Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 6
39
Diseases
4,487
Unique genes
0.082
Avg. similarity score
Coronary artery disease
Most-connected disease (12 links)
Disease
Searched: Heart failure
Pinned (dragged)
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Heart failure
Coronary artery disease
Ischemic heart disease
Hypertension
Atherosclerosis
Myocardial infarction
Cerebrovascular disorder
Congestive heart failure
Migraine
Myocardial ischemia
Cardiovascular disease
Heart disease
Peripheral vascular disease
Stroke
Kidney failure
Large artery stroke
Peripheral arterial disease
Vascular disease
Venous thromboembolism
Atrial fibrillation
Kidney disease
Preeclampsia
Acetyl-coa carboxylase deficiency
Arteriosclerosis
Brain aneurysm
Erectile dysfunction
Moyamoya disease
Charcot-Marie-Tooth disease type 4B2
Endometriosis
Yoon-bellen neurodevelopmental syndrome
phosphoenolpyruvate carboxykinase deficiency, cytosolic
Intellectual developmental disorder growth metabolic
Trimethylaminuria
band heterotopia of brain
Corneal injury
Peho-like syndrome
Trichilemmal cyst
Zaki syndrome
Hemorrhagic destruction of the brain subependymal calcification and cataracts
Member diseases (most connected first ‐ the cluster's core)
Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| ABO | 17 / 39 | Atrial fibrillation, Cerebrovascular disorder, Coronary artery disease, Endometriosis and 13 more |
| EDNRA | 17 / 39 | Atherosclerosis, Brain aneurysm, Cerebrovascular disorder, Congestive heart failure and 13 more |
| MTHFR | 17 / 39 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Cerebrovascular disorder and 13 more |
| NOS3 | 17 / 39 | Arteriosclerosis, Atherosclerosis, Atrial fibrillation, Cardiovascular disease and 13 more |
| LPA | 16 / 39 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Cerebrovascular disorder and 12 more |
| AGT | 15 / 39 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Cerebrovascular disorder and 11 more |
| ATXN2 | 15 / 39 | Atherosclerosis, Cardiovascular disease, Cerebrovascular disorder, Coronary artery disease and 11 more |
| CELSR2 | 15 / 39 | Atrial fibrillation, Cardiovascular disease, Cerebrovascular disorder, Congestive heart failure and 11 more |
| EDN1 | 15 / 39 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Cerebrovascular disorder and 11 more |
| PTGS2 | 15 / 39 | Arteriosclerosis, Atherosclerosis, Cardiovascular disease, Cerebrovascular disorder and 11 more |
| TNF | 15 / 39 | Atherosclerosis, Cerebrovascular disorder, Congestive heart failure, Coronary artery disease and 11 more |
| ACE | 14 / 39 | Atrial fibrillation, Cardiovascular disease, Cerebrovascular disorder, Congestive heart failure and 10 more |
| FTO | 14 / 39 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 10 more |
| HDAC9 | 14 / 39 | Atherosclerosis, Brain aneurysm, Cardiovascular disease, Cerebrovascular disorder and 10 more |
| TWIST1 | 14 / 39 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Cerebrovascular disorder and 10 more |
| VEGFA | 14 / 39 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Congestive heart failure and 10 more |
| APOE | 13 / 39 | Arteriosclerosis, Atherosclerosis, Cardiovascular disease, Cerebrovascular disorder and 9 more |
| PHACTR1 | 13 / 39 | Atherosclerosis, Cardiovascular disease, Coronary artery disease, Heart disease and 9 more |
| TCF7L2 | 13 / 39 | Atherosclerosis, Atrial fibrillation, Coronary artery disease, Heart failure and 9 more |
| ATP2B1 | 12 / 39 | Atrial fibrillation, Brain aneurysm, Cardiovascular disease, Coronary artery disease and 8 more |
| F5 | 12 / 39 | Atrial fibrillation, Cardiovascular disease, Cerebrovascular disorder, Endometriosis and 8 more |
| SH2B3 | 12 / 39 | Cardiovascular disease, Cerebrovascular disorder, Coronary artery disease, Heart failure and 8 more |
