Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 78
12
Diseases
3,515
Unique genes
0.071
Avg. similarity score
Coronary artery disease
Most-connected disease (8 links)
Disease
Searched: Myocardial infarction
Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details ·
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Myocardial infarction
Coronary artery disease
Hypertension
Migraine
Venous thromboembolism
Atrial fibrillation
Cardiovascular disease
Endometriosis
Intellectual developmental disorder growth metabolic
band heterotopia of brain
Trichilemmal cyst
Hemorrhagic destruction of the brain subependymal calcification and cataracts
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Coronary artery disease | 8 | 6 | 1,143 |
| Hypertension | 7 | 7 | 1,149 |
| Migraine | 5 | 5 | 404 |
| Myocardial infarction | 5 | 5 | 580 |
| Venous thromboembolism | 4 | 4 | 342 |
| Atrial fibrillation | 4 | 2 | 863 |
| Cardiovascular disease | 3 | 3 | 432 |
| Endometriosis | 2 | 2 | 376 |
| Intellectual developmental disorder growth metabolic | 2 | 1 | 1 |
| band heterotopia of brain | 2 | 0 | 1 |
| Trichilemmal cyst | 1 | 1 | 1 |
| Hemorrhagic destruction of the brain subependymal calcification and cataracts | 1 | 0 | 1 |
Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| ABO | 7 / 12 | Atrial fibrillation, Coronary artery disease, Endometriosis, Hypertension and 3 more |
| ATP2B1 | 6 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| CDH13 | 6 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| MTHFR | 6 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| NOS3 | 6 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| PCCB | 6 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| SMG6 | 6 / 12 | Atrial fibrillation, Coronary artery disease, Hypertension, Migraine and 2 more |
| THADA | 6 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| TNF | 6 / 12 | Coronary artery disease, Endometriosis, Hypertension, Migraine and 2 more |
| ZFPM2 | 6 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| ABHD17C | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Endometriosis, Hypertension and 1 more |
| ACE | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| AGT | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| ARHGAP42 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Endometriosis, Hypertension and 1 more |
| ASTN2 | 5 / 12 | Atrial fibrillation, Coronary artery disease, Endometriosis, Migraine and 1 more |
| ATP1B1 | 5 / 12 | Coronary artery disease, Endometriosis, Hypertension, Myocardial infarction and 1 more |
| BCAS3 | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| C1GALT1 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| CASZ1 | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| CNNM2 | 5 / 12 | Atrial fibrillation, Coronary artery disease, Hypertension, Migraine and 1 more |
| CUX2 | 5 / 12 | Atrial fibrillation, Coronary artery disease, Hypertension, Myocardial infarction and 1 more |
| F5 | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Endometriosis, Myocardial infarction and 1 more |
| FBN2 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| FES | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| FGD5 | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| FGF5 | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| FIGN | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| FTO | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| GOSR2 | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| KCNE2 | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Migraine and 1 more |
| KCNK5 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| LPL | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| MAD1L1 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| MC4R | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| MRPS6 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| NPPB | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| NR3C1 | 5 / 12 | Atrial fibrillation, Coronary artery disease, Endometriosis, Hypertension and 1 more |
| NT5C2 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| PAPPA | 5 / 12 | Atrial fibrillation, Coronary artery disease, Endometriosis, Migraine and 1 more |
