Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	3556
Gene name	Interleukin 1 receptor accessory protein
Gene symbol	IL1RAP
Synonyms (NCBI Gene)	C3orf13IL-1RAcPIL1R3
Chromosome	3
Chromosome location	3q28
Summary	This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differ

177 Show/Hide all (177)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005831	hsa-miR-204-5p	Microarray	21282569
MIRT020058	hsa-miR-375	Microarray	20215506
MIRT024630	hsa-miR-215-5p	Microarray	19074876
MIRT026944	hsa-miR-192-5p	Microarray	19074876
MIRT036392	hsa-miR-1228-3p	CLASH	23622248
MIRT437619	hsa-miR-146a-5p	MicroarrayqRT-PCR	22815788
MIRT437625	hsa-miR-146b-5p	MicroarrayqRT-PCR	22815788
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22291592
MIRT448178	hsa-miR-4635	PAR-CLIP	22291592
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22291592
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22291592
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT448178	hsa-miR-4635	PAR-CLIP	22100165
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22100165
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT448178	hsa-miR-4635	PAR-CLIP	22100165
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22100165
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22291592
MIRT448178	hsa-miR-4635	PAR-CLIP	22291592
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22291592
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22291592
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT448178	hsa-miR-4635	PAR-CLIP	22100165
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22100165
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT448179	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT448178	hsa-miR-4635	PAR-CLIP	22100165
MIRT448177	hsa-miR-494-3p	PAR-CLIP	22100165
MIRT448176	hsa-miR-510-3p	PAR-CLIP	22100165
MIRT1064296	hsa-miR-1206	CLIP-seq
MIRT1064297	hsa-miR-1261	CLIP-seq
MIRT1064298	hsa-miR-1270	CLIP-seq
MIRT1064299	hsa-miR-1290	CLIP-seq
MIRT1064300	hsa-miR-141	CLIP-seq
MIRT1064301	hsa-miR-181a	CLIP-seq
MIRT1064302	hsa-miR-181b	CLIP-seq
MIRT1064303	hsa-miR-181c	CLIP-seq
MIRT1064304	hsa-miR-181d	CLIP-seq
MIRT1064305	hsa-miR-192	CLIP-seq
MIRT1064306	hsa-miR-194	CLIP-seq
MIRT1064307	hsa-miR-200a	CLIP-seq
MIRT1064308	hsa-miR-208a	CLIP-seq
MIRT1064309	hsa-miR-208b	CLIP-seq
MIRT1064310	hsa-miR-21	CLIP-seq
MIRT1064311	hsa-miR-215	CLIP-seq
MIRT1064312	hsa-miR-23a	CLIP-seq
MIRT1064313	hsa-miR-23b	CLIP-seq
MIRT1064314	hsa-miR-23c	CLIP-seq
MIRT1064315	hsa-miR-27a	CLIP-seq
MIRT1064316	hsa-miR-27b	CLIP-seq
MIRT1064317	hsa-miR-299-3p	CLIP-seq
MIRT1064318	hsa-miR-3143	CLIP-seq
MIRT1064319	hsa-miR-3158-3p	CLIP-seq
MIRT1064320	hsa-miR-3163	CLIP-seq
MIRT1064321	hsa-miR-3167	CLIP-seq
MIRT1064322	hsa-miR-346	CLIP-seq
MIRT1064323	hsa-miR-34b	CLIP-seq
MIRT1064324	hsa-miR-3607-5p	CLIP-seq
MIRT1064325	hsa-miR-3661	CLIP-seq
MIRT1064326	hsa-miR-3691-5p	CLIP-seq
MIRT1064327	hsa-miR-3924	CLIP-seq
MIRT1064328	hsa-miR-3940-5p	CLIP-seq
MIRT1064329	hsa-miR-3976	CLIP-seq
MIRT1064330	hsa-miR-4262	CLIP-seq
MIRT1064331	hsa-miR-4263	CLIP-seq
MIRT1064332	hsa-miR-4288	CLIP-seq
MIRT1064333	hsa-miR-4432	CLIP-seq
MIRT1064334	hsa-miR-4491	CLIP-seq
MIRT1064335	hsa-miR-4507	CLIP-seq
MIRT1064336	hsa-miR-451b	CLIP-seq
MIRT1064337	hsa-miR-4646-5p	CLIP-seq
MIRT1064338	hsa-miR-4652-3p	CLIP-seq
MIRT1064339	hsa-miR-4655-5p	CLIP-seq
MIRT1064340	hsa-miR-4657	CLIP-seq
MIRT1064341	hsa-miR-4662a-3p	CLIP-seq
MIRT1064342	hsa-miR-4666-5p	CLIP-seq