| CRP | 11 / 39 | Atherosclerosis, Cardiovascular disease, Cerebrovascular disorder, Congestive heart failure and 7 more |
| EPO | 11 / 39 | Congestive heart failure, Coronary artery disease, Heart disease, Heart failure and 7 more |
| LPL | 11 / 39 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 7 more |
| MMP1 | 11 / 39 | Arteriosclerosis, Atherosclerosis, Atrial fibrillation, Congestive heart failure and 7 more |
| NPPB | 11 / 39 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Congestive heart failure and 7 more |
| PON1 | 11 / 39 | Arteriosclerosis, Atherosclerosis, Cardiovascular disease, Congestive heart failure and 7 more |
| PSRC1 | 11 / 39 | Cerebrovascular disorder, Coronary artery disease, Heart disease, Heart failure and 7 more |
| SERPINE1 | 11 / 39 | Atherosclerosis, Congestive heart failure, Coronary artery disease, Heart failure and 7 more |
| SMARCA4 | 11 / 39 | Atherosclerosis, Cardiovascular disease, Cerebrovascular disorder, Coronary artery disease and 7 more |
| TDRD15 | 11 / 39 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Coronary artery disease and 7 more |
| TGFB1 | 11 / 39 | Cardiovascular disease, Cerebrovascular disorder, Coronary artery disease, Heart disease and 7 more |
| ZC3HC1 | 11 / 39 | Cardiovascular disease, Coronary artery disease, Erectile dysfunction, Heart disease and 7 more |
| AGTR1 | 10 / 39 | Cerebrovascular disorder, Congestive heart failure, Coronary artery disease, Heart failure and 6 more |
| APOB | 10 / 39 | Arteriosclerosis, Atherosclerosis, Atrial fibrillation, Cardiovascular disease and 6 more |
| APOC1 | 10 / 39 | Atherosclerosis, Atrial fibrillation, Congestive heart failure, Coronary artery disease and 6 more |
| CCL2 | 10 / 39 | Atherosclerosis, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 6 more |
| FGF5 | 10 / 39 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 6 more |
| IL1B | 10 / 39 | Arteriosclerosis, Cerebrovascular disorder, Congestive heart failure, Endometriosis and 6 more |
| IL6 | 10 / 39 | Atherosclerosis, Cerebrovascular disorder, Congestive heart failure, Heart failure and 6 more |
| LDLR | 10 / 39 | Arteriosclerosis, Atherosclerosis, Cardiovascular disease, Cerebrovascular disorder and 6 more |
| PLG | 10 / 39 | Cardiovascular disease, Coronary artery disease, Heart disease, Hypertension and 6 more |
| PLPP3 | 10 / 39 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 6 more |
| PRDM8 | 10 / 39 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 6 more |
| ZPR1 | 10 / 39 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 6 more |
| ADAMTS7 | 9 / 39 | Cardiovascular disease, Coronary artery disease, Heart disease, Ischemic heart disease and 5 more |
| ADIPOQ | 9 / 39 | Atherosclerosis, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 5 more |
| ALB | 9 / 39 | Cardiovascular disease, Cerebrovascular disorder, Congestive heart failure, Heart disease and 5 more |
| APOA1 | 9 / 39 | Atherosclerosis, Cerebrovascular disorder, Coronary artery disease, Hypertension and 5 more |
| CDH13 | 9 / 39 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Erectile dysfunction and 5 more |
| CNNM2 | 9 / 39 | Atrial fibrillation, Brain aneurysm, Coronary artery disease, Hypertension and 5 more |
| COL4A1 | 9 / 39 | Cardiovascular disease, Coronary artery disease, Heart failure, Kidney disease and 5 more |
| ESR1 | 9 / 39 | Arteriosclerosis, Atherosclerosis, Coronary artery disease, Endometriosis and 5 more |
| HECTD4 | 9 / 39 | Coronary artery disease, Heart failure, Hypertension, Ischemic heart disease and 5 more |
| HMGCR | 9 / 39 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 5 more |
| ICAM1 | 9 / 39 | Arteriosclerosis, Atherosclerosis, Atrial fibrillation, Cardiovascular disease and 5 more |
