KRAS (KRAS proto-oncogene, GTPase)

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Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 3845
• Gene name: KRAS proto-oncogene, GTPase
• Gene symbol: KRAS
• Synonyms (NCBI Gene): 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, K-Ras 2, KI-RAS, KRAS1, KRAS2, NS, NS3, OES, RALD, RASK2, c-Ki-ras, c-Ki-ras2
• Chromosome: 12
• Chromosome location: 12p12.1
• Summary: This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that res

SNPs Show/Hide all (46)

SNP ID	Visualize variation	Clinical significance	Consequence
rs17851045	T>A,G	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs104894359	C>G,T	Pathogenic	Coding sequence variant, missense variant
rs104894360	T>A,C	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant, 3 prime UTR variant
rs104894361	T>A,C,G	Pathogenic, uncertain-significance	Coding sequence variant, synonymous variant, missense variant
rs104894362	G>C	Pathogenic	Missense variant, coding sequence variant, 3 prime UTR variant
rs104894364	G>A	Pathogenic	Coding sequence variant, missense variant
rs104894365	C>T	Pathogenic, not-provided	Coding sequence variant, missense variant
rs104894366	G>A,C	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs104894367	A>C	Pathogenic	Missense variant, coding sequence variant, 3 prime UTR variant
rs112445441	C>A,G,T	Drug-response, pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs121913236	G>C,T	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs121913238	G>C,T	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs121913240	T>A,C,G	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs121913527	C>A,G,T	Pathogenic, likely-pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs121913528	C>A,T	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs121913529	C>A,G,T	Not-provided, pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs121913530	C>A,G,T	Likely-pathogenic, pathogenic, not-provided, uncertain-significance	Coding sequence variant, missense variant
rs121913535	C>A,G,T	Pathogenic	Coding sequence variant, missense variant
rs121913538	C>A,G	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs193929331	T>C	Pathogenic, likely-pathogenic	Missense variant, coding sequence variant
rs201170656	T>G	Conflicting-interpretations-of-pathogenicity	Intron variant, missense variant, coding sequence variant
rs373169526	A>T	Conflicting-interpretations-of-pathogenicity	Intron variant, coding sequence variant, stop gained
rs387907205	A>C,G	Likely-pathogenic, pathogenic	Missense variant, coding sequence variant
rs387907206	T>C	Pathogenic, pathogenic-likely-pathogenic	Missense variant, coding sequence variant
rs397517040	G>A,T	Likely-pathogenic	Coding sequence variant, synonymous variant
rs397517041	C>A	Likely-pathogenic	Missense variant, 3 prime UTR variant, coding sequence variant
rs397517042	A>C,T	Likely-pathogenic, pathogenic	Missense variant, 3 prime UTR variant, coding sequence variant
rs397517476	A>G,T	Conflicting-interpretations-of-pathogenicity, likely-benign	Intron variant, missense variant, coding sequence variant
rs606231202	->CCA	Pathogenic	Coding sequence variant, inframe insertion
rs727503106	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs727503108	C>A	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs727503109	T>C	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs727503110	T>A,C	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs727504662	T>A	Pathogenic	Coding sequence variant, missense variant
rs730880469	CTC>-	Likely-pathogenic	Coding sequence variant, inframe deletion
rs730880471	C>T	Likely-pathogenic, not-provided	Coding sequence variant, missense variant
rs730880472	A>C	Likely-pathogenic	Coding sequence variant, missense variant
rs770248150	T>A,G	Pathogenic, likely-pathogenic	Coding sequence variant, missense variant
rs1057519725	G>A	Not-provided, pathogenic	Missense variant, coding sequence variant
rs1064796748	->GCC	Pathogenic	Inframe indel, coding sequence variant
rs1135401776	T>C	Pathogenic	Missense variant, coding sequence variant
rs1555194026	C>A	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs1555195579	C>A	Likely-pathogenic	Missense variant, coding sequence variant
rs1565878932	C>T	Pathogenic	3 prime UTR variant, missense variant, coding sequence variant
rs1592798693	T>A	Likely-pathogenic	Missense variant, intron variant, coding sequence variant
rs1592808357	C>A,G	Likely-pathogenic	Missense variant, coding sequence variant