MIRT1064343	hsa-miR-4683	CLIP-seq
MIRT1064344	hsa-miR-4711-3p	CLIP-seq
MIRT1064345	hsa-miR-4729	CLIP-seq
MIRT1064346	hsa-miR-4731-5p	CLIP-seq
MIRT1064347	hsa-miR-4752	CLIP-seq
MIRT1064348	hsa-miR-4766-3p	CLIP-seq
MIRT1064349	hsa-miR-4778-5p	CLIP-seq
MIRT1064350	hsa-miR-4789-5p	CLIP-seq
MIRT1064351	hsa-miR-4799-5p	CLIP-seq
MIRT1064352	hsa-miR-4803	CLIP-seq
MIRT1064353	hsa-miR-499-5p	CLIP-seq
MIRT1064354	hsa-miR-513a-5p	CLIP-seq
MIRT1064355	hsa-miR-539	CLIP-seq
MIRT1064356	hsa-miR-543	CLIP-seq
MIRT1064357	hsa-miR-548ac	CLIP-seq
MIRT1064358	hsa-miR-548ad	CLIP-seq
MIRT1064359	hsa-miR-548ae	CLIP-seq
MIRT1064360	hsa-miR-548aj	CLIP-seq
MIRT1064361	hsa-miR-548am	CLIP-seq
MIRT1064362	hsa-miR-548d-3p	CLIP-seq
MIRT1064363	hsa-miR-548x	CLIP-seq
MIRT1064364	hsa-miR-548z	CLIP-seq
MIRT1064365	hsa-miR-563	CLIP-seq
MIRT1064366	hsa-miR-568	CLIP-seq
MIRT1064367	hsa-miR-576-5p	CLIP-seq
MIRT1064368	hsa-miR-579	CLIP-seq
MIRT1064369	hsa-miR-582-5p	CLIP-seq
MIRT1064370	hsa-miR-590-5p	CLIP-seq
MIRT1064371	hsa-miR-620	CLIP-seq
MIRT1064372	hsa-miR-631	CLIP-seq
MIRT1064373	hsa-miR-632	CLIP-seq
MIRT1064374	hsa-miR-664	CLIP-seq
MIRT1064375	hsa-miR-876-5p	CLIP-seq
MIRT1064376	hsa-miR-1249	CLIP-seq
MIRT1064308	hsa-miR-208a	CLIP-seq
MIRT1064309	hsa-miR-208b	CLIP-seq
MIRT1064377	hsa-miR-3065-5p	CLIP-seq
MIRT1064318	hsa-miR-3143	CLIP-seq
MIRT1064378	hsa-miR-3149	CLIP-seq
MIRT1064379	hsa-miR-34c-3p	CLIP-seq
MIRT1064380	hsa-miR-3616-5p	CLIP-seq
MIRT1064381	hsa-miR-3647-5p	CLIP-seq
MIRT1064382	hsa-miR-3663-3p	CLIP-seq
MIRT1064383	hsa-miR-3671	CLIP-seq
MIRT1064327	hsa-miR-3924	CLIP-seq
MIRT1064384	hsa-miR-421	CLIP-seq
MIRT1064385	hsa-miR-4275	CLIP-seq
MIRT1064386	hsa-miR-4307	CLIP-seq
MIRT1064333	hsa-miR-4432	CLIP-seq
MIRT1064336	hsa-miR-451b	CLIP-seq
MIRT1064387	hsa-miR-4666-3p	CLIP-seq
MIRT1064342	hsa-miR-4666-5p	CLIP-seq
MIRT1064388	hsa-miR-4709-5p	CLIP-seq
MIRT1064389	hsa-miR-4795-5p	CLIP-seq
MIRT1064352	hsa-miR-4803	CLIP-seq
MIRT1064390	hsa-miR-494	CLIP-seq
MIRT1064353	hsa-miR-499-5p	CLIP-seq
MIRT1064358	hsa-miR-548ad	CLIP-seq
MIRT1064366	hsa-miR-568	CLIP-seq
MIRT1064391	hsa-miR-573	CLIP-seq
MIRT1064392	hsa-miR-607	CLIP-seq
MIRT1064393	hsa-miR-935	CLIP-seq
MIRT1064394	hsa-miR-4292	CLIP-seq
MIRT1064395	hsa-miR-4308	CLIP-seq
MIRT1064337	hsa-miR-4646-5p	CLIP-seq
MIRT1550105	hsa-miR-29a	CLIP-seq
MIRT1550106	hsa-miR-29b	CLIP-seq
MIRT1550107	hsa-miR-29c	CLIP-seq
MIRT1550108	hsa-miR-3183	CLIP-seq
MIRT1550109	hsa-miR-4266	CLIP-seq
MIRT1550110	hsa-miR-4469	CLIP-seq
MIRT1550111	hsa-miR-4723-3p	CLIP-seq
MIRT1550112	hsa-miR-4777-3p	CLIP-seq
MIRT1550113	hsa-miR-642a	CLIP-seq
MIRT1550114	hsa-miR-767-5p	CLIP-seq
MIRT1064323	hsa-miR-34b	CLIP-seq
MIRT2247647	hsa-miR-1245b-5p	CLIP-seq
MIRT2247648	hsa-miR-1303	CLIP-seq
MIRT2247649	hsa-miR-3142	CLIP-seq
MIRT2247650	hsa-miR-3182	CLIP-seq
MIRT2247651	hsa-miR-4303	CLIP-seq
MIRT2247652	hsa-miR-4649-3p	CLIP-seq
MIRT2247653	hsa-miR-877	CLIP-seq
MIRT2551056	hsa-miR-1208	CLIP-seq
MIRT2551057	hsa-miR-221	CLIP-seq
MIRT2551058	hsa-miR-222	CLIP-seq
MIRT2551059	hsa-miR-3680	CLIP-seq
MIRT1064344	hsa-miR-4711-3p	CLIP-seq
MIRT2551060	hsa-miR-4798-3p	CLIP-seq
MIRT2551061	hsa-miR-592	CLIP-seq
MIRT2551062	hsa-miR-599	CLIP-seq
MIRT2551056	hsa-miR-1208	CLIP-seq
MIRT2551057	hsa-miR-221	CLIP-seq
MIRT2551058	hsa-miR-222	CLIP-seq
MIRT2551059	hsa-miR-3680	CLIP-seq
MIRT1064344	hsa-miR-4711-3p	CLIP-seq
MIRT2551060	hsa-miR-4798-3p	CLIP-seq
MIRT2551061	hsa-miR-592	CLIP-seq
MIRT2551062	hsa-miR-599	CLIP-seq

