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Gene Gene information from NCBI Gene database.
Entrez ID 2353
Gene name Fos proto-oncogene, AP-1 transcription factor subunit
Gene symbol FOS
Synonyms (NCBI Gene)
AP-1C-FOSp55
Chromosome 14
Chromosome location 14q24.3
Summary The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have b
miRNA miRNA information provided by mirtarbase database.
366 Show/Hide all (366)
miRTarBase ID miRNA Experiments Reference
MIRT001219 hsa-miR-101-3p qRT-PCRLuciferase reporter assayWestern blot 19133651
MIRT001219 hsa-miR-101-3p qRT-PCRLuciferase reporter assayWestern blot 19133651
MIRT004484 hsa-miR-221-3p qRT-PCRLuciferase reporter assayWestern blotNorthern blot 20299489
MIRT004485 hsa-miR-222-3p qRT-PCRLuciferase reporter assayWestern blotNorthern blot 20299489
MIRT001219 hsa-miR-101-3p Luciferase reporter assay 19133651
Transcription factors Transcription factors information provided by TRRUST V2 database.
36 Show/Hide all (36)
Transcription factor Regulation Reference
AHR Unknown 10478842
ARNT Repression 21544813
BRCA1 Unknown 11313879
CREB1 Unknown 12432566
CREM Repression 21757709
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
110 Show/Hide all (110)
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription cis-regulatory region binding IDA 9732876
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 30670568
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
164810 3796 ENSG00000170345
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P01100
Protein name Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)
Protein function Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activatio
PDB 1A02 , 1FOS , 1S9K
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00170 bZIP_1 135 → 197 bZIP transcription factor Coiled-coil
Sequence
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFIL
AAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL
Sequence length 380
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Endocrine resistance Oxidative Stress Induced Senescence
MAPK signaling pathway Senescence-Associated Secretory Phenotype (SASP)
cAMP signaling pathway FCERI mediated MAPK activation
Apoptosis Activation of the AP-1 family of transcription factors
Osteoclast differentiation Interleukin-4 and Interleukin-13 signaling
Toll-like receptor signaling pathway TP53 Regulates Transcription of DNA Repair Genes
IL-17 signaling pathway Estrogen-dependent gene expression
Th1 and Th2 cell differentiation NGF-stimulated transcription
Th17 cell differentiation Estrogen-dependent nuclear events downstream of ESR-membrane signaling
T cell receptor signaling pathway  
B cell receptor signaling pathway  
TNF signaling pathway  
Circadian entrainment  
Cholinergic synapse  
Dopaminergic synapse  
Estrogen signaling pathway  
Prolactin signaling pathway  
Oxytocin signaling pathway  
Relaxin signaling pathway  
Parathyroid hormone synthesis, secretion and action  
Non-alcoholic fatty liver disease  
Growth hormone synthesis, secretion and action  
Amphetamine addiction  
Pathogenic Escherichia coli infection  
Salmonella infection  
Pertussis  
Yersinia infection  
Leishmaniasis  
Chagas disease  
Hepatitis B  
Measles  
Human T-cell leukemia virus 1 infection  
Kaposi sarcoma-associated herpesvirus infection  
Human immunodeficiency virus 1 infection  
Coronavirus disease - COVID-19  
Pathways in cancer  
Chemical carcinogenesis - receptor activation  
Chemical carcinogenesis - reactive oxygen species  
Colorectal cancer  
Breast cancer  
Choline metabolism in cancer  
PD-L1 expression and PD-1 checkpoint pathway in cancer  
Rheumatoid arthritis  
Lipid and atherosclerosis  
Fluid shear stress and atherosclerosis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
43
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (43)
Phenotype Name Clinical Significance Source Reference Evidence Score
Acute myeloid leukemia Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AMPHETAMINE OR RELATED ACTING SYMPATHOMIMETIC ABUSE — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AMPHETAMINE-RELATED DISORDERS — CTD 19689456
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AMYOTROPHIC LATERAL SCLEROSIS 1 — CTD, Disgenet
CTD, Disgenet
11796754
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (509)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acanthosis Nigricans Acanthosis Nigricans HPO_DG
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 2243505, 22869147
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 2834348
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 10713684
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 18032824
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 18436711
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 16166335
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 2842040
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 2842040
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 22869147
★★★★★
★☆☆☆☆
Found in Text Mining only