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Gene Gene information from NCBI Gene database.
Entrez ID 598
Gene name BCL2 like 1
Gene symbol BCL2L1
Synonyms (NCBI Gene)
BCL-XL/SBCL2LBCLXBcl-XPPP1R52
Chromosome 20
Chromosome location 20q11.21
Summary The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gen
miRNA miRNA information provided by mirtarbase database.
572 Show/Hide all (572)
miRTarBase ID miRNA Experiments Reference
MIRT004285 hsa-miR-491-5p Luciferase reporter assayWestern blot 20039318
MIRT004490 hsa-let-7g-5p Luciferase reporter assayqRT-PCRWestern blot 20347499
MIRT004491 hsa-let-7c-5p Luciferase reporter assayqRT-PCRWestern blot 20347499
MIRT004491 hsa-let-7c-5p Luciferase reporter assayqRT-PCRWestern blot 22917031
MIRT004491 hsa-let-7c-5p Luciferase reporter assayqRT-PCRWestern blot 22917031
Transcription factors Transcription factors information provided by TRRUST V2 database.
23 Show/Hide all (23)
Transcription factor Regulation Reference
BCL6 Repression 11777915
CEBPB Unknown 19043455
FOS Unknown 16911523
JUN Unknown 16911523
MTA1 Activation 11948399
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
100 Show/Hide all (100)
GO ID Ontology Definition Evidence Reference
GO:0001541 Process Ovarian follicle development IEA
GO:0001701 Process In utero embryonic development IEA
GO:0001836 Process Release of cytochrome c from mitochondria IBA
GO:0001836 Process Release of cytochrome c from mitochondria IDA 9843949
GO:0001836 Process Release of cytochrome c from mitochondria IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600039 992 ENSG00000171552
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q07817
Protein name Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
Protein function Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochond
PDB 1BXL , 1G5J , 1LXL , 1MAZ , 1R2D , 1R2E , 1R2G , 1R2H , 1R2I , 1YSG , 1YSI , 1YSN , 2B48 , 2LP8 , 2LPC , 2M03 , 2M04 , 2ME8 , 2ME9 , 2MEJ , 2O1Y , 2O2M , 2O2N , 2P1L , 2PON , 2YJ1 , 2YQ6 , 2YQ7 , 2YXJ , 3CVA , 3FDL , 3FDM , 3INQ , 3IO8 , 3PL7 , 3QKD , 3R85 , 3SP7 , 3SPF , 3WIZ , 3ZK6 , 3ZLN , 3ZLO , 3ZLR , 4A1U , 4A1W , 4AQ3 , 4BPK , 4C52 , 4C5D , 4CIN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00452 Bcl-2 90 → 188 Apoptosis regulator proteins, Bcl-2 family Family
PF02180 BH4 1 → 26 Bcl-2 homology region 4 Family
Tissue specificity TISSUE SPECIFICITY: Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Sequence
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGW
DTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Sequence length 233
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
EGFR tyrosine kinase inhibitor resistance BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Platinum drug resistance Interleukin-4 and Interleukin-13 signaling
Ras signaling pathway The NLRP1 inflammasome
NF-kappa B signaling pathway  
p53 signaling pathway  
Mitophagy - animal  
Autophagy - animal  
PI3K-Akt signaling pathway  
Apoptosis  
Apoptosis - multiple species  
NOD-like receptor signaling pathway  
JAK-STAT signaling pathway  
Parkinson disease  
Amyotrophic lateral sclerosis  
Pathways of neurodegeneration - multiple diseases  
Shigellosis  
Toxoplasmosis  
Measles  
Human T-cell leukemia virus 1 infection  
Herpes simplex virus 1 infection  
Human immunodeficiency virus 1 infection  
Pathways in cancer  
Transcriptional misregulation in cancer  
Pancreatic cancer  
Chronic myeloid leukemia  
Small cell lung cancer  
Hepatocellular carcinoma  
Lipid and atherosclerosis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
24
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (24)
Phenotype Name Clinical Significance Source Reference Evidence Score
ALZHEIMER DISEASE — GWAS catalog 39998322
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AMYOTROPHIC LATERAL SCLEROSIS 1 — CTD, Disgenet
CTD, Disgenet
11796754
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA — CTD 10426811
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR — CTD 10629087, 11509945
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CEREBRAL HEMORRHAGE — CTD 12721362
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (335)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Abdominal Cryptorchidism Cryptorchidism CTD_human_DG 26050606
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 11801602
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 8625322
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 29596435
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma CTD_human_DG 10426811
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 26048755
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma of large intestine Colorectal adenoma BEFREE 22009326
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma, Basal Cell Adenoma CTD_human_DG 10426811
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma, Microcystic Adenoma CTD_human_DG 10426811
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma, Monomorphic Adenoma CTD_human_DG 10426811
★★★★★
★☆☆☆☆
Found in Text Mining only