Gene Gene information from NCBI Gene database.
Entrez ID 3620
Gene name Indoleamine 2,3-dioxygenase 1
Gene symbol IDO1
Synonyms (NCBI Gene)
IDOIDO-1INDO
Chromosome 8
Chromosome location 8p11.21
Summary This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5
miRNA miRNA information provided by mirtarbase database.
268
miRTarBase ID miRNA Experiments Reference
MIRT1059501 hsa-miR-106a CLIP-seq
MIRT1059502 hsa-miR-106b CLIP-seq
MIRT1059503 hsa-miR-1234 CLIP-seq
MIRT1059504 hsa-miR-150 CLIP-seq
MIRT1059505 hsa-miR-17 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
EGR2 Unknown 24007274
PTMA Activation 21176371;21575365
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
41
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0002666 Process Positive regulation of T cell tolerance induction IEA
GO:0002678 Process Positive regulation of chronic inflammatory response IEA
GO:0002830 Process Positive regulation of type 2 immune response IEA
GO:0004833 Function Tryptophan 2,3-dioxygenase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
147435 6059 ENSG00000131203
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P14902
Protein name Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase)
Protein function Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing a
PDB 2D0T , 2D0U , 4PK5 , 4PK6 , 4U72 , 4U74 , 5EK2 , 5EK3 , 5EK4 , 5ETW , 5WHR , 5WMU , 5WMV , 5WMW , 5WMX , 5WN8 , 5XE1 , 6AZU , 6AZV , 6AZW , 6CXU , 6CXV , 6DPQ , 6DPR , 6E35 , 6E40 , 6E41 , 6E42 , 6E43 , 6E44 , 6E45 , 6E46 , 6F0A , 6KOF , 6KPS , 6KW7 , 6MQ6 , 6O3I , 6PU7 , 6PZ1 , 6R63 , 6UBP , 6V52 , 6WJY , 6WPE , 6X5Y , 7A62 , 7AH4 , 7AH5 , 7AH6 , 7B1O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01231 IDO 11 398 Indoleamine 2,3-dioxygenase Family
Tissue specificity TISSUE SPECIFICITY: Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as
Sequence
Sequence length 403
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANHEDONIA Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC DEPRESSION Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DEGENERATIVE DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Ablepharon macrostomia syndrome Ablepharon macrostomia syndrome Pubtator 26110930 Stimulate
★☆☆☆☆
Found in Text Mining only
Acute intermittent porphyria Intermittent Porphyria BEFREE 31135488
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 29038460
★☆☆☆☆
Found in Text Mining only
Adamantinous Craniopharyngioma Adamantinous Craniopharyngioma BEFREE 28859336
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 29526824, 29805749, 29901571, 30448912
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 30014971, 30194181, 30367104, 30448912, 31163080
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 30747725
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 27174915
★☆☆☆☆
Found in Text Mining only
Allergic rhinitis (disorder) Allergic rhinitis BEFREE 30623620
★☆☆☆☆
Found in Text Mining only
alpha 1-Antitrypsin Deficiency Alpha 1-Antitrypsin Deficiency BEFREE 30666511
★☆☆☆☆
Found in Text Mining only