Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 8
31
Diseases
3,919
Unique genes
0.072
Avg. similarity score
Coronary artery disease
Most-connected disease (11 links)
Disease
Searched: Leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate
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Leukoencephalopathy, acute reversible, with increased urinary alpha-ketoglutarate
Coronary artery disease
Ischemic heart disease
Myocardial infarction
Hypertension
Myocardial ischemia
Atherosclerosis
Cardiovascular disease
Kidney disease
Kidney failure
Preeclampsia
Atrial fibrillation
Erectile dysfunction
Heart disease
Large artery stroke
Migraine
Venous thromboembolism
Abdominal obesity-metabolic syndrome 4
Arteriosclerosis
Moyamoya disease
Neurodevelopmental disorder with microcephaly and sensorineural hearing loss
Intellectual developmental disorder growth metabolic
Pre-eclampsia/eclampsia 4
Band heterotopia of brain
Acetyl-coa carboxylase deficiency
Corneal injury
Neurodevelopmental disorder with cerebellar hypoplasia and spasticity
Spastic paraplegia 87, autosomal recessive
Trichilemmal cyst
Zaki syndrome
Hemorrhagic destruction of the brain subependymal calcification and cataracts
Member diseases (most connected first ‐ the cluster's core)
Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| NOS3 | 15 / 31 | Arteriosclerosis, Atherosclerosis, Atrial fibrillation, Cardiovascular disease and 11 more |
| MTHFR | 13 / 31 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Coronary artery disease and 9 more |
| VEGFA | 12 / 31 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Coronary artery disease and 8 more |
| AGT | 11 / 31 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Coronary artery disease and 7 more |
| EDN1 | 11 / 31 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Coronary artery disease and 7 more |
| FTO | 11 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 7 more |
| PHACTR1 | 11 / 31 | Atherosclerosis, Cardiovascular disease, Coronary artery disease, Heart disease and 7 more |
| ABO | 10 / 31 | Atrial fibrillation, Coronary artery disease, Heart disease, Hypertension and 6 more |
| ACE | 10 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 6 more |
| APOE | 10 / 31 | Arteriosclerosis, Atherosclerosis, Cardiovascular disease, Coronary artery disease and 6 more |
| PTGS2 | 10 / 31 | Arteriosclerosis, Atherosclerosis, Cardiovascular disease, Coronary artery disease and 6 more |
| ATP2B1 | 9 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 5 more |
| ATXN2 | 9 / 31 | Atherosclerosis, Cardiovascular disease, Coronary artery disease, Heart disease and 5 more |
| CDH13 | 9 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Erectile dysfunction and 5 more |
| EDNRA | 9 / 31 | Atherosclerosis, Coronary artery disease, Erectile dysfunction, Heart disease and 5 more |
| LPA | 9 / 31 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Coronary artery disease and 5 more |
| MMP1 | 9 / 31 | Arteriosclerosis, Atherosclerosis, Atrial fibrillation, Coronary artery disease and 5 more |
| MMP3 | 9 / 31 | Arteriosclerosis, Atrial fibrillation, Coronary artery disease, Heart disease and 5 more |
| NPPB | 9 / 31 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Coronary artery disease and 5 more |
| PLG | 9 / 31 | Cardiovascular disease, Coronary artery disease, Heart disease, Hypertension and 5 more |
| PON1 | 9 / 31 | Arteriosclerosis, Atherosclerosis, Cardiovascular disease, Coronary artery disease and 5 more |
| SERPINE1 | 9 / 31 | Atherosclerosis, Coronary artery disease, Hypertension, Ischemic heart disease and 5 more |
