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Gene Gene information from NCBI Gene database.
Entrez ID 5170
Gene name 3-phosphoinositide dependent protein kinase 1
Gene symbol PDPK1
Synonyms (NCBI Gene)
PDK1PDPK2PDPK2PPRO0461
Chromosome 16
Chromosome location 16p13.3
miRNA miRNA information provided by mirtarbase database.
1001 Show/Hide all (1001)
miRTarBase ID miRNA Experiments Reference
MIRT021308 hsa-miR-125a-5p Sequencing 20371350
MIRT021893 hsa-miR-128-3p Microarray 17612493
MIRT025610 hsa-miR-10a-5p Sequencing 20371350
MIRT030439 hsa-miR-24-3p Microarray 19748357
MIRT051003 hsa-miR-17-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
66 Show/Hide all (66)
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003323 Process Type B pancreatic cell development IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IDA 9094314, 9368760
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605213 8816 ENSG00000140992
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15530
Protein name 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)
Protein function Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases (PubMed:10226025, PubMed:10480933, PubMed:10995762, PubMed:12167717, PubMed:14585963, PubMed:14604990, PubMed:1
PDB 1H1W , 1OKY , 1OKZ , 1UU3 , 1UU7 , 1UU8 , 1UU9 , 1UVR , 1W1D , 1W1G , 1W1H , 1Z5M , 2BIY , 2PE0 , 2PE1 , 2PE2 , 2R7B , 2VKI , 2XCH , 2XCK , 3H9O , 3HRC , 3HRF , 3ION , 3IOP , 3NAX , 3NAY , 3NUN , 3NUS , 3NUU , 3NUY , 3ORX , 3ORZ , 3OTU , 3PWY , 3QC4 , 3QCQ , 3QCS , 3QCX , 3QCY , 3QD0 , 3QD3 , 3QD4 , 3RCJ , 3RWP , 3RWQ , 3SC1 , 4A06 , 4A07 , 4AW0 , 4AW1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14593 PH_3 446 → 548 PH domain Domain
PF00069 Pkinase 82 → 342 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Appears to be expressed ubiquitously. The Tyr-9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast. {ECO:0000269|PubMed:18024423}.
Sequence
Sequence length 556
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Platinum drug resistance GPVI-mediated activation cascade
PPAR signaling pathway PIP3 activates AKT signaling
FoxO signaling pathway Activation of AKT2
Sphingolipid signaling pathway Downstream TCR signaling
Autophagy - animal Role of LAT2/NTAL/LAB on calcium mobilization
mTOR signaling pathway FCERI mediated NF-kB activation
PI3K-Akt signaling pathway Integrin signaling
AMPK signaling pathway CD28 dependent PI3K/Akt signaling
Apoptosis G beta:gamma signalling through PI3Kgamma
Axon guidance VEGFR2 mediated vascular permeability
Focal adhesion VEGFR2 mediated cell proliferation
T cell receptor signaling pathway CLEC7A (Dectin-1) signaling
Fc epsilon RI signaling pathway RHO GTPases activate PKNs
Neurotrophin signaling pathway Constitutive Signaling by AKT1 E17K in Cancer
Insulin signaling pathway Regulation of TP53 Degradation
Thyroid hormone signaling pathway Estrogen-stimulated signaling through PRKCZ
Insulin resistance  
Aldosterone-regulated sodium reabsorption  
Toxoplasmosis  
Proteoglycans in cancer  
Chemical carcinogenesis - reactive oxygen species  
Endometrial cancer  
Prostate cancer  
Non-small cell lung cancer  
Choline metabolism in cancer  
Lipid and atherosclerosis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
BREAST NEOPLASMS — CTD 24739482
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONGESTIVE HEART FAILURE — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEART FAILURE — CTD, Disgenet
CTD, Disgenet
19429709
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LYMPHOMA, LARGE B-CELL, DIFFUSE — CTD 21173233
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PDPK1-related disorder Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (194)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute myelomonocytic leukemia Myelomonocytic Leukemia BEFREE 24334295
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 26919807
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of prostate Prostate adenocarcinoma BEFREE 19443706
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenal Gland Pheochromocytoma Adrenal Gland Pheochromocytoma BEFREE 30759304
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Diffuse Large B-Cell Lymphoma B-cell Lymphoma BEFREE 29287939, 30912195
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 28831118 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 23453624, 31088502
★★★★★
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 28536634
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 31234900 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 28536634
★★★★★
★☆☆☆☆
Found in Text Mining only