Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 34
17
Diseases
3,802
Unique genes
0.077
Avg. similarity score
Coronary artery disease
Most-connected disease (10 links)
Disease
Pinned (dragged)
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Coronary artery disease
Heart failure
Hypertension
Migraine
Myocardial infarction
Venous thromboembolism
Atrial fibrillation
Cardiovascular disease
Stroke
Congestive heart failure
Endometriosis
Yoon-bellen neurodevelopmental syndrome
phosphoenolpyruvate carboxykinase deficiency, cytosolic
Intellectual developmental disorder growth metabolic
band heterotopia of brain
Trichilemmal cyst
Hemorrhagic destruction of the brain subependymal calcification and cataracts
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Coronary artery disease | 10 | 8 | 1,143 |
| Heart failure | 7 | 7 | 470 |
| Hypertension | 7 | 7 | 1,149 |
| Migraine | 6 | 6 | 404 |
| Myocardial infarction | 5 | 5 | 580 |
| Venous thromboembolism | 5 | 5 | 342 |
| Atrial fibrillation | 5 | 3 | 863 |
| Cardiovascular disease | 4 | 4 | 432 |
| Stroke | 4 | 4 | 323 |
| Congestive heart failure | 3 | 3 | 179 |
| Endometriosis | 2 | 2 | 376 |
| Yoon-bellen neurodevelopmental syndrome | 2 | 2 | 1 |
| phosphoenolpyruvate carboxykinase deficiency, cytosolic | 2 | 2 | 1 |
| Intellectual developmental disorder growth metabolic | 2 | 1 | 1 |
| band heterotopia of brain | 2 | 0 | 1 |
| Trichilemmal cyst | 1 | 1 | 1 |
| Hemorrhagic destruction of the brain subependymal calcification and cataracts | 1 | 0 | 1 |
Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| ABO | 9 / 17 | Atrial fibrillation, Coronary artery disease, Endometriosis, Heart failure and 5 more |
| NOS3 | 9 / 17 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 5 more |
| TNF | 9 / 17 | Congestive heart failure, Coronary artery disease, Endometriosis, Heart failure and 5 more |
| ACE | 8 / 17 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 4 more |
| ATP2B1 | 8 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 4 more |
| FTO | 8 / 17 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 4 more |
| PTGS2 | 8 / 17 | Cardiovascular disease, Congestive heart failure, Coronary artery disease, Endometriosis and 4 more |
| ABHD17C | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Endometriosis, Heart failure and 3 more |
| AGT | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 3 more |
| APOC1 | 7 / 17 | Atrial fibrillation, Congestive heart failure, Coronary artery disease, Heart failure and 3 more |
| CASZ1 | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 3 more |
| CELSR2 | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 3 more |
| EDN1 | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 3 more |
| EDNRA | 7 / 17 | Congestive heart failure, Coronary artery disease, Heart failure, Hypertension and 3 more |
| FGF5 | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 3 more |
| GOSR2 | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 3 more |
| LPA | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 3 more |
| LPL | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 3 more |
| MTHFR | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 3 more |
| NPPB | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 3 more |
| PHACTR1 | 7 / 17 | Cardiovascular disease, Coronary artery disease, Heart failure, Hypertension and 3 more |
| PRDM8 | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 3 more |