| MLXIPL | 9 / 39 | Atrial fibrillation, Coronary artery disease, Heart failure, Ischemic heart disease and 5 more |
| MMP3 | 9 / 39 | Arteriosclerosis, Atrial fibrillation, Coronary artery disease, Ischemic heart disease and 5 more |
| NOS2 | 9 / 39 | Atherosclerosis, Cerebrovascular disorder, Congestive heart failure, Heart failure and 5 more |
| NPPA | 9 / 39 | Atrial fibrillation, Congestive heart failure, Coronary artery disease, Heart failure and 5 more |
| TLR4 | 9 / 39 | Arteriosclerosis, Atherosclerosis, Coronary artery disease, Hypertension and 5 more |
| VWF | 9 / 39 | Atrial fibrillation, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 5 more |
| ABCG8 | 8 / 39 | Arteriosclerosis, Cardiovascular disease, Coronary artery disease, Heart disease and 4 more |
| AGER | 8 / 39 | Atherosclerosis, Cardiovascular disease, Coronary artery disease, Hypertension and 4 more |
| ALDH2 | 8 / 39 | Atrial fibrillation, Brain aneurysm, Coronary artery disease, Heart failure and 4 more |
| CASZ1 | 8 / 39 | Atrial fibrillation, Cardiovascular disease, Cerebrovascular disorder, Coronary artery disease and 4 more |
| CFDP1 | 8 / 39 | Atherosclerosis, Brain aneurysm, Cardiovascular disease, Coronary artery disease and 4 more |
| COL4A2 | 8 / 39 | Atherosclerosis, Coronary artery disease, Heart disease, Heart failure and 4 more |
| F2 | 8 / 39 | Cerebrovascular disorder, Coronary artery disease, Heart disease, Ischemic heart disease and 4 more |
| FGB | 8 / 39 | Cardiovascular disease, Coronary artery disease, Ischemic heart disease, Kidney failure and 4 more |
| FURIN | 8 / 39 | Coronary artery disease, Heart disease, Hypertension, Ischemic heart disease and 4 more |
| GCKR | 8 / 39 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart failure and 4 more |
| HMOX1 | 8 / 39 | Congestive heart failure, Coronary artery disease, Heart failure, Hypertension and 4 more |
| IL1RN | 8 / 39 | Cardiovascular disease, Cerebrovascular disorder, Hypertension, Kidney disease and 4 more |
| KCNE2 | 8 / 39 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Heart disease and 4 more |
| KIF6 | 8 / 39 | Coronary artery disease, Hypertension, Ischemic heart disease, Kidney disease and 4 more |
| LEPR | 8 / 39 | Coronary artery disease, Hypertension, Ischemic heart disease, Kidney disease and 4 more |
| MRPS6 | 8 / 39 | Cardiovascular disease, Coronary artery disease, Heart disease, Hypertension and 4 more |
| NR3C1 | 8 / 39 | Atrial fibrillation, Coronary artery disease, Endometriosis, Heart failure and 4 more |
| NYAP2 | 8 / 39 | Cardiovascular disease, Coronary artery disease, Heart disease, Hypertension and 4 more |
| PLAT | 8 / 39 | Atherosclerosis, Cerebrovascular disorder, Congestive heart failure, Heart failure and 4 more |
| PLCE1 | 8 / 39 | Brain aneurysm, Cardiovascular disease, Coronary artery disease, Endometriosis and 4 more |
| PPARG | 8 / 39 | Atherosclerosis, Cardiovascular disease, Congestive heart failure, Coronary artery disease and 4 more |
| PRDM16 | 8 / 39 | Cardiovascular disease, Coronary artery disease, Hypertension, Ischemic heart disease and 4 more |
| PROCR | 8 / 39 | Coronary artery disease, Heart disease, Ischemic heart disease, Migraine and 4 more |
| PTPRD | 8 / 39 | Atrial fibrillation, Brain aneurysm, Coronary artery disease, Endometriosis and 4 more |
| SOD1 | 8 / 39 | Atherosclerosis, Cerebrovascular disorder, Congestive heart failure, Heart failure and 4 more |
| SOD2 | 8 / 39 | Atherosclerosis, Congestive heart failure, Heart failure, Hypertension and 4 more |
| SOD3 | 8 / 39 | Congestive heart failure, Coronary artery disease, Heart disease, Heart failure and 4 more |
| STN1 | 8 / 39 | Atrial fibrillation, Cerebrovascular disorder, Coronary artery disease, Heart disease and 4 more |