miRNA Show/Hide all (884)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000312	hsa-miR-143-3p	qRT-PCR, Luciferase reporter assay, Microarray	19137007
MIRT000312	hsa-miR-143-3p	qRT-PCR, Luciferase reporter assay, Microarray	19137007
MIRT000399	hsa-let-7g-5p	Luciferase reporter assay	18308936
MIRT000312	hsa-miR-143-3p	Luciferase reporter assay	19137007
MIRT000312	hsa-miR-143-3p	Luciferase reporter assay	19137007
MIRT003521	hsa-miR-133b	Review	20144549
MIRT001855	hsa-let-7a-5p	Western blot	20033209
MIRT003210	hsa-miR-181c-5p	Luciferase reporter assay, qRT-PCR, Western blot	20080834
MIRT001855	hsa-let-7a-5p	Luciferase reporter assay, Microarray	15766527
MIRT005100	hsa-miR-155-5p	pSILAC	18668040
MIRT001855	hsa-let-7a-5p	qRT-PCR, Western blot	16651716
MIRT000312	hsa-miR-143-3p	qRT-PCR, Western blot	19157460
MIRT005100	hsa-miR-155-5p	Microarray	19193853
MIRT000230	hsa-miR-18a-3p	Luciferase reporter assay, qRT-PCR, Western blot	19372139
MIRT005553	hsa-miR-96-5p	Immunoblot, Immunohistochemistry, Northern blot, Quantitative proteomic approach, Western blot	20610624
MIRT005553	hsa-miR-96-5p	Immunoblot, Immunohistochemistry, Northern blot, Quantitative proteomic approach, Western blot	20610624
MIRT006144	hsa-miR-216b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21878506
MIRT006144	hsa-miR-216b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21878506
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006144	hsa-miR-216b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21878506
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006501	hsa-miR-217	Luciferase reporter assay	20675343
MIRT006501	hsa-miR-217	Luciferase reporter assay	20675343
MIRT006144	hsa-miR-216b-5p	Luciferase reporter assay, qRT-PCR, Western blot	21878506
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006450	hsa-miR-126-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22384141
MIRT006501	hsa-miR-217	Luciferase reporter assay	20675343
MIRT006220	hsa-miR-622	Luciferase reporter assay	22016468
MIRT006220	hsa-miR-622	Luciferase reporter assay	22016468
MIRT006220	hsa-miR-622	Luciferase reporter assay, Western blot	22016468
MIRT006220	hsa-miR-622	Luciferase reporter assay, Western blot	22016468
MIRT006220	hsa-miR-622	Luciferase reporter assay, Western blot	22016468
MIRT006220	hsa-miR-622	Luciferase reporter assay	22016468
MIRT000312	hsa-miR-143-3p	Western blot	23276710
MIRT000312	hsa-miR-143-3p	Western blot	23276710
MIRT016516	hsa-miR-193b-3p	Microarray	20304954
MIRT005100	hsa-miR-155-5p	Proteomics	18668040
MIRT005100	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT000312	hsa-miR-143-3p	Other	19157460
MIRT006501	hsa-miR-217	Reporter assay	20675343
MIRT025201	hsa-miR-181a-5p	Sequencing	20371350
MIRT005553	hsa-miR-96-5p	Sequencing	20371350
MIRT005553	hsa-miR-96-5p	Reporter assay;Western blot;qRT-PCR;Other	20610624
MIRT053090	hsa-miR-16-5p	Luciferase reporter assay, Western blot	23507142
MIRT053090	hsa-miR-16-5p	Luciferase reporter assay, Western blot	23507142
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, qRT-PCR, Western blot	23775631
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, qRT-PCR, Western blot	23775631
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, qRT-PCR, Western blot	23775631
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, qRT-PCR, Western blot	23775631
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, qRT-PCR, Western blot	23775631
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, qRT-PCR, Western blot	23775631
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, qRT-PCR, Western blot	23775631
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, qRT-PCR, Western blot	23775631
MIRT000312	hsa-miR-143-3p	Luciferase reporter assay, qRT-PCR, Western blot	23128394
MIRT000312	hsa-miR-143-3p	Luciferase reporter assay, qRT-PCR, Western blot	23128394
MIRT053521	hsa-miR-224-5p	qRT-PCR, Western blot	23667495
MIRT053523	hsa-miR-452-5p	qRT-PCR, Western blot	23667495
MIRT053524	hsa-miR-152-3p	qRT-PCR, Western blot	23667495
MIRT053525	hsa-miR-340-5p	qRT-PCR, Western blot	23667495
MIRT003210	hsa-miR-181c-5p	qRT-PCR, Western blot	23667495
MIRT053561	hsa-miR-433-3p	Luciferase reporter assay, qRT-PCR, Western blot	23880861
MIRT053561	hsa-miR-433-3p	Luciferase reporter assay, qRT-PCR, Western blot	23880861
MIRT005553	hsa-miR-96-5p	Luciferase reporter assay, qRT-PCR, Western blot	23752186
MIRT025201	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	23752186
MIRT053135	hsa-miR-134-5p	Immunoblot, Luciferase reporter assay, qRT-PCR, Western blot	24440911
MIRT437854	hsa-miR-487b-3p	ChIP-seq, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	23426183
MIRT438292	hsa-miR-206	Flow, qRT-PCR	24855559
MIRT438292	hsa-miR-206	Luciferase reporter assay, Western blot, qRT-PCR	25246801
MIRT438292	hsa-miR-206	Luciferase reporter assay, Western blot, qRT-PCR	25246801
MIRT438156	hsa-miR-27a-3p	Luciferase reporter assay	24154848
MIRT438156	hsa-miR-27a-3p	Luciferase reporter assay	24154848
MIRT438156	hsa-miR-27a-3p	Luciferase reporter assay	24154848
MIRT438156	hsa-miR-27a-3p	Luciferase reporter assay	24154848
MIRT438025	hsa-miR-200c-3p	Luciferase reporter assay, Western blot, qRT-PCR	24368337
MIRT016516	hsa-miR-193b-3p	In situ hybridization, RTPCR, Luciferase reporter assay, Microarray, Western blot	24374827
MIRT438022	hsa-miR-365a-3p	In situ hybridization, RTPCR, Luciferase reporter assay, Microarray, Western blot	24374827
MIRT438292	hsa-miR-206	Flow, qRT-PCR	24855559
MIRT438292	hsa-miR-206	Luciferase reporter assay, Western blot, qRT-PCR	25246801
MIRT438292	hsa-miR-206	Luciferase reporter assay, Western blot, qRT-PCR	25246801
MIRT438156	hsa-miR-27a-3p	Luciferase reporter assay	24154848
MIRT438156	hsa-miR-27a-3p	Luciferase reporter assay	24154848
MIRT438156	hsa-miR-27a-3p	Luciferase reporter assay	24154848
MIRT438156	hsa-miR-27a-3p	Luciferase reporter assay	24154848
MIRT438025	hsa-miR-200c-3p	Luciferase reporter assay, Western blot, qRT-PCR	24368337
MIRT016516	hsa-miR-193b-3p	In situ hybridization, RTPCR, Luciferase reporter assay, Microarray, Western blot	24374827
MIRT438022	hsa-miR-365a-3p	In situ hybridization, RTPCR, Luciferase reporter assay, Microarray, Western blot	24374827
MIRT566996	hsa-miR-4698	PAR-CLIP	20371350
MIRT566995	hsa-miR-4328	PAR-CLIP	20371350
MIRT566993	hsa-miR-4666b	PAR-CLIP	20371350
MIRT566994	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT566992	hsa-miR-30a-3p	PAR-CLIP	20371350
MIRT566991	hsa-miR-30d-3p	PAR-CLIP	20371350
MIRT566990	hsa-miR-30e-3p	PAR-CLIP	20371350
MIRT562040	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT562039	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT562038	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT562037	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT562036	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT562035	hsa-miR-124-5p	PAR-CLIP	20371350
MIRT562034	hsa-miR-642b-5p	PAR-CLIP	20371350
MIRT562033	hsa-miR-642a-5p	PAR-CLIP	20371350
MIRT562032	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT502087	hsa-miR-877-5p	PAR-CLIP	24398324
MIRT502086	hsa-miR-183-5p	PAR-CLIP	24398324
MIRT016516	hsa-miR-193b-3p	PAR-CLIP	24398324
MIRT502085	hsa-miR-193a-3p	PAR-CLIP	24398324
MIRT502084	hsa-miR-200b-3p	PAR-CLIP	24398324
MIRT438025	hsa-miR-200c-3p	PAR-CLIP	24398324
MIRT502083	hsa-miR-429	PAR-CLIP	24398324
MIRT502082	hsa-miR-548ae-3p	PAR-CLIP	24398324
MIRT502081	hsa-miR-548ah-3p	PAR-CLIP	24398324
MIRT502080	hsa-miR-548aj-3p	PAR-CLIP	24398324
MIRT502079	hsa-miR-548am-3p	PAR-CLIP	24398324
MIRT502078	hsa-miR-548aq-3p	PAR-CLIP	24398324
MIRT502077	hsa-miR-548j-3p	PAR-CLIP	24398324
MIRT502076	hsa-miR-548x-3p	PAR-CLIP	24398324
MIRT502075	hsa-miR-5582-3p	PAR-CLIP	24398324
MIRT502074	hsa-miR-514a-5p	PAR-CLIP	24398324
MIRT502073	hsa-miR-892b	PAR-CLIP	24398324
MIRT502072	hsa-miR-3125	PAR-CLIP	24398324
MIRT502071	hsa-miR-3916	PAR-CLIP	24398324
MIRT502070	hsa-miR-6859-5p	PAR-CLIP	24398324
MIRT502069	hsa-miR-326	PAR-CLIP	24398324
MIRT502068	hsa-miR-330-5p	PAR-CLIP	24398324
MIRT502067	hsa-miR-204-3p	PAR-CLIP	24398324
MIRT502066	hsa-miR-4646-5p	PAR-CLIP	24398324
MIRT502065	hsa-miR-3192-5p	PAR-CLIP	24398324
MIRT502064	hsa-miR-619-5p	PAR-CLIP	24398324
MIRT502063	hsa-miR-6506-5p	PAR-CLIP	24398324
MIRT502062	hsa-miR-3148	PAR-CLIP	24398324
MIRT502060	hsa-miR-6716-5p	PAR-CLIP	24398324
MIRT502061	hsa-miR-6866-5p	PAR-CLIP	24398324
MIRT502059	hsa-miR-4314	PAR-CLIP	24398324
MIRT005100	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT005100	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT438156	hsa-miR-27a-3p	qRT-PCR, Luciferase reporter assay, Western blot	25436011
MIRT438156	hsa-miR-27a-3p	qRT-PCR, Luciferase reporter assay, Western blot	25436011
MIRT438156	hsa-miR-27a-3p	qRT-PCR, Luciferase reporter assay, Western blot	25436011
MIRT438292	hsa-miR-206	Luciferase reporter assay, qRT-PCR, Immunohistochemistry, Western blot	25500542
MIRT438292	hsa-miR-206	MiaPaca-2	25500542
MIRT438025	hsa-miR-200c-3p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	26392416