| SH2B3 | 7 / 17 | Cardiovascular disease, Coronary artery disease, Heart failure, Hypertension and 3 more |
| SMG6 | 7 / 17 | Atrial fibrillation, Coronary artery disease, Heart failure, Hypertension and 3 more |
| VEGFA | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 3 more |
| VWF | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 3 more |
| ZFPM2 | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 3 more |
| ZPR1 | 7 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 3 more |
| ALDH1A2 | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 2 more |
| ALDH2 | 6 / 17 | Atrial fibrillation, Coronary artery disease, Heart failure, Hypertension and 2 more |
| APOB | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 2 more |
| APOE | 6 / 17 | Cardiovascular disease, Congestive heart failure, Coronary artery disease, Heart failure and 2 more |
| ATXN2 | 6 / 17 | Cardiovascular disease, Coronary artery disease, Heart failure, Hypertension and 2 more |
| CCL2 | 6 / 17 | Cardiovascular disease, Congestive heart failure, Coronary artery disease, Heart failure and 2 more |
| CDH13 | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| CETP | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 2 more |
| COL4A1 | 6 / 17 | Cardiovascular disease, Coronary artery disease, Heart failure, Migraine and 2 more |
| F5 | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Endometriosis, Myocardial infarction and 2 more |
| GCKR | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 2 more |
| HMGCR | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 2 more |
| IL1B | 6 / 17 | Congestive heart failure, Endometriosis, Heart failure, Hypertension and 2 more |
| MAD1L1 | 6 / 17 | Cardiovascular disease, Coronary artery disease, Heart failure, Hypertension and 2 more |
| MLXIPL | 6 / 17 | Atrial fibrillation, Coronary artery disease, Heart failure, Migraine and 2 more |
| MMP1 | 6 / 17 | Atrial fibrillation, Congestive heart failure, Coronary artery disease, Heart failure and 2 more |
| NPPA | 6 / 17 | Atrial fibrillation, Congestive heart failure, Coronary artery disease, Heart failure and 2 more |
| NR3C1 | 6 / 17 | Atrial fibrillation, Coronary artery disease, Endometriosis, Heart failure and 2 more |
| NR3C2 | 6 / 17 | Atrial fibrillation, Congestive heart failure, Endometriosis, Heart failure and 2 more |
| PCCB | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| PITX2 | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 2 more |
| PLAT | 6 / 17 | Congestive heart failure, Heart failure, Hypertension, Myocardial infarction and 2 more |
| PLPP3 | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 2 more |
| PON1 | 6 / 17 | Cardiovascular disease, Congestive heart failure, Coronary artery disease, Heart failure and 2 more |
| PRDM16 | 6 / 17 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 2 more |
| RUNX1 | 6 / 17 | Atrial fibrillation, Endometriosis, Hypertension, Migraine and 2 more |
| SERPINE1 | 6 / 17 | Congestive heart failure, Coronary artery disease, Heart failure, Hypertension and 2 more |
| TBX20 | 6 / 17 | Atrial fibrillation, Congestive heart failure, Coronary artery disease, Heart failure and 2 more |
| TCF7L2 | 6 / 17 | Atrial fibrillation, Coronary artery disease, Heart failure, Hypertension and 2 more |
| TDRD15 | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 2 more |
| TGFB1 | 6 / 17 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 2 more |
