Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID	489
Gene name	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
Gene symbol	ATP2A3
Synonyms (NCBI Gene)	SERCA3
Chromosome	17
Chromosome location	17p13.2
Summary	This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to

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miRTarBase ID	miRNA	Experiments	Reference
MIRT489870	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT489869	hsa-miR-1321	PAR-CLIP	23592263
MIRT489868	hsa-miR-4739	PAR-CLIP	23592263
MIRT489867	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT489865	hsa-miR-4270	PAR-CLIP	23592263
MIRT489866	hsa-miR-4441	PAR-CLIP	23592263
MIRT489864	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT489863	hsa-miR-4419a	PAR-CLIP	23592263
MIRT489862	hsa-miR-4510	PAR-CLIP	23592263
MIRT489861	hsa-miR-6127	PAR-CLIP	23592263
MIRT489860	hsa-miR-6129	PAR-CLIP	23592263
MIRT489859	hsa-miR-6130	PAR-CLIP	23592263
MIRT489858	hsa-miR-6133	PAR-CLIP	23592263
MIRT489857	hsa-miR-938	PAR-CLIP	23592263
MIRT489856	hsa-miR-6886-3p	PAR-CLIP	23592263
MIRT489855	hsa-miR-3656	PAR-CLIP	23592263
MIRT489854	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT489853	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT489851	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT489852	hsa-miR-8085	PAR-CLIP	23592263
MIRT489850	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT489849	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT489848	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT489847	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT441153	hsa-miR-127-5p	HITS-CLIP	24374217
MIRT441153	hsa-miR-127-5p	HITS-CLIP	24374217
MIRT489870	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT489869	hsa-miR-1321	PAR-CLIP	23592263
MIRT489868	hsa-miR-4739	PAR-CLIP	23592263
MIRT489867	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT489865	hsa-miR-4270	PAR-CLIP	23592263
MIRT489866	hsa-miR-4441	PAR-CLIP	23592263
MIRT489864	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT489863	hsa-miR-4419a	PAR-CLIP	23592263
MIRT489862	hsa-miR-4510	PAR-CLIP	23592263
MIRT489861	hsa-miR-6127	PAR-CLIP	23592263
MIRT489860	hsa-miR-6129	PAR-CLIP	23592263
MIRT489859	hsa-miR-6130	PAR-CLIP	23592263
MIRT489858	hsa-miR-6133	PAR-CLIP	23592263
MIRT489857	hsa-miR-938	PAR-CLIP	23592263
MIRT489856	hsa-miR-6886-3p	PAR-CLIP	23592263
MIRT489855	hsa-miR-3656	PAR-CLIP	23592263
MIRT489854	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT489853	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT489851	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT489852	hsa-miR-8085	PAR-CLIP	23592263
MIRT489850	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT489849	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT489848	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT489847	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT807424	hsa-miR-1184	CLIP-seq
MIRT807425	hsa-miR-1205	CLIP-seq