| PHACTR1 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| PLCE1 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Endometriosis, Hypertension and 1 more |
| PRDM16 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| PRDM8 | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| PTGS2 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Endometriosis, Hypertension and 1 more |
| PTPRD | 5 / 12 | Atrial fibrillation, Coronary artery disease, Endometriosis, Hypertension and 1 more |
| PTPRJ | 5 / 12 | Atrial fibrillation, Coronary artery disease, Hypertension, Myocardial infarction and 1 more |
| RUNX1 | 5 / 12 | Atrial fibrillation, Endometriosis, Hypertension, Migraine and 1 more |
| SAYSD1 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| SH2B3 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Myocardial infarction and 1 more |
| TGFB1 | 5 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| VEGFA | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| VWF | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| ZNF831 | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| ZPR1 | 5 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| ABCC10 | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension |
| ACTRT2 | 4 / 12 | Atrial fibrillation, Coronary artery disease, Hypertension, Myocardial infarction |
| AGER | 4 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Myocardial infarction |
| ALDH1A2 | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension |
| ALDH2 | 4 / 12 | Atrial fibrillation, Coronary artery disease, Hypertension, Myocardial infarction |
| APOB | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Myocardial infarction |
| APOC1 | 4 / 12 | Atrial fibrillation, Coronary artery disease, Hypertension, Myocardial infarction |
| APOE | 4 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Myocardial infarction |
| ARHGAP26 | 4 / 12 | Atrial fibrillation, Coronary artery disease, Endometriosis, Myocardial infarction |
| ATXN2 | 4 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Myocardial infarction |
| BCAR1 | 4 / 12 | Coronary artery disease, Hypertension, Migraine, Myocardial infarction |
| BCL2 | 4 / 12 | Endometriosis, Hypertension, Migraine, Myocardial infarction |
| BICC1 | 4 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine |
| C2 | 4 / 12 | Coronary artery disease, Endometriosis, Hypertension, Myocardial infarction |
| CCDC170 | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Endometriosis, Venous thromboembolism |
| CCL2 | 4 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Myocardial infarction |
| CDC25A | 4 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Myocardial infarction |
| CELSR2 | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Myocardial infarction |
| CETP | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension |
| CFDP1 | 4 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine |
| CLCN6 | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension |
| CMIP | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension |
| COL4A1 | 4 / 12 | Cardiovascular disease, Coronary artery disease, Migraine, Myocardial infarction |
| CSK | 4 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Myocardial infarction |
| DGKZ | 4 / 12 | Coronary artery disease, Migraine, Myocardial infarction, Venous thromboembolism |
| DPP6 | 4 / 12 | Coronary artery disease, Endometriosis, Migraine, Venous thromboembolism |
| EBF2 | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Hypertension, Venous thromboembolism |
| EDN1 | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension |
| EDNRA | 4 / 12 | Coronary artery disease, Hypertension, Migraine, Myocardial infarction |
| ERBB4 | 4 / 12 | Atrial fibrillation, Coronary artery disease, Endometriosis, Migraine |
| ESR1 | 4 / 12 | Coronary artery disease, Endometriosis, Migraine, Myocardial infarction |
| ESR2 | 4 / 12 | Atrial fibrillation, Coronary artery disease, Endometriosis, Hypertension |
| F7 | 4 / 12 | Coronary artery disease, Hypertension, Myocardial infarction, Venous thromboembolism |