MIRT438025	hsa-miR-200c-3p	In situ hybridization, Luciferase reporter assay, qRT-PCR, Western blot	26392416
MIRT731362	hsa-miR-1-3p	Luciferase reporter assay	26852690
MIRT731362	hsa-miR-1-3p	Luciferase reporter assay	26852690
MIRT731362	hsa-miR-1-3p	Luciferase reporter assay, qRT-PCR, Western blot	26275461
MIRT731362	hsa-miR-1-3p	Luciferase reporter assay, qRT-PCR, Western blot	26275461
MIRT731362	hsa-miR-1-3p	Luciferase reporter assay, qRT-PCR, Western blot	26275461
MIRT731362	hsa-miR-1-3p	Luciferase reporter assay, qRT-PCR, Western blot	26275461
MIRT731411	hsa-miR-199a-5p	qRT-PCR, Western blot	26027911
MIRT731411	hsa-miR-199a-5p	qRT-PCR, Western blot	26027911
MIRT005553	hsa-miR-96-5p	qRT-PCR, Western blot	25256312
MIRT732188	hsa-miR-543	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26968810
MIRT732188	hsa-miR-543	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	26968810
MIRT732429	hsa-miR-384	Luciferase reporter assay, qRT-PCR, Western blot	27769041
MIRT732429	hsa-miR-384	Luciferase reporter assay, qRT-PCR, Western blot	27769041
MIRT053135	hsa-miR-134-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27830015
MIRT053135	hsa-miR-134-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27830015
MIRT053135	hsa-miR-134-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27830015
MIRT053135	hsa-miR-134-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27830015
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	6pl, HeyA8, SKOV3.ip1"	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	6pl, HeyA8, SKOV3.ip1"	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	6pl, HeyA8, SKOV3.ip1"	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT502085	hsa-miR-193a-3p	5.0	27669434
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT053135	hsa-miR-134-5p	Luciferase reporter assay, Western blot, RT-PCR	27012554
MIRT025201	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	27517749
MIRT025201	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	27517749
MIRT025201	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	27517749
MIRT025201	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	27517749
MIRT016516	hsa-miR-193b-3p	Luciferase reporter assay, Western blot	25905463
MIRT016516	hsa-miR-193b-3p	Luciferase reporter assay, Western blot	25905463
MIRT016516	hsa-miR-193b-3p	Luciferase reporter assay, Western blot	25905463
MIRT016516	hsa-miR-193b-3p	Luciferase reporter assay, Western blot	25905463
MIRT001855	hsa-let-7a-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	25955298
MIRT005553	hsa-miR-96-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blotting	33973871
MIRT732808	hsa-miR-455-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blotting	33505218
MIRT733424	hsa-miR-1184	Immunohistochemistry (IHC), Immunoprecipitaion (IP), Luciferase reporter assay, qRT-PCR	34234808
MIRT734175	hsa-miR-210-3p	Immunofluorescence, qRT-PCR, Western blotting	31927946
MIRT734177	hsa-miR-636	Luciferase reporter assay, Western blotting	33192092
MIRT000312	hsa-miR-143-3p	Microarray	33825830
MIRT734573	hsa-miR-145-3p	Microarray	33825830
MIRT734573	hsa-miR-145-3p	qRT-PCR	33250681
MIRT003210	hsa-miR-181c-5p	Western blotting, Microarray, qRT-PCR	31441360
MIRT735861	hsa-miR-27b-3p	qRT-PCR	32676506
MIRT735862	miR-let7d-5p	qRT-PCR	32676506
MIRT735863	hsa-miR-149-5p	qRT-PCR	32676506
MIRT735864	hsa-miR-150-5p	qRT-PCR	32676506
MIRT735865	hsa-miR-9-5p	qRT-PCR	32676506
MIRT735866	hsa-miR-215-5p	qRT-PCR	32676506
MIRT735867	hsa-miR-15b-5p	qRT-PCR	32676506
MIRT735868	hsa-miR-10a-5p	qRT-PCR	32676506
MIRT735869	hsa-miR-135b-5p	qRT-PCR	32676506
MIRT735870	hsa-miR-191-5p	qRT-PCR	32676506
MIRT735871	hsa-miR-138-5p	qRT-PCR	32676506
MIRT735874	hsa-miR-139-5p	Luciferase reporter assay, Western blotting, Microarray, Immunohistochemistry (IHC), Immunofluorescence, ChIP-seq, qRT-PCR, in vivo gain/loss-of-function experiments	32641995
MIRT735874	hsa-miR-139-5p	Luciferase reporter assay, Western blotting, Microarray, Immunohistochemistry (IHC), Immunofluorescence, ChIP-seq, qRT-PCR, In situ hybridization	32641995
MIRT001855	hsa-let-7a-5p	Microarray, qRT-PCR	32651898
MIRT438156	hsa-miR-27a-3p	Western blotting	31717759
MIRT737080	hsa-miR-125b-5p	Microarray, qRT-PCR	31497299
MIRT566996	hsa-miR-4698	PAR-CLIP	20371350
MIRT566995	hsa-miR-4328	PAR-CLIP	20371350
MIRT566993	hsa-miR-4666b	PAR-CLIP	20371350
MIRT566994	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT566992	hsa-miR-30a-3p	PAR-CLIP	20371350
MIRT566991	hsa-miR-30d-3p	PAR-CLIP	20371350
MIRT566990	hsa-miR-30e-3p	PAR-CLIP	20371350
MIRT562040	hsa-miR-3606-3p	PAR-CLIP	20371350
MIRT562039	hsa-miR-513a-3p	PAR-CLIP	20371350
MIRT562038	hsa-miR-513c-3p	PAR-CLIP	20371350
MIRT562037	hsa-miR-873-5p	PAR-CLIP	20371350
MIRT562036	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT562035	hsa-miR-124-5p	PAR-CLIP	20371350
MIRT562034	hsa-miR-642b-5p	PAR-CLIP	20371350
MIRT562033	hsa-miR-642a-5p	PAR-CLIP	20371350
MIRT562032	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT502087	hsa-miR-877-5p	PAR-CLIP	24398324
MIRT502086	hsa-miR-183-5p	PAR-CLIP	24398324
MIRT016516	hsa-miR-193b-3p	PAR-CLIP	24398324
MIRT502085	hsa-miR-193a-3p	PAR-CLIP	24398324
MIRT502084	hsa-miR-200b-3p	PAR-CLIP	24398324
MIRT438025	hsa-miR-200c-3p	PAR-CLIP	24398324
MIRT502083	hsa-miR-429	PAR-CLIP	24398324
MIRT502082	hsa-miR-548ae-3p	PAR-CLIP	24398324
MIRT502081	hsa-miR-548ah-3p	PAR-CLIP	24398324
MIRT502080	hsa-miR-548aj-3p	PAR-CLIP	24398324
MIRT502079	hsa-miR-548am-3p	PAR-CLIP	24398324
MIRT502078	hsa-miR-548aq-3p	PAR-CLIP	24398324
MIRT502077	hsa-miR-548j-3p	PAR-CLIP	24398324
MIRT502076	hsa-miR-548x-3p	PAR-CLIP	24398324
MIRT502075	hsa-miR-5582-3p	PAR-CLIP	24398324
MIRT502074	hsa-miR-514a-5p	PAR-CLIP	24398324
MIRT502073	hsa-miR-892b	PAR-CLIP	24398324
MIRT502072	hsa-miR-3125	PAR-CLIP	24398324
MIRT502071	hsa-miR-3916	PAR-CLIP	24398324
MIRT502070	hsa-miR-6859-5p	PAR-CLIP	24398324
MIRT502069	hsa-miR-326	PAR-CLIP	24398324
MIRT502068	hsa-miR-330-5p	PAR-CLIP	24398324
MIRT502067	hsa-miR-204-3p	PAR-CLIP	24398324
MIRT502066	hsa-miR-4646-5p	PAR-CLIP	24398324
MIRT502065	hsa-miR-3192-5p	PAR-CLIP	24398324
MIRT502064	hsa-miR-619-5p	PAR-CLIP	24398324
MIRT502063	hsa-miR-6506-5p	PAR-CLIP	24398324
MIRT502062	hsa-miR-3148	PAR-CLIP	24398324
MIRT502060	hsa-miR-6716-5p	PAR-CLIP	24398324
MIRT502061	hsa-miR-6866-5p	PAR-CLIP	24398324
MIRT502059	hsa-miR-4314	PAR-CLIP	24398324
MIRT755565	hsa-miR-532-3p	Western blotting	36324898
MIRT755927	hsa-miR-142-3p	Western blotting, qRT-PCR, in vitro cullelar assays	35194440
MIRT755999	hsa-miR-557	Luciferase reporter assay, Western blotting, qRT-PCR	35087570
MIRT1100513	hsa-miR-1208	CLIP-seq
MIRT1100514	hsa-miR-1256	CLIP-seq
MIRT1100515	hsa-miR-1262	CLIP-seq
MIRT1100516	hsa-miR-1283	CLIP-seq
MIRT1100517	hsa-miR-1323	CLIP-seq
MIRT1100518	hsa-miR-1470	CLIP-seq
MIRT1100519	hsa-miR-181a	CLIP-seq
MIRT1100520	hsa-miR-181b	CLIP-seq
MIRT1100521	hsa-miR-181c	CLIP-seq
MIRT1100522	hsa-miR-181d	CLIP-seq
MIRT1100523	hsa-miR-188-5p	CLIP-seq
MIRT1100524	hsa-miR-193b	CLIP-seq
MIRT1100525	hsa-miR-200b	CLIP-seq
MIRT1100526	hsa-miR-200c	CLIP-seq
MIRT1100527	hsa-miR-204	CLIP-seq
MIRT1100528	hsa-miR-211	CLIP-seq
MIRT1100529	hsa-miR-2114	CLIP-seq
MIRT1100530	hsa-miR-216b	CLIP-seq
MIRT1100531	hsa-miR-23a	CLIP-seq
MIRT1100532	hsa-miR-23b	CLIP-seq
MIRT1100533	hsa-miR-23c	CLIP-seq
MIRT1100534	hsa-miR-30a	CLIP-seq
MIRT1100535	hsa-miR-30b	CLIP-seq
MIRT1100536	hsa-miR-30c	CLIP-seq
MIRT1100537	hsa-miR-30d	CLIP-seq
MIRT1100538	hsa-miR-30e	CLIP-seq
MIRT1100539	hsa-miR-3157-3p	CLIP-seq
MIRT1100540	hsa-miR-3185	CLIP-seq
MIRT1100541	hsa-miR-3192	CLIP-seq
MIRT1100542	hsa-miR-323-3p	CLIP-seq
MIRT1100543	hsa-miR-335	CLIP-seq
MIRT1100544	hsa-miR-34b	CLIP-seq
MIRT1100545	hsa-miR-3613-3p	CLIP-seq
MIRT1100546	hsa-miR-3614-5p	CLIP-seq
MIRT1100547	hsa-miR-3622a-5p	CLIP-seq
MIRT1100548	hsa-miR-362-5p	CLIP-seq
MIRT1100549	hsa-miR-3653	CLIP-seq
MIRT1100550	hsa-miR-3658	CLIP-seq
MIRT1100551	hsa-miR-3660	CLIP-seq
MIRT1100552	hsa-miR-3664-3p	CLIP-seq
MIRT1100553	hsa-miR-3675-3p	CLIP-seq
MIRT1100554	hsa-miR-3688-3p	CLIP-seq
MIRT1100555	hsa-miR-3713	CLIP-seq
MIRT1100556	hsa-miR-380	CLIP-seq
MIRT1100557	hsa-miR-3924	CLIP-seq
MIRT1100558	hsa-miR-3942-3p	CLIP-seq
MIRT1100559	hsa-miR-3973	CLIP-seq
MIRT1100560	hsa-miR-4252	CLIP-seq
MIRT1100561	hsa-miR-4262	CLIP-seq
MIRT1100562	hsa-miR-4433	CLIP-seq
MIRT1100563	hsa-miR-4495	CLIP-seq
MIRT1100564	hsa-miR-4504	CLIP-seq
MIRT1100565	hsa-miR-452	CLIP-seq
MIRT1100566	hsa-miR-4522	CLIP-seq
MIRT1100567	hsa-miR-4526	CLIP-seq
MIRT1100568	hsa-miR-4667-3p	CLIP-seq
MIRT1100569	hsa-miR-4668-3p	CLIP-seq
MIRT1100570	hsa-miR-4676-3p	CLIP-seq
MIRT1100571	hsa-miR-4684-5p	CLIP-seq
MIRT1100572	hsa-miR-4694-3p	CLIP-seq
MIRT1100573	hsa-miR-4695-5p	CLIP-seq
MIRT1100574	hsa-miR-4701-3p	CLIP-seq
MIRT1100575	hsa-miR-4709-3p	CLIP-seq
MIRT1100576	hsa-miR-4714-5p	CLIP-seq
MIRT1100577	hsa-miR-4761-5p	CLIP-seq
MIRT1100578	hsa-miR-4762-5p	CLIP-seq
MIRT1100579	hsa-miR-500b	CLIP-seq
MIRT1100580	hsa-miR-501-5p	CLIP-seq
MIRT1100581	hsa-miR-510	CLIP-seq
