004708	Function	MAP kinase kinase activity	IBA
GO:0004708	Function	MAP kinase kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	9808624, 15299019, 16533805, 21900206, 32707033, 34439869, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007165	Process	Signal transduction	TAS	7716521
GO:0007254	Process	JNK cascade	TAS	7716521
GO:0008545	Function	JUN kinase kinase activity	TAS
GO:0009611	Process	Response to wounding	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0033554	Process	Cellular response to stress	IEA
GO:0034390	Process	Smooth muscle cell apoptotic process	IEA
GO:0036481	Process	Intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IEA
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0060090	Function	Molecular adaptor activity	EXP	34439869
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445
GO:0090398	Process	Cellular senescence	TAS
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000672	Process	Negative regulation of motor neuron apoptotic process	IEA

MIM	HGNC	e!Ensembl
601335	6844	ENSG00000065559

P45985

Protein name

Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1)

Protein function

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,

PDB

3ALN , 3ALO , 3VUT , 8YP5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	102 → 367	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Sequence

MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT
LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV
HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL
MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS
GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE
LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD

Sequence length

399

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANTI-GAD65 AUTOIMMUNE NEUROLOGICAL SYNDROMES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	-	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMORRHOID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHROLITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neuroblastoma	other	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESPIRATORY SYSTEM DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UROLITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (109)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	15623633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of colon	Adenocarcinoma Of Colon	BEFREE	28454307		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of large intestine	Colorectal Cancer	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of large intestine	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	21896780		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma, Endometrioid	Endometrial Cancer	BEFREE	21372598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma of large intestine	Colorectal adenoma	BEFREE	28423721		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	26080319	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	30537492		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	13130464, 16802349, 25732927	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	BEFREE	24721794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	32510852	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Benign tumor of pancreas	Benign Tumor Of Pancreas	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	15592684	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast adenocarcinoma	Breast Adenocarcinoma	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	11754110, 15592684, 27509166, 29710529, 31761784, 9622070		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	15592684, 22522925, 22722193, 28027327, 35589867, 36656864, 39264897	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms Male	Male breast neoplasms	Pubtator	24194916	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	21518142, 22335172	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	12376211, 15623633, 16627982, 17116802, 29975246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Endometrioid	Endometrioid carcinoma	Pubtator	21575258	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Intraductal Noninfiltrating	Intraductal noninfiltrating carcinoma	Pubtator	26249178, 28338653	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	12714585, 20554746, 21702039, 30072581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	33341545	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Endometrioid	Endometrioid cancer	BEFREE	21372598, 21575258		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	12438272, 17276500, 20309881, 21487811		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	22335172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	22335172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Diseases	Colonic disease	Pubtator	28179590	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	LHGDN	18436711		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	19610067, 21702039, 28423721, 31157265		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	28423721, 32686686	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	29072705		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	21372598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	31418419, 31678285		★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Lobar Degeneration	Frontotemporal dementia	BEFREE	30999060		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gallbladder Carcinoma	Gallbladder cancer	BEFREE	31369289		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastric Adenocarcinoma	Gastric Cancer	BEFREE	16492916, 17116802		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	LHGDN	16964394		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glycogen Storage Disease Type II	Glycogen storage disease	Pubtator	23940728	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	BEFREE	10620019		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	26856463		★★★★★ ★☆☆☆☆ Found in Text Mining only
Laryngeal Squamous Cell Carcinoma	Laryngeal Carcinoma	BEFREE	19513509		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	15494423	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid	Myeloid leukemia	Pubtator	9858570	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	21518142	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	21518142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lewy Body Disease	Lewy body disease	Pubtator	32887355	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Diseases	Liver disease	Pubtator	26165383	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	26165383, 28777004	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	12714585, 26560124	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	17158870		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	11754110, 15592684, 24194916, 27509166, 29710529, 31761784		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	21372598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of gallbladder	Gallbladder cancer	BEFREE	31369289		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	12714585, 20554746, 21702039, 30072581		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	12438272, 17276500, 20309881, 21487811		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	12097290, 15623633, 19260747, 23299404, 24532253, 31075266		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	10554023, 11306453, 18337456, 19638505, 22526163, 25019290, 27594411, 29328468, 30917169		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15184866, 16721048, 18337456, 19012245, 19610067, 20554746, 21518142, 21575258, 21896780, 22335172, 22526163, 26554761, 29328468, 29472518, 29899543, 30537492, 9331070 View all (2 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	22335172		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	11754110, 15592684		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	29472518		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	24008424	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metastatic melanoma	Metastatic Melanoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	21702039, 31594754		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11694646, 11754110, 12097290, 12376211, 12645656, 12734425, 15184866, 15592684, 16721048, 16740690, 17116802, 21372598, 21487811, 21575258, 21702039 View all (11 more)		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	21638028, 24253178		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	15136468, 16115952, 17158870		★★★★★ ★☆☆☆☆ Found in Text Mining only
Noninfiltrating Intraductal Carcinoma	Ductal carcinoma	BEFREE	28084333, 28338653		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	29409330		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoglophonic dwarfism	Osteoglophonic dwarfism	Pubtator	31251836	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	LHGDN	16167336		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	22154052, 24556602		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	24556602	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Carcinoma	Ovarian Carcinoma	BEFREE	12438272		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Diseases	Ovarian diseases	Pubtator	17276500	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	12438272, 17276500, 20309881, 21487811, 21575258		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	16627982, 17276500	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	18337456, 21575258	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Serous Adenocarcinoma	Ovarian serous adenocarcinoma	BEFREE	16627982		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Serous Adenocarcinoma	Ovarian serous adenocarcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	15623633, 23299404, 24532253, 31075266		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	30537492		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasm	Pancreatic Neoplasm	BEFREE	15184866		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasm	Pancreatic Neoplasm	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Peutz-Jeghers Syndrome	Peutz-Jeghers Syndrome	BEFREE	10436774		★★★★★ ★☆☆☆☆ Found in Text Mining only
Progressive supranuclear palsy	Progressive Supranuclear Palsy	BEFREE	30999060		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	10554023, 11306453, 18337456, 19638505, 22526163, 25019290, 27594411, 29328468, 30917169		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Intraepithelial Neoplasia	Prostatic intraepithelial neoplasia	Pubtator	32740981	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	18337456	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	26444865	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	BEFREE	19012245		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	LHGDN	19012245		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	Pubtator	23797008	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	LHGDN	13130464		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	14734742, 16802349, 25732927		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	29801054	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	28319306, 36916400	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of tongue	Tongue carcinoma	BEFREE	28319306		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	10854223, 21097718, 23921907, 25198898	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroiditis	Thyroiditis	Pubtator	27353001	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	29472518		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	19010820, 22335172	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MAP2K4 (mitogen-activated protein kinase kinase 4)