Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	3082
Gene name	Hepatocyte growth factor
Gene symbol	HGF
Synonyms (NCBI Gene)	DFNB39F-TCFHGFBHPTASF
Chromosome	7
Chromosome location	7q21.11
Summary	This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which

SNP ID	Visualize variation	Clinical significance	Consequence
rs137853235	C>T	Pathogenic	Synonymous variant, intron variant, coding sequence variant
rs145494248	C>G,T	Benign, conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, coding sequence variant, missense variant
rs145598174	A>G	Likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs148714837	C>T	Benign-likely-benign, likely-benign, conflicting-interpretations-of-pathogenicity	Synonymous variant, genic downstream transcript variant, coding sequence variant
rs367800414	A>G	Conflicting-interpretations-of-pathogenicity	Synonymous variant, genic downstream transcript variant, coding sequence variant

58 Show/Hide all (58)

miRTarBase ID	miRNA	Experiments	Reference
MIRT054477	hsa-miR-199a-3p	Luciferase reporter assayQRTPCRWestern blot	23657814
MIRT054645	hsa-miR-26a-5p	ELISAImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	28393839
MIRT054645	hsa-miR-26a-5p	ELISAImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	28393839
MIRT054645	hsa-miR-26a-5p	ELISALuciferase reporter assayqRT-PCR	28386375
MIRT732936	hsa-miR-144-3p	RNA-seq	33804111
MIRT734648	hsa-miR-28-3p	Western blottingImmunoprecipitaion (IP)ImmunofluorescenceqRT-PCRFlow cytometryELISA	34094709
MIRT734649	hsa-miR-193a-5p	Western blottingImmunoprecipitaion (IP)ImmunofluorescenceqRT-PCRFlow cytometryELISA	34094709
MIRT1044894	hsa-miR-4446-5p	CLIP-seq
MIRT1044895	hsa-miR-3168	CLIP-seq
MIRT1044896	hsa-miR-4277	CLIP-seq
MIRT1044897	hsa-miR-4424	CLIP-seq
MIRT1044898	hsa-miR-4645-3p	CLIP-seq
MIRT1044899	hsa-miR-4795-3p	CLIP-seq
MIRT1044900	hsa-miR-570	CLIP-seq
MIRT1044901	hsa-miR-582-5p	CLIP-seq
MIRT2451140	hsa-miR-4495	CLIP-seq
MIRT2545797	hsa-miR-1244	CLIP-seq
MIRT2545798	hsa-miR-1305	CLIP-seq
MIRT2545799	hsa-miR-199b-3p	CLIP-seq
MIRT2545800	hsa-miR-3065-5p	CLIP-seq
MIRT2545801	hsa-miR-3129-5p	CLIP-seq
MIRT2545802	hsa-miR-3159	CLIP-seq
MIRT2545803	hsa-miR-3613-5p	CLIP-seq
MIRT2545804	hsa-miR-3692	CLIP-seq
MIRT2545805	hsa-miR-3925-3p	CLIP-seq
MIRT2545806	hsa-miR-421	CLIP-seq
MIRT2545807	hsa-miR-4445	CLIP-seq
MIRT2545808	hsa-miR-4522	CLIP-seq
MIRT2545809	hsa-miR-4703-3p	CLIP-seq
MIRT2545810	hsa-miR-4712-5p	CLIP-seq
MIRT2545811	hsa-miR-495	CLIP-seq
MIRT2545812	hsa-miR-511	CLIP-seq
MIRT1044900	hsa-miR-570	CLIP-seq
MIRT2545813	hsa-miR-580	CLIP-seq
MIRT2545814	hsa-miR-651	CLIP-seq
MIRT2545815	hsa-miR-766	CLIP-seq
MIRT2545816	hsa-miR-770-5p	CLIP-seq
MIRT2545797	hsa-miR-1244	CLIP-seq
MIRT2545798	hsa-miR-1305	CLIP-seq
MIRT2545799	hsa-miR-199b-3p	CLIP-seq
MIRT2545800	hsa-miR-3065-5p	CLIP-seq
MIRT2545801	hsa-miR-3129-5p	CLIP-seq
MIRT2545802	hsa-miR-3159	CLIP-seq
MIRT2545803	hsa-miR-3613-5p	CLIP-seq
MIRT2545804	hsa-miR-3692	CLIP-seq
MIRT2545805	hsa-miR-3925-3p	CLIP-seq
MIRT2545806	hsa-miR-421	CLIP-seq
MIRT2545807	hsa-miR-4445	CLIP-seq
MIRT2545808	hsa-miR-4522	CLIP-seq
MIRT2545809	hsa-miR-4703-3p	CLIP-seq
MIRT2545810	hsa-miR-4712-5p	CLIP-seq
MIRT2545811	hsa-miR-495	CLIP-seq
MIRT2545812	hsa-miR-511	CLIP-seq
MIRT1044900	hsa-miR-570	CLIP-seq
MIRT2545813	hsa-miR-580	CLIP-seq
MIRT2545814	hsa-miR-651	CLIP-seq
MIRT2545815	hsa-miR-766	CLIP-seq
MIRT2545816	hsa-miR-770-5p	CLIP-seq