43 Show/Hide all (43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002114	Function	Interleukin-33 receptor activity	IEA
GO:0002376	Process	Immune system process	IEA
GO:0004908	Function	Interleukin-1 receptor activity	IBA
GO:0004908	Function	Interleukin-1 receptor activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IC	10854325
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	7775431
GO:0006954	Process	Inflammatory response	IEA
GO:0006954	Process	Inflammatory response	TAS	9065432
GO:0006955	Process	Immune response	TAS	9065432
GO:0007165	Process	Signal transduction	IEA
GO:0009986	Component	Cell surface	IBA
GO:0015026	Function	Coreceptor activity	IDA	10854325
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0032736	Process	Positive regulation of interleukin-13 production	IEA
GO:0032753	Process	Positive regulation of interleukin-4 production	IEA
GO:0032754	Process	Positive regulation of interleukin-5 production	IEA
GO:0032755	Process	Positive regulation of interleukin-6 production	IEA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0038172	Process	Interleukin-33-mediated signaling pathway	IDA	11960013, 18802081, 20532808
GO:0038172	Process	Interleukin-33-mediated signaling pathway	IDA	17675517
GO:0038172	Process	Interleukin-33-mediated signaling pathway	IEA
GO:0038172	Process	Interleukin-33-mediated signaling pathway	IMP	31435003
GO:0045087	Process	Innate immune response	IEA
GO:0045202	Component	Synapse	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0051965	Process	Positive regulation of synapse assembly	ISS
GO:0061809	Function	NAD+ nucleosidase activity, cyclic ADP-ribose generating	IEA
GO:0065003	Process	Protein-containing complex assembly	TAS	7775431
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IDA	10854325, 14625308
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IDA	9065432
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099151	Process	Regulation of postsynaptic density assembly	IEA
GO:0099545	Process	Trans-synaptic signaling by trans-synaptic complex	IEA
GO:0099560	Process	Synaptic membrane adhesion	IEA
GO:1905606	Process	Regulation of presynapse assembly	IEA

