Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 72

13 diseases · 36 shared-gene connections
13 Diseases
1,350 Unique genes
0.286 Avg. similarity score
Gastric cancer Most-connected disease (10 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Gastric cancer 10 10 218
Endometrial cancer 9 9 174
Esophageal cancer 9 9 157
Biliary tract cancer 8 8 118
Non-hodgkins lymphoma 8 8 135
Hepatocellular carcinoma 6 6 649
Cervical cancer 5 5 227
Pancreatic cancer 5 5 251
friedreich ataxia 5 5 1
Endometrial neoplasms 2 2 132
Polycystic ovary syndrome 2 2 227
thrombotic disease 2 2 1
Cardiofacio-neurodevelopmental syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
ATXN2 9 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Endometrial neoplasms and 5 more
AZGP1 9 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 5 more
ESR1 9 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Endometrial neoplasms and 5 more
FGFR2 9 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Endometrial neoplasms and 5 more
FXN 9 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 5 more
HNF1B 9 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Endometrial neoplasms and 5 more
SH2B3 9 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Endometrial neoplasms and 5 more
TOX3 9 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 5 more
ANKRD11 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
ARHGEF10L 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
ASIP 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
BABAM1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
BAD 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
BCL2L11 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
BNC2 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
BPIFA3 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
BRCA2 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
C11ORF65 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
CASP8 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
CCDC170 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
CDK5RAP1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
CELF2 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
CERS2 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
CHMP4B 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
CLK1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
DCAF4 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
DLGAP4 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
DPEP1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
EPB41L1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
EPHB6 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
FAM76B 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
FAM83C 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
FANCA 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
FARP1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
FBRSL1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
FIGLA 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
FOXP1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
FRY 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
GOLPH3L 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
GPR137 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
GRHPR 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
GRM5 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
HLA-B 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
HLA-DQB1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
HLA-DRA 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
HOXB13 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
IGF2BP2 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
IRF4 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
JRK 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
KCNH1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
KCNQ1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
KIF20B 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
KRT5 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
LCTL 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
LDLRAD4 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
LRRIQ4 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
LY6K 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
MAP3K1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
MCL1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
MECOM 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
MLC1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
MMP9 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
MRTFA 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
MTAP 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
MTX1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
MYO9B 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
NCOA6 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
NHLRC1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
OCA2 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
OR6C6 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
PADI6 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
PALB2 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
PHF20 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
PIGU 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
POU2AF3 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
POU5F1B 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
PRMT6 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
PSCA 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
RAD51B 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
RALY 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
RBM25 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
RCC2 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
RCCD1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
RGS22 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
RHOU 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
RNF19A 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
SEPTIN4 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
SLC45A2 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
SLK 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
SMAD7 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
SMC2 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
STMN3 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
STN1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
TAB2 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
TERT 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
TESPA1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
TEX29 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
TGM3 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
TMX1 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
TP53 8 / 13 Biliary tract cancer, Cervical cancer, Endometrial cancer, Esophageal cancer and 4 more
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Pathways in cancer
BAD, BCL2L11, BRCA2, CASP8, ESR1, FGFR2, MECOM, MMP9, TERT, TP53, ETS1, AKT1
 KEGG 119 / 533 2.0× 5.22e-14 1.39e-11 ✓ sig.
Human T-cell leukemia virus 1 infection
HLA-B, HLA-DQB1, HLA-DRA, MAP3K1, TERT, TP53, ETS1, AKT1, ATM, BCL2L1, BUB1B, CCNA1
 KEGG 63 / 224 2.5× 2.16e-12 4.45e-10 ✓ sig.
Gastric cancer
FGFR2, TERT, TP53, ABCB1, AKT1, APC, AXIN1, BRAF, CCND1, CCNE1, CDKN1B, CDKN2B
 KEGG 47 / 150 2.8× 2.36e-11 3.89e-9 ✓ sig.
