CXCL8 (C-X-C motif chemokine ligand 8)

Gene Gene information from NCBI Gene database.
Gene SNPs Transcription factors Other IDs Associated diseases
Entrez ID 3576
Gene name C-X-C motif chemokine ligand 8
Gene symbol CXCL8
Synonyms (NCBI Gene)
GCP-1GCP1IL8LECTLUCTLYNAPMDNCFMONAPNAFNAP-1NAP1SCYB8
Chromosome 4
Chromosome location 4q13.3
Summary The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, e
miRNA miRNA information provided by mirtarbase database.
11
Gene SNPs Transcription factors Other IDs Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT438087 hsa-miR-93-5p Luciferase reporter assayqRT-PCR 24433094
MIRT438087 hsa-miR-93-5p Luciferase reporter assayqRT-PCR 24433094
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
MIRT731479 hsa-miR-203a-3p qRT-PCR 26304234
Transcription factors Transcription factors information provided by TRRUST V2 database.
39
Gene SNPs Transcription factors Other IDs Associated diseases
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Transcription factor Regulation Reference
ATF4 Unknown 16931790
CEBPB Activation 15085176;15688424
CEBPB Unknown 11120852
DDIT3 Unknown 18772138
DEK Unknown 16829531
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
54
Gene SNPs Transcription factors Other IDs Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis TAS 11483765
GO:0002237 Process Response to molecule of bacterial origin IDA 19912257
GO:0005125 Function Cytokine activity IEA
GO:0005153 Function Interleukin-8 receptor binding IPI 1840701
GO:0005515 Function Protein binding IPI 10880251, 22904195, 23597562, 24501198, 26829648, 28381538
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene SNPs Transcription factors Other IDs Associated diseases
MIM HGNC e!Ensembl
146930 6025 ENSG00000169429
Protein Protein information from UniProt database.
Gene SNPs Transcription factors Other IDs Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P10145
Protein name Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Ne
Protein function Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection (PubMed:18692776, PubMed:7636208). Also plays an important role in neutrophil activat
PDB 1ICW , 1IKL , 1IKM , 1IL8 , 1ILP , 1ILQ , 1QE6 , 1ROD , 2IL8 , 3IL8 , 4XDX , 5D14 , 5WDZ , 6LFM , 6LFO , 6N2U , 6WZM , 6XMN , 8IC0 , 8XWN , 8XX6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00048 IL8 32 → 92 Small cytokines (intecrine/chemokine), interleukin-8 like Domain
Sequence
Sequence length 99
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene SNPs Transcription factors Other IDs Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (61)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANGINA, UNSTABLE — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTHRITIS, PSORIATIC — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTHRITIS, RHEUMATOID — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE UVEITIS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (1282)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acanthosis Nigricans Acanthosis Nigricans BEFREE 30724385
★★★★★
★☆☆☆☆
Found in Text Mining only
Acne Acne BEFREE 18667861, 26547713, 28193081, 29782471, 29964032
★★★★★
★☆☆☆☆
Found in Text Mining only
Acne Vulgaris Acne BEFREE 26547713, 28193081, 29964032
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome BEFREE 21763153, 31550669
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute encephalopathy Encephalopathy BEFREE 31709864
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute intermittent porphyria Intermittent Porphyria BEFREE 31219205
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 21298741, 30217873
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia LHGDN 17914409
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 21745629, 25810490
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 17124436, 18837094, 24072654, 25730090, 25872171, 26125871, 29073601, 29215544, 30945511, 31242405, 31340771
★★★★★
★☆☆☆☆
Found in Text Mining only