Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	3101
Gene name	Hexokinase 3
Gene symbol	HK3
Synonyms (NCBI Gene)	HKIIIHXK3
Chromosome	5
Chromosome location	5q35.2
Summary	Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [

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miRTarBase ID	miRNA	Experiments
MIRT2010958	hsa-miR-2467-3p	CLIP-seq
MIRT2010959	hsa-miR-2964a-5p	CLIP-seq
MIRT2010960	hsa-miR-3652	CLIP-seq
MIRT2010961	hsa-miR-377	CLIP-seq
MIRT2010962	hsa-miR-4430	CLIP-seq
MIRT2010963	hsa-miR-4505	CLIP-seq
MIRT2010964	hsa-miR-4643	CLIP-seq
MIRT2010965	hsa-miR-4717-3p	CLIP-seq
MIRT2243164	hsa-miR-1266	CLIP-seq
MIRT2010958	hsa-miR-2467-3p	CLIP-seq
MIRT2243165	hsa-miR-3064-5p	CLIP-seq
MIRT2243166	hsa-miR-3153	CLIP-seq
MIRT2010960	hsa-miR-3652	CLIP-seq
MIRT2243167	hsa-miR-3664-3p	CLIP-seq
MIRT2243168	hsa-miR-3682-5p	CLIP-seq
MIRT2010961	hsa-miR-377	CLIP-seq
MIRT2243169	hsa-miR-4261	CLIP-seq
MIRT2243170	hsa-miR-4270	CLIP-seq
MIRT2010962	hsa-miR-4430	CLIP-seq
MIRT2243171	hsa-miR-4441	CLIP-seq
MIRT2010963	hsa-miR-4505	CLIP-seq
MIRT2243172	hsa-miR-4514	CLIP-seq
MIRT2243173	hsa-miR-4518	CLIP-seq
MIRT2010964	hsa-miR-4643	CLIP-seq
MIRT2243174	hsa-miR-4646-5p	CLIP-seq
MIRT2243175	hsa-miR-4668-5p	CLIP-seq
MIRT2243176	hsa-miR-4692	CLIP-seq
MIRT2010965	hsa-miR-4717-3p	CLIP-seq
MIRT2243177	hsa-miR-4768-5p	CLIP-seq
MIRT2243178	hsa-miR-942	CLIP-seq
MIRT2451222	hsa-miR-1254	CLIP-seq
MIRT2451223	hsa-miR-3116	CLIP-seq
MIRT2451224	hsa-miR-3689d	CLIP-seq
MIRT2451225	hsa-miR-4254	CLIP-seq
MIRT2451226	hsa-miR-769-5p	CLIP-seq

Transcription factor	Regulation	Reference
CEBPA	Unknown	24584857

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001678	Process	Intracellular glucose homeostasis	IBA
GO:0001678	Process	Intracellular glucose homeostasis	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004340	Function	Glucokinase activity	IBA
GO:0004340	Function	Glucokinase activity	IEA
GO:0004340	Function	Glucokinase activity	ISS
GO:0004340	Function	Glucokinase activity	TAS
GO:0004396	Function	Hexokinase activity	IDA	8717435
GO:0004396	Function	Hexokinase activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005536	Function	D-glucose binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005739	Component	Mitochondrion	IBA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006002	Process	Fructose 6-phosphate metabolic process	ISS
GO:0006006	Process	Glucose metabolic process	IBA
GO:0006096	Process	Glycolytic process	IBA
GO:0006096	Process	Glycolytic process	IEA
GO:0008865	Function	Fructokinase activity	IBA
GO:0008865	Function	Fructokinase activity	IEA
GO:0008865	Function	Fructokinase activity	ISS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016773	Function	Phosphotransferase activity, alcohol group as acceptor	IEA
GO:0019158	Function	Mannokinase activity	IBA
GO:0019318	Process	Hexose metabolic process	IEA
GO:0019637	Process	Organophosphate metabolic process	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0046835	Process	Carbohydrate phosphorylation	IEA
GO:0051156	Process	Glucose 6-phosphate metabolic process	IBA
GO:0051156	Process	Glucose 6-phosphate metabolic process	ISS
GO:0061621	Process	Canonical glycolysis	TAS
GO:1901135	Process	Carbohydrate derivative metabolic process	IEA
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

MIM	HGNC	e!Ensembl
142570	4925	ENSG00000160883

P52790

Protein name

Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) (Hexokinase-C)

Protein function

Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:8717435). Mediates the initial step of glycolysis by catalyzing phosphoryla

PDB

3HM8

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00349	Hexokinase_1	482 → 673	Hexokinase	Domain
PF00349	Hexokinase_1	32 → 231	Hexokinase	Domain
PF03727	Hexokinase_2	679 → 913	Hexokinase	Domain
PF03727	Hexokinase_2	238 → 472	Hexokinase	Domain

Sequence

MDSIGSSGLRQGEETLSCSEEGLPGPSDSSELVQECLQQFKVTRAQLQQIQASLLGSMEQ
ALRGQASPAPAVRMLPTYVGSTPHGTEQGDFVVLELGATGASLRVLWVTLTGIEGHRVEP
RSQEFVIPQEVMLGAGQQLFDFAAHCLSEFLDAQPVNKQGLQLGFSFSFPCHQTGLDRST
LISWTKGFRCSGVEGQDVVQLLRDAIRRQGAYNIDVVAVVNDTVGTMMGCEPGVRPCEVG
LVVDTGTNACYMEEARHVAVLDEDRGRVCVSVEWGSFSDDGALGPVLTTFDHTLDHESLN
PGAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTSPALLSQGSILLEHVAEMEDPST
GAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQQTLQ
VAVATGGRVCERHPRFCSVLQGTVMLLAPECDVSLIPSVDGGGRGVAMVTAVAARLAAHR
RLLEETLAPFRLNHDQLAAVQAQMRKAMAKGLRGEASSLRMLPTFVRATPDGSERGDFLA
LDLGGTNFRVLLVRVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQGLSGQ
SLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAI
VNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCINMEWGAFGD
DGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLFRGQQIQ
RLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAVSQRAAQLC
GAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRCVVTFLQSE
DGSGKGAALVTAVACRLAQLTRV

Sequence length

923

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Glycolysis / Gluconeogenesis	Neutrophil degranulation
Fructose and mannose metabolism	Glycolysis
Galactose metabolism
Starch and sucrose metabolism
Amino sugar and nucleotide sugar metabolism
Neomycin, kanamycin and gentamicin biosynthesis
Metabolic pathways
Carbon metabolism
Biosynthesis of nucleotide sugars
HIF-1 signaling pathway
Insulin signaling pathway
Type II diabetes mellitus
Carbohydrate digestion and absorption
Shigellosis
Central carbon metabolism in cancer

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (6)
Cervical cancer	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER DISEASES	—	CTD, Disgenet CTD, Disgenet	19784758	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long QT syndrome	Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	30194396	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

HK3 (hexokinase 3)

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