| TCF21 | 8 / 39 | Coronary artery disease, Heart disease, Hypertension, Ischemic heart disease and 4 more |
| TP53 | 8 / 39 | Congestive heart failure, Coronary artery disease, Heart failure, Hypertension and 4 more |
| ABHD17C | 7 / 39 | Atrial fibrillation, Cardiovascular disease, Endometriosis, Heart failure and 3 more |
| ACAD10 | 7 / 39 | Atrial fibrillation, Coronary artery disease, Heart failure, Kidney disease and 3 more |
| AGXT2 | 7 / 39 | Atrial fibrillation, Congestive heart failure, Coronary artery disease, Heart failure and 3 more |
| ANK2 | 7 / 39 | Atrial fibrillation, Cerebrovascular disorder, Heart disease, Peripheral vascular disease and 3 more |
| CETP | 7 / 39 | Atherosclerosis, Atrial fibrillation, Cardiovascular disease, Coronary artery disease and 3 more |
| CLCN6 | 7 / 39 | Atrial fibrillation, Cardiovascular disease, Coronary artery disease, Hypertension and 3 more |
| CUX2 | 7 / 39 | Atrial fibrillation, Coronary artery disease, Hypertension, Kidney disease and 3 more |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| AGE-RAGE signaling pathway in diabetic complications | KEGG | 74 / 101 | 2.0× | 1.96e-13 | 4.35e-11 ✓ sig. |
| Thyroid hormone signaling pathway | KEGG | 74 / 122 | 1.6× | 1.35e-7 | 8.22e-6 ✓ sig. |
| Prostate cancer | KEGG | 61 / 98 | 1.7× | 4.68e-7 | 2.42e-5 ✓ sig. |
| Complement and coagulation cascades | KEGG | 55 / 88 | 1.7× | 1.41e-6 | 6.32e-5 ✓ sig. |
| Proteoglycans in cancer | KEGG | 109 / 204 | 1.4× | 1.83e-6 | 7.84e-5 ✓ sig. |
| Lipid and atherosclerosis | KEGG | 114 / 216 | 1.4× | 2.38e-6 | 9.82e-5 ✓ sig. |
| HIF-1 signaling pathway | KEGG | 65 / 110 | 1.6× | 2.80e-6 | 1.13e-4 ✓ sig. |
| cGMP-PKG signaling pathway | KEGG | 91 / 166 | 1.5× | 3.14e-6 | 1.25e-4 ✓ sig. |
| Hormone signaling | KEGG | 114 / 219 | 1.4× | 5.62e-6 | 2.03e-4 ✓ sig. |
| Efferocytosis | KEGG | 86 / 157 | 1.5× | 6.04e-6 | 2.13e-4 ✓ sig. |
| Interleukin-4 and Interleukin-13 signaling | Reactome | 63 / 108 | 1.6× | 7.17e-6 | 2.46e-4 ✓ sig. |
| Physiological factors | Reactome | 12 / 12 | 2.7× | 7.33e-6 | 2.50e-4 ✓ sig. |
| cAMP signaling pathway | KEGG | 116 / 226 | 1.4× | 1.10e-5 | 3.53e-4 ✓ sig. |
| Chagas disease | KEGG | 60 / 103 | 1.6× | 1.25e-5 | 3.93e-4 ✓ sig. |
| Platelet degranulation | Reactome | 69 / 123 | 1.5× | 1.70e-5 | 5.10e-4 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| positive regulation of transcription by RNA polymerase II | GO:0045944 | 468 / 1,208 | 1.6× | 3.24e-32 | 2.16e-28 ✓ sig. |
| response to xenobiotic stimulus | GO:0009410 | 132 / 248 | 2.2× | 2.08e-23 | 5.57e-20 ✓ sig. |
| regulation of blood pressure | GO:0008217 | 62 / 83 | 3.1× | 2.56e-22 | 5.71e-19 ✓ sig. |
| angiogenesis | GO:0001525 | 143 / 284 | 2.1× | 3.53e-22 | 7.75e-19 ✓ sig. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | GO:0051897 | 116 / 217 | 2.2× | 6.18e-21 | 1.13e-17 ✓ sig. |
| negative regulation of apoptotic process | GO:0043066 | 219 / 524 | 1.7× | 6.69e-20 | 1.05e-16 ✓ sig. |
| positive regulation of gene expression | GO:0010628 | 210 / 504 | 1.7× | 6.00e-19 | 7.96e-16 ✓ sig. |
| heart development | GO:0007507 | 132 / 273 | 2.0× | 1.23e-18 | 1.56e-15 ✓ sig. |
| response to hypoxia | GO:0001666 | 95 / 176 | 2.2× | 9.01e-18 | 1.00e-14 ✓ sig. |
| positive regulation of MAPK cascade | GO:0043410 | 110 / 224 | 2.0× | 2.28e-16 | 2.04e-13 ✓ sig. |
| positive regulation of DNA-templated transcription | GO:0045893 | 286 / 778 | 1.5× | 3.09e-16 | 2.70e-13 ✓ sig. |
| positive regulation of angiogenesis | GO:0045766 | 85 / 159 | 2.2× | 1.02e-15 | 7.88e-13 ✓ sig. |
| blood coagulation | GO:0007596 | 64 / 106 | 2.5× | 1.41e-15 | 1.07e-12 ✓ sig. |
| negative regulation of cell population proliferation | GO:0008285 | 181 / 444 | 1.7× | 2.12e-15 | 1.56e-12 ✓ sig. |
| kidney development | GO:0001822 | 78 / 146 | 2.2× | 1.60e-14 | 1.01e-11 ✓ sig. |