Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

Log in to save this analysis

Save This Analysis

What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Chloracne Thalassemia
5 genes
Show details
5 of 5 corroborated by 2+ sources
HBA1(2), HBA2(2), GSTM1(2), HBB(2), HBD(2)
0.147 1.000 3.29e-14 4.42e-13 ✓ sig. Cluster 72 →
Dravet syndrome Generalized epilepsy with febrile seizures plus
5 genes
Show details
5 of 5 corroborated by 2+ sources
GABRG2(4), SCN1A(8), SCN1B(7), SCN2A(2), SCN9A(2)
0.250 0.625 3.39e-14 4.54e-13 ✓ sig. Cluster 47 →
Dermatologic disorder Pulmonary fibrosis
12 genes
Show details
10 of 12 corroborated by 2+ sources
HSPA1B(2), IL1A(1), IL1B(2), TNF(2), IL6(2), PTGS2(1), IL1RN(2), CXCL2(2), CCL4(2), OGG1(2), PTX3(2), SKIL(2)
0.073 0.176 3.55e-14 4.76e-13 ✓ sig. —
Male infertility globozoospermia Spermatogenic failure
7 genes
Show details
7 of 7 corroborated by 2+ sources
PPP2R3C(4), SPATA16(4), SEPTIN4(2), DPY19L2(7), ZPBP(4), CATSPERT(3), GGN(4)
0.060 0.778 3.60e-14 4.82e-13 ✓ sig. —
Spastic ataxia Spinocerebellar ataxia
12 genes
Show details
11 of 12 corroborated by 2+ sources
CACNA1A(6), CACNA1G(5), DAB1(4), SETX(6), ITPR1(7), SYNE1(3), PIK3R5(2), AFG3L2(6), CCDC88C(6), TUBB6(1), ELOVL4(5), PUM1(3)
0.074 0.171 3.61e-14 4.83e-13 ✓ sig. Cluster 79 →
Nervous system disease Seizures
13 genes
Show details
13 of 13 corroborated by 2+ sources
FOXG1(2), APOE(2), KCNQ2(5), SCN8A(5), ACHE(2), BDNF(2), NOS1(2), NGF(2), FOS(2), CHRNA4(2), PTGS2(2), ABCC2(2) +1 more
0.066 0.191 3.70e-14 4.95e-13 ✓ sig. —
Congenital hydrocephalus Hydrocephalus
6 genes
Show details
6 of 6 corroborated by 2+ sources
MPDZ(5), SMARCC1(2), WDR81(3), L1CAM(4), CCDC88C(5), TRIM71(4)
0.171 0.429 3.71e-14 4.95e-13 ✓ sig. Cluster 293 →
Fatty liver Hepatomegaly
11 genes
Show details
10 of 11 corroborated by 2+ sources
LDLR(2), LEP(2), NFE2L2(2), PPARA(2), AKT1(2), IFNA2(1), CYP1B1(2), MET(2), NR1H4(2), NR1I2(2), LEPR(2)
0.078 0.190 3.83e-14 5.11e-13 ✓ sig. —
Anxiety disorder Memory disorders
12 genes
Show details
12 of 12 corroborated by 2+ sources
APP(2), HTR1A(2), HTR7(2), MAPT(2), NPY(2), DRD2(3), SLC6A3(2), SLC6A4(3), CNR1(2), MAGI2(2), MDK(2), MIF(2)
0.065 0.235 3.86e-14 5.16e-13 ✓ sig. —
Aortic disease Marfan syndrome
7 genes
Show details
7 of 7 corroborated by 2+ sources
CAT(2), SOD2(2), SOD1(2), MMP9(2), MMP2(2), LAMC1(2), SMAD4(2)
0.125 0.368 3.90e-14 5.20e-13 ✓ sig. —
Iga nephropathy Sclerosing cholangitis
23 genes
Show details
6 of 23 corroborated by 2+ sources
ANKRD55(1), ETS1(1), HLA-DQA1(1), HLA-DQB3(1), HLA-DRA(1), HLA-DRB1(1), IKZF1(1), TTC33(1), PLAU(2), OSMR(1), HLA-DQB1(2), FCGR2A(1) +11 more
0.056 0.113 3.98e-14 5.31e-13 ✓ sig. Cluster 28 →
Lymphocytic b-cell leukemia Lymphocytic leukemia
10 genes
Show details
10 of 10 corroborated by 2+ sources
FARP2(2), BCL2(2), IRF4(2), SP140(2), ACOXL(2), QPCT(2), LEF1(2), BMF(2), C11orf21(2), PRKD2(2)
0.071 0.294 4.09e-14 5.45e-13 ✓ sig. Cluster 225 →
