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Gene Gene information from NCBI Gene database.
Entrez ID 1869
Gene name E2F transcription factor 1
Gene symbol E2F1
Synonyms (NCBI Gene)
E2F-1RBAP1RBBP3RBP3
Chromosome 20
Chromosome location 20q11.22
Summary The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DN
miRNA miRNA information provided by mirtarbase database.
326 Show/Hide all (326)
miRTarBase ID miRNA Experiments Reference
MIRT003045 hsa-miR-106b-5p Luciferase reporter assay 18676839
MIRT003045 hsa-miR-106b-5p qRT-PCR 18676839
MIRT001191 hsa-miR-21-5p qRT-PCRWestern blot 19906824
MIRT001124 hsa-miR-98-5p Luciferase reporter assay 19528081
MIRT001191 hsa-miR-21-5p Luciferase reporter assay 19528081
Transcription factors Transcription factors information provided by TRRUST V2 database.
35 Show/Hide all (35)
Transcription factor Regulation Reference
ARID3A Unknown 23659165
E2F1 Unknown 7958836
E2F6 Repression 18562691
E2F7 Repression 18202719
E2F8 Repression 18202719
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
81 Show/Hide all (81)
GO ID Ontology Definition Evidence Reference
GO:0000077 Process DNA damage checkpoint signaling IMP 12717439
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 20224733
GO:0000228 Component Nuclear chromosome IEA
GO:0000785 Component Chromatin IDA 21454377
GO:0000785 Component Chromatin IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
189971 3113 ENSG00000101412
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q01094
Protein name Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)
Protein function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication
PDB 1H24 , 1O9K , 2AZE , 5M9N , 5M9O , 6G0P , 6ULS , 9CB3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02319 E2F_TDP 128 → 192 E2F/DP family winged-helix DNA-binding domain Domain
PF16421 E2F_CC-MB 206 → 299 E2F transcription factor CC-MB domain Domain
Sequence
MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCD
PDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVK
SPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLI
AKKSKNHIQWLG
SHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDS
QRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCP
E
ETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLS
RMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEG
IRDLFDCDFGDLTPLDF
Sequence length 437
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Endocrine resistance Activation of NOXA and translocation to mitochondria
Cell cycle Transcription of E2F targets under negative control by DREAM complex
Mitophagy - animal Activation of PUMA and translocation to mitochondria
Cellular senescence Pre-NOTCH Transcription and Translation
Cushing syndrome Oxidative Stress Induced Senescence
Hepatitis C Oncogene Induced Senescence
Hepatitis B TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Human cytomegalovirus infection CDC6 association with the ORC:origin complex
Human papillomavirus infection G2 Phase
Human T-cell leukemia virus 1 infection Cyclin E associated events during G1/S transition
Kaposi sarcoma-associated herpesvirus infection G1/S-Specific Transcription
Epstein-Barr virus infection Cyclin D associated events in G1
Pathways in cancer Cyclin A:Cdk2-associated events at S phase entry
MicroRNAs in cancer Transcriptional Regulation by E2F6
Chemical carcinogenesis - receptor activation Transcriptional regulation of granulopoiesis
Pancreatic cancer  
Glioma  
Prostate cancer  
Melanoma  
Bladder cancer  
Chronic myeloid leukemia  
Small cell lung cancer  
Non-small cell lung cancer  
Breast cancer  
Hepatocellular carcinoma  
Gastric cancer  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (11)
Phenotype Name Clinical Significance Source Reference Evidence Score
Acute myeloid leukemia Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS — CTD 14672398
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR — CTD 12029619, 15565109, 28284560
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, NON-SMALL-CELL LUNG — CTD 29754146
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
E2F1-related disorder Likely benign; Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (337)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acromegaly Acromegaly BEFREE 31828584
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Erythroblastic Leukemia Erythroblastic Leukemia BEFREE 7774910
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 26239033, 29768346
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute monocytic leukemia Monocytic Leukemia BEFREE 24516045
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 30914194
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 10713684, 15221933, 23745020
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 15517914, 16052233
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of colon Adenocarcinoma Of Colon BEFREE 30362161
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 23745020
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 16052233, 24341432, 24691991, 25174355, 31071530, 31194977
★★★★★
★☆☆☆☆
Found in Text Mining only