| TDRD15 | 9 / 31 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Coronary artery disease and 5 more |
| TGFB1 | 9 / 31 | Cardiovascular disease, Coronary artery disease, Heart disease, Hypertension and 5 more |
| TLR4 | 9 / 31 | Arteriosclerosis, Atherosclerosis, Coronary artery disease, Hypertension and 5 more |
| TNF | 9 / 31 | Atherosclerosis, Coronary artery disease, Hypertension, Ischemic heart disease and 5 more |
| TWIST1 | 9 / 31 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Coronary artery disease and 5 more |
| ZC3HC1 | 9 / 31 | Cardiovascular disease, Coronary artery disease, Erectile dysfunction, Heart disease and 5 more |
| ABCG8 | 8 / 31 | Arteriosclerosis, Cardiovascular disease, Coronary artery disease, Heart disease and 4 more |
| ADAMTS7 | 8 / 31 | Cardiovascular disease, Coronary artery disease, Heart disease, Ischemic heart disease and 4 more |
| AGER | 8 / 31 | Atherosclerosis, Cardiovascular disease, Coronary artery disease, Hypertension and 4 more |
| APOB | 8 / 31 | Arteriosclerosis, Atherosclerosis, Atrial fibrillation, Cardiovascular disease and 4 more |
| CCL2 | 8 / 31 | Atherosclerosis, Cardiovascular disease, Coronary artery disease, Hypertension and 4 more |
| CELSR2 | 8 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 4 more |
| CNNM2 | 8 / 31 | Atrial fibrillation, Coronary artery disease, Hypertension, Kidney disease and 4 more |
| CRP | 8 / 31 | Atherosclerosis, Cardiovascular disease, Coronary artery disease, Heart disease and 4 more |
| EPO | 8 / 31 | Coronary artery disease, Heart disease, Hypertension, Ischemic heart disease and 4 more |
| FGF5 | 8 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 4 more |
| HDAC9 | 8 / 31 | Atherosclerosis, Cardiovascular disease, Coronary artery disease, Heart disease and 4 more |
| HECTD4 | 8 / 31 | Coronary artery disease, Hypertension, Ischemic heart disease, Kidney disease and 4 more |
| KCNE2 | 8 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 4 more |
| KIF6 | 8 / 31 | Coronary artery disease, Hypertension, Ischemic heart disease, Kidney disease and 4 more |
| LDLR | 8 / 31 | Arteriosclerosis, Atherosclerosis, Cardiovascular disease, Coronary artery disease and 4 more |
| LEPR | 8 / 31 | Coronary artery disease, Hypertension, Ischemic heart disease, Kidney disease and 4 more |
| LPL | 8 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 4 more |
| MRPS6 | 8 / 31 | Cardiovascular disease, Coronary artery disease, Heart disease, Hypertension and 4 more |
| PLPP3 | 8 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 4 more |
| PRDM8 | 8 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 4 more |
| SH2B3 | 8 / 31 | Cardiovascular disease, Coronary artery disease, Hypertension, Ischemic heart disease and 4 more |
| TCF7L2 | 8 / 31 | Atherosclerosis, Atrial fibrillation, Coronary artery disease, Hypertension and 4 more |
| ZPR1 | 8 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 4 more |
| ADIPOQ | 7 / 31 | Atherosclerosis, Cardiovascular disease, Coronary artery disease, Hypertension and 3 more |
| AGTR1 | 7 / 31 | Coronary artery disease, Hypertension, Ischemic heart disease, Kidney disease and 3 more |
| APOA1 | 7 / 31 | Atherosclerosis, Coronary artery disease, Hypertension, Ischemic heart disease and 3 more |
| APOC1 | 7 / 31 | Atherosclerosis, Atrial fibrillation, Coronary artery disease, Heart disease and 3 more |
| CLCN6 | 7 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 3 more |
| CUX2 | 7 / 31 | Atrial fibrillation, Coronary artery disease, Hypertension, Kidney disease and 3 more |
| CYBA | 7 / 31 | Atherosclerosis, Coronary artery disease, Heart disease, Hypertension and 3 more |