6 Show/Hide all (6)

Transcription factor	Regulation	Reference
NFIC	Unknown	10860846
SP1	Activation	9223667
SP3	Activation	9223667
STAT3	Activation	12168776
STAT3	Unknown	23954444
TFAP2A	Repression	10860846

50 Show/Hide all (50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000278	Process	Mitotic cell cycle	NAS	2531289
GO:0000902	Process	Cell morphogenesis	IEA
GO:0001837	Process	Epithelial to mesenchymal transition	TAS	14679171
GO:0001889	Process	Liver development	IEA
GO:0004175	Function	Endopeptidase activity	IBA
GO:0004252	Function	Serine-type endopeptidase activity	NAS	2531289
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005515	Function	Protein binding	IPI	1846706, 12694198, 15167892, 16537482, 17804794, 17981115, 18585357, 20624990, 22897854, 25416956
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0006508	Process	Proteolysis	NAS	2531289
GO:0007165	Process	Signal transduction	IEA
GO:0008083	Function	Growth factor activity	IEA
GO:0008083	Function	Growth factor activity	NAS	2531289
GO:0010507	Process	Negative regulation of autophagy	NAS	24743740
GO:0014856	Process	Skeletal muscle cell proliferation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0022603	Process	Regulation of anatomical structure morphogenesis	IEA
GO:0030335	Process	Positive regulation of cell migration	IDA	21245381
GO:0031093	Component	Platelet alpha granule lumen	TAS
GO:0032715	Process	Negative regulation of interleukin-6 production	IEA
GO:0032733	Process	Positive regulation of interleukin-10 production	IEA
GO:0035729	Process	Cellular response to hepatocyte growth factor stimulus	IDA	21245381
GO:0042056	Function	Chemoattractant activity	IDA	21245381
GO:0042802	Function	Identical protein binding	IPI	17804794, 20624990, 22897854
GO:0043066	Process	Negative regulation of apoptotic process	IBA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	20655899
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0045669	Process	Positive regulation of osteoblast differentiation	NAS	22521434
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	NAS	22521434
GO:0048012	Process	Hepatocyte growth factor receptor signaling pathway	IBA
GO:0048012	Process	Hepatocyte growth factor receptor signaling pathway	IDA	21245381
GO:0048012	Process	Hepatocyte growth factor receptor signaling pathway	IEA
GO:0048513	Process	Animal organ development	IEA
GO:0050673	Process	Epithelial cell proliferation	IEA
GO:0050728	Process	Negative regulation of inflammatory response	IEA
GO:0050918	Process	Positive chemotaxis	IEA
GO:0051239	Process	Regulation of multicellular organismal process	IEA
GO:0051450	Process	Myoblast proliferation	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	20655899
GO:0060326	Process	Cell chemotaxis	IDA	21245381
GO:0060665	Process	Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IDA	14517989
GO:0060665	Process	Regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IEA
GO:0090201	Process	Negative regulation of release of cytochrome c from mitochondria	IDA	20655899
GO:1900744	Process	Regulation of p38MAPK cascade	IEA
GO:1901299	Process	Negative regulation of hydrogen peroxide-mediated programmed cell death	IDA	20655899
GO:1902042	Process	Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IEA
GO:2000573	Process	Positive regulation of DNA biosynthetic process	IDA	2531289

MIM	HGNC	e!Ensembl
142409	4893	ENSG00000019991

P14210

Protein name

Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]

Protein function

Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). Activating ligand for the receptor tyrosine kinase MET by b

