ACTRT2 (actin related protein T2)

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Gene Gene information from NCBI Gene database.
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Entrez ID 140625
Gene name Actin related protein T2
Gene symbol ACTRT2
Synonyms (NCBI Gene)
ARPM2ARPT2Arp-T2HARPM2
Chromosome 1
Chromosome location 1p36.32
Summary The protein encoded by this intronless gene belongs to the actin family. Studies have shown that this protein may be involved in cytoskeletal organization similar to other cytoplasmic actin-related protein (ARP) subfamily members. Antibody raised against
miRNA miRNA information provided by mirtarbase database.
1
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miRTarBase ID miRNA Experiments Reference
MIRT017952 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
4
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005856 Component Cytoskeleton IEA
GO:0015629 Component Actin cytoskeleton IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
608535 24026 ENSG00000169717
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8TDY3
Protein name Actin-related protein T2 (ARP-T2) (Actin-related protein M2)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00022 Actin 6 → 377 Actin Family
Sequence
Sequence length 377
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
13
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (13)
Phenotype Name Clinical Significance Source Reference Evidence Score
ATRIAL FIBRILLATION — GWAS catalog 40645996
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER — GWAS catalog 34099189
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CERVICAL CARCINOMA — GWAS catalog 33794208
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONDUCTION SYSTEM DISORDER — GWAS catalog 39024449
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Asthenozoospermia Asthenozoospermia Pubtator 25293813 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Obesity Obesity Pubtator 25293813 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
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TTC34 2 shared diseasesCervical cancer, Conduction disorder of the heart 2 shared evidence sourcesGWAS catalog (Cervical cancer), GWAS catalog (Conduction disorder of the heart) Related via 2 shared diseases including Cervical cancer, Conduction disorder of the heart — evidence mostly GWAS catalog. KCNQ1 2 shared diseasesCervical cancer, Conduction disorder of the heart 1 shared evidence sourceGWAS catalog (Cervical cancer) Related via 2 shared diseases including Cervical cancer, Conduction disorder of the heart — evidence mostly GWAS catalog.
Hypothyroidism Linked via 1 of 2 related genesTTC34 Multiple sclerosis Linked via 1 of 2 related genesTTC34 Rheumatoid arthritis Linked via 1 of 2 related genesTTC34 Cardiac arrhythmia Linked via 1 of 2 related genesKCNQ1 Beckwith-wiedemann syndrome Linked via 1 of 2 related genesKCNQ1