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Gene Gene information from NCBI Gene database.
Entrez ID 3725
Gene name Jun proto-oncogene, AP-1 transcription factor subunit
Gene symbol JUN
Synonyms (NCBI Gene)
AP-1AP1c-JuncJUNp39
Chromosome 1
Chromosome location 1p32.1
Summary This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless
miRNA miRNA information provided by mirtarbase database.
363 Show/Hide all (363)
miRTarBase ID miRNA Experiments Reference
MIRT000868 hsa-miR-15a-5p Microarray 18362358
MIRT000867 hsa-miR-16-5p Microarray 18362358
MIRT005128 hsa-miR-30a-5p pSILAC 18668040
MIRT006208 hsa-miR-155-5p Luciferase reporter assayqRT-PCRWestern blot 22508041
MIRT006208 hsa-miR-155-5p Luciferase reporter assayqRT-PCRWestern blot 22508041
Transcription factors Transcription factors information provided by TRRUST V2 database.
38 Show/Hide all (38)
Transcription factor Regulation Reference
ABL1 Activation 15145216
ABL1 Repression 19357699
AR Activation 20148354
ARNT Repression 21544813
ATF2 Activation 9502786
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
99 Show/Hide all (99)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 2833704
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 21113145
GO:0000228 Component Nuclear chromosome TAS 10918580
GO:0000785 Component Chromatin IDA 31341047
GO:0000785 Component Chromatin ISA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
165160 6204 ENSG00000177606
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P05412
Protein name Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
Protein function Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA bind
PDB 1A02 , 1FOS , 1JNM , 1JUN , 1S9K , 1T2K , 5FV8 , 5T01 , 6Y3V , 8SOS
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00170 bZIP_1 250 → 313 bZIP transcription factor Coiled-coil
PF03957 Jun 5 → 241 Jun-like transcription factor Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the developing and adult prostate and prostate cancer cells. {ECO:0000269|PubMed:24263171, ECO:0000269|PubMed:24559171}.
Sequence
Sequence length 331
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Endocrine resistance Pre-NOTCH Transcription and Translation
MAPK signaling pathway Oxidative Stress Induced Senescence
ErbB signaling pathway Senescence-Associated Secretory Phenotype (SASP)
cAMP signaling pathway FCERI mediated MAPK activation
Mitophagy - animal Activation of the AP-1 family of transcription factors
Apoptosis MAPK6/MAPK4 signaling
Wnt signaling pathway TP53 Regulates Transcription of DNA Repair Genes
Osteoclast differentiation Regulation of PTEN gene transcription
Focal adhesion Estrogen-dependent gene expression
Tight junction WNT5:FZD7-mediated leishmania damping
Toll-like receptor signaling pathway  
NOD-like receptor signaling pathway  
C-type lectin receptor signaling pathway  
IL-17 signaling pathway  
Th1 and Th2 cell differentiation  
Th17 cell differentiation  
T cell receptor signaling pathway  
B cell receptor signaling pathway  
TNF signaling pathway  
Neurotrophin signaling pathway  
GnRH signaling pathway  
Estrogen signaling pathway  
Oxytocin signaling pathway  
Relaxin signaling pathway  
Non-alcoholic fatty liver disease  
AGE-RAGE signaling pathway in diabetic complications  
Cocaine addiction  
Amphetamine addiction  
Epithelial cell signaling in Helicobacter pylori infection  
Pathogenic Escherichia coli infection  
Shigellosis  
Salmonella infection  
Pertussis  
Yersinia infection  
Leishmaniasis  
Chagas disease  
Hepatitis B  
Measles  
Human T-cell leukemia virus 1 infection  
Kaposi sarcoma-associated herpesvirus infection  
Epstein-Barr virus infection  
Human immunodeficiency virus 1 infection  
Coronavirus disease - COVID-19  
Pathways in cancer  
Viral carcinogenesis  
Chemical carcinogenesis - receptor activation  
Chemical carcinogenesis - reactive oxygen species  
Colorectal cancer  
Renal cell carcinoma  
Breast cancer  
Choline metabolism in cancer  
PD-L1 expression and PD-1 checkpoint pathway in cancer  
Inflammatory bowel disease  
Rheumatoid arthritis  
Lipid and atherosclerosis  
Fluid shear stress and atherosclerosis  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
25
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Breast neoplasm Pathogenic rs2524557470 RCV002285232
★★★★★
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (24)
Phenotype Name Clinical Significance Source Reference Evidence Score
ARTHRITIS, JUVENILE — CTD 19565504
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRAIN INJURIES — CTD 21549006
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRAIN ISCHEMIA — CTD, Disgenet
CTD, Disgenet
17901229
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS — CTD 16298037
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (383)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 22869147
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 16911523, 16951171
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 18436711
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 16166335, 27323831
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 22869147
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 10845928, 22493372, 27600282, 30066853
★★★★★
★☆☆☆☆
Found in Text Mining only
Agenesis of corpus callosum Agenesis Of Corpus Callosum BEFREE 20826579
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 17712163, 8774439 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 19162185, 24346217, 32437347, 38049398, 40363838, 8063812, 9880041 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease, Early Onset Alzheimer disease BEFREE 15917097
★★★★★
★☆☆☆☆
Found in Text Mining only