MIRT1100582	hsa-miR-512-5p	CLIP-seq
MIRT1100583	hsa-miR-514	CLIP-seq
MIRT1100584	hsa-miR-514b-3p	CLIP-seq
MIRT1100585	hsa-miR-520g	CLIP-seq
MIRT1100586	hsa-miR-520h	CLIP-seq
MIRT1100587	hsa-miR-522	CLIP-seq
MIRT1100588	hsa-miR-548aa	CLIP-seq
MIRT1100589	hsa-miR-548ac	CLIP-seq
MIRT1100590	hsa-miR-548ag	CLIP-seq
MIRT1100591	hsa-miR-548ai	CLIP-seq
MIRT1100592	hsa-miR-548d-3p	CLIP-seq
MIRT1100593	hsa-miR-548m	CLIP-seq
MIRT1100594	hsa-miR-548o	CLIP-seq
MIRT1100595	hsa-miR-548z	CLIP-seq
MIRT1100596	hsa-miR-554	CLIP-seq
MIRT1100597	hsa-miR-584	CLIP-seq
MIRT1100598	hsa-miR-595	CLIP-seq
MIRT1100599	hsa-miR-605	CLIP-seq
MIRT1100600	hsa-miR-661	CLIP-seq
MIRT1100601	hsa-miR-877	CLIP-seq
MIRT1100602	hsa-miR-105	CLIP-seq
MIRT1100603	hsa-miR-1271	CLIP-seq
MIRT1100604	hsa-miR-1273f	CLIP-seq
MIRT1100605	hsa-miR-1278	CLIP-seq
MIRT1100606	hsa-miR-1305	CLIP-seq
MIRT1100607	hsa-miR-143	CLIP-seq
MIRT1100608	hsa-miR-19a	CLIP-seq
MIRT1100609	hsa-miR-19b	CLIP-seq
MIRT1100610	hsa-miR-2053	CLIP-seq
MIRT1100611	hsa-miR-3143	CLIP-seq
MIRT1100612	hsa-miR-3163	CLIP-seq
MIRT1100613	hsa-miR-3189-5p	CLIP-seq
MIRT1100542	hsa-miR-323-3p	CLIP-seq
MIRT1100614	hsa-miR-340	CLIP-seq
MIRT1100615	hsa-miR-3651	CLIP-seq
MIRT1100549	hsa-miR-3653	CLIP-seq
MIRT1100550	hsa-miR-3658	CLIP-seq
MIRT1100616	hsa-miR-3923	CLIP-seq
MIRT1100617	hsa-miR-4275	CLIP-seq
MIRT1100618	hsa-miR-4282	CLIP-seq
MIRT1100563	hsa-miR-4495	CLIP-seq
MIRT1100569	hsa-miR-4668-3p	CLIP-seq
MIRT1100619	hsa-miR-4708-5p	CLIP-seq
MIRT1100620	hsa-miR-4731-3p	CLIP-seq
MIRT1100621	hsa-miR-4758-3p	CLIP-seq
MIRT1100622	hsa-miR-4770	CLIP-seq
MIRT1100623	hsa-miR-4795-3p	CLIP-seq
MIRT1100624	hsa-miR-4801	CLIP-seq
MIRT1100625	hsa-miR-548c-3p	CLIP-seq
MIRT1100626	hsa-miR-548g	CLIP-seq
MIRT1100627	hsa-miR-561	CLIP-seq
MIRT1100628	hsa-miR-628-3p	CLIP-seq
MIRT1100629	hsa-miR-888	CLIP-seq
MIRT1100630	hsa-miR-944	CLIP-seq
MIRT1100631	hsa-miR-96	CLIP-seq
MIRT1100517	hsa-miR-1323	CLIP-seq
MIRT1100524	hsa-miR-193b	CLIP-seq
MIRT1100525	hsa-miR-200b	CLIP-seq
MIRT1100526	hsa-miR-200c	CLIP-seq
MIRT1100541	hsa-miR-3192	CLIP-seq
MIRT1550624	hsa-miR-338-5p	CLIP-seq
MIRT1100594	hsa-miR-548o	CLIP-seq
MIRT1100601	hsa-miR-877	CLIP-seq
MIRT2027371	hsa-miR-154	CLIP-seq
MIRT2027372	hsa-miR-194	CLIP-seq
MIRT2027373	hsa-miR-2110	CLIP-seq
MIRT2027374	hsa-miR-3150a-3p	CLIP-seq
MIRT2027375	hsa-miR-337-3p	CLIP-seq
MIRT1100556	hsa-miR-380	CLIP-seq
MIRT2027376	hsa-miR-4260	CLIP-seq
MIRT2027377	hsa-miR-4270	CLIP-seq
MIRT1100618	hsa-miR-4282	CLIP-seq
MIRT2027378	hsa-miR-4426	CLIP-seq
MIRT1100562	hsa-miR-4433	CLIP-seq
MIRT2027379	hsa-miR-4436b-5p	CLIP-seq
MIRT2027380	hsa-miR-4441	CLIP-seq
MIRT1100563	hsa-miR-4495	CLIP-seq
MIRT2027381	hsa-miR-4647	CLIP-seq
MIRT2027382	hsa-miR-4662b	CLIP-seq
MIRT2027383	hsa-miR-4699-5p	CLIP-seq
MIRT2027384	hsa-miR-4712-3p	CLIP-seq
MIRT2027385	hsa-miR-4803	CLIP-seq
MIRT2027386	hsa-miR-548ae	CLIP-seq
MIRT2027387	hsa-miR-548aj	CLIP-seq
MIRT2027388	hsa-miR-548am	CLIP-seq
MIRT1100625	hsa-miR-548c-3p	CLIP-seq
MIRT2027389	hsa-miR-548n	CLIP-seq
MIRT2027390	hsa-miR-548x	CLIP-seq
MIRT2027391	hsa-miR-580	CLIP-seq
MIRT2027392	hsa-miR-593	CLIP-seq
MIRT2027393	hsa-miR-616	CLIP-seq
MIRT2027394	hsa-miR-642b	CLIP-seq
MIRT2027395	hsa-miR-654-3p	CLIP-seq
MIRT2027396	hsa-miR-1912	CLIP-seq
MIRT2027397	hsa-miR-4534	CLIP-seq
MIRT2027398	hsa-miR-4775	CLIP-seq
MIRT1100589	hsa-miR-548ac	CLIP-seq
MIRT1100592	hsa-miR-548d-3p	CLIP-seq
MIRT2027389	hsa-miR-548n	CLIP-seq
MIRT1100595	hsa-miR-548z	CLIP-seq
MIRT1100602	hsa-miR-105	CLIP-seq
MIRT2258623	hsa-miR-1205	CLIP-seq
MIRT2258624	hsa-miR-1233	CLIP-seq
MIRT2258625	hsa-miR-1236	CLIP-seq
MIRT2258626	hsa-miR-1243	CLIP-seq
MIRT2258627	hsa-miR-1245	CLIP-seq
MIRT2258628	hsa-miR-1246	CLIP-seq
MIRT2258629	hsa-miR-1248	CLIP-seq
MIRT2258630	hsa-miR-125a-5p	CLIP-seq
MIRT2258631	hsa-miR-125b	CLIP-seq
MIRT1100515	hsa-miR-1262	CLIP-seq
MIRT2258632	hsa-miR-1264	CLIP-seq
MIRT1100603	hsa-miR-1271	CLIP-seq
MIRT1100604	hsa-miR-1273f	CLIP-seq
MIRT2258633	hsa-miR-1286	CLIP-seq
MIRT2258634	hsa-miR-1292	CLIP-seq
MIRT2258635	hsa-miR-132	CLIP-seq
MIRT2258636	hsa-miR-134	CLIP-seq
MIRT2258637	hsa-miR-140-3p	CLIP-seq
MIRT1100607	hsa-miR-143	CLIP-seq
MIRT2027371	hsa-miR-154	CLIP-seq
MIRT2258638	hsa-miR-155	CLIP-seq
MIRT1100519	hsa-miR-181a	CLIP-seq
MIRT1100520	hsa-miR-181b	CLIP-seq
MIRT1100521	hsa-miR-181c	CLIP-seq
MIRT1100522	hsa-miR-181d	CLIP-seq
MIRT2258639	hsa-miR-1825	CLIP-seq
MIRT2027372	hsa-miR-194	CLIP-seq
MIRT2258640	hsa-miR-199b-5p	CLIP-seq
MIRT1100610	hsa-miR-2053	CLIP-seq
MIRT2027373	hsa-miR-2110	CLIP-seq
MIRT2258641	hsa-miR-212	CLIP-seq
MIRT2258642	hsa-miR-214	CLIP-seq
MIRT2258643	hsa-miR-216a	CLIP-seq
MIRT2258644	hsa-miR-218	CLIP-seq
MIRT2258645	hsa-miR-224	CLIP-seq
MIRT2258646	hsa-miR-298	CLIP-seq
MIRT1100534	hsa-miR-30a	CLIP-seq
MIRT1100535	hsa-miR-30b	CLIP-seq
MIRT1100536	hsa-miR-30c	CLIP-seq
MIRT1100537	hsa-miR-30d	CLIP-seq
MIRT1100538	hsa-miR-30e	CLIP-seq
MIRT2258647	hsa-miR-3117-5p	CLIP-seq
MIRT2258648	hsa-miR-3118	CLIP-seq
MIRT2258649	hsa-miR-3134	CLIP-seq
MIRT2027374	hsa-miR-3150a-3p	CLIP-seq
MIRT2258650	hsa-miR-3157-5p	CLIP-seq
MIRT2258651	hsa-miR-3158-5p	CLIP-seq
MIRT2258652	hsa-miR-3160-3p	CLIP-seq
MIRT2258653	hsa-miR-3164	CLIP-seq
MIRT1100540	hsa-miR-3185	CLIP-seq
MIRT1100541	hsa-miR-3192	CLIP-seq
MIRT1100542	hsa-miR-323-3p	CLIP-seq
MIRT2258654	hsa-miR-331-5p	CLIP-seq
MIRT1100543	hsa-miR-335	CLIP-seq
MIRT2027375	hsa-miR-337-3p	CLIP-seq
MIRT1550624	hsa-miR-338-5p	CLIP-seq
MIRT2258655	hsa-miR-3606	CLIP-seq
MIRT1100545	hsa-miR-3613-3p	CLIP-seq
MIRT2258656	hsa-miR-3619-5p	CLIP-seq
MIRT2258657	hsa-miR-3622a-3p	CLIP-seq
MIRT1100547	hsa-miR-3622a-5p	CLIP-seq
MIRT2258658	hsa-miR-3622b-3p	CLIP-seq
MIRT2258659	hsa-miR-3647-3p	CLIP-seq
MIRT2258660	hsa-miR-365	CLIP-seq
MIRT1100549	hsa-miR-3653	CLIP-seq
MIRT1100550	hsa-miR-3658	CLIP-seq
MIRT1100552	hsa-miR-3664-3p	CLIP-seq
MIRT2258661	hsa-miR-3675-5p	CLIP-seq
MIRT2258662	hsa-miR-3679-3p	CLIP-seq
MIRT1100554	hsa-miR-3688-3p	CLIP-seq
MIRT2258663	hsa-miR-3689d	CLIP-seq
MIRT2258664	hsa-miR-3692	CLIP-seq
MIRT1100556	hsa-miR-380	CLIP-seq
MIRT2258665	hsa-miR-3915	CLIP-seq
MIRT2258666	hsa-miR-3928	CLIP-seq
MIRT2258667	hsa-miR-3978	CLIP-seq
MIRT2258668	hsa-miR-421	CLIP-seq
MIRT1100560	hsa-miR-4252	CLIP-seq
MIRT2258669	hsa-miR-4253	CLIP-seq
MIRT2027376	hsa-miR-4260	CLIP-seq
MIRT1100561	hsa-miR-4262	CLIP-seq
MIRT2258670	hsa-miR-4269	CLIP-seq
MIRT2027377	hsa-miR-4270	CLIP-seq
MIRT2258671	hsa-miR-4274	CLIP-seq
MIRT1100618	hsa-miR-4282	CLIP-seq
MIRT2258672	hsa-miR-4291	CLIP-seq
MIRT2258673	hsa-miR-4311	CLIP-seq
MIRT2258674	hsa-miR-4312	CLIP-seq
MIRT2258675	hsa-miR-4317	CLIP-seq
MIRT2258676	hsa-miR-4319	CLIP-seq
MIRT2258677	hsa-miR-4422	CLIP-seq
MIRT2258678	hsa-miR-4423-3p	CLIP-seq
MIRT2027378	hsa-miR-4426	CLIP-seq
MIRT2258679	hsa-miR-4428	CLIP-seq
MIRT1100562	hsa-miR-4433	CLIP-seq
MIRT2027379	hsa-miR-4436b-5p	CLIP-seq
MIRT2027380	hsa-miR-4441	CLIP-seq
MIRT2258680	hsa-miR-4446-5p	CLIP-seq
MIRT2258681	hsa-miR-4450	CLIP-seq
MIRT2258682	hsa-miR-4471	CLIP-seq
MIRT2258683	hsa-miR-4477b	CLIP-seq
MIRT2258684	hsa-miR-4487	CLIP-seq
MIRT2258685	hsa-miR-4490	CLIP-seq
MIRT2258686	hsa-miR-4491	CLIP-seq
MIRT1100563	hsa-miR-4495	CLIP-seq
MIRT1100564	hsa-miR-4504	CLIP-seq
MIRT2258687	hsa-miR-4514	CLIP-seq
MIRT2258688	hsa-miR-4517	CLIP-seq
MIRT2258689	hsa-miR-4519	CLIP-seq
MIRT2258690	hsa-miR-4521	CLIP-seq
MIRT2027397	hsa-miR-4534	CLIP-seq
MIRT2258691	hsa-miR-4641	CLIP-seq
MIRT2027381	hsa-miR-4647	CLIP-seq
MIRT2258692	hsa-miR-4657	CLIP-seq
MIRT2027382	hsa-miR-4662b	CLIP-seq
MIRT2258693	hsa-miR-4663	CLIP-seq
MIRT2258694	hsa-miR-4666-3p	CLIP-seq
MIRT2258695	hsa-miR-4686	CLIP-seq
MIRT2258696	hsa-miR-4691-3p	CLIP-seq
MIRT2258697	hsa-miR-4692	CLIP-seq
MIRT1100573	hsa-miR-4695-5p	CLIP-seq
MIRT2027383	hsa-miR-4699-5p	CLIP-seq
MIRT1100574	hsa-miR-4701-3p	CLIP-seq
MIRT2258698	hsa-miR-4704-5p	CLIP-seq
MIRT1100619	hsa-miR-4708-5p	CLIP-seq
MIRT2258699	hsa-miR-4711-5p	CLIP-seq
MIRT2027384	hsa-miR-4712-3p	CLIP-seq
MIRT2258700	hsa-miR-4729	CLIP-seq
MIRT2258701	hsa-miR-4742-5p	CLIP-seq
MIRT2258702	hsa-miR-4760-3p	CLIP-seq
MIRT1100578	hsa-miR-4762-5p	CLIP-seq
MIRT2258703	hsa-miR-4768-5p	CLIP-seq
MIRT1100622	hsa-miR-4770	CLIP-seq
MIRT2258704	hsa-miR-4774-5p	CLIP-seq
MIRT2027398	hsa-miR-4775	CLIP-seq
MIRT2258705	hsa-miR-4778-3p	CLIP-seq
MIRT2258706	hsa-miR-4797-5p	CLIP-seq
MIRT2258707	hsa-miR-4802-5p	CLIP-seq
MIRT2027385	hsa-miR-4803	CLIP-seq
MIRT2258708	hsa-miR-486-3p	CLIP-seq
MIRT2258709	hsa-miR-491-5p	CLIP-seq
MIRT2258710	hsa-miR-499-3p	CLIP-seq
MIRT2258711	hsa-miR-499a-3p	CLIP-seq
MIRT2258712	hsa-miR-5096	CLIP-seq
MIRT1100581	hsa-miR-510	CLIP-seq
MIRT1100582	hsa-miR-512-5p	CLIP-seq
MIRT2258713	hsa-miR-513b	CLIP-seq
MIRT2258714	hsa-miR-513c	CLIP-seq
MIRT2258715	hsa-miR-514b-5p	CLIP-seq
MIRT2258716	hsa-miR-544b	CLIP-seq
MIRT2258717	hsa-miR-545	CLIP-seq
MIRT2258718	hsa-miR-548a-3p	CLIP-seq
MIRT1100589	hsa-miR-548ac	CLIP-seq
MIRT2027386	hsa-miR-548ae	CLIP-seq
MIRT1100590	hsa-miR-548ag	CLIP-seq
MIRT1100591	hsa-miR-548ai	CLIP-seq
MIRT2027387	hsa-miR-548aj	CLIP-seq
MIRT2027388	hsa-miR-548am	CLIP-seq
