Gene Gene information from NCBI Gene database.
Entrez ID 572
Gene name BCL2 associated agonist of cell death
Gene symbol BAD
Synonyms (NCBI Gene)
BBC2BCL2L8
Chromosome 11
Chromosome location 11q13.1
Summary The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large)
miRNA miRNA information provided by mirtarbase database.
44
miRTarBase ID miRNA Experiments Reference
MIRT038239 hsa-miR-330-5p CLASH 23622248
MIRT814403 hsa-miR-1915 CLIP-seq
MIRT814404 hsa-miR-3124-5p CLIP-seq
MIRT814405 hsa-miR-361-3p CLIP-seq
MIRT814406 hsa-miR-4281 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
Transcription factor Regulation Reference
NR3C1 Activation 17496926
PPARG Activation 14960510
RELA Activation 20596645
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
73
GO ID Ontology Definition Evidence Reference
GO:0001836 Process Release of cytochrome c from mitochondria IBA
GO:0001836 Process Release of cytochrome c from mitochondria IEA
GO:0005515 Function Protein binding IPI 9388232, 9463381, 9973195, 10949025, 11526496, 15131699, 15694340, 16189514, 17446862, 17485524, 17979178, 19427857, 19427863, 19667065, 20005908, 20179209, 20603619, 20936779, 21081150, 21900206, 21988832, 22000515, 23397142, 24008843, 24255178, 25241761, 25416956, 26871637, 285144
GO:0005543 Function Phospholipid binding IMP 21081150
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603167 936 ENSG00000002330
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92934
Protein name Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)
Protein function Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (B
PDB 1G5J , 7Q16
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10514 Bcl-2_BAD 1 168 Pro-apoptotic Bcl-2 protein, BAD Family
Tissue specificity TISSUE SPECIFICITY: Expressed in a wide variety of tissues.
Sequence
Sequence length 168
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
26
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BILIARY TRACT CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 15033904
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 30577817
★☆☆☆☆
Found in Text Mining only
Aggressive Periodontitis Aggressive Periodontitis BEFREE 24182354
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 16646081, 23566222, 28529565, 28599489, 29562785, 29956797, 30008912
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma LHGDN 16785131
★☆☆☆☆
Found in Text Mining only
Brain Stem Ischemia, Transient Cerebral Ischemia CTD_human_DG 12629175
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 17670745, 19882362, 20691103, 22957045, 27485113, 28569785, 30635657, 31236965
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Breast neoplasm Pubtator 27485113 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 17696955
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 30008870
★☆☆☆☆
Found in Text Mining only