Prostate cancer
BAD, FGFR2, MMP9, TP53, AKT1, AR, BRAF, CCND1, CCNE1, CDKN1B, CTNNB1, E2F1
 KEGG 36 / 98 3.3× 3.27e-11 5.26e-9 ✓ sig.
Colorectal cancer
BAD, BCL2L11, TP53, AKT1, APC, AXIN1, BIRC5, BRAF, CCND1, CTNNB1, EGF, EGFR
 KEGG 33 / 87 3.4× 7.97e-11 1.18e-8 ✓ sig.
EGFR tyrosine kinase inhibitor resistance
BAD, BCL2L11, FGFR2, AKT1, BCL2L1, BRAF, EGF, EGFR, HGF, HRAS, IGF1, IGF1R
 KEGG 31 / 80 3.4× 1.58e-10 2.19e-8 ✓ sig.
Cell cycle
TP53, ATM, AURKB, BUB1, BUB1B, CCNA1, CCNB1, CCNB2, CCND1, CCNE1, CDC20, CDC25C
 KEGG 46 / 158 2.6× 5.99e-10 7.07e-8 ✓ sig.
Endocrine resistance
BAD, ESR1, MMP9, TP53, AKT1, BRAF, CCND1, CDK4, CDKN1B, CDKN2A, CDKN2C, E2F1
 KEGG 34 / 99 3.1× 9.24e-10 1.04e-7 ✓ sig.
Melanoma
BAD, TP53, AKT1, BRAF, CCND1, CDK4, CDKN2A, E2F1, EGF, EGFR, FGF19, FGF3
 KEGG 28 / 73 3.4× 1.60e-9 1.69e-7 ✓ sig.
Breast cancer
BRCA2, ESR1, TP53, AKT1, APC, AXIN1, BRAF, CCND1, CDK4, CTNNB1, E2F1, EGF
 KEGG 43 / 148 2.6× 2.33e-9 2.36e-7 ✓ sig.
PIP3 activates AKT signaling
ESR1, FGFR2, AKT1, EGF, EGFR, EREG, FGF19, FGF3, FGF4, FGFR1, HGF, IL1RAP
 Reactome 31 / 93 3.0× 1.15e-8 9.82e-7 ✓ sig.
Constitutive Signaling by Aberrant PI3K in Cancer
ESR1, FGFR2, EGF, EGFR, EREG, FGF19, FGF3, FGF4, FGFR1, HGF, IRS1, IRS2
 Reactome 27 / 75 3.2× 1.56e-8 1.29e-6 ✓ sig.
Bladder cancer
MMP9, TP53, BRAF, CCND1, CDK4, CDKN2A, CXCL8, E2F1, EGF, EGFR, HRAS, KRAS
 KEGG 19 / 41 4.1× 1.75e-8 1.42e-6 ✓ sig.
Hepatocellular carcinoma
BAD, TERT, TP53, ACTB, AKT1, APC, ARID1A, ARID1B, ARID2, AXIN1, BCL2L1, BRAF
 KEGG 45 / 170 2.4× 2.39e-8 1.89e-6 ✓ sig.
Pancreatic cancer
BAD, BRCA2, TP53, AKT1, BCL2L1, BRAF, CCND1, CDK4, CDKN2A, E2F1, EGF, EGFR
 KEGG 27 / 77 3.1× 2.98e-8 2.28e-6 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
cell division
BABAM1, KIF20B, RCC2, SEPTIN4, SMC2, ANLN, ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B
 GO:0051301 86 / 406 2.9× 5.51e-20 8.97e-17 ✓ sig.
cell population proliferation
BRCA2, OCA2, TP53, TYR, AKT1, CCND1, CDC25C, CDKN2C, CEBPA, CTNNB1, EGF, EGFR
 GO:0008283 66 / 263 3.5× 1.24e-19 1.89e-16 ✓ sig.
positive regulation of transcription by RNA polymerase II
ESR1, FGFR2, FIGLA, HNF1B, IRF4, MECOM, MRTFA, NCOA6, TOX3, TP53, ETS1, AKT1
 GO:0045944 174 / 1,208 2.0× 2.41e-19 3.56e-16 ✓ sig.