| THADA | 6 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| ZC3HC1 | 6 / 17 | Cardiovascular disease, Coronary artery disease, Heart failure, Hypertension and 2 more |
| ZHX3 | 6 / 17 | Atrial fibrillation, Coronary artery disease, Heart failure, Migraine and 2 more |
| ABCC10 | 5 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 1 more |
| ACAD10 | 5 / 17 | Atrial fibrillation, Coronary artery disease, Heart failure, Myocardial infarction and 1 more |
| ADIPOQ | 5 / 17 | Cardiovascular disease, Congestive heart failure, Coronary artery disease, Heart failure and 1 more |
| AGTR1 | 5 / 17 | Congestive heart failure, Coronary artery disease, Heart failure, Hypertension and 1 more |
| AGXT2 | 5 / 17 | Atrial fibrillation, Congestive heart failure, Coronary artery disease, Heart failure and 1 more |
| ALB | 5 / 17 | Cardiovascular disease, Congestive heart failure, Heart failure, Hypertension and 1 more |
| ANKRD31 | 5 / 17 | Atrial fibrillation, Coronary artery disease, Heart failure, Myocardial infarction and 1 more |
| ARHGAP26 | 5 / 17 | Atrial fibrillation, Coronary artery disease, Endometriosis, Heart failure and 1 more |
| ARHGAP42 | 5 / 17 | Cardiovascular disease, Coronary artery disease, Endometriosis, Hypertension and 1 more |
| ASTN2 | 5 / 17 | Atrial fibrillation, Coronary artery disease, Endometriosis, Migraine and 1 more |
| ATP1B1 | 5 / 17 | Coronary artery disease, Endometriosis, Hypertension, Myocardial infarction and 1 more |
| ATP2A2 | 5 / 17 | Atrial fibrillation, Congestive heart failure, Heart failure, Hypertension and 1 more |
| BAZ1B | 5 / 17 | Atrial fibrillation, Coronary artery disease, Heart failure, Migraine and 1 more |
| BCAS3 | 5 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| C1GALT1 | 5 / 17 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| CDK6 | 5 / 17 | Atrial fibrillation, Cardiovascular disease, Heart failure, Hypertension and 1 more |
| CDKN1A | 5 / 17 | Atrial fibrillation, Congestive heart failure, Coronary artery disease, Heart failure and 1 more |
| CERT1 | 5 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 1 more |
| CFDP1 | 5 / 17 | Cardiovascular disease, Coronary artery disease, Heart failure, Hypertension and 1 more |
| CMIP | 5 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 1 more |
| CNNM2 | 5 / 17 | Atrial fibrillation, Coronary artery disease, Hypertension, Migraine and 1 more |
| COL4A2 | 5 / 17 | Coronary artery disease, Heart failure, Hypertension, Myocardial infarction and 1 more |
| CRP | 5 / 17 | Cardiovascular disease, Congestive heart failure, Coronary artery disease, Heart failure and 1 more |
| CUX2 | 5 / 17 | Atrial fibrillation, Coronary artery disease, Hypertension, Myocardial infarction and 1 more |
| CXCL8 | 5 / 17 | Coronary artery disease, Heart failure, Hypertension, Myocardial infarction and 1 more |
| DPP6 | 5 / 17 | Coronary artery disease, Endometriosis, Migraine, Stroke and 1 more |
| EPO | 5 / 17 | Congestive heart failure, Coronary artery disease, Heart failure, Hypertension and 1 more |
| FADS1 | 5 / 17 | Atrial fibrillation, Coronary artery disease, Heart failure, Stroke and 1 more |
| FADS2 | 5 / 17 | Atrial fibrillation, Coronary artery disease, Heart failure, Stroke and 1 more |
| FBN2 | 5 / 17 | Cardiovascular disease, Coronary artery disease, Hypertension, Migraine and 1 more |
| FES | 5 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| FGB | 5 / 17 | Cardiovascular disease, Coronary artery disease, Myocardial infarction, Stroke and 1 more |