| ESR1 | 7 / 31 | Arteriosclerosis, Atherosclerosis, Coronary artery disease, Ischemic heart disease and 3 more |
| FES | 7 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 3 more |
| FGB | 7 / 31 | Cardiovascular disease, Coronary artery disease, Ischemic heart disease, Kidney failure and 3 more |
| FURIN | 7 / 31 | Coronary artery disease, Heart disease, Hypertension, Ischemic heart disease and 3 more |
| GUCY1A1 | 7 / 31 | Cardiovascular disease, Coronary artery disease, Hypertension, Ischemic heart disease and 3 more |
| HMGCR | 7 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Ischemic heart disease and 3 more |
| ICAM1 | 7 / 31 | Arteriosclerosis, Atherosclerosis, Atrial fibrillation, Cardiovascular disease and 3 more |
| IL6R | 7 / 31 | Atrial fibrillation, Coronary artery disease, Heart disease, Large artery stroke and 3 more |
| JCAD | 7 / 31 | Coronary artery disease, Heart disease, Ischemic heart disease, Large artery stroke and 3 more |
| MLXIPL | 7 / 31 | Atrial fibrillation, Coronary artery disease, Ischemic heart disease, Kidney failure and 3 more |
| NPPA | 7 / 31 | Atrial fibrillation, Coronary artery disease, Hypertension, Ischemic heart disease and 3 more |
| NYAP2 | 7 / 31 | Cardiovascular disease, Coronary artery disease, Heart disease, Hypertension and 3 more |
| PCCB | 7 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 3 more |
| PPARA | 7 / 31 | Coronary artery disease, Hypertension, Ischemic heart disease, Kidney disease and 3 more |
| PRDM16 | 7 / 31 | Cardiovascular disease, Coronary artery disease, Hypertension, Ischemic heart disease and 3 more |
| PROCR | 7 / 31 | Coronary artery disease, Heart disease, Ischemic heart disease, Migraine and 3 more |
| SERPINA1 | 7 / 31 | Arteriosclerosis, Coronary artery disease, Kidney failure, Large artery stroke and 3 more |
| SMARCA4 | 7 / 31 | Atherosclerosis, Cardiovascular disease, Coronary artery disease, Heart disease and 3 more |
| TCF21 | 7 / 31 | Coronary artery disease, Heart disease, Hypertension, Ischemic heart disease and 3 more |
| VWF | 7 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 3 more |
| ALOX5AP | 6 / 31 | Atherosclerosis, Coronary artery disease, Ischemic heart disease, Kidney disease and 2 more |
| BCAS3 | 6 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| CFDP1 | 6 / 31 | Atherosclerosis, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| COL4A1 | 6 / 31 | Cardiovascular disease, Coronary artery disease, Kidney disease, Migraine and 2 more |
| COL4A2 | 6 / 31 | Atherosclerosis, Coronary artery disease, Heart disease, Hypertension and 2 more |
| F2 | 6 / 31 | Coronary artery disease, Heart disease, Ischemic heart disease, Myocardial infarction and 2 more |
| F5 | 6 / 31 | Atrial fibrillation, Cardiovascular disease, Heart disease, Kidney failure and 2 more |
| F7 | 6 / 31 | Coronary artery disease, Hypertension, Ischemic heart disease, Myocardial infarction and 2 more |
| FGD5 | 6 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| FIGN | 6 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 2 more |
| GCKR | 6 / 31 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Kidney disease and 2 more |
| GPX1 | 6 / 31 | Cardiovascular disease, Coronary artery disease, Hypertension, Ischemic heart disease and 2 more |
| GSTT1 | 6 / 31 | Cardiovascular disease, Coronary artery disease, Hypertension, Ischemic heart disease and 2 more |
| HHIPL1 | 6 / 31 | Cardiovascular disease, Coronary artery disease, Heart disease, Ischemic heart disease and 2 more |
| HMOX1 | 6 / 31 | Coronary artery disease, Hypertension, Ischemic heart disease, Kidney failure and 2 more |
