CGA (glycoprotein hormones, alpha polypeptide)

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Gene Gene information from NCBI Gene database.
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Entrez ID 1081
Gene name Glycoprotein hormones, alpha polypeptide
Gene symbol CGA
Synonyms (NCBI Gene)
CG-ALPHAFSHAGPA1GPHA1GPHaHCGLHATSHA
Chromosome 6
Chromosome location 6q14.3
Summary The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The a
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT018742 hsa-miR-335-5p Microarray 18185580
MIRT888049 hsa-miR-2682 CLIP-seq
MIRT888050 hsa-miR-320a CLIP-seq
MIRT888051 hsa-miR-320b CLIP-seq
MIRT888052 hsa-miR-320c CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
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Transcription factor Regulation Reference
ATF1 Unknown 10341006
CREB1 Unknown 10341006
DLX3 Activation 22446105
ETS2 Activation 15637148
MSX1 Unknown 18379900
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IEA
GO:0005179 Function Hormone activity IMP 11207219
GO:0005515 Function Protein binding IPI 7922031, 11222739, 15662415, 22802634, 31467278
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
118850 1885 ENSG00000135346
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P01215
Protein name Glycoprotein hormones alpha chain (Anterior pituitary glycoprotein hormones common subunit alpha) (Choriogonadotropin alpha chain) (Chorionic gonadotrophin subunit alpha) (CG-alpha) (Follicle-stimulating hormone alpha chain) (FSH-alpha) (Follitropin alpha
Protein function Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specif
PDB 1DZ7 , 1E9J , 1FL7 , 1HCN , 1HD4 , 1HRP , 1QFW , 1XWD , 4AY9 , 4MQW , 7FIG , 7FIH , 7FII , 7T9I , 7UTZ , 7XW5 , 8I2G
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00236 Hormone_6 23 → 116 Glycoprotein hormone Domain
Sequence
Sequence length 116
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
cAMP signaling pathway Androgen biosynthesis
Neuroactive ligand-receptor interaction Mineralocorticoid biosynthesis
Hormone signaling Glycoprotein hormones
GnRH signaling pathway Thyroxine biosynthesis
Ovarian steroidogenesis Hormone ligand-binding receptors
Prolactin signaling pathway G alpha (s) signalling events
Thyroid hormone synthesis TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Regulation of lipolysis in adipocytes ADORA2B mediated anti-inflammatory cytokines production
GnRH secretion Reactions specific to the complex N-glycan synthesis pathway
Autoimmune thyroid disease  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
ATRIAL FIBRILLATION — CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog 		30061737, 35872910, 39537608
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEMIPLEGIA — CTD 10566621
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OVARIAN DISEASES — CTD, Disgenet
CTD, Disgenet 		20146381
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
THYROID CANCER, FOLLICULAR — CTD 10566621
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
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LHB 13 shared pathwayscAMP signaling pathway, Hormone signaling, GnRH signaling pathway, Ovarian steroidogenesis, Prolactin signaling pathway, GnRH secretion, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production, Androgen biosynthesis, Mineralocorticoid biosynthesis, Glycoprotein hormones, Hormone ligand-binding receptors +1 more Related via 13 shared pathways including cAMP signaling pathway, Hormone signaling. TSHB 10 shared pathwayscAMP signaling pathway, Hormone signaling, Thyroid hormone synthesis, Regulation of lipolysis in adipocytes, Autoimmune thyroid disease, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production, Glycoprotein hormones, Thyroxine biosynthesis, Hormone ligand-binding receptors Related via 10 shared pathways including cAMP signaling pathway, Hormone signaling. FSHB 8 shared pathwayscAMP signaling pathway, Hormone signaling, GnRH signaling pathway, Ovarian steroidogenesis, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production, Glycoprotein hormones, Hormone ligand-binding receptors Related via 8 shared pathways including cAMP signaling pathway, Hormone signaling. TSHR 8 shared pathwayscAMP signaling pathway, Hormone signaling, Thyroid hormone synthesis, Regulation of lipolysis in adipocytes, Autoimmune thyroid disease, G alpha (s) signalling events, ADORA2B mediated anti-inflammatory cytokines production, Hormone ligand-binding receptors Related via 8 shared pathways including cAMP signaling pathway, Hormone signaling. HSF2 2 shared evidence sourcesCTD (Atrial fibrillation), Disgenet (Atrial fibrillation) Related via 2 shared evidence sources.
Hypogonadism Linked via 2 of 5 related genesLHB, FSHB Hypogonadotropic hypogonadism Linked via 2 of 5 related genesLHB, FSHB Female infertility Linked via 2 of 5 related genesLHB, FSHB Male infertility Linked via 2 of 5 related genesLHB, FSHB Thyroid agenesis Linked via 2 of 5 related genesTSHB, TSHR