CCL4 (C-C motif chemokine ligand 4)

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Gene Gene information from NCBI Gene database.
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Entrez ID 6351
Gene name C-C motif chemokine ligand 4
Gene symbol CCL4
Synonyms (NCBI Gene)
ACT2AT744.1G-26HC21LAG-1LAG1MIP-1-betaMIP1BMIP1B1SCYA2SCYA4
Chromosome 17
Chromosome location 17q12
Summary The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]
miRNA miRNA information provided by mirtarbase database.
1
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miRTarBase ID miRNA Experiments Reference
MIRT004669 hsa-miR-195-5p ELISAImmunoprecipitaionqRT-PCRWestern blot 20952681
Transcription factors Transcription factors information provided by TRRUST V2 database.
3
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Transcription factor Regulation Reference
CREM Repression 16443828
NFKB1 Unknown 11342414
RELA Unknown 11342414
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
35 Show/Hide all (35)
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GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IEA
GO:0005125 Function Cytokine activity TAS 2462251
GO:0005515 Function Protein binding IPI 23597562, 25416956, 31515488, 32296183
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
182284 10630 ENSG00000275302
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Cytokine-cytokine receptor interaction Chemokine receptors bind chemokines
Viral protein interaction with cytokine and cytokine receptor G alpha (i) signalling events
Chemokine signaling pathway Interleukin-10 signaling
NF-kappa B signaling pathway  
Toll-like receptor signaling pathway  
Cytosolic DNA-sensing pathway  
Human cytomegalovirus infection  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (10)
Phenotype Name Clinical Significance Source Reference Evidence Score
ATHEROSCLEROSIS — CTD, Disgenet
CTD, Disgenet 		24370436
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRAIN ISCHEMIA — CTD, Disgenet
CTD, Disgenet 		15829914
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER — GWAS catalog 37359372
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DERMATOLOGIC DISORDERS — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GLOMERULONEPHRITIS — CTD, Disgenet
CTD, Disgenet 		10385480
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (285)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 30940905
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 31385574
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 29722145
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 12901792
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 30940905
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Hodgkin Lymphoma Hodgkin Lymphoma BEFREE 27632954
★★★★★
★☆☆☆☆
Found in Text Mining only
Alveolitis, Fibrosing Alveolitis CTD_human_DG 17720292
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 32171317, 9665462 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 29029824
★★★★★
★☆☆☆☆
Found in Text Mining only
Anal carcinoma Anal Cancer BEFREE 28834078
★★★★★
★☆☆☆☆
Found in Text Mining only
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CCL3 5 shared diseasesAtherosclerosis, Brain ischemia, Glomerulonephritis, Hypersensitivity, Pulmonary fibrosis 7 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway, Human cytomegalovirus infection, Chemokine receptors bind chemokines, Interleukin-10 signaling 10 shared evidence sourcesCTD (Atherosclerosis), Disgenet (Atherosclerosis), CTD (Brain ischemia), Disgenet (Brain ischemia), Disgenet (Glomerulonephritis), CTD (Glomerulonephritis), CTD (Hypersensitivity), CTD (Myocardial ischemia), CTD (Pulmonary fibrosis), Disgenet (Pulmonary fibrosis) Related via 7 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor — evidence mostly CTD. CCL11 3 shared diseasesBrain ischemia, Hypersensitivity, Pulmonary fibrosis 4 shared pathwaysCytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Chemokine receptors bind chemokines 5 shared evidence sourcesCTD (Brain ischemia), Disgenet (Brain ischemia), CTD (Hypersensitivity), CTD (Pulmonary fibrosis), Disgenet (Pulmonary fibrosis) Related via 4 shared pathways including Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor — evidence mostly CTD. SKIL 3 shared diseasesDermatologic disorder, Pulmonary fibrosis, Skin disease 5 shared evidence sourcesDisgenet (Dermatologic disorder), CTD (Pulmonary fibrosis), Disgenet (Pulmonary fibrosis), CTD (Skin disease), Disgenet (Skin disease) Related via 3 shared diseases including Dermatologic disorder, Pulmonary fibrosis — evidence mostly Disgenet. HSPA1B 5 shared diseasesAtherosclerosis, Brain ischemia, Dermatologic disorder, Pulmonary fibrosis, Skin disease 8 shared evidence sourcesCTD (Atherosclerosis), Disgenet (Atherosclerosis), Disgenet (Brain ischemia), Disgenet (Dermatologic disorder), CTD (Pulmonary fibrosis), Disgenet (Pulmonary fibrosis), CTD (Skin disease), Disgenet (Skin disease) Related via 5 shared diseases including Atherosclerosis, Brain ischemia — evidence mostly Disgenet. PTX3 3 shared diseasesDermatologic disorder, Pulmonary fibrosis, Skin disease 5 shared evidence sourcesDisgenet (Dermatologic disorder), CTD (Pulmonary fibrosis), Disgenet (Pulmonary fibrosis), CTD (Skin disease), Disgenet (Skin disease) Related via 3 shared diseases including Dermatologic disorder, Pulmonary fibrosis — evidence mostly Disgenet.
Major depressive disorder Linked via 2 of 5 related genesHSPA1B, PTX3 Depression Linked via 2 of 5 related genesHSPA1B, PTX3 Hepatocellular carcinoma Linked via 1 of 5 related genesCCL3 Colonic neoplasms Linked via 1 of 5 related genesCCL3 Mesothelioma Linked via 1 of 5 related genesCCL3