MIRT1100625	hsa-miR-548c-3p	CLIP-seq
MIRT1100592	hsa-miR-548d-3p	CLIP-seq
MIRT2258719	hsa-miR-548e	CLIP-seq
MIRT2258720	hsa-miR-548f	CLIP-seq
MIRT2258721	hsa-miR-548l	CLIP-seq
MIRT2027389	hsa-miR-548n	CLIP-seq
MIRT2027390	hsa-miR-548x	CLIP-seq
MIRT1100595	hsa-miR-548z	CLIP-seq
MIRT2258722	hsa-miR-549	CLIP-seq
MIRT1100596	hsa-miR-554	CLIP-seq
MIRT2258723	hsa-miR-558	CLIP-seq
MIRT2258724	hsa-miR-566	CLIP-seq
MIRT2258725	hsa-miR-569	CLIP-seq
MIRT2258726	hsa-miR-570	CLIP-seq
MIRT2027391	hsa-miR-580	CLIP-seq
MIRT1100597	hsa-miR-584	CLIP-seq
MIRT2258727	hsa-miR-587	CLIP-seq
MIRT2027392	hsa-miR-593	CLIP-seq
MIRT1100599	hsa-miR-605	CLIP-seq
MIRT2027393	hsa-miR-616	CLIP-seq
MIRT2027394	hsa-miR-642b	CLIP-seq
MIRT2258728	hsa-miR-652	CLIP-seq
MIRT2027395	hsa-miR-654-3p	CLIP-seq
MIRT1100600	hsa-miR-661	CLIP-seq
MIRT2258729	hsa-miR-7	CLIP-seq
MIRT2258730	hsa-miR-759	CLIP-seq
MIRT1100601	hsa-miR-877	CLIP-seq
MIRT1100629	hsa-miR-888	CLIP-seq
MIRT2258731	hsa-miR-921	CLIP-seq
MIRT2258732	hsa-miR-922	CLIP-seq
MIRT1100631	hsa-miR-96	CLIP-seq
MIRT1100515	hsa-miR-1262	CLIP-seq
MIRT2027371	hsa-miR-154	CLIP-seq
MIRT2027372	hsa-miR-194	CLIP-seq
MIRT2027373	hsa-miR-2110	CLIP-seq
MIRT2258644	hsa-miR-218	CLIP-seq
MIRT2027374	hsa-miR-3150a-3p	CLIP-seq
MIRT2390024	hsa-miR-3175	CLIP-seq
MIRT1100541	hsa-miR-3192	CLIP-seq
MIRT2027375	hsa-miR-337-3p	CLIP-seq
MIRT1100544	hsa-miR-34b	CLIP-seq
MIRT1100546	hsa-miR-3614-5p	CLIP-seq
MIRT1100547	hsa-miR-3622a-5p	CLIP-seq
MIRT2258668	hsa-miR-421	CLIP-seq
MIRT2027376	hsa-miR-4260	CLIP-seq
MIRT2027377	hsa-miR-4270	CLIP-seq
MIRT1100618	hsa-miR-4282	CLIP-seq
MIRT2258674	hsa-miR-4312	CLIP-seq
MIRT2027378	hsa-miR-4426	CLIP-seq
MIRT1100562	hsa-miR-4433	CLIP-seq
MIRT2027380	hsa-miR-4441	CLIP-seq
MIRT2027381	hsa-miR-4647	CLIP-seq
MIRT2027382	hsa-miR-4662b	CLIP-seq
MIRT2258693	hsa-miR-4663	CLIP-seq
MIRT1100574	hsa-miR-4701-3p	CLIP-seq
MIRT2027384	hsa-miR-4712-3p	CLIP-seq
MIRT1100577	hsa-miR-4761-5p	CLIP-seq
MIRT2027385	hsa-miR-4803	CLIP-seq
MIRT1100625	hsa-miR-548c-3p	CLIP-seq
MIRT2258727	hsa-miR-587	CLIP-seq
MIRT2027394	hsa-miR-642b	CLIP-seq
MIRT1100620	hsa-miR-4731-3p	CLIP-seq
MIRT1100624	hsa-miR-4801	CLIP-seq
MIRT2258726	hsa-miR-570	CLIP-seq
MIRT2559422	hsa-miR-101	CLIP-seq
MIRT2559423	hsa-miR-1197	CLIP-seq
MIRT1100515	hsa-miR-1262	CLIP-seq
MIRT2258635	hsa-miR-132	CLIP-seq
MIRT2559424	hsa-miR-1322	CLIP-seq
MIRT2559425	hsa-miR-142-5p	CLIP-seq
MIRT2559426	hsa-miR-144	CLIP-seq
MIRT2027371	hsa-miR-154	CLIP-seq
MIRT2258639	hsa-miR-1825	CLIP-seq
MIRT2559427	hsa-miR-185	CLIP-seq
MIRT2559428	hsa-miR-186	CLIP-seq
MIRT2027372	hsa-miR-194	CLIP-seq
MIRT2258640	hsa-miR-199b-5p	CLIP-seq
MIRT2258641	hsa-miR-212	CLIP-seq
MIRT2258644	hsa-miR-218	CLIP-seq
MIRT2559429	hsa-miR-2276	CLIP-seq
MIRT2559430	hsa-miR-2355-3p	CLIP-seq
MIRT2258647	hsa-miR-3117-5p	CLIP-seq
MIRT2559431	hsa-miR-3135	CLIP-seq
MIRT2559432	hsa-miR-3151	CLIP-seq
MIRT2390024	hsa-miR-3175	CLIP-seq
MIRT2559433	hsa-miR-3177-5p	CLIP-seq
MIRT1100540	hsa-miR-3185	CLIP-seq
MIRT2559434	hsa-miR-3201	CLIP-seq
MIRT1100544	hsa-miR-34b	CLIP-seq
MIRT1100545	hsa-miR-3613-3p	CLIP-seq
MIRT1100546	hsa-miR-3614-5p	CLIP-seq
MIRT1100547	hsa-miR-3622a-5p	CLIP-seq
MIRT1100548	hsa-miR-362-5p	CLIP-seq
MIRT2559435	hsa-miR-3646	CLIP-seq
MIRT1100554	hsa-miR-3688-3p	CLIP-seq
MIRT2559436	hsa-miR-369-5p	CLIP-seq
MIRT1100555	hsa-miR-3713	CLIP-seq
MIRT2559437	hsa-miR-3976	CLIP-seq
MIRT2559438	hsa-miR-4276	CLIP-seq
MIRT1100618	hsa-miR-4282	CLIP-seq
MIRT2559439	hsa-miR-4306	CLIP-seq
MIRT2559440	hsa-miR-433	CLIP-seq
MIRT2258678	hsa-miR-4423-3p	CLIP-seq
MIRT2027378	hsa-miR-4426	CLIP-seq
MIRT2559441	hsa-miR-4427	CLIP-seq
MIRT2559442	hsa-miR-4447	CLIP-seq
MIRT2559443	hsa-miR-4453	CLIP-seq
MIRT2559444	hsa-miR-4455	CLIP-seq
MIRT2559445	hsa-miR-4472	CLIP-seq
MIRT2258683	hsa-miR-4477b	CLIP-seq
MIRT2258684	hsa-miR-4487	CLIP-seq
MIRT2258685	hsa-miR-4490	CLIP-seq
MIRT2258688	hsa-miR-4517	CLIP-seq
MIRT2559446	hsa-miR-4538	CLIP-seq
MIRT2559447	hsa-miR-4642	CLIP-seq
MIRT2559448	hsa-miR-4644	CLIP-seq
MIRT2027381	hsa-miR-4647	CLIP-seq
MIRT2027382	hsa-miR-4662b	CLIP-seq
MIRT2258693	hsa-miR-4663	CLIP-seq
MIRT2027383	hsa-miR-4699-5p	CLIP-seq
MIRT1100574	hsa-miR-4701-3p	CLIP-seq
MIRT2559449	hsa-miR-4723-5p	CLIP-seq
MIRT1100577	hsa-miR-4761-5p	CLIP-seq
MIRT2559450	hsa-miR-4772-3p	CLIP-seq
MIRT2258704	hsa-miR-4774-5p	CLIP-seq
MIRT2559451	hsa-miR-4791	CLIP-seq
MIRT2027385	hsa-miR-4803	CLIP-seq
MIRT2258709	hsa-miR-491-5p	CLIP-seq
MIRT1100579	hsa-miR-500b	CLIP-seq
MIRT1100580	hsa-miR-501-5p	CLIP-seq
MIRT2258712	hsa-miR-5096	CLIP-seq
MIRT2559452	hsa-miR-544	CLIP-seq
MIRT2559453	hsa-miR-548a-5p	CLIP-seq
MIRT2559454	hsa-miR-548ab	CLIP-seq
MIRT2559455	hsa-miR-548ad	CLIP-seq
MIRT1100590	hsa-miR-548ag	CLIP-seq
MIRT1100591	hsa-miR-548ai	CLIP-seq
MIRT2559456	hsa-miR-548ak	CLIP-seq
MIRT2559457	hsa-miR-548b-5p	CLIP-seq
MIRT1100625	hsa-miR-548c-3p	CLIP-seq
MIRT2559458	hsa-miR-548c-5p	CLIP-seq
MIRT2559459	hsa-miR-548d-5p	CLIP-seq
MIRT2559460	hsa-miR-548h	CLIP-seq
MIRT2559461	hsa-miR-548i	CLIP-seq
MIRT2559462	hsa-miR-548j	CLIP-seq
MIRT2559463	hsa-miR-548k	CLIP-seq
MIRT2258721	hsa-miR-548l	CLIP-seq
MIRT2027389	hsa-miR-548n	CLIP-seq
MIRT2559464	hsa-miR-548p	CLIP-seq
MIRT2559465	hsa-miR-548w	CLIP-seq
MIRT2559466	hsa-miR-548y	CLIP-seq
MIRT1100596	hsa-miR-554	CLIP-seq
MIRT2559467	hsa-miR-559	CLIP-seq
MIRT2559468	hsa-miR-562	CLIP-seq
MIRT1100598	hsa-miR-595	CLIP-seq
MIRT2027393	hsa-miR-616	CLIP-seq
MIRT2559469	hsa-miR-628-5p	CLIP-seq
MIRT2559470	hsa-miR-676	CLIP-seq
MIRT2258729	hsa-miR-7	CLIP-seq
MIRT2559423	hsa-miR-1197	CLIP-seq
MIRT2258623	hsa-miR-1205	CLIP-seq
MIRT2258629	hsa-miR-1248	CLIP-seq
MIRT1100604	hsa-miR-1273f	CLIP-seq
MIRT2683667	hsa-miR-129-5p	CLIP-seq
MIRT2559424	hsa-miR-1322	CLIP-seq
MIRT1100517	hsa-miR-1323	CLIP-seq
MIRT2559425	hsa-miR-142-5p	CLIP-seq
MIRT2258639	hsa-miR-1825	CLIP-seq
MIRT2559427	hsa-miR-185	CLIP-seq
MIRT2258640	hsa-miR-199b-5p	CLIP-seq
MIRT2559429	hsa-miR-2276	CLIP-seq
MIRT2683668	hsa-miR-296-5p	CLIP-seq
MIRT2258647	hsa-miR-3117-5p	CLIP-seq
MIRT2683669	hsa-miR-3127-3p	CLIP-seq
MIRT2683670	hsa-miR-3130-5p	CLIP-seq
MIRT2559431	hsa-miR-3135	CLIP-seq
MIRT2559432	hsa-miR-3151	CLIP-seq
MIRT2258651	hsa-miR-3158-5p	CLIP-seq
MIRT2390024	hsa-miR-3175	CLIP-seq
MIRT1100540	hsa-miR-3185	CLIP-seq
MIRT2559434	hsa-miR-3201	CLIP-seq
MIRT1100545	hsa-miR-3613-3p	CLIP-seq
MIRT1100547	hsa-miR-3622a-5p	CLIP-seq
MIRT2559435	hsa-miR-3646	CLIP-seq
MIRT2683671	hsa-miR-3671	CLIP-seq
MIRT1100553	hsa-miR-3675-3p	CLIP-seq
MIRT2683672	hsa-miR-3676	CLIP-seq
MIRT1100554	hsa-miR-3688-3p	CLIP-seq
MIRT2559436	hsa-miR-369-5p	CLIP-seq
MIRT1100558	hsa-miR-3942-3p	CLIP-seq
MIRT2559437	hsa-miR-3976	CLIP-seq
MIRT2683673	hsa-miR-412	CLIP-seq
MIRT2683674	hsa-miR-4272	CLIP-seq
MIRT2559438	hsa-miR-4276	CLIP-seq
MIRT2559439	hsa-miR-4306	CLIP-seq
MIRT2258675	hsa-miR-4317	CLIP-seq
MIRT2559440	hsa-miR-433	CLIP-seq
MIRT2258678	hsa-miR-4423-3p	CLIP-seq
MIRT2559441	hsa-miR-4427	CLIP-seq
MIRT2027379	hsa-miR-4436b-5p	CLIP-seq
MIRT2559442	hsa-miR-4447	CLIP-seq
MIRT2559443	hsa-miR-4453	CLIP-seq
MIRT2559444	hsa-miR-4455	CLIP-seq
MIRT2559445	hsa-miR-4472	CLIP-seq
MIRT2258683	hsa-miR-4477b	CLIP-seq
MIRT2683675	hsa-miR-4482	CLIP-seq
MIRT2258684	hsa-miR-4487	CLIP-seq
MIRT2258685	hsa-miR-4490	CLIP-seq
MIRT2683676	hsa-miR-450b-5p	CLIP-seq
MIRT2258688	hsa-miR-4517	CLIP-seq
MIRT2559446	hsa-miR-4538	CLIP-seq
MIRT2559447	hsa-miR-4642	CLIP-seq
MIRT2559448	hsa-miR-4644	CLIP-seq
MIRT2258695	hsa-miR-4686	CLIP-seq
MIRT1100572	hsa-miR-4694-3p	CLIP-seq
MIRT2027383	hsa-miR-4699-5p	CLIP-seq
MIRT2559449	hsa-miR-4723-5p	CLIP-seq
MIRT1100577	hsa-miR-4761-5p	CLIP-seq
MIRT2559450	hsa-miR-4772-3p	CLIP-seq
MIRT2258704	hsa-miR-4774-5p	CLIP-seq
MIRT2559451	hsa-miR-4791	CLIP-seq
MIRT2258709	hsa-miR-491-5p	CLIP-seq
MIRT2258712	hsa-miR-5096	CLIP-seq
MIRT2683677	hsa-miR-518a-5p	CLIP-seq
MIRT2683678	hsa-miR-527	CLIP-seq
MIRT2559452	hsa-miR-544	CLIP-seq
MIRT2559453	hsa-miR-548a-5p	CLIP-seq
MIRT2559454	hsa-miR-548ab	CLIP-seq
MIRT2559455	hsa-miR-548ad	CLIP-seq
MIRT2027386	hsa-miR-548ae	CLIP-seq
MIRT1100590	hsa-miR-548ag	CLIP-seq
MIRT1100591	hsa-miR-548ai	CLIP-seq
MIRT2027387	hsa-miR-548aj	CLIP-seq
MIRT2559456	hsa-miR-548ak	CLIP-seq
MIRT2027388	hsa-miR-548am	CLIP-seq
MIRT2559457	hsa-miR-548b-5p	CLIP-seq
MIRT1100625	hsa-miR-548c-3p	CLIP-seq
MIRT2559458	hsa-miR-548c-5p	CLIP-seq
MIRT2559459	hsa-miR-548d-5p	CLIP-seq
MIRT2559460	hsa-miR-548h	CLIP-seq
MIRT2559461	hsa-miR-548i	CLIP-seq
MIRT2559462	hsa-miR-548j	CLIP-seq
MIRT2559463	hsa-miR-548k	CLIP-seq
MIRT2258721	hsa-miR-548l	CLIP-seq
MIRT2027389	hsa-miR-548n	CLIP-seq
MIRT1100594	hsa-miR-548o	CLIP-seq
MIRT2559464	hsa-miR-548p	CLIP-seq
MIRT2559465	hsa-miR-548w	CLIP-seq
MIRT2027390	hsa-miR-548x	CLIP-seq
MIRT2559466	hsa-miR-548y	CLIP-seq
MIRT1100596	hsa-miR-554	CLIP-seq
MIRT2559467	hsa-miR-559	CLIP-seq
MIRT2559468	hsa-miR-562	CLIP-seq
MIRT2683679	hsa-miR-607	CLIP-seq
MIRT2027393	hsa-miR-616	CLIP-seq
MIRT2559469	hsa-miR-628-5p	CLIP-seq
MIRT2258729	hsa-miR-7	CLIP-seq
MIRT1100601	hsa-miR-877	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MYC	Activation	21252116