| HP | 6 / 31 | Arteriosclerosis, Atherosclerosis, Cardiovascular disease, Hypertension and 2 more |
| ICA1L | 6 / 31 | Coronary artery disease, Heart disease, Ischemic heart disease, Migraine and 2 more |
| IGF1 | 6 / 31 | Coronary artery disease, Hypertension, Kidney disease, Kidney failure and 2 more |
| IL10 | 6 / 31 | Arteriosclerosis, Coronary artery disease, Ischemic heart disease, Kidney failure and 2 more |
| LIPA | 6 / 31 | Coronary artery disease, Heart disease, Ischemic heart disease, Large artery stroke and 2 more |
| LRP1 | 6 / 31 | Coronary artery disease, Large artery stroke, Migraine, Moyamoya disease and 2 more |
| MIA3 | 6 / 31 | Cardiovascular disease, Coronary artery disease, Heart disease, Ischemic heart disease and 2 more |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| AGE-RAGE signaling pathway in diabetic complications | KEGG | 68 / 101 | 2.1× | 8.30e-13 | 1.62e-10 ✓ sig. |
| Complement and coagulation cascades | KEGG | 52 / 88 | 1.8× | 2.81e-7 | 1.38e-5 ✓ sig. |
| HIF-1 signaling pathway | KEGG | 59 / 110 | 1.6× | 4.01e-6 | 1.37e-4 ✓ sig. |
| Lipid and atherosclerosis | KEGG | 102 / 216 | 1.4× | 4.87e-6 | 1.61e-4 ✓ sig. |
| Cholesterol metabolism | KEGG | 32 / 51 | 1.9× | 9.56e-6 | 2.81e-4 ✓ sig. |
| Interleukin-4 and Interleukin-13 signaling | Reactome | 57 / 108 | 1.6× | 1.11e-5 | 3.18e-4 ✓ sig. |
| Platelet degranulation | Reactome | 63 / 123 | 1.6× | 1.39e-5 | 3.84e-4 ✓ sig. |
| Hormone signaling | KEGG | 101 / 219 | 1.4× | 1.89e-5 | 4.99e-4 ✓ sig. |
| Chagas disease | KEGG | 54 / 103 | 1.6× | 2.41e-5 | 6.08e-4 ✓ sig. |
| Physiological factors | Reactome | 11 / 12 | 2.8× | 3.72e-5 | 8.63e-4 ✓ sig. |
| cGMP-PKG signaling pathway | KEGG | 79 / 166 | 1.5× | 3.92e-5 | 9.01e-4 ✓ sig. |
| Proteoglycans in cancer | KEGG | 93 / 204 | 1.4× | 6.85e-5 | 1.40e-3 ✓ sig. |
| Renin secretion | KEGG | 38 / 69 | 1.7× | 9.62e-5 | 1.84e-3 ✓ sig. |
| Efferocytosis | KEGG | 74 / 157 | 1.4× | 1.00e-4 | 1.90e-3 ✓ sig. |
| Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) | Reactome | 8 / 8 | 3.1× | 1.28e-4 | 2.30e-3 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| positive regulation of transcription by RNA polymerase II | GO:0045944 | 411 / 1,208 | 1.6× | 8.32e-28 | 3.72e-24 ✓ sig. |
| response to xenobiotic stimulus | GO:0009410 | 121 / 248 | 2.3× | 1.17e-22 | 2.70e-19 ✓ sig. |
| regulation of blood pressure | GO:0008217 | 59 / 83 | 3.4× | 1.30e-22 | 2.99e-19 ✓ sig. |
| response to hypoxia | GO:0001666 | 90 / 176 | 2.4× | 6.65e-19 | 9.00e-16 ✓ sig. |
| angiogenesis | GO:0001525 | 123 / 284 | 2.1× | 1.16e-17 | 1.34e-14 ✓ sig. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | GO:0051897 | 100 / 217 | 2.2× | 8.33e-17 | 8.30e-14 ✓ sig. |
| blood coagulation | GO:0007596 | 60 / 106 | 2.7× | 9.80e-16 | 8.02e-13 ✓ sig. |
| positive regulation of angiogenesis | GO:0045766 | 78 / 159 | 2.3× | 2.86e-15 | 2.14e-12 ✓ sig. |
| heart development | GO:0007507 | 114 / 273 | 2.0× | 4.30e-15 | 3.14e-12 ✓ sig. |
| negative regulation of apoptotic process | GO:0043066 | 186 / 524 | 1.7× | 5.28e-15 | 3.81e-12 ✓ sig. |
| negative regulation of cell population proliferation | GO:0008285 | 162 / 444 | 1.7× | 2.10e-14 | 1.37e-11 ✓ sig. |
| positive regulation of gene expression | GO:0010628 | 177 / 504 | 1.7× | 7.41e-14 | 4.39e-11 ✓ sig. |
| kidney development | GO:0001822 | 70 / 146 | 2.3× | 3.14e-13 | 1.64e-10 ✓ sig. |
| positive regulation of MAPK cascade | GO:0043410 | 94 / 224 | 2.0× | 7.64e-13 | 3.67e-10 ✓ sig. |
| positive regulation of DNA-templated transcription | GO:0045893 | 244 / 778 | 1.5× | 2.65e-12 | 1.15e-9 ✓ sig. |