MIM	HGNC	e!Ensembl
602626	5995	ENSG00000196083

Q9NPH3

Protein name

Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)

Protein function

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-de

PDB

3O4O , 4DEP , 7FCC

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01582	TIR	404 → 570	TIR domain	Family
PF13927	Ig_3	242 → 336		Domain
PF18452	Ig_6	88 → 137	Immunoglobulin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with ac

Sequence

MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST
AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT
YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG
CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA
VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE
SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVEL
ACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEF
VLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQAL
LELKAGLENMASRGNINVILVQYKAVKETKVKELKRAKTVLTVIKWKGEKSKYPQGRFWK
QLQVAMPVKKSPRRSSSDEQGLSYSSLKNV

Sequence length

570

Interactions

View interactions

KEGG Pathway	Reactome Pathway
MAPK signaling pathway	PIP3 activates AKT signaling
Cytokine-cytokine receptor interaction	Receptor-type tyrosine-protein phosphatases
Th17 cell differentiation	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Inflammatory mediator regulation of TRP channels	Interleukin-36 pathway
	Interleukin-33 signaling
	Interleukin-1 signaling

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (10)
CARCINOMA, HEPATOCELLULAR	—	CTD	28284560	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High myopia	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	34343768	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER DISEASES	—	CTD, Disgenet CTD, Disgenet	19784758	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	18385676	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	18385676	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	18385676	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	18385676	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA OF HEAD AND NECK	—	CTD	27738319	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (59)
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	22723552, 29773641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of pancreas	Pancreatic adenocarcinoma	BEFREE	22819319		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	26268530, 30792413, 33522999, 34654853	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	25016825, 31376255	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	31396542	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	Pubtator	35986608	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrophy	Atrophy	Pubtator	26268530	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	28576939		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	36351892	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Diseases	Brain disease	Pubtator	33522999	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Merkel Cell	Merkel cell carcinoma	Pubtator	35409061	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	35395492	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	29429992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	29429992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	25595648		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	26268530, 30792413	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34083590	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital hypoplasia of adrenal gland	Congenital adrenal hypoplasia	BEFREE	12940459		★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	25517029		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	BEFREE	21272866, 21958553, 24935223		★★★★★ ★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Hypertension	Pubtator	40075282	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastroenteritis	Gastroenteritis	BEFREE	29217619		★★★★★ ★☆☆☆☆ Found in Text Mining only
Graft vs Host Disease	Graft-versus-host disease	Pubtator	32492155	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	30792413		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	12940459, 28576939		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	22723552, 33121233, 34138728	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	22723552, 23479569, 33121233, 34138728, 34543390, 39582863	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	22723552, 29773641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	LHGDN	15528363		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	19508382		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	34475499	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	31396542		★★★★★ ★☆☆☆☆ Found in Text Mining only
Macular Degeneration	Macular degeneration	Pubtator	32871771	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29773641		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	29429992		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	12940459		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation, X-Linked	Mental retardation	BEFREE	15300857		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mild cognitive disorder	Cognitive disorder	BEFREE	26268530		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mucocutaneous Lymph Node Syndrome	Kawasaki disease	GWASDB_DG	21221998		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	22723552, 34543390	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	20805474, 30514753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	21373837, 30257318, 30514753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	24915116		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	24915116	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatitis, Chronic	Pancreatitis	BEFREE	28099250		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	38485911	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	31427775		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	25595648	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	31376255, 31396542		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	34021002	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma Ewing	Sarcoma	Pubtator	34021002	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	27738319		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	CTD_human_DG	27738319		★★★★★ ★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	31396542		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombosis	Thrombosis	Pubtator	32203583	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	30257318		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveitis	Uveitis	BEFREE	29424312		★★★★★ ★☆☆☆☆ Found in Text Mining only
X-linked Adrenal Hypoplasia	Adrenal Hypoplasia, X-Linked	BEFREE	12940459		★★★★★ ★☆☆☆☆ Found in Text Mining only

IL1RAP (interleukin 1 receptor accessory protein)

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