Gene ontology (GO) Show/Hide all (69)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0000165	Process	MAPK cascade	IEA
GO:0000165	Process	MAPK cascade	TAS
GO:0000166	Function	Nucleotide binding	IEA
GO:0001889	Process	Liver development	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	IMP	26037647
GO:0003924	Function	GTPase activity	TAS
GO:0003925	Function	G protein activity	IEA
GO:0005515	Function	Protein binding	IPI	10673434, 12732644, 15451670, 20080631, 20802526, 24415755, 25416956, 25852190, 28619714, 30194290, 31980649, 32814053
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	23698361
GO:0005737	Component	Cytoplasm	IEA
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	28619714
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007165	Process	Signal transduction	IEA
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0007265	Process	Ras protein signal transduction	IEA
GO:0007565	Process	Female pregnancy	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0008542	Process	Visual learning	IEA
GO:0009629	Process	Response to gravity	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	23698361
GO:0010467	Process	Gene expression	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0010628	Process	Positive regulation of gene expression	IMP	22065586
GO:0012505	Component	Endomembrane system	IEA
GO:0014009	Process	Glial cell proliferation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016601	Process	Rac protein signal transduction	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019002	Function	GMP binding	IEA
GO:0019003	Function	GDP binding	IBA
GO:0019003	Function	GDP binding	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0021897	Process	Forebrain astrocyte development	IEA
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030275	Function	LRR domain binding	IEA
GO:0030857	Process	Negative regulation of epithelial cell differentiation	IEA
GO:0032228	Process	Regulation of synaptic transmission, GABAergic	IEA
GO:0035022	Process	Positive regulation of Rac protein signal transduction	IEA
GO:0035900	Process	Response to isolation stress	IEA
GO:0035914	Process	Skeletal muscle cell differentiation	IEA
GO:0042802	Function	Identical protein binding	IPI	26051715
GO:0043495	Function	Protein-membrane adaptor activity	IEA
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0044877	Function	Protein-containing complex binding	IDA	23209302
GO:0048169	Process	Regulation of long-term neuronal synaptic plasticity	IEA
GO:0048873	Process	Homeostasis of number of cells within a tissue	IEA
GO:0051146	Process	Striated muscle cell differentiation	IEA
GO:0051384	Process	Response to glucocorticoid	IEA
GO:0051385	Process	Response to mineralocorticoid	IEA
GO:0051402	Process	Neuron apoptotic process	IEA
GO:0051450	Process	Myoblast proliferation	IEA
GO:0060038	Process	Cardiac muscle cell proliferation	IEA
GO:0060252	Process	Positive regulation of glial cell proliferation	IEA
GO:0060441	Process	Epithelial tube branching involved in lung morphogenesis	IEA
GO:0060509	Process	Type I pneumocyte differentiation	IEA
GO:2000774	Process	Positive regulation of cellular senescence	IEA