MIRT807426	hsa-miR-1252	CLIP-seq
MIRT807427	hsa-miR-1915	CLIP-seq
MIRT807428	hsa-miR-1972	CLIP-seq
MIRT807429	hsa-miR-216b	CLIP-seq
MIRT807430	hsa-miR-3144-5p	CLIP-seq
MIRT807431	hsa-miR-3158-5p	CLIP-seq
MIRT807432	hsa-miR-3190	CLIP-seq
MIRT807433	hsa-miR-3191	CLIP-seq
MIRT807434	hsa-miR-3615	CLIP-seq
MIRT807435	hsa-miR-4267	CLIP-seq
MIRT807436	hsa-miR-4269	CLIP-seq
MIRT807437	hsa-miR-4537	CLIP-seq
MIRT807438	hsa-miR-4636	CLIP-seq
MIRT807439	hsa-miR-4652-5p	CLIP-seq
MIRT807440	hsa-miR-4716-3p	CLIP-seq
MIRT807441	hsa-miR-4723-5p	CLIP-seq
MIRT807442	hsa-miR-4726-3p	CLIP-seq
MIRT807443	hsa-miR-4752	CLIP-seq
MIRT807444	hsa-miR-4793-3p	CLIP-seq
MIRT807445	hsa-miR-4795-5p	CLIP-seq
MIRT807446	hsa-miR-491-5p	CLIP-seq
MIRT807447	hsa-miR-671-5p	CLIP-seq
MIRT807448	hsa-miR-759	CLIP-seq
MIRT807449	hsa-miR-766	CLIP-seq
MIRT807450	hsa-miR-939	CLIP-seq
MIRT807451	hsa-miR-129-5p	CLIP-seq
MIRT807452	hsa-miR-190	CLIP-seq
MIRT807453	hsa-miR-190b	CLIP-seq
MIRT807454	hsa-miR-214	CLIP-seq
MIRT807455	hsa-miR-3130-3p	CLIP-seq
MIRT807456	hsa-miR-3163	CLIP-seq
MIRT807457	hsa-miR-3183	CLIP-seq
MIRT807458	hsa-miR-320a	CLIP-seq
MIRT807459	hsa-miR-320b	CLIP-seq
MIRT807460	hsa-miR-320c	CLIP-seq
MIRT807461	hsa-miR-320d	CLIP-seq
MIRT807462	hsa-miR-338-3p	CLIP-seq
MIRT807463	hsa-miR-3619-5p	CLIP-seq
MIRT807464	hsa-miR-3665	CLIP-seq
MIRT807465	hsa-miR-3973	CLIP-seq
MIRT807466	hsa-miR-4326	CLIP-seq
MIRT807467	hsa-miR-4424	CLIP-seq
MIRT807468	hsa-miR-4429	CLIP-seq
MIRT807469	hsa-miR-4530	CLIP-seq
MIRT807470	hsa-miR-4668-3p	CLIP-seq
MIRT807471	hsa-miR-4682	CLIP-seq
MIRT807472	hsa-miR-4691-5p	CLIP-seq
MIRT807473	hsa-miR-4723-3p	CLIP-seq
MIRT807474	hsa-miR-4757-3p	CLIP-seq
MIRT807475	hsa-miR-4776-3p	CLIP-seq
MIRT807444	hsa-miR-4793-3p	CLIP-seq
MIRT807476	hsa-miR-544	CLIP-seq
MIRT807477	hsa-miR-548p	CLIP-seq
MIRT807478	hsa-miR-562	CLIP-seq
MIRT807479	hsa-miR-622	CLIP-seq
MIRT807480	hsa-miR-657	CLIP-seq
MIRT807481	hsa-miR-761	CLIP-seq
MIRT807449	hsa-miR-766	CLIP-seq
MIRT807424	hsa-miR-1184	CLIP-seq
MIRT807425	hsa-miR-1205	CLIP-seq
MIRT1938405	hsa-miR-1275	CLIP-seq
MIRT1938406	hsa-miR-1587	CLIP-seq
MIRT807452	hsa-miR-190	CLIP-seq
MIRT807453	hsa-miR-190b	CLIP-seq
MIRT1938407	hsa-miR-1976	CLIP-seq
MIRT807454	hsa-miR-214	CLIP-seq
MIRT1938408	hsa-miR-299-3p	CLIP-seq
MIRT1938409	hsa-miR-3132	CLIP-seq
MIRT1938410	hsa-miR-3151	CLIP-seq
MIRT1938411	hsa-miR-3153	CLIP-seq
MIRT1938412	hsa-miR-3154	CLIP-seq
MIRT1938413	hsa-miR-3157-5p	CLIP-seq
MIRT807431	hsa-miR-3158-5p	CLIP-seq
MIRT807456	hsa-miR-3163	CLIP-seq
MIRT807457	hsa-miR-3183	CLIP-seq
MIRT1938414	hsa-miR-3606	CLIP-seq
MIRT807463	hsa-miR-3619-5p	CLIP-seq
MIRT1938415	hsa-miR-3657	CLIP-seq
MIRT1938416	hsa-miR-378g	CLIP-seq
MIRT1938417	hsa-miR-3913-3p	CLIP-seq
MIRT1938418	hsa-miR-3929	CLIP-seq
MIRT1938419	hsa-miR-4257	CLIP-seq
MIRT1938420	hsa-miR-4290	CLIP-seq
MIRT807466	hsa-miR-4326	CLIP-seq
MIRT1938421	hsa-miR-4419b	CLIP-seq
MIRT1938422	hsa-miR-4440	CLIP-seq
