Gene Gene information from NCBI Gene database.
Entrez ID 481
Gene name ATPase Na+/K+ transporting subunit beta 1
Gene symbol ATP1B1
Synonyms (NCBI Gene)
ATP1B
Chromosome 1
Chromosome location 1q24.2
Summary The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemica
miRNA miRNA information provided by mirtarbase database.
434
miRTarBase ID miRNA Experiments Reference
MIRT007176 hsa-miR-192-5p Luciferase reporter assay 23221637
MIRT007176 hsa-miR-192-5p Luciferase reporter assay 23221637
MIRT007176 hsa-miR-192-5p Luciferase reporter assay 23221637
MIRT441154 hsa-miR-218-5p HITS-CLIP 23212916
MIRT441154 hsa-miR-218-5p HITS-CLIP 23212916
Transcription factors Transcription factors information provided by TRRUST V2 database.
5
Transcription factor Regulation Reference
NR3C1 Repression 9694812
NR3C1 Unknown 11216640
NR3C2 Repression 9694812
NR3C2 Unknown 11216640
PGR Unknown 22330642
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
94
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0001671 Function ATPase activator activity IBA
GO:0001671 Function ATPase activator activity IDA 10636900, 19542013, 23954377
GO:0001671 Function ATPase activator activity IEA
GO:0001671 Function ATPase activator activity IGI 16861705, 18728015, 20100892
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
182330 804 ENSG00000143153
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P05026
Protein name Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)
Protein function This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers,
PDB 7E1Z , 7E20 , 7E21 , 8D3U , 8D3V , 8D3W , 8D3X , 8D3Y , 8ZYJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00287 Na_K-ATPase 3 297 Sodium / potassium ATPase beta chain Family
Tissue specificity TISSUE SPECIFICITY: Found in most tissues.
Sequence
Sequence length 303
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
13
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BLOOD COAGULATION DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARDIAC ARRHYTHMIA Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CATARACT GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Myeloid Leukemia (AML-M2) Leukemia CTD_human_DG 17330099
★☆☆☆☆
Found in Text Mining only
Acute Myeloid Leukemia, M1 Myeloid Leukemia CTD_human_DG 17330099
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 36094096 Associate
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 36835202 Associate
★☆☆☆☆
Found in Text Mining only
Atrial Fibrillation Atrial fibrillation Pubtator 37967346 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 22330642
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 22330642 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Basal Cell Basal cell carcinoma Pubtator 25227856 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 33868261 Stimulate
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Renal cell carcinoma Pubtator 24452105 Associate
★☆☆☆☆
Found in Text Mining only