positive regulation of cell population proliferation
FGFR2, KIF20B, RAD51B, SFRP1, ACTB, AKR1C2, APLN, AR, BIRC5, CCL14, CCND1, CDC20
 GO:0008284 99 / 532 2.6× 1.27e-18 1.67e-15 ✓ sig.
positive regulation of MAPK cascade
FGFR2, GRM5, ADRA1A, ADRA2B, AR, CSPG4, CTNNB1, EGF, EGFR, ERP29, FGF19, FGF3
 GO:0043410 54 / 224 3.3× 1.71e-15 1.28e-12 ✓ sig.
male gonad development
BCL2L11, ESR1, FANCA, SFRP1, ACE, AR, ASPM, BCL2L1, CSMD1, HMGB2, HOXA10, MMP14
 GO:0008584 37 / 117 4.4× 5.17e-15 3.54e-12 ✓ sig.
positive regulation of DNA-templated transcription
BRCA2, ESR1, HNF1B, IRF4, MECOM, NCOA6, PHF20, TP53, ETS1, SFRP1, ACTB, AR
 GO:0045893 117 / 778 2.1× 1.50e-14 9.44e-12 ✓ sig.
positive regulation of gene expression
HNF1B, TP53, ETS1, NRXN1, AKT1, AR, ATM, BRAF, CCL3, CD34, CDK1, CDKN2A
 GO:0010628 85 / 504 2.3× 1.34e-13 7.22e-11 ✓ sig.
positive regulation of miRNA transcription
MRTFA, TERT, TP53, ETS1, APLN, AR, EGFR, EGR1, FOS, IL6, JUN, MYC
 GO:1902895 23 / 56 5.7× 1.47e-12 6.50e-10 ✓ sig.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
NRXN1, ADRA2B, AKR1C2, CAT, CCL3, DCN, EGF, EGFR, F2, FGFR1, GDF15, HGF
 GO:0051897 47 / 217 3.0× 7.24e-12 2.74e-9 ✓ sig.
negative regulation of transcription by RNA polymerase II
ESR1, FGFR2, FOXP1, HNF1B, HOXB13, PRMT6, RALY, SMAD7, TP53, ANXA4, AR, AURKB
 GO:0000122 131 / 1,002 1.8× 1.35e-11 4.83e-9 ✓ sig.
negative regulation of apoptotic process
BAD, FXN, HNF1B, MCL1, MMP9, PALB2, TERT, TP53, SFRP1, AKR1A1, AKT1, ANXA4
 GO:0043066 82 / 524 2.2× 2.03e-11 6.94e-9 ✓ sig.
mitotic spindle assembly checkpoint signaling
APC, ATM, BIRC5, BUB1, BUB1B, CDC20, CENPF, MAD2L1, NDC80, NUF2, PLK1, SPC25
 GO:0007094 16 / 30 7.4× 2.78e-11 9.11e-9 ✓ sig.
stem cell proliferation
BRCA2, TP53, ABCB1, CD34, CDKN2C, CTNNB1, FGF4, FGFR1, SFN, SHH, TGFB1, NF1
 GO:0072089 20 / 54 5.1× 3.90e-10 9.60e-8 ✓ sig.
negative regulation of cell population proliferation
AZGP1, SH2B3, TP53, ETS1, SFRP1, ZNF503, ADAMTS1, ADRA1A, APC, AR, ARID2, BTG2
 GO:0008285 70 / 444 2.2× 4.45e-10 1.08e-7 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Biliary tract cancer Non-hodgkins lymphoma 0.740 108 1.96e-236 1.23e-233 ✓ sig.
Biliary tract cancer Esophageal cancer 0.643 108 1.50e-223 8.50e-221 ✓ sig.
Esophageal cancer Gastric cancer 0.504 126 7.61e-221 3.81e-218 ✓ sig.