PDB

1BHT , 1GMN , 1GMO , 1GP9 , 1NK1 , 1SHY , 1SI5 , 2HGF , 2QJ2 , 3HMS , 3HMT , 3HN4 , 3MKP , 3SP8 , 4D3C , 4K3J , 4O3T , 4O3U , 5COE , 5CP9 , 5CS1 , 5CS3 , 5CS5 , 5CS9 , 5CSQ , 5CT1 , 5CT2 , 5CT3 , 7MO7 , 7MO8 , 7MO9 , 7MOA , 7MOB , 7OCL , 7OCM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00024	PAN_1	40 → 124	PAN domain	Domain
PF00051	Kringle	211 → 288	Kringle domain	Domain
PF00051	Kringle	305 → 383	Kringle domain	Domain
PF00051	Kringle	128 → 206	Kringle domain	Domain
PF00051	Kringle	391 → 469	Kringle domain	Domain
PF00089	Trypsin	495 → 716	Trypsin	Domain

Sequence

MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIK
TKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYE
NKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNP
RGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTP
HRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPL
ETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGS
ESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNME
DLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNL
DHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRD
LKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLP
NYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAG
AEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKII
LTYKVPQS

Sequence length

728

Interactions

View interactions

KEGG Pathway	Reactome Pathway
EGFR tyrosine kinase inhibitor resistance	Platelet degranulation
MAPK signaling pathway	PIP3 activates AKT signaling
Ras signaling pathway	Constitutive Signaling by Aberrant PI3K in Cancer
Rap1 signaling pathway	RAF/MAP kinase cascade
Calcium signaling pathway	Interleukin-4 and Interleukin-13 signaling
PI3K-Akt signaling pathway	MET Receptor Activation
Focal adhesion	Negative regulation of MET activity
Malaria	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Pathways in cancer	MET activates RAS signaling
Proteoglycans in cancer	MET activates PI3K/AKT signaling
Chemical carcinogenesis - reactive oxygen species	MET activates PTPN11
Renal cell carcinoma	MET activates PTK2 signaling
Melanoma	MET interacts with TNS proteins
Non-small cell lung cancer	MET activates RAP1 and RAC1
Hepatocellular carcinoma	MET receptor recycling
Gastric cancer	MET activates STAT3