MIRT1938423	hsa-miR-4447	CLIP-seq
MIRT1938424	hsa-miR-4448	CLIP-seq
MIRT1938425	hsa-miR-4472	CLIP-seq
MIRT1938426	hsa-miR-4478	CLIP-seq
MIRT1938427	hsa-miR-4492	CLIP-seq
MIRT1938428	hsa-miR-4496	CLIP-seq
MIRT1938429	hsa-miR-4498	CLIP-seq
MIRT1938430	hsa-miR-4505	CLIP-seq
MIRT1938431	hsa-miR-4525	CLIP-seq
MIRT1938432	hsa-miR-4529-5p	CLIP-seq
MIRT1938433	hsa-miR-4650-3p	CLIP-seq
MIRT807439	hsa-miR-4652-5p	CLIP-seq
MIRT1938434	hsa-miR-4656	CLIP-seq
MIRT1938435	hsa-miR-4665-5p	CLIP-seq
MIRT1938436	hsa-miR-4667-3p	CLIP-seq
MIRT807470	hsa-miR-4668-3p	CLIP-seq
MIRT1938437	hsa-miR-4669	CLIP-seq
MIRT1938438	hsa-miR-4675	CLIP-seq
MIRT1938439	hsa-miR-4691-3p	CLIP-seq
MIRT807472	hsa-miR-4691-5p	CLIP-seq
MIRT1938440	hsa-miR-4722-3p	CLIP-seq
MIRT807473	hsa-miR-4723-3p	CLIP-seq
MIRT807441	hsa-miR-4723-5p	CLIP-seq
MIRT1938441	hsa-miR-4741	CLIP-seq
MIRT1938442	hsa-miR-4755-3p	CLIP-seq
MIRT807474	hsa-miR-4757-3p	CLIP-seq
MIRT1938443	hsa-miR-4764-5p	CLIP-seq
MIRT1938444	hsa-miR-4768-5p	CLIP-seq
MIRT1938445	hsa-miR-489	CLIP-seq
MIRT807446	hsa-miR-491-5p	CLIP-seq
MIRT1938446	hsa-miR-501-5p	CLIP-seq
MIRT1938447	hsa-miR-581	CLIP-seq
MIRT1938448	hsa-miR-592	CLIP-seq
MIRT1938449	hsa-miR-599	CLIP-seq
MIRT1938450	hsa-miR-625	CLIP-seq
MIRT1938451	hsa-miR-627	CLIP-seq
MIRT807481	hsa-miR-761	CLIP-seq
MIRT1938452	hsa-miR-762	CLIP-seq
MIRT1938453	hsa-miR-921	CLIP-seq
MIRT1938454	hsa-miR-924	CLIP-seq
MIRT807451	hsa-miR-129-5p	CLIP-seq
MIRT1938407	hsa-miR-1976	CLIP-seq
MIRT807454	hsa-miR-214	CLIP-seq
MIRT807455	hsa-miR-3130-3p	CLIP-seq
MIRT807456	hsa-miR-3163	CLIP-seq
MIRT2177797	hsa-miR-3189-3p	CLIP-seq
MIRT2177798	hsa-miR-361-3p	CLIP-seq
MIRT2177799	hsa-miR-3617	CLIP-seq
MIRT807463	hsa-miR-3619-5p	CLIP-seq
MIRT2177800	hsa-miR-362-5p	CLIP-seq
MIRT807464	hsa-miR-3665	CLIP-seq
MIRT2177801	hsa-miR-3667-5p	CLIP-seq
MIRT2177802	hsa-miR-3677-5p	CLIP-seq
MIRT2177803	hsa-miR-370	CLIP-seq
MIRT2177804	hsa-miR-3918	CLIP-seq
MIRT2177805	hsa-miR-3926	CLIP-seq
MIRT2177806	hsa-miR-4286	CLIP-seq
MIRT2177807	hsa-miR-4639-5p	CLIP-seq
MIRT807470	hsa-miR-4668-3p	CLIP-seq
MIRT1938444	hsa-miR-4768-5p	CLIP-seq
MIRT807475	hsa-miR-4776-3p	CLIP-seq
MIRT807444	hsa-miR-4793-3p	CLIP-seq
MIRT2177808	hsa-miR-500a	CLIP-seq
MIRT2177809	hsa-miR-500b	CLIP-seq
MIRT807476	hsa-miR-544	CLIP-seq
MIRT2177810	hsa-miR-548s	CLIP-seq
MIRT807479	hsa-miR-622	CLIP-seq
MIRT2177811	hsa-miR-641	CLIP-seq
MIRT807480	hsa-miR-657	CLIP-seq
MIRT807481	hsa-miR-761	CLIP-seq
MIRT2444376	hsa-miR-1237	CLIP-seq
MIRT807427	hsa-miR-1915	CLIP-seq
MIRT2444377	hsa-miR-3127-3p	CLIP-seq
MIRT2177798	hsa-miR-361-3p	CLIP-seq
MIRT2444378	hsa-miR-4685-5p	CLIP-seq
MIRT2444379	hsa-miR-4762-3p	CLIP-seq
MIRT807454	hsa-miR-214	CLIP-seq
MIRT807463	hsa-miR-3619-5p	CLIP-seq
MIRT807481	hsa-miR-761	CLIP-seq
MIRT807454	hsa-miR-214	CLIP-seq
MIRT807463	hsa-miR-3619-5p	CLIP-seq
MIRT807481	hsa-miR-761	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
SP1	Activation	22851172