Biliary tract cancer Endometrial cancer 0.584 108 9.11e-216 4.46e-213 ✓ sig.
Esophageal cancer Non-hodgkins lymphoma 0.584 108 2.73e-209 1.23e-206 ✓ sig.
Endometrial cancer Non-hodgkins lymphoma 0.542 109 1.74e-204 6.98e-202 ✓ sig.
Biliary tract cancer Cervical cancer 0.460 109 6.22e-201 2.40e-198 ✓ sig.
Biliary tract cancer Gastric cancer 0.472 108 2.24e-200 8.50e-198 ✓ sig.
Cervical cancer Non-hodgkins lymphoma 0.440 111 9.03e-192 3.02e-189 ✓ sig.
Biliary tract cancer Pancreatic cancer 0.412 108 1.54e-191 5.08e-189 ✓ sig.
Gastric cancer Non-hodgkins lymphoma 0.445 109 6.82e-189 2.21e-186 ✓ sig.
Endometrial cancer Esophageal cancer 0.482 108 1.15e-188 3.68e-186 ✓ sig.
Non-hodgkins lymphoma Pancreatic cancer 0.387 108 2.52e-177 6.70e-175 ✓ sig.
Cervical cancer Esophageal cancer 0.395 109 3.37e-173 8.54e-171 ✓ sig.
Endometrial cancer Gastric cancer 0.389 110 2.57e-170 6.37e-168 ✓ sig.
Esophageal cancer Pancreatic cancer 0.368 110 2.80e-169 6.86e-167 ✓ sig.
Cervical cancer Endometrial cancer 0.372 109 2.44e-165 5.72e-163 ✓ sig.
Endometrial cancer Pancreatic cancer 0.348 110 2.67e-161 5.89e-159 ✓ sig.
Cervical cancer Gastric cancer 0.327 110 5.68e-152 1.13e-149 ✓ sig.
Gastric cancer Pancreatic cancer 0.317 113 8.85e-152 1.74e-149 ✓ sig.
Biliary tract cancer Hepatocellular carcinoma 0.169 111 6.28e-147 1.18e-144 ✓ sig.
Hepatocellular carcinoma Non-hodgkins lymphoma 0.163 110 1.94e-129 3.17e-127 ✓ sig.
Esophageal cancer Hepatocellular carcinoma 0.156 109 1.45e-114 2.13e-112 ✓ sig.
Endometrial cancer Hepatocellular carcinoma 0.156 111 2.99e-110 4.22e-108 ✓ sig.
Gastric cancer Hepatocellular carcinoma 0.153 115 9.93e-101 1.18e-98 ✓ sig.
Endometrial cancer Endometrial neoplasms 0.195 50 7.87e-65 5.54e-63 ✓ sig.
Hepatocellular carcinoma Polycystic ovary syndrome 0.031 26 3.67e-6 2.07e-5 ✓ sig.
Endometrial neoplasms Polycystic ovary syndrome 0.032 11 4.06e-6 2.26e-5 ✓ sig.
Biliary tract cancer friedreich ataxia 0.008 1 7.66e-3 8.96e-3 ✓ sig.
friedreich ataxia Non-hodgkins lymphoma 0.007 1 8.77e-3 1.01e-2 ✓ sig.
Esophageal cancer thrombotic disease 0.006 1 1.02e-2 1.15e-2 ✓ sig.
Esophageal cancer friedreich ataxia 0.006 1 1.02e-2 1.15e-2 ✓ sig.
Endometrial cancer friedreich ataxia 0.006 1 1.13e-2 1.27e-2 ✓ sig.
friedreich ataxia Gastric cancer 0.005 1 1.42e-2 1.58e-2 ✓ sig.
Cardiofacio-neurodevelopmental syndrome Gastric cancer 0.005 1 1.42e-2 1.58e-2 ✓ sig.
Gastric cancer thrombotic disease 0.005 1 1.42e-2 1.58e-2 ✓ sig.