Other IDs

• MIM: 190070
• HGNC: 6407
• e!Ensembl: ENSG00000133703

Protein

• UniProt ID: P01116
• Protein name: GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
• Protein function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621, PubMed:39809765). Plays an important role in the regulation of cell proliferation (PubMed:22711838, PubMed:23698361). Plays a role in promoting oncogenic events by
• PDB: 1D8D , 1D8E , 1KZO , 1KZP , 1N4P , 1N4Q , 1N4R , 1N4S , 2MSC , 2MSD , 2MSE , 3GFT , 4DSN , 4DSO , 4EPR , 4EPT , 4EPV , 4EPW , 4EPX , 4EPY , 4L8G , 4LDJ , 4LPK , 4LRW , 4LUC , 4LV6 , 4LYF , 4LYH , 4LYJ , 4M1O , 4M1S , 4M1T , 4M1W , 4M1Y , 4M21 , 4M22 , 4NMM , 4OBE , 4PZY , 4PZZ , 4Q01 , 4Q02 , 4Q03 , 4QL3 , 4TQ9 , 4TQA , 4WA7 , 5F2E , 5KYK , 5MLA , 5MLB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	5 → 165	Ras family	Domain

• Sequence:

  MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
  QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
  PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC
  VKIKKCIIM

• Sequence length: 189

Pathways

KEGG Pathway	Reactome Pathway
EGFR tyrosine kinase inhibitor resistance	Activation of RAS in B cells
Endocrine resistance	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
MAPK signaling pathway	SHC1 events in ERBB4 signaling
ErbB signaling pathway	Signaling by SCF-KIT
Ras signaling pathway	p38MAPK events
Rap1 signaling pathway	GRB2 events in EGFR signaling
Chemokine signaling pathway	SHC1 events in EGFR signaling
FoxO signaling pathway	Downstream signal transduction
Sphingolipid signaling pathway	GRB2 events in ERBB2 signaling
Phospholipase D signaling pathway	Tie2 Signaling
Mitophagy - animal	EGFR Transactivation by Gastrin
Autophagy - animal	DAP12 signaling
mTOR signaling pathway	FCERI mediated MAPK activation
PI3K-Akt signaling pathway	NCAM signaling for neurite out-growth
Apoptosis	Ca2+ pathway
Longevity regulating pathway	VEGFR2 mediated cell proliferation
Longevity regulating pathway - multiple species	CD209 (DC-SIGN) signaling
Cellular senescence	Constitutive Signaling by EGFRvIII
Axon guidance	SHC-mediated cascade:FGFR1
VEGF signaling pathway	FRS-mediated FGFR1 signaling
Apelin signaling pathway	SHC-mediated cascade:FGFR2
Gap junction	FRS-mediated FGFR2 signaling
Signaling pathways regulating pluripotency of stem cells	SHC-mediated cascade:FGFR3
C-type lectin receptor signaling pathway	FRS-mediated FGFR3 signaling
Natural killer cell mediated cytotoxicity	FRS-mediated FGFR4 signaling
T cell receptor signaling pathway	SHC-mediated cascade:FGFR4
B cell receptor signaling pathway	Signaling by FGFR2 in disease
Fc epsilon RI signaling pathway	Signaling by FGFR4 in disease
Thermogenesis	Signaling by FGFR1 in disease
Long-term potentiation	Regulation of RAS by GAPs
Neurotrophin signaling pathway	RAF activation
Cholinergic synapse	RAF/MAP kinase cascade
Serotonergic synapse	MAP2K and MAPK activation
Long-term depression	Negative regulation of MAPK pathway
Regulation of actin cytoskeleton	Signaling by moderate kinase activity BRAF mutants
Insulin signaling pathway	Signaling by high-kinase activity BRAF mutants
GnRH signaling pathway	Signaling by BRAF and RAF fusions
Progesterone-mediated oocyte maturation	RAS signaling downstream of NF1 loss-of-function variants
Estrogen signaling pathway	Paradoxical activation of RAF signaling by kinase inactive BRAF
Melanogenesis	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Prolactin signaling pathway	MET activates RAS signaling
Thyroid hormone signaling pathway	Signaling by FGFR3 fusions in cancer
Oxytocin signaling pathway	Signaling by FGFR3 point mutants in cancer
Relaxin signaling pathway	RUNX3 regulates p14-ARF
GnRH secretion	FLT3 Signaling
AGE-RAGE signaling pathway in diabetic complications	Constitutive Signaling by Overexpressed ERBB2
Growth hormone synthesis, secretion and action	Estrogen-stimulated signaling through PRKCZ
Aldosterone-regulated sodium reabsorption	RAS GTPase cycle mutants
Alzheimer disease	Signaling downstream of RAS mutants
Pathways of neurodegeneration - multiple diseases	Signaling by ERBB2 KD Mutants
Alcoholism	Signaling by ERBB2 ECD mutants
Hepatitis C	Signaling by ERBB2 TMD/JMD mutants
Hepatitis B	Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Human cytomegalovirus infection	Signaling by PDGFRA extracellular domain mutants
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Lipid and atherosclerosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal Show/Hide Causal Diseases (73)
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Acute myeloid leukemia	Pathogenic; Likely pathogenic	rs112445441, rs121913529, rs606231202, rs104894366, rs730880471	RCV005887479 RCV000433573 RCV000013415 RCV000850569 RCV000850568	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Adenocarcinoma of the large intestine	Likely pathogenic; Pathogenic	rs121913530, rs112445441, rs121913529	RCV006253513 RCV006253517 RCV006253525 RCV006253529	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Adenoid cystic carcinoma	Likely pathogenic; Pathogenic	rs121913530	RCV004813033	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Alveolar rhabdomyosarcoma	Likely pathogenic; Pathogenic	rs121913529	RCV006253520	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Atypical endometrial hyperplasia	Likely pathogenic; Pathogenic	rs121913529	RCV003327361	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Autoimmune lymphoproliferative syndrome type 4	Pathogenic; Likely pathogenic	rs112445441, rs121913529, rs104894366, rs121913527, rs730880471, rs121913535	RCV000144968 RCV000144970 RCV000850569 RCV002259922 RCV000850568 RCV000144972	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Bladder cancer, transitional cell, somatic	Pathogenic	rs121913528	RCV000013410	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Breast adenocarcinoma	Pathogenic	rs112445441	RCV000013409	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Capillary malformation-arteriovenous malformation 1	Likely pathogenic; Pathogenic	rs121913529	RCV001799604	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Capillary Telangiectasia, Brain	Pathogenic	rs2141509932	RCV001526874	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Carcinoma of pancreas	Likely pathogenic; Pathogenic	rs121913529	RCV000013411 RCV000013413	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Cardio-facio-cutaneous syndrome	Pathogenic; Likely pathogenic	rs397517042, rs727503109, rs727503108, rs387907205, rs104894359, rs104894360, rs104894365, rs104894366	RCV000150884 RCV000844636 RCV000157936 RCV000221667 RCV000521390 RCV000844634 RCV000844637 RCV000211723	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Cardiofaciocutaneous syndrome 1	Likely pathogenic; Pathogenic	rs727503109	RCV000856729	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Cardiofaciocutaneous syndrome 2	Likely pathogenic; Pathogenic	rs2548920539, rs121913530, rs104894359, rs104894360, rs104894366, rs104894361, rs104894362, rs387907205, rs387907206, rs727503110, rs730880471	RCV003140510 RCV004795403 RCV000013416 RCV000013417 RCV000043674 RCV000013425 RCV000013426 RCV002470709 RCV000024617 RCV000024618 RCV000576784 RCV000850568	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Cardiovascular phenotype	Likely pathogenic; Pathogenic	rs727503109, rs121913529, rs104894360, rs104894365, rs2141506236	RCV002444616 RCV004018620 RCV004018621 RCV005647456 RCV004519282	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Cerebral arteriovenous malformation	Likely pathogenic; Pathogenic	rs121913529, rs17851045	RCV000585796 RCV000585801 RCV003445113	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Cervical cancer	Pathogenic	rs112445441	RCV005887481	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Chronic myelogenous leukemia, BCR-ABL1 positive	Pathogenic	rs121913529	RCV002291496	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Colon adenocarcinoma	Pathogenic	rs121913238	RCV005888473	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Colorectal cancer	Pathogenic; Likely pathogenic	rs112445441, rs121913529, rs104894365, rs770248150	RCV005887482 RCV006250158 RCV006250159 RCV006250160 RCV005603620	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Congenital Pulmonary Airway Malformations	Likely pathogenic; Pathogenic	rs121913529	RCV004554600	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Diffuse midline glioma, H3 K27M-mutant	Pathogenic; Likely pathogenic	rs112445441, rs121913529	RCV006253516 RCV006253524	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype	Likely pathogenic; Pathogenic	rs121913530, rs121913529	RCV006253512 RCV006253523	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Embryonal rhabdomyosarcoma	Likely pathogenic; Pathogenic	rs121913530, rs112445441, rs121913529, rs770248150, rs121913236	RCV006253511 RCV006253515 RCV006253522 RCV006253962 RCV006253998	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Encephalocraniocutaneous lipomatosis	Pathogenic; Likely pathogenic	rs121913538, rs112445441, rs121913529, rs1057519725, rs770248150	RCV001839449 RCV001839444 RCV001839445 RCV001839452 RCV001731671	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Endometrial carcinoma	Likely pathogenic; Pathogenic	rs121913530, rs104894365	RCV000119791 RCV000119792	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Endometrial hyperplasia without atypia	Likely pathogenic; Pathogenic	rs121913529	RCV003327361	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Epidermal nevus	Likely pathogenic; Pathogenic	rs121913529	RCV000022799	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Familial pancreatic carcinoma	Pathogenic; Likely pathogenic	rs112445441, rs1057519725	RCV004813034 RCV004760489	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Gallbladder cancer	Likely pathogenic; Pathogenic	rs121913530, rs121913529	RCV001292543 RCV001374446	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Gastric cancer	Likely pathogenic; Pathogenic	rs121913529, rs121913530	RCV002508117 RCV000013414	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Germinoma	Pathogenic	rs121913529, rs121913240	RCV006253528 RCV006253742	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Glioma	Likely pathogenic; Pathogenic	rs121913529	RCV006253521	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hereditary breast ovarian cancer syndrome	Likely pathogenic	rs2141481712	RCV001374475	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
High-grade astrocytoma with piloid features	Likely pathogenic; Pathogenic	rs121913236, rs121913529	RCV006254000 RCV006253744	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Juvenile myelomonocytic leukemia	Pathogenic; Likely pathogenic	rs112445441, rs121913529, rs121913530	RCV000144967 RCV000144969 RCV000150895 RCV000144971	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
KRAS-related disorder	Likely pathogenic; Pathogenic	rs727503109, rs112445441, rs104894360, rs104894362, rs193929331, rs104894366, rs121913529, rs121913535, rs1592798693	RCV004551310 RCV004549358 RCV006261936 RCV004549359 RCV004549360 RCV004550646 RCV004739314 RCV004549454 RCV003335071 RCV005225146	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
KRAS-related RASopathy	Likely pathogenic	rs730880471	RCV001269478	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Linear nevus sebaceous syndrome	Likely pathogenic; Pathogenic	rs121913529, rs121913236	RCV000029215 RCV003455987 RCV001078206	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Low grade glioma	Likely pathogenic; Pathogenic	rs121913236	RCV006253999	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Lung adenocarcinoma	Likely pathogenic	rs121913530	RCV000431049	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Lung cancer	Likely pathogenic; Pathogenic	rs121913530, rs121913529	RCV003996092 RCV003996396	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Lung carcinoma	Likely pathogenic	rs121913530	RCV000013406	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Lung sarcomatoid carcinoma	Pathogenic	rs121913529	RCV003322589	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Malignant tumor of urinary bladder	Likely pathogenic; Pathogenic	rs121913530, rs112445441, rs1057519725	RCV000013408 RCV005887480 RCV003332167	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Medullary thyroid carcinoma	Pathogenic	rs121913240	RCV004813050	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Medulloblastoma non-WNT/non-SHH	Likely pathogenic; Pathogenic	rs121913529	RCV006253526	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Melanoma	Pathogenic	rs112445441	RCV005887483	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Multiple myeloma	Likely pathogenic; Pathogenic	rs121913527, rs121913240, rs121913529	RCV000984134 RCV000984128 RCV000984117	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neoplasm	Likely pathogenic; Pathogenic	rs121913530, rs112445441, rs121913529, rs121913538, rs121913236, rs121913240	RCV004668721 RCV004668722 RCV004668723 RCV004668724 RCV004668725 RCV004668726 RCV004668928 RCV005230296 RCV004668757 RCV004668758	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Neuroblastoma	Pathogenic	rs121913530	RCV006253531	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Nevus sebaceous	Pathogenic; Likely pathogenic	rs112445441, rs121913529	RCV001526657 RCV000029214 RCV000029216	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Non-small cell lung carcinoma	Likely pathogenic; Pathogenic	rs727503106, rs121913238, rs727503108, rs397517040, rs121913530, rs112445441, rs121913529, rs121913535, rs121913240, rs17851045	RCV000150887 RCV000154402 RCV000150889 RCV000150894 RCV000038265 RCV000154401 RCV000038269 RCV000150896 RCV000154262 RCV000038264 RCV000038267 RCV000038258 RCV000038259 RCV000038266 RCV000038268 RCV000038270	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan syndrome	Pathogenic; Likely pathogenic	rs397517042, rs727504662, rs727503109, rs727503108, rs104894359, rs104894360, rs104894364, rs104894365, rs104894366, rs193929331, rs727503110, rs397517041, rs1951405479, rs1592798693	RCV000150884 RCV000155926 RCV000844636 RCV000157936 RCV000844635 RCV000844634 RCV000211785 RCV000844637 RCV000211723 RCV000605141 RCV000150893 RCV000150892 RCV000038274 RCV000038273 RCV000038275 RCV001261057 RCV001261058	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan syndrome 1	Likely pathogenic; Pathogenic	rs202247812, rs104894360, rs104894366	RCV000144422 RCV003450634 RCV003450654	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Noonan syndrome 3	Likely pathogenic; Pathogenic	rs2141509652, rs2135806030, rs2141509973, rs397517042, rs1135401776, rs104894359, rs104894360, rs104894364, rs104894365, rs104894366, rs104894367, rs193929331, rs2141509883, rs1555194026, rs727503110, rs730880471, rs1592798693, rs1951405809	RCV002221879 RCV002264903 RCV002264904 RCV001813760 RCV002468736 RCV003313917 RCV000013418 RCV000013419 RCV000013420 RCV000850569 RCV000013422 RCV000013427 RCV000013428 RCV004566627 RCV000496202 RCV000505640 RCV000576784 RCV003152670 RCV000850568 RCV000789016 RCV001264745	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan syndrome and Noonan-related syndrome	Pathogenic	rs112445441, rs104894365	RCV001813183 RCV001813184	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
OCULOECTODERMAL SYNDROME, SOMATIC	Pathogenic; Likely pathogenic	rs121913538, rs112445441, rs1057519725	RCV000201922 RCV000791297 RCV000791299	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Ovarian mucinous adenocarcinoma	Likely pathogenic; Pathogenic	rs121913530, rs121913529	RCV006253514 RCV006253527 RCV006253530	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Ovarian neoplasm	Likely pathogenic; Pathogenic	rs121913529, rs121913530	RCV000150897 RCV000119790	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Papillary thyroid carcinoma	Likely pathogenic; Pathogenic	rs121913529	RCV006253519	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Pilocytic astrocytoma	Pathogenic; Likely pathogenic	rs121913535, rs121913236, rs121913529	RCV000013424 RCV006253997 RCV006253743	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Precursor B-cell acute lymphoblastic leukemia	Likely pathogenic; Pathogenic	rs121913529	RCV006253518	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Primary intracranial sarcoma, DICER1-mutant	Pathogenic	rs770248150	RCV006253963	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Primary low grade serous adenocarcinoma of ovary	Likely pathogenic; Pathogenic	rs121913529	RCV000856666	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Prostate cancer, hereditary, 1	Likely pathogenic; Pathogenic	rs193929331	RCV002291547	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
RASopathy	Likely pathogenic; Pathogenic	rs727504662, rs727503109, rs727503108, rs193929331, rs121913538, rs2135806346, rs121913530, rs112445441, rs121913529, rs104894359, rs104894360, rs104894364, rs104894365, rs104894366, rs104894361, rs104894362, rs2548909825, rs2141505570, rs2141509883, rs1057519725, rs121913527, rs121913236, rs1555194026, rs727503110	RCV001315183 RCV001857536 RCV000150891 RCV001850055 RCV002833819 RCV003654222 RCV003230833 RCV003654176 RCV002513010 RCV001857340 RCV000548006 RCV003539760 RCV001851824 RCV000157935 RCV000157940 RCV000704828 RCV000157945 RCV001851825 RCV005252032 RCV001205658 RCV000149836 RCV000689097 RCV003539689 RCV003540291 RCV003655814 RCV002524688 RCV001861474 RCV005090693 RCV000680027 RCV000654936 RCV000157946 RCV000232330 RCV000526276	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Rhabdomyosarcoma	Pathogenic	rs121913530	RCV006253532	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Squamous cell lung carcinoma	Likely pathogenic; Pathogenic	rs121913530	RCV000013407	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Thyroid cancer, nonmedullary, 1	Likely pathogenic; Pathogenic	rs2141505552, rs121913238	RCV001789706 RCV005888474	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Vascular malformation	Pathogenic; Likely pathogenic	rs121913530, rs2548920482, rs121913236, rs17851045	RCV004562205 RCV003458962 RCV005251123 RCV005251049	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Vascular Tumors Including Pyogenic Granuloma	Likely pathogenic; Pathogenic	rs121913529	RCV000662266	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Venous malformation	Likely pathogenic	rs2141509708	RCV001533002	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (69)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ANEMIA	—	CTD, Disgenet CTD, Disgenet	27725143	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
APLASIA CUTIS CONGENITA WITH EPIBULBAR DERMOIDS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARTERIOVENOUS MALFORMATIONS OF THE BRAIN	—	HPO	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARTERIOVENOUS MALFORMATIONS, CEREBRAL	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARTHRITIS, JUVENILE	—	CTD	19565504	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA	—	CTD	23817572	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BLADDER CANCER	—	HPO	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	HPO	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS	—	CTD	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOGENESIS	—	CTD	26595770, 29247004	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA	—	CTD	10545420, 20565773	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	11286481, 11563603	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, NON-SMALL-CELL LUNG	—	CTD	21336183, 22617245, 22787409, 22887466, 23435014, 24688052, 27588471	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, PANCREATIC DUCTAL	—	CTD	25347530, 30654191	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, SQUAMOUS CELL	—	CTD	19435901, 25125259	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOFACIOCUTANEOUS SYNDROME	—	CTD, ClinGen, GWAS catalog, Orphanet CTD, ClinGen, GWAS catalog, Orphanet CTD, ClinGen, GWAS catalog, Orphanet	16474404, 16825433, 17056636, 17601930, 17703371, 17704260, 18456719, 20301365, 20949621, 21871821, 23875798	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, HYPERTROPHIC, FAMILIAL	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CECAL NEOPLASMS	—	CTD	14688030	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLANGIOCARCINOMA	—	CTD	22561520, 8968066	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Classic Hodgkin lymphoma	Conflicting classifications of pathogenicity	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLONIC NEOPLASMS	—	CTD	10813127, 12800193, 12839936, 17192441, 18372904, 19424582	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL NEOPLASMS	—	CTD	20565773, 21369707, 25280562	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX ENDOMETRIAL HYPERPLASIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL ABNORMALITY OF VEIN	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COSTELLO SYNDROME	—	CTD, ClinGen CTD, ClinGen	17468812, 17703371	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DESBUQUOIS SYNDROME	—	CTD	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIFFERENTIATED THYROID CARCINOMA	—	Orphanet	23625203, 25132659, 25648502	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL HYPERPLASIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	CTD, Disgenet CTD, Disgenet	23284138	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	not provided	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GALLBLADDER NEOPLASMS	—	CTD	24997986	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMANGIOSARCOMA	—	CTD	10930038, 12211074, 13678655, 20737008	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYDROPS FETALIS, NON-IMMUNE	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTRACRANIAL ARTERIOVENOUS MALFORMATION	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTRACRANIAL ARTERIOVENOUS MALFORMATIONS	—	CTD	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE CHRONIC POLYARTHRITIS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	27770636	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKEMIA, ACUTE MYELOID	—	HPO	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKEMIA, MYELOID, ACUTE	—	CTD	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER DISEASES, PARASITIC	—	CTD, Disgenet CTD, Disgenet	22561520	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS	—	CTD	10629081, 12211074	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG NEOPLASMS	—	CTD	10223196, 10545420, 10874023, 11641043, 11745231, 11884234, 12376484, 12725029, 16247444, 16271038, 16289808, 16410370, 16823377, 17233834, 17290066, 17325976, 18062963, 18758463, 18927287, 19336973, 19424582, 19555203, 20101149, 21519798, 22028818, 25851	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHOMA	—	CTD	9205081	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYNCH SYNDROME	—	Disgenet, Orphanet Disgenet, Orphanet	19731079	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL RETARDATION	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MONOARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOUTH NEOPLASMS	—	CTD	19435901	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYELODYSPLASTIC SYNDROMES	—	CTD	27992414	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NASOPHARYNGEAL CARCINOMA	—	CTD	24952746	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Non-immune hydrops fetalis	Conflicting classifications of pathogenicity	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN NEOPLASMS	—	CTD	21372221	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC CANCER	—	HPO	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATIC NEOPLASMS	—	CTD	14520703, 19424582, 21699781, 24694877, 25961927, 26390243	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PAUCIARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PENILE NEOPLASMS	—	CTD	18355852	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Primary familial hypertrophic cardiomyopathy	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	29610475	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	not provided; Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIMMELPENNING-FEUERSTEIN-MIMS SYNDROME	—	HPO	22683711,30891959	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPLENOMEGALY	—	CTD	27725143	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS	—	CTD	10874023, 11397402	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Teratoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TETRALOGY OF FALLOT	—	CTD	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THYROID NEOPLASMS	—	CTD	3078959	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Toriello-Lacassie-Droste syndrome	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TRIPLE NEGATIVE BREAST NEOPLASMS	—	CTD	30654191	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URINARY BLADDER NEOPLASMS	—	CTD	29644616	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE NEOPLASMS	—	CTD	17325976	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