Show/Hide all (43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005246	Function	Calcium channel regulator activity	IMP	18068335
GO:0005388	Function	P-type calcium transporter activity	IBA
GO:0005388	Function	P-type calcium transporter activity	IDA	9843705
GO:0005388	Function	P-type calcium transporter activity	IEA
GO:0005388	Function	P-type calcium transporter activity	TAS	8809064
GO:0005515	Function	Protein binding	IPI	28890335, 32814053, 34513312
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	8809064
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006816	Process	Calcium ion transport	TAS	8809064
GO:0006874	Process	Intracellular calcium ion homeostasis	IBA
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	IMP	18068335
GO:0008656	Function	Cysteine-type endopeptidase activator activity involved in apoptotic process	IDA	16725111
GO:0015085	Function	Calcium ion transmembrane transporter activity	IDA	11956212, 15028735
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016529	Component	Sarcoplasmic reticulum	IDA	8809064
GO:0016529	Component	Sarcoplasmic reticulum	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0030899	Function	Calcium-dependent ATPase activity	IDA	9843705
GO:0031090	Component	Organelle membrane	IDA	15028735
GO:0031095	Component	Platelet dense tubular network membrane	IEA
GO:0031095	Component	Platelet dense tubular network membrane	TAS
GO:0031965	Component	Nuclear membrane	IEA
GO:0033017	Component	Sarcoplasmic reticulum membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	TAS
GO:0044325	Function	Transmembrane transporter binding	IPI	18068335
GO:0046872	Function	Metal ion binding	IEA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	16725111
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IBA
GO:0070588	Process	Calcium ion transmembrane transport	IDA	9843705, 11956212
GO:0150104	Process	Transport across blood-brain barrier	NAS	30280653
GO:1903515	Process	Calcium ion transport from cytosol to endoplasmic reticulum	IDA	15028735
GO:1903779	Process	Regulation of cardiac conduction	IEA
GO:1903779	Process	Regulation of cardiac conduction	TAS

