Gene Gene information from NCBI Gene database.
Entrez ID 7412
Gene name Vascular cell adhesion molecule 1
Gene symbol VCAM1
Synonyms (NCBI Gene)
CD106INCAM-100
Chromosome 1
Chromosome location 1p21.2
Summary This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in
miRNA miRNA information provided by mirtarbase database.
310
miRTarBase ID miRNA Experiments Reference
MIRT004007 hsa-miR-200a-3p Microarray 17875710
MIRT004081 hsa-miR-126-3p Luciferase reporter assayWestern blot 18227515
MIRT004081 hsa-miR-126-3p Luciferase reporter assayWestern blot 18227515
MIRT020917 hsa-miR-155-5p qRT-PCR 21310411
MIRT004081 hsa-miR-126-3p Reporter assay;Other 18227515
Transcription factors Transcription factors information provided by TRRUST V2 database.
11
Transcription factor Regulation Reference
EP300 Activation 19281832
HDAC4 Activation 19281832
HOXA9 Unknown 22269951
IKBKB Repression 18600306
IRF1 Unknown 15265939;22182512
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
60
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IEA
GO:0002102 Component Podosome IDA 15220135
GO:0002544 Process Chronic inflammatory response IEA
GO:0005178 Function Integrin binding IBA
GO:0005178 Function Integrin binding IDA 1377228, 15220135, 23620790
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
192225 12663 ENSG00000162692
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P19320
Protein name Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106) [Cleaved into: Soluble Vascular Cell Adhesion Molecule-1]
Protein function Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium thr
PDB 1IJ9 , 1VCA , 1VSC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07679 I-set 25 112 Immunoglobulin I-set domain Domain
PF05790 C2-set 133 221 Immunoglobulin C2-set domain Domain
PF00047 ig 229 306 Immunoglobulin domain Domain
PF07679 I-set 314 400 Immunoglobulin I-set domain Domain
PF05790 C2-set 421 509 Immunoglobulin C2-set domain Domain
PF13927 Ig_3 515 583 Domain
PF07679 I-set 605 685 Immunoglobulin I-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Sequence
Sequence length 739
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
25
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANEMIA, SICKLE CELL CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARTERIOSCLEROSIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATHEROSCLEROSIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Coronary Syndrome Coronary Syndrome LHGDN 11922919
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 20112284
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 31059081
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 16327982
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 18473733
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 30389659
★☆☆☆☆
Found in Text Mining only
Adult Hepatocellular Carcinoma Liver carcinoma BEFREE 28473332
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 16453001, 19533685, 28110427
★☆☆☆☆
Found in Text Mining only
Aggressive Periodontitis Aggressive Periodontitis BEFREE 20714794
★☆☆☆☆
Found in Text Mining only
alpha-Thalassemia alpha Thalassemia BEFREE 25175566
★☆☆☆☆
Found in Text Mining only