Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	64968
Gene name	Mitochondrial ribosomal protein S6
Gene symbol	MRPS6
Synonyms (NCBI Gene)	C21orf101MRP-S6RPMS6S6mtbS6m
Chromosome	21
Chromosome location	21q22.11
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

93 Show/Hide all (93)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050858	hsa-miR-17-5p	CLASH	23622248
MIRT1160477	hsa-miR-1237	CLIP-seq
MIRT1160478	hsa-miR-1248	CLIP-seq
MIRT1160479	hsa-miR-142-5p	CLIP-seq
MIRT1160480	hsa-miR-1915	CLIP-seq
MIRT1160481	hsa-miR-202	CLIP-seq
MIRT1160482	hsa-miR-330-3p	CLIP-seq
MIRT1160483	hsa-miR-340	CLIP-seq
MIRT1160484	hsa-miR-3611	CLIP-seq
MIRT1160485	hsa-miR-3692	CLIP-seq
MIRT1160486	hsa-miR-369-3p	CLIP-seq
MIRT1160487	hsa-miR-374a	CLIP-seq
MIRT1160488	hsa-miR-374b	CLIP-seq
MIRT1160489	hsa-miR-374c	CLIP-seq
MIRT1160490	hsa-miR-382	CLIP-seq
MIRT1160491	hsa-miR-3926	CLIP-seq
MIRT1160492	hsa-miR-3929	CLIP-seq
MIRT1160493	hsa-miR-3941	CLIP-seq
MIRT1160494	hsa-miR-409-5p	CLIP-seq
MIRT1160495	hsa-miR-410	CLIP-seq
MIRT1160496	hsa-miR-4419b	CLIP-seq
MIRT1160497	hsa-miR-4438	CLIP-seq
MIRT1160498	hsa-miR-4459	CLIP-seq
MIRT1160499	hsa-miR-4478	CLIP-seq
MIRT1160500	hsa-miR-4484	CLIP-seq
MIRT1160501	hsa-miR-4643	CLIP-seq
MIRT1160502	hsa-miR-466	CLIP-seq
MIRT1160503	hsa-miR-4661-5p	CLIP-seq
MIRT1160504	hsa-miR-4672	CLIP-seq
MIRT1160505	hsa-miR-4678	CLIP-seq
MIRT1160506	hsa-miR-4717-3p	CLIP-seq
MIRT1160507	hsa-miR-4726-3p	CLIP-seq
MIRT1160508	hsa-miR-4753-5p	CLIP-seq
MIRT1160509	hsa-miR-4772-3p	CLIP-seq
MIRT1160510	hsa-miR-518a-5p	CLIP-seq
MIRT1160511	hsa-miR-527	CLIP-seq
MIRT1160512	hsa-miR-548an	CLIP-seq
MIRT1160513	hsa-miR-548p	CLIP-seq
MIRT1160514	hsa-miR-655	CLIP-seq
MIRT1160515	hsa-miR-665	CLIP-seq
MIRT1160516	hsa-miR-888	CLIP-seq
MIRT1160479	hsa-miR-142-5p	CLIP-seq
MIRT1160483	hsa-miR-340	CLIP-seq
MIRT1160495	hsa-miR-410	CLIP-seq
MIRT2275185	hsa-miR-3117-5p	CLIP-seq
MIRT1160486	hsa-miR-369-3p	CLIP-seq
MIRT1160487	hsa-miR-374a	CLIP-seq
MIRT1160488	hsa-miR-374b	CLIP-seq
MIRT1160489	hsa-miR-374c	CLIP-seq
MIRT1160490	hsa-miR-382	CLIP-seq
MIRT2275186	hsa-miR-570	CLIP-seq
MIRT1160514	hsa-miR-655	CLIP-seq
MIRT2574195	hsa-miR-1205	CLIP-seq
MIRT2574196	hsa-miR-1224-3p	CLIP-seq
MIRT2574197	hsa-miR-217	CLIP-seq
MIRT2574198	hsa-miR-223	CLIP-seq
MIRT2574199	hsa-miR-2355-5p	CLIP-seq
MIRT2574200	hsa-miR-3065-3p	CLIP-seq
MIRT2275185	hsa-miR-3117-5p	CLIP-seq
MIRT2574201	hsa-miR-3665	CLIP-seq
MIRT2574202	hsa-miR-3919	CLIP-seq
MIRT2574203	hsa-miR-4276	CLIP-seq
MIRT2574204	hsa-miR-4286	CLIP-seq
MIRT2574205	hsa-miR-4418	CLIP-seq
MIRT2574206	hsa-miR-4468	CLIP-seq
MIRT2574207	hsa-miR-4697-3p	CLIP-seq
MIRT2574208	hsa-miR-4797-5p	CLIP-seq
MIRT2574209	hsa-miR-509-3-5p	CLIP-seq
MIRT2574210	hsa-miR-509-5p	CLIP-seq
MIRT2574211	hsa-miR-548c-3p	CLIP-seq
MIRT2275186	hsa-miR-570	CLIP-seq
MIRT2574212	hsa-miR-657	CLIP-seq
MIRT2574195	hsa-miR-1205	CLIP-seq
MIRT2574196	hsa-miR-1224-3p	CLIP-seq
MIRT2574197	hsa-miR-217	CLIP-seq
MIRT2574198	hsa-miR-223	CLIP-seq
MIRT2574199	hsa-miR-2355-5p	CLIP-seq
MIRT2574200	hsa-miR-3065-3p	CLIP-seq
MIRT2275185	hsa-miR-3117-5p	CLIP-seq
MIRT2574201	hsa-miR-3665	CLIP-seq
MIRT2574202	hsa-miR-3919	CLIP-seq
MIRT2574203	hsa-miR-4276	CLIP-seq
MIRT2574204	hsa-miR-4286	CLIP-seq
MIRT2574205	hsa-miR-4418	CLIP-seq
MIRT2574206	hsa-miR-4468	CLIP-seq
MIRT2574207	hsa-miR-4697-3p	CLIP-seq
MIRT1160509	hsa-miR-4772-3p	CLIP-seq
MIRT2574208	hsa-miR-4797-5p	CLIP-seq
MIRT2574209	hsa-miR-509-3-5p	CLIP-seq
MIRT2574210	hsa-miR-509-5p	CLIP-seq
MIRT2574211	hsa-miR-548c-3p	CLIP-seq
MIRT2275186	hsa-miR-570	CLIP-seq
MIRT2574212	hsa-miR-657	CLIP-seq