| FBRSL1 | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension |
| FGB | 4 / 12 | Cardiovascular disease, Coronary artery disease, Myocardial infarction, Venous thromboembolism |
| FGD6 | 4 / 12 | Coronary artery disease, Endometriosis, Migraine, Myocardial infarction |
| FHL5 | 4 / 12 | Coronary artery disease, Endometriosis, Migraine, Myocardial infarction |
| FN1 | 4 / 12 | Coronary artery disease, Endometriosis, Hypertension, Myocardial infarction |
| FOXC1 | 4 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Myocardial infarction |
| GATA4 | 4 / 12 | Atrial fibrillation, Endometriosis, Hypertension, Myocardial infarction |
| GCKR | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Venous thromboembolism |
| GMDS | 4 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Myocardial infarction |
| GPR149 | 4 / 12 | Cardiovascular disease, Coronary artery disease, Migraine, Myocardial infarction |
| GTF2I | 4 / 12 | Atrial fibrillation, Cardiovascular disease, Hypertension, Migraine |
| GUCY1A1 | 4 / 12 | Cardiovascular disease, Coronary artery disease, Hypertension, Myocardial infarction |
| HECTD4 | 4 / 12 | Coronary artery disease, Hypertension, Myocardial infarction, Venous thromboembolism |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| AGE-RAGE signaling pathway in diabetic complications | KEGG | 64 / 101 | 2.2× | 1.07e-12 | 2.30e-10 ✓ sig. |
| cGMP-PKG signaling pathway | KEGG | 76 / 166 | 1.6× | 4.26e-6 | 1.79e-4 ✓ sig. |
| Cholesterol metabolism | KEGG | 30 / 51 | 2.0× | 1.03e-5 | 3.62e-4 ✓ sig. |
| Thyroid hormone signaling pathway | KEGG | 58 / 122 | 1.6× | 1.42e-5 | 4.74e-4 ✓ sig. |
| Prostate cancer | KEGG | 48 / 98 | 1.7× | 2.90e-5 | 8.56e-4 ✓ sig. |
| Proteoglycans in cancer | KEGG | 86 / 204 | 1.4× | 5.18e-5 | 1.38e-3 ✓ sig. |
| Renin secretion | KEGG | 36 / 69 | 1.8× | 5.28e-5 | 1.40e-3 ✓ sig. |
| Nuclear Receptor transcription pathway | Reactome | 29 / 52 | 1.9× | 5.72e-5 | 1.49e-3 ✓ sig. |
| Interleukin-4 and Interleukin-13 signaling | Reactome | 51 / 108 | 1.6× | 5.72e-5 | 1.49e-3 ✓ sig. |
| Complement and coagulation cascades | KEGG | 43 / 88 | 1.7× | 7.95e-5 | 1.94e-3 ✓ sig. |
| Hormone signaling | KEGG | 90 / 219 | 1.4× | 1.08e-4 | 2.46e-3 ✓ sig. |
| NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux | Reactome | 22 / 37 | 2.0× | 1.25e-4 | 2.77e-3 ✓ sig. |
| RUNX3 regulates CDKN1A transcription | Reactome | 7 / 7 | 3.4× | 1.83e-4 | 3.75e-3 ✓ sig. |
| Aldosterone-regulated sodium reabsorption | KEGG | 22 / 38 | 2.0× | 2.15e-4 | 4.24e-3 ✓ sig. |
| Cytoskeleton in muscle cells | KEGG | 93 / 232 | 1.4× | 2.40e-4 | 4.63e-3 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| positive regulation of transcription by RNA polymerase II | GO:0045944 | 380 / 1,208 | 1.7× | 6.27e-28 | 2.74e-24 ✓ sig. |
| regulation of blood pressure | GO:0008217 | 56 / 83 | 3.6× | 3.60e-22 | 7.72e-19 ✓ sig. |
| response to xenobiotic stimulus | GO:0009410 | 110 / 248 | 2.4× | 1.61e-20 | 2.73e-17 ✓ sig. |
| response to hypoxia | GO:0001666 | 79 / 176 | 2.4× | 1.74e-15 | 1.34e-12 ✓ sig. |
| angiogenesis | GO:0001525 | 109 / 284 | 2.0× | 7.05e-15 | 4.84e-12 ✓ sig. |
| negative regulation of cell population proliferation | GO:0008285 | 151 / 444 | 1.8× | 1.09e-14 | 7.19e-12 ✓ sig. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | GO:0051897 | 89 / 217 | 2.2× | 2.31e-14 | 1.42e-11 ✓ sig. |
| heart development | GO:0007507 | 104 / 273 | 2.0× | 5.16e-14 | 2.99e-11 ✓ sig. |
| positive regulation of MAPK cascade | GO:0043410 | 90 / 224 | 2.1× | 7.05e-14 | 3.96e-11 ✓ sig. |
| positive regulation of DNA-templated transcription | GO:0045893 | 229 / 778 | 1.6× | 1.59e-13 | 8.43e-11 ✓ sig. |
| blood coagulation | GO:0007596 | 53 / 106 | 2.7× | 3.73e-13 | 1.84e-10 ✓ sig. |
| regulation of heart rate by cardiac conduction | GO:0086091 | 30 / 43 | 3.7× | 4.23e-13 | 2.08e-10 ✓ sig. |
| negative regulation of apoptotic process | GO:0043066 | 165 / 524 | 1.7× | 1.19e-12 | 5.42e-10 ✓ sig. |
| positive regulation of angiogenesis | GO:0045766 | 68 / 159 | 2.3× | 2.59e-12 | 1.10e-9 ✓ sig. |
| cardiac muscle contraction | GO:0060048 | 29 / 43 | 3.6× | 3.99e-12 | 1.64e-9 ✓ sig. |