MIM	HGNC	e!Ensembl
601929	813	ENSG00000074370

Q93084

Protein name

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3)

Protein function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in m

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00690	Cation_ATPase_N	4 → 72	Cation transporter/ATPase, N-terminus	Domain
PF00122	E1-E2_ATPase	121 → 329		Family
PF13246	Cation_ATPase	418 → 528		Family
PF00689	Cation_ATPase_C	784 → 987	Cation transporting ATPase, C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelia

Sequence

MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDL
LVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALK
EYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSIL
TGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMA
AVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALC
NDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMR
KEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPT
SREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGML
DPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDD
LSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAM
GSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAI
LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAI
GVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMA
LSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVT
PLSGRQWVVVLQISLPVILLDEALKYLSRNHMHEEMSQK

Sequence length

999

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATP2A3-related disorder	Likely benign; Benign; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, NON-INSULIN-DEPENDENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, TYPE 2	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ORAL CAVITY CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (75)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	11986315, 15972967, 24213720		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	LHGDN	11986315		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma	Adenoma	BEFREE	15972967, 24213720		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma	Adenoma	CTD_human_DG	23913004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma of large intestine	Colorectal adenoma	BEFREE	24213720		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma, Basal Cell	Adenoma	CTD_human_DG	23913004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma, Microcystic	Adenoma	CTD_human_DG	23913004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma, Monomorphic	Adenoma	CTD_human_DG	23913004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma, Trabecular	Adenoma	CTD_human_DG	23913004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenomatous Polyposis Coli	Multiple polyposis syndrome	BEFREE	15972967		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	21285369, 30822648	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	28800327	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	19541629	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	30102794		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	BEFREE	31609246		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Barrett Esophagus	Barrett esophagus	BEFREE	21829465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Barrett Esophagus	Barrett esophagus	Pubtator	21829465	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26331238, 28150875, 29185755, 31146004, 31173924		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	34684111, 35133336	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt`s Lymphoma	BEFREE	19650915		★★★★★ ★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt lymphoma	Pubtator	19650915	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	15972967	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	22948776	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	11986315, 22948776		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	26331238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	27510531		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	30657210		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Diseases	Colonic disease	Pubtator	15972967	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	30657210		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	36532007, 37626132	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	24213720		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	21152695		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	17883705, 26584293	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	17883705	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	10525666, 31554135		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	CTD_human_DG	16123366		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ductus Arteriosus Patent	Patent ductus arteriosus	Pubtator	33837257	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Follicular adenoma	Adenoma	CTD_human_DG	23913004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastroesophageal Reflux	Gastroesophageal reflux disease	Pubtator	21829465	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastroesophageal reflux disease	Gastroesophageal Reflux Disease	BEFREE	21829465		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Gastrointestinal stromal tumor	Pubtator	38184384	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	21152695		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	28393439, 36834924	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	BEFREE	10525666		★★★★★ ★☆☆☆☆ Found in Text Mining only
Keratosis Follicularis	Keratosis Follicularis	BEFREE	10441323, 11121153, 11390201, 12670936, 15099360, 19840814, 20423818		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	15336970		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	28651627	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	25535724, 31146004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	23157274	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	22948776	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26331238, 28150875, 29185755, 31146004, 31173924		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	26331238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31023247		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	15336970, 19100511, 27433831, 31554135		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	11986315, 30657210		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Diseases	Metabolic syndrome	Pubtator	35364719	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	36073642	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11986315, 15972967, 19100511, 22851172, 22948776, 25820259		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	30650444		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary adenoma	Papillary Adenoma	CTD_human_DG	23913004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	Pubtator	36894919	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral Arterial Disease	Peripheral arterial disease	Pubtator	26584293	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31023247		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	35133336	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	15718407	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Scoliosis, unspecified	Scoliosis	LHGDN	16973504		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	LHGDN	18295663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	19840814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	18295663, 19100511		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Neoplasms	Neoplasm	BEFREE	19840814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	22948776	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tetralogy of Fallot	Tetralogy of fallot	Pubtator	39969158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombocytopenia	Thrombocytopenia	Pubtator	17883705	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
von Willebrand Disease Type 2	Von willebrand disorder	Pubtator	17883705	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3)