Gene Gene information from NCBI Gene database.
Entrez ID 3569
Gene name Interleukin 6
Gene symbol IL6
Synonyms (NCBI Gene)
BSF-2BSF2CDFHGFHSFIFN-beta-2IFNB2IL-6
Chromosome 7
Chromosome location 7p15.3
Summary This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein
miRNA miRNA information provided by mirtarbase database.
108
miRTarBase ID miRNA Experiments Reference
MIRT005420 hsa-let-7a-5p Luciferase reporter assayqRT-PCRWestern blot 19878981
MIRT006061 hsa-miR-203a-3p ELISAqRT-PCR 21279994
MIRT006061 hsa-miR-203a-3p ELISAqRT-PCR 21279994
MIRT006061 hsa-miR-203a-3p ELISAqRT-PCR 21279994
MIRT006790 hsa-miR-142-3p ELISAImmunoblotMicroarrayqRT-PCR 21474672
Transcription factors Transcription factors information provided by TRRUST V2 database.
40
Transcription factor Regulation Reference
AHR Activation 20511231
AHR Unknown 18483242;23349129
ATF4 Unknown 16931790
CEBPA Unknown 11975924
CEBPB Activation 10903137;8725624
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
143
GO ID Ontology Definition Evidence Reference
GO:0001781 Process Neutrophil apoptotic process IDA 7595060
GO:0002314 Process Germinal center B cell differentiation ISS
GO:0002384 Process Hepatic immune response IDA 2444978
GO:0002384 Process Hepatic immune response TAS 12832423
GO:0002446 Process Neutrophil mediated immunity TAS 16034137
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
147620 6018 ENSG00000136244
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P05231
Protein name Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
Protein function Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable).
PDB 1ALU , 1IL6 , 1P9M , 2IL6 , 4CNI , 4J4L , 4NI7 , 4NI9 , 4O9H , 4ZS7 , 5FUC , 7NXZ , 8D82 , 8QY5 , 8QY6 , 8YWQ , 8YWR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00489 IL6 27 212 Interleukin-6/G-CSF/MGF family Domain
Tissue specificity TISSUE SPECIFICITY: Produced by skeletal muscle. {ECO:0000269|PubMed:11080265}.
Sequence
Sequence length 212
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
163
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AMNESIA CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AMNESTIC DISORDER Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANEURYSM CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANGIOFOLLICULAR GANGLIONIC HYPERPLASIA Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
AA amyloidosis AA amyloidosis BEFREE 28558744, 30132351
★☆☆☆☆
Found in Text Mining only
ABLEPHARON-MACROSTOMIA SYNDROME Ablepharon macrostomia syndrome BEFREE 29608374
★☆☆☆☆
Found in Text Mining only
Acanthosis Nigricans Acanthosis Nigricans BEFREE 30724385
★☆☆☆☆
Found in Text Mining only
Acne Acne BEFREE 25432444, 28193081, 30652337
★☆☆☆☆
Found in Text Mining only
Acne Vulgaris Acne BEFREE 25432444, 28193081, 30652337
★☆☆☆☆
Found in Text Mining only
Acoustic Neuroma Acoustic Neuroma BEFREE 25738867
★☆☆☆☆
Found in Text Mining only
Acquired Hypogammaglobulinemia Common Variable Immunodeficiency BEFREE 2229813, 8485909
★☆☆☆☆
Found in Text Mining only
ACTH-Secreting Pituitary Adenoma Pituitary adenoma BEFREE 10926317, 7550294
★☆☆☆☆
Found in Text Mining only
Acute Cerebrovascular Accidents Stroke BEFREE 12843357
★☆☆☆☆
Found in Text Mining only
Acute Cerebrovascular Accidents Stroke CTD_human_DG 18319729
★☆☆☆☆
Found in Text Mining only