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Autosomal recessive nonsyndromic hearing loss 39	Pathogenic	rs137853235, rs1788701297, rs900334407	RCV000016089 RCV000016090 RCV000016091	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Sensorineural hearing loss disorder	Pathogenic	rs1788701297	RCV005420504	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (51)
ANGLE CLOSURE GLAUCOMA	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA	—	CTD	11223164	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	CTD	35663546	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL RECESSIVE ISOLATED SENSORINEURAL DEAFNESS TYPE DFNB	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BARRETT ESOPHAGUS	—	CTD, Disgenet CTD, Disgenet	15387324	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	11896611, 9932610	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, SQUAMOUS CELL	—	CTD	21273587	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHIES	—	CTD, Disgenet CTD, Disgenet	16109756, 18083897	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COPPER-OVERLOAD CIRRHOSIS	—	CTD, Disgenet CTD, Disgenet	22879914	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 39	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	19576567	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEUROPATHIES	—	CTD, Disgenet CTD, Disgenet	26000320	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	22179738, 32238385	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GRAFT-VS-HOST DISEASE	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hearing impairment	Uncertain significance	ClinVar Disgenet	—	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
HEARING LOSS, AUTOSOMAL RECESSIVE	—	Disgenet	20301607, 24148127	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HGF-related disorder	Uncertain significance; Conflicting classifications of pathogenicity; Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERBILIRUBINEMIA	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERBILIRUBINEMIA, HEREDITARY	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSIVE DISEASE	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATOCONUS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKEMIA, MYELOID, ACUTE	—	CTD	22683780	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS	—	CTD, Disgenet CTD, Disgenet	17097021	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER FAILURE, ACUTE	—	CTD, Disgenet CTD, Disgenet	12479984	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS	—	CTD	8807143	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG DISEASES, INTERSTITIAL	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MESOTHELIOMA, MALIGNANT	—	CTD	25162674	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE MYELOMA	—	GWAS catalog	30213928	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	12447174	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOPIA	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROBLASTOMA	—	CTD	16051641	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
nonsyndromic genetic hearing loss	—	ClinGen	ClinGen report	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonsyndromic Hearing Loss, Mixed	Conflicting classifications of pathogenicity; Uncertain significance; Likely benign; Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	36810956	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATITIS	—	CTD, Disgenet CTD, Disgenet	14751415	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	CTD, Disgenet CTD, Disgenet	16791285	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY CARDIOMYOPATHY	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	37945903	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	37945903	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PULMONARY FIBROSIS	—	CTD, Disgenet CTD, Disgenet	16324872	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS OF BILATERAL EARS	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC SCLERODERMA	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THROMBOSIS	—	CTD	15367830	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VASCULAR DISEASES	—	CTD, Disgenet CTD, Disgenet	15071489	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VITILIGO	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
MET	8	["Myeloid leukemia","Isolated sensorineural deafness","Nonsyndromic hearing loss","Copper overload cirrhosis","Deafness","Mesothelioma","Neuroblastoma","nonsyndromic genetic hearing loss"]	28	["EGFR tyrosine kinase inhibitor resistance","MAPK signaling pathway","Ras signaling pathway","Rap1 signaling pathway","Calcium signaling pathway","Focal adhesion","Malaria","Proteoglycans in cancer","Chemical carcinogenesis - reactive oxygen species","Renal cell carcinoma","Melanoma","Non-small cell lung cancer"]	14	["CTD (Astrocytoma)","Disgenet (Isolated sensorineural deafness)","Disgenet (Nonsyndromic hearing loss)","CTD (Squamous cell carcinoma)","CTD (Copper overload cirrhosis)","Disgenet (Copper overload cirrhosis)","CTD (Deafness)","Disgenet (Deafness)","HPO (Deafness)","Disgenet (Hearing loss)","CTD (Myeloid leukemia)","CTD (Mesothelioma)"]
KITLG	4	["Isolated sensorineural deafness","Nonsyndromic hearing loss","Deafness","nonsyndromic genetic hearing loss"]	7	["MAPK signaling pathway","Ras signaling pathway","Rap1 signaling pathway","PIP3 activates AKT signaling","RAF\/MAP kinase cascade","Constitutive Signaling by Aberrant PI3K in Cancer","PI5P, PP2A and IER3 Regulate PI3K\/AKT Signaling"]	9	["Disgenet (Isolated sensorineural deafness)","Disgenet (Nonsyndromic hearing loss)","CTD (Nonsyndromic hearing loss)","ClinVar (Nonsyndromic hearing loss)","CTD (Deafness)","Disgenet (Deafness)","HPO (Deafness)","CTD (Myocardial ischemia)","ClinGen (nonsyndromic genetic hearing loss)"]
KCNQ4	5	["Isolated sensorineural deafness","Nonsyndromic hearing loss","Deafness","Hereditary hearing loss","nonsyndromic genetic hearing loss"]	0	[]	9	["Disgenet (Isolated sensorineural deafness)","Disgenet (Nonsyndromic hearing loss)","ClinVar (Nonsyndromic hearing loss)","CTD (Deafness)","Disgenet (Deafness)","HPO (Deafness)","Disgenet (Hearing loss)","ClinVar (Hereditary hearing loss)","ClinGen (nonsyndromic genetic hearing loss)"]
ESRRB	5	["Isolated sensorineural deafness","Nonsyndromic hearing loss","Deafness","Hereditary hearing loss","nonsyndromic genetic hearing loss"]	0	[]	9	["Disgenet (Isolated sensorineural deafness)","Disgenet (Nonsyndromic hearing loss)","ClinVar (Nonsyndromic hearing loss)","CTD (Deafness)","Disgenet (Deafness)","HPO (Deafness)","Disgenet (Hearing loss)","ClinVar (Hereditary hearing loss)","ClinGen (nonsyndromic genetic hearing loss)"]
MYO3A	5	["Isolated sensorineural deafness","Nonsyndromic hearing loss","Deafness","Hereditary hearing loss","nonsyndromic genetic hearing loss"]	0	[]	9	["Disgenet (Isolated sensorineural deafness)","Disgenet (Nonsyndromic hearing loss)","ClinVar (Nonsyndromic hearing loss)","CTD (Deafness)","Disgenet (Deafness)","HPO (Deafness)","Disgenet (Hearing loss)","ClinVar (Hereditary hearing loss)","ClinGen (nonsyndromic genetic hearing loss)"]

HGF (hepatocyte growth factor)

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