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Gene Gene information from NCBI Gene database.
Entrez ID 1870
Gene name E2F transcription factor 2
Gene symbol E2F2
Synonyms (NCBI Gene)
E2F-2
Chromosome 1
Chromosome location 1p36.12
Summary The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DN
miRNA miRNA information provided by mirtarbase database.
787 Show/Hide all (787)
miRTarBase ID miRNA Experiments Reference
MIRT001126 hsa-miR-98-5p Northern blot 19528081
MIRT001126 hsa-miR-98-5p Western blot 19528081
MIRT001126 hsa-miR-98-5p qRT-PCR 19528081
MIRT001126 hsa-miR-98-5p ChIP 19528081
MIRT001126 hsa-miR-98-5p Luciferase reporter assay 19528081
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
RB1 Repression 9671466
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35 Show/Hide all (35)
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000977 Function RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA 7739537
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600426 3114 ENSG00000007968
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14209
Protein name Transcription factor E2F2 (E2F-2)
Protein function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication
PDB 1N4M
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02319 E2F_TDP 130 → 194 E2F/DP family winged-helix DNA-binding domain Domain
PF16421 E2F_CC-MB 210 → 304 E2F transcription factor CC-MB domain Domain
Tissue specificity TISSUE SPECIFICITY: Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.
Sequence
MLQGPRALASAAGQTPKVVPAMSPTELWPSGLSSPQLCPATATYYTPLYPQTAPPAAAPG
TCLDATPHGPEGQVVRCLPAGRLPAKRKLDLEGIGRPVVPEFPTPKGKCIRVDGLPSPKT
PKSPGEKTRYDTSLGLLTKKFIYLLSESEDGVLDLNWAAEVLDVQKRRIYDITNVLEGIQ
LIRKKAKNNIQWVG
RGMFEDPTRPGKQQQLGQELKELMNTEQALDQLIQSCSLSFKHLTE
DKANKRLAYVTYQDIRAVGNFKEQTVIAVKAPPQTRLEVPDRTEDNLQIYLKSTQGPIEV
YLCP
EEVQEPDSPSEEPLPSTSTLCPSPDSAQPSSSTDPSIMEPTASSVPAPAPTPQQAP
PPPSLVPLEATDSLLELPHPLLQQTEDQFLSPTLACSSPLISFSPSLDQDDYLWGLEAGE
GISDLFDSYDLGDLLIN
Sequence length 437
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Endocrine resistance Oxidative Stress Induced Senescence
Cell cycle Oncogene Induced Senescence
Cellular senescence CDC6 association with the ORC:origin complex
Cushing syndrome Cyclin D associated events in G1
Hepatitis C  
Hepatitis B  
Human cytomegalovirus infection  
Human T-cell leukemia virus 1 infection  
Kaposi sarcoma-associated herpesvirus infection  
Epstein-Barr virus infection  
Pathways in cancer  
MicroRNAs in cancer  
Pancreatic cancer  
Glioma  
Prostate cancer  
Melanoma  
Bladder cancer  
Chronic myeloid leukemia  
Small cell lung cancer  
Non-small cell lung cancer  
Breast cancer  
Hepatocellular carcinoma  
Gastric cancer  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
CARCINOMA, NON-SMALL-CELL LUNG — CTD 29754146
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OROPHARYNX CANCER — GWAS catalog 34642315
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (85)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 29072692
★★★★★
★☆☆☆☆
Found in Text Mining only
Age related macular degeneration Age-related macular degeneration BEFREE 29188796
★★★★★
★☆☆☆☆
Found in Text Mining only
Anemia Anemia BEFREE 27795297
★★★★★
★☆☆☆☆
Found in Text Mining only
Ankylosing spondylitis Ankylosing Spondylitis BEFREE 24397353
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 24397353 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 29422529, 33952803 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Ataxia Telangiectasia Ataxia telangiectasia Pubtator 40579780 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases BEFREE 11754817
★★★★★
★☆☆☆☆
Found in Text Mining only
Bloom Syndrome Bloom syndrome Pubtator 32073752 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain neoplasms Pubtator 33381564 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only