25 Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0003735	Function	Structural constituent of ribosome	ISS	11402041
GO:0003735	Function	Structural constituent of ribosome	NAS	11279123
GO:0005515	Function	Protein binding	IPI	22458338, 25416956, 32296183, 33961781
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005763	Component	Mitochondrial small ribosomal subunit	IBA
GO:0005763	Component	Mitochondrial small ribosomal subunit	IDA	25838379
GO:0005763	Component	Mitochondrial small ribosomal subunit	IEA
GO:0005763	Component	Mitochondrial small ribosomal subunit	ISS	11402041
GO:0005763	Component	Mitochondrial small ribosomal subunit	NAS	25838379
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	NAS	11279123
GO:0015935	Component	Small ribosomal subunit	NAS	11279123
GO:0019843	Function	RRNA binding	IEA
GO:0032543	Process	Mitochondrial translation	ISS	11402041
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:0070181	Function	Small ribosomal subunit rRNA binding	IBA
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611973	14051	ENSG00000243927

P82932

Protein name

Small ribosomal subunit protein bS6m (28S ribosomal protein S6, mitochondrial) (MRP-S6) (S6mt)

PDB

3J9M , 6NU2 , 6NU3 , 6RW4 , 6RW5 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5I , 7A5K , 7L08 , 7OG4 , 7P2E , 7PNX , 7PNY , 7PNZ , 7PO0 , 7PO1 , 7PO2 , 7PO3 , 7QI4 , 7QI5 , 7QI6 , 8ANY , 8CSP , 8CSQ , 8CSR , 8CSS , 8CST , 8CSU , 8K2A , 8OIR , 8OIS , 8QRK , 8QRL , 8QRM , 8QRN , 8RRI , 8XT0 , 8XT2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01250	Ribosomal_S6	3 → 95	Ribosomal protein S6	Domain

Sequence

MPRYELALILKAMQRPETAATLKRTIEALMDRGAIVRDLENLGERALPYRISAHSQQHNR
GGYFLVDFYAPTAAVESMVEHLSRDIDVIRGNIVKHPLTQELKECEGIVPVPLAEKLYST
KKRKK

Sequence length

125

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ribosome	Mitochondrial translation elongation
	Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (16)
CARDIOVASCULAR DISEASE	—	GWAS catalog	37947095	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC ISCHEMIC HEART DISEASE	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	30804561	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	29228715	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERIOSCLEROSIS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	CTD, GWAS catalog CTD, GWAS catalog	21378990, 21378990, 34961328, 24262325, 26343387, 28714974, 28714975, 29212778, 30104761, 32374345, 32469254, 32887874, 33020668, 35285134, 36474045, 37248441, 37947095, 38965376, 39024449, 39537608	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ATHEROSCLEROSIS	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY HEART DISEASE	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART DISEASE	—	GWAS catalog	39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	32632093, 34294844, 35115687	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	19198609, 26343387, 26708285, 33532862, 34594039, 37947095, 38072966, 39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	30104761, 39024449	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	37340002, 37612283, 37945903	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	37340002, 37612283, 37945903	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	38162683	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	39379762	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (8)
Breast Neoplasms	Breast neoplasm	Pubtator	35739158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	CTD_human_DG	21378990		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	CTD_human_DG	21378990		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitochondrial Diseases	Mitochondrial disease	Pubtator	17193926	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	25697262		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial infarction	Pubtator	25697262	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	30972876	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	17193926	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MRPS6 (mitochondrial ribosomal protein S6)

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