Sort by: Blended Diseases Pathways Evidence source

HRAS 18 shared diseasesBladder cancer, Carcinoma, Cardiofaciocutaneous syndrome, Costello syndrome, Differentiated thyroid carcinoma, Epidermal nevus, Hemangiosarcoma, Non-immune hydrops fetalis, Liver neoplasms, Lung neoplasms, Urinary bladder cancer, Mouth neoplasms +6 more 126 shared pathwaysEGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Mitophagy - animal, Autophagy - animal +114 more 24 shared evidence sourcesHPO (Bladder cancer), CTD (Carcinoma), CTD (Squamous cell carcinoma), CTD (Cardiofaciocutaneous syndrome), Disgenet (Cardiofaciocutaneous syndrome), CTD (Costello syndrome), ClinGen (Costello syndrome), Disgenet (Costello syndrome), Orphanet (Differentiated thyroid carcinoma), Disgenet (Epidermal nevus), CTD (Hemangiosarcoma), Disgenet (Non-immune hydrops fetalis) +12 more Related via 126 shared pathways including EGFR tyrosine kinase inhibitor resistance, Endocrine resistance — evidence mostly CTD. NRAS 14 shared diseasesMyeloid leukemia, Anemia, Autoimmune lymphoproliferative disorder, Cardiofaciocutaneous syndrome, Myelomonocytic leukemia, Colorectal neoplasms, Costello syndrome, Differentiated thyroid carcinoma, Epidermal nevus, Lymphoma, Neuroblastoma, Noonan syndrome +2 more 126 shared pathwaysEGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Mitophagy - animal, Autophagy - animal +114 more 22 shared evidence sourcesDisgenet (Anemia), ClinVar (Autoimmune lymphoproliferative disorder), ClinGen (Cardiofaciocutaneous syndrome), Disgenet (Cardiofaciocutaneous syndrome), Orphanet (Myelomonocytic leukemia), CTD (Colorectal neoplasms), ClinGen (Costello syndrome), Disgenet (Costello syndrome), Orphanet (Differentiated thyroid carcinoma), Disgenet (Epidermal nevus), CTD (Myeloid leukemia), CTD (Lymphoma) +10 more Related via 126 shared pathways including EGFR tyrosine kinase inhibitor resistance, Endocrine resistance — evidence mostly Disgenet. RAF1 8 shared diseasesNon-small-cell lung carcinoma, Cardiofaciocutaneous syndrome, Cardiomyopathy, Costello syndrome, Liver neoplasms, Lung neoplasms, Noonan syndrome, Tetralogy of fallot 75 shared pathwaysEGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Autophagy - animal, mTOR signaling pathway +63 more 16 shared evidence sourcesCTD (Non-small-cell lung carcinoma), ClinGen (Cardiofaciocutaneous syndrome), Disgenet (Cardiofaciocutaneous syndrome), Disgenet (Cardiomyopathy), ClinGen (Costello syndrome), Disgenet (Costello syndrome), CTD (Liver neoplasms), CTD (Lung neoplasms), ClinGen (Noonan syndrome), Disgenet (Noonan syndrome), CTD (Noonan syndrome), GWAS catalog (Noonan syndrome) +4 more Related via 75 shared pathways including EGFR tyrosine kinase inhibitor resistance, Endocrine resistance — evidence mostly CTD. BRAF 11 shared diseasesCerebral arteriovenous malformations, Carcinogenesis, Cardiofaciocutaneous syndrome, Colorectal neoplasms, Costello syndrome, Differentiated thyroid carcinoma, Liver neoplasms, Lung neoplasms, Noonan syndrome, Tetralogy of fallot, Thyroid neoplasms 44 shared pathwaysEGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Rap1 signaling pathway, Chemokine signaling pathway, FoxO signaling pathway, mTOR signaling pathway, Natural killer cell mediated cytotoxicity, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse +32 more 28 shared evidence sourcesDisgenet (Cerebral arteriovenous malformations), CTD (Astrocytoma), CTD (Carcinogenesis), CTD (Cardiofaciocutaneous syndrome), ClinGen (Cardiofaciocutaneous syndrome), GWAS catalog (Cardiofaciocutaneous syndrome), Orphanet (Cardiofaciocutaneous syndrome), Disgenet (Cardiofaciocutaneous syndrome), ClinVar (Cardiofaciocutaneous syndrome), HPO (Cardiofaciocutaneous syndrome), CTD (Colorectal neoplasms), CTD (Costello syndrome) +16 more Related via 44 shared pathways including EGFR tyrosine kinase inhibitor resistance, Endocrine resistance — evidence mostly CTD. SOS1 4 shared diseasesCardiofaciocutaneous syndrome, Costello syndrome, Noonan syndrome, Tetralogy of fallot 77 shared pathwaysEGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Chemokine signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, Gap junction, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway +65 more 12 shared evidence sourcesClinGen (Cardiofaciocutaneous syndrome), Disgenet (Cardiofaciocutaneous syndrome), ClinGen (Costello syndrome), Disgenet (Costello syndrome), ClinGen (Noonan syndrome), Disgenet (Noonan syndrome), CTD (Noonan syndrome), GWAS catalog (Noonan syndrome), Orphanet (Noonan syndrome), ClinVar (Noonan syndrome), HPO (Noonan syndrome), CTD (Tetralogy of fallot) Related via 77 shared pathways including EGFR tyrosine kinase inhibitor resistance, Endocrine resistance — evidence mostly ClinGen.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
HRAS	18	["Bladder cancer","Carcinoma","Cardiofaciocutaneous syndrome","Costello syndrome","Differentiated thyroid carcinoma","Epidermal nevus","Hemangiosarcoma","Non-immune hydrops fetalis","Liver neoplasms","Lung neoplasms","Urinary bladder cancer","Mouth neoplasms"]	126	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","MAPK signaling pathway","ErbB signaling pathway","Ras signaling pathway","Rap1 signaling pathway","Chemokine signaling pathway","FoxO signaling pathway","Sphingolipid signaling pathway","Phospholipase D signaling pathway","Mitophagy - animal","Autophagy - animal"]	24	["HPO (Bladder cancer)","CTD (Carcinoma)","CTD (Squamous cell carcinoma)","CTD (Cardiofaciocutaneous syndrome)","Disgenet (Cardiofaciocutaneous syndrome)","CTD (Costello syndrome)","ClinGen (Costello syndrome)","Disgenet (Costello syndrome)","Orphanet (Differentiated thyroid carcinoma)","Disgenet (Epidermal nevus)","CTD (Hemangiosarcoma)","Disgenet (Non-immune hydrops fetalis)"]
NRAS	14	["Myeloid leukemia","Anemia","Autoimmune lymphoproliferative disorder","Cardiofaciocutaneous syndrome","Myelomonocytic leukemia","Colorectal neoplasms","Costello syndrome","Differentiated thyroid carcinoma","Epidermal nevus","Lymphoma","Neuroblastoma","Noonan syndrome"]	126	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","MAPK signaling pathway","ErbB signaling pathway","Ras signaling pathway","Rap1 signaling pathway","Chemokine signaling pathway","FoxO signaling pathway","Sphingolipid signaling pathway","Phospholipase D signaling pathway","Mitophagy - animal","Autophagy - animal"]	22	["Disgenet (Anemia)","ClinVar (Autoimmune lymphoproliferative disorder)","ClinGen (Cardiofaciocutaneous syndrome)","Disgenet (Cardiofaciocutaneous syndrome)","Orphanet (Myelomonocytic leukemia)","CTD (Colorectal neoplasms)","ClinGen (Costello syndrome)","Disgenet (Costello syndrome)","Orphanet (Differentiated thyroid carcinoma)","Disgenet (Epidermal nevus)","CTD (Myeloid leukemia)","CTD (Lymphoma)"]
RAF1	8	["Non-small-cell lung carcinoma","Cardiofaciocutaneous syndrome","Cardiomyopathy","Costello syndrome","Liver neoplasms","Lung neoplasms","Noonan syndrome","Tetralogy of fallot"]	75	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","MAPK signaling pathway","ErbB signaling pathway","Ras signaling pathway","Rap1 signaling pathway","Chemokine signaling pathway","FoxO signaling pathway","Sphingolipid signaling pathway","Phospholipase D signaling pathway","Autophagy - animal","mTOR signaling pathway"]	16	["CTD (Non-small-cell lung carcinoma)","ClinGen (Cardiofaciocutaneous syndrome)","Disgenet (Cardiofaciocutaneous syndrome)","Disgenet (Cardiomyopathy)","ClinGen (Costello syndrome)","Disgenet (Costello syndrome)","CTD (Liver neoplasms)","CTD (Lung neoplasms)","ClinGen (Noonan syndrome)","Disgenet (Noonan syndrome)","CTD (Noonan syndrome)","GWAS catalog (Noonan syndrome)"]
BRAF	11	["Cerebral arteriovenous malformations","Carcinogenesis","Cardiofaciocutaneous syndrome","Colorectal neoplasms","Costello syndrome","Differentiated thyroid carcinoma","Liver neoplasms","Lung neoplasms","Noonan syndrome","Tetralogy of fallot","Thyroid neoplasms"]	44	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","MAPK signaling pathway","ErbB signaling pathway","Rap1 signaling pathway","Chemokine signaling pathway","FoxO signaling pathway","mTOR signaling pathway","Natural killer cell mediated cytotoxicity","Long-term potentiation","Neurotrophin signaling pathway","Serotonergic synapse"]	28	["Disgenet (Cerebral arteriovenous malformations)","CTD (Astrocytoma)","CTD (Carcinogenesis)","CTD (Cardiofaciocutaneous syndrome)","ClinGen (Cardiofaciocutaneous syndrome)","GWAS catalog (Cardiofaciocutaneous syndrome)","Orphanet (Cardiofaciocutaneous syndrome)","Disgenet (Cardiofaciocutaneous syndrome)","ClinVar (Cardiofaciocutaneous syndrome)","HPO (Cardiofaciocutaneous syndrome)","CTD (Colorectal neoplasms)","CTD (Costello syndrome)"]
SOS1	4	["Cardiofaciocutaneous syndrome","Costello syndrome","Noonan syndrome","Tetralogy of fallot"]	77	["EGFR tyrosine kinase inhibitor resistance","Endocrine resistance","MAPK signaling pathway","ErbB signaling pathway","Ras signaling pathway","Chemokine signaling pathway","FoxO signaling pathway","Phospholipase D signaling pathway","mTOR signaling pathway","Gap junction","Natural killer cell mediated cytotoxicity","T cell receptor signaling pathway"]	12	["ClinGen (Cardiofaciocutaneous syndrome)","Disgenet (Cardiofaciocutaneous syndrome)","ClinGen (Costello syndrome)","Disgenet (Costello syndrome)","ClinGen (Noonan syndrome)","Disgenet (Noonan syndrome)","CTD (Noonan syndrome)","GWAS catalog (Noonan syndrome)","Orphanet (Noonan syndrome)","ClinVar (Noonan syndrome)","HPO (Noonan syndrome)","CTD (Tetralogy of fallot)"]

Diseases Linked via Similar Genes

Glioma Linked via 3 of 5 related genesHRAS, RAF1, BRAF Melanoma Linked via 3 of 5 related genesHRAS, NRAS, BRAF Leopard syndrome Linked via 3 of 5 related genesNRAS, RAF1, BRAF noonan syndrome with multiple lentigines Linked via 3 of 5 related genesNRAS, RAF1, BRAF Dilated cardiomyopathy Linked via 3 of 5 related genesRAF1, BRAF, SOS1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Glioma	3	["HRAS","RAF1","BRAF"]
Melanoma	3	["HRAS","NRAS","BRAF"]
Leopard syndrome	3	["NRAS","RAF1","BRAF"]
noonan syndrome with multiple lentigines	3	["NRAS","RAF1","BRAF"]
Dilated cardiomyopathy	3	["RAF1","BRAF","SOS1"]