| FGD5 | 5 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| FIGN | 5 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 1 more |
| GTF2I | 5 / 17 | Atrial fibrillation, Cardiovascular disease, Heart failure, Hypertension and 1 more |
| HECTD4 | 5 / 17 | Coronary artery disease, Heart failure, Hypertension, Myocardial infarction and 1 more |
| HERPUD1 | 5 / 17 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 1 more |
| HTRA1 | 5 / 17 | Coronary artery disease, Hypertension, Migraine, Myocardial infarction and 1 more |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| AGE-RAGE signaling pathway in diabetic complications | KEGG | 66 / 101 | 2.1× | 3.10e-12 | 6.10e-10 ✓ sig. |
| Thyroid hormone signaling pathway | KEGG | 68 / 122 | 1.8× | 2.89e-8 | 2.22e-6 ✓ sig. |
| cGMP-PKG signaling pathway | KEGG | 85 / 166 | 1.6× | 1.11e-7 | 7.17e-6 ✓ sig. |
| Prostate cancer | KEGG | 56 / 98 | 1.8× | 1.52e-7 | 9.44e-6 ✓ sig. |
| Proteoglycans in cancer | KEGG | 95 / 204 | 1.5× | 5.13e-6 | 1.94e-4 ✓ sig. |
| cAMP signaling pathway | KEGG | 102 / 226 | 1.4× | 1.28e-5 | 4.12e-4 ✓ sig. |
| Aldosterone-regulated sodium reabsorption | KEGG | 25 / 38 | 2.1× | 1.56e-5 | 4.87e-4 ✓ sig. |
| Hormone signaling | KEGG | 99 / 219 | 1.4× | 1.57e-5 | 4.90e-4 ✓ sig. |
| Renin secretion | KEGG | 39 / 69 | 1.8× | 1.64e-5 | 5.05e-4 ✓ sig. |
| Integrin cell surface interactions | Reactome | 44 / 81 | 1.7× | 1.89e-5 | 5.73e-4 ✓ sig. |
| Adrenoceptors | Reactome | 9 / 9 | 3.2× | 3.17e-5 | 8.75e-4 ✓ sig. |
| Small cell lung cancer | KEGG | 48 / 93 | 1.6× | 4.77e-5 | 1.23e-3 ✓ sig. |
| Cholesterol metabolism | KEGG | 30 / 51 | 1.9× | 5.53e-5 | 1.39e-3 ✓ sig. |
| ECM-receptor interaction | KEGG | 46 / 89 | 1.6× | 6.50e-5 | 1.58e-3 ✓ sig. |
| Hypertrophic cardiomyopathy | KEGG | 50 / 99 | 1.6× | 6.97e-5 | 1.67e-3 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| positive regulation of transcription by RNA polymerase II | GO:0045944 | 407 / 1,208 | 1.7× | 2.03e-29 | 9.87e-26 ✓ sig. |
| regulation of blood pressure | GO:0008217 | 59 / 83 | 3.5× | 2.57e-23 | 6.72e-20 ✓ sig. |
| response to xenobiotic stimulus | GO:0009410 | 117 / 248 | 2.3× | 1.45e-21 | 2.85e-18 ✓ sig. |
| angiogenesis | GO:0001525 | 120 / 284 | 2.1× | 2.53e-17 | 2.75e-14 ✓ sig. |
| negative regulation of apoptotic process | GO:0043066 | 188 / 524 | 1.8× | 4.64e-17 | 4.80e-14 ✓ sig. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | GO:0051897 | 98 / 217 | 2.2× | 1.09e-16 | 1.03e-13 ✓ sig. |
| positive regulation of DNA-templated transcription | GO:0045893 | 251 / 778 | 1.6× | 9.97e-16 | 7.72e-13 ✓ sig. |
| response to hypoxia | GO:0001666 | 83 / 176 | 2.3× | 1.08e-15 | 8.32e-13 ✓ sig. |
| heart development | GO:0007507 | 112 / 273 | 2.0× | 3.61e-15 | 2.58e-12 ✓ sig. |
| positive regulation of MAPK cascade | GO:0043410 | 97 / 224 | 2.1× | 4.39e-15 | 3.06e-12 ✓ sig. |
| negative regulation of cell population proliferation | GO:0008285 | 160 / 444 | 1.8× | 6.77e-15 | 4.51e-12 ✓ sig. |
| regulation of heart rate by cardiac conduction | GO:0086091 | 31 / 43 | 3.5× | 3.73e-13 | 1.85e-10 ✓ sig. |
| blood coagulation | GO:0007596 | 55 / 106 | 2.6× | 5.33e-13 | 2.59e-10 ✓ sig. |
| positive regulation of angiogenesis | GO:0045766 | 72 / 159 | 2.2× | 1.04e-12 | 4.77e-10 ✓ sig. |
| negative regulation of transcription by RNA polymerase II | GO:0000122 | 294 / 1,002 | 1.4× | 2.11e-12 | 9.00e-10 ✓ sig. |