Polymyositis Sjogren syndrome
8 genes
Show details
6 of 8 corroborated by 2+ sources
DGKQ(3), THSD7A(1), TNF(2), IL6(2), HLA-DQB1(2), PTPN22(2), STAT4(3), BLK(1)
0.093 0.364 4.13e-14 5.50e-13 ✓ sig. Cluster 25 →
Myeloid leukemia Promyelocytic leukemia
12 genes
Show details
5 of 12 corroborated by 2+ sources
WT1(1), CEBPA(3), IDH2(1), NRAS(1), DNMT3A(2), IDH1(1), KIT(2), AQP9(1), PTPN11(1), FLT3(2), NPM1(2), CD44(1)
0.063 0.240 4.13e-14 5.50e-13 ✓ sig. Cluster 53 →
Stroke Venous thromboembolism
34 genes
Show details
10 of 34 corroborated by 2+ sources
WWOX(1), SH2B3(2), FGA(3), AGBL1(1), FADS1(1), FADS2(1), GRK5(1), KALRN(1), LRAT(1), NALF1(1), PLCG2(1), F2(3) +22 more
0.054 0.105 4.35e-14 5.78e-13 ✓ sig. —
Mitochondrial dna depletion syndrome Progressive external ophthalmoplegia
6 genes
Show details
6 of 6 corroborated by 2+ sources
RRM2B(7), POLG2(6), POLG(7), TWNK(5), SLC25A4(7), TK2(7)
0.162 0.462 4.37e-14 5.81e-13 ✓ sig. —
Corneal disease Corneal dystrophy
6 genes
Show details
2 of 6 corroborated by 2+ sources
COL5A1(1), TCF4(6), RXRA(1), COL24A1(1), LAMB1(1), KRT3(4)
0.154 0.500 4.49e-14 5.96e-13 ✓ sig. —
Distal hereditary motor neuropathy Motor neuron disease
9 genes
Show details
7 of 9 corroborated by 2+ sources
SETX(3), TRPV4(3), DCTN1(7), DYNC1H1(2), NEFL(1), PLEKHG5(3), GARS1(6), MPZ(1), IGHMBP2(2)
0.091 0.250 4.75e-14 6.31e-13 ✓ sig. Cluster 15 →
Osteopetrosis Osteosclerosis
5 genes
Show details
5 of 5 corroborated by 2+ sources
TNFRSF11A(6), LRP5(6), CLCN7(7), TCIRG1(8), TNFSF11(5)
0.238 0.625 4.80e-14 6.36e-13 ✓ sig. Cluster 108 →
Brain ischemia Necrosis
10 genes
Show details
10 of 10 corroborated by 2+ sources
CAT(2), IL1B(2), MTHFR(2), SOD2(2), TNF(2), IL6(2), SOD1(2), IL17A(2), NOS2(2), IL1RN(2)
0.086 0.182 4.80e-14 6.37e-13 ✓ sig. Cluster 114 →
Atrophic macular degeneration C3 glomerulonephritis
6 genes
Show details
6 of 6 corroborated by 2+ sources
CFHR1(3), CFI(3), C3(3), CFB(3), CFH(4), CFHR5(6)
0.102 0.750 4.89e-14 6.47e-13 ✓ sig. —
Atrophic macular degeneration Mesangiocapillary glomerulonephritis
6 genes
Show details
6 of 6 corroborated by 2+ sources
CFHR1(2), CFI(2), C3(2), CFB(2), CFH(2), CFHR5(2)
0.102 0.750 4.89e-14 6.47e-13 ✓ sig. —
Fatty liver Hyperinsulinism
10 genes
Show details
10 of 10 corroborated by 2+ sources
INS(2), MTTP(2), LEP(2), TNF(2), GPX1(2), CCL2(2), COL3A1(2), UCP2(3), LEPR(2), NEIL1(2)
0.079 0.238 4.93e-14 6.53e-13 ✓ sig. —
Lymphoma Multiple myeloma
12 genes
Show details
3 of 12 corroborated by 2+ sources
HLA-DQA1(1), HLA-DRB1(1), BCL2(2), CSF2(1), EPHX1(1), HLA-DQB1(1), EXOC2(1), IRF4(2), CSF3(1), IFNA2(1), CDKN2A(2), TNFSF8(1)
0.065 0.226 4.96e-14 6.57e-13 ✓ sig. —
Anencephaly Aprosencephaly
4 genes
Show details
2 of 4 corroborated by 2+ sources
TRIM36(4), MTRR(1), NUAK2(3), RPGRIP1L(1)
0.400 1.000 5.38e-14 7.11e-13 ✓ sig. Cluster 121 →

Showing 25 of 20813 pairs, sorted by significance (ascending). Click a column header to sort.