Gene Gene information from NCBI Gene database.
Entrez ID 3440
Gene name Interferon alpha 2
Gene symbol IFNA2
Synonyms (NCBI Gene)
IFN-alpha-2IFN-alphaAIFNAIFNA2BleIF A
Chromosome 9
Chromosome location 9p21.3
Summary This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral,
miRNA miRNA information provided by mirtarbase database.
23
miRTarBase ID miRNA Experiments Reference
MIRT736417 hsa-miR-491-3p qRT-PCRFlow cytometry 33679688
MIRT1060630 hsa-miR-103b CLIP-seq
MIRT1060631 hsa-miR-19a CLIP-seq
MIRT1060632 hsa-miR-19b CLIP-seq
MIRT1060633 hsa-miR-203 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
IRF7 Activation 17236232
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IBA
GO:0002286 Process T cell activation involved in immune response IBA
GO:0002312 Process B cell activation involved in immune response IBA
GO:0002323 Process Natural killer cell activation involved in immune response IBA
GO:0005125 Function Cytokine activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
147562 5423 ENSG00000188379
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P01563
Protein name Interferon alpha-2 (IFN-alpha-2) (Interferon alpha-A) (LeIF A)
Protein function Produced by macrophages, IFN-alpha have antiviral activities.
PDB 1ITF , 1RH2 , 2HYM , 2KZ1 , 2LAG , 2LMS , 3S9D , 3SE3 , 4YPG , 4Z5R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00143 Interferon 26 184 Interferon alpha/beta domain Domain
Sequence
Sequence length 188
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
47
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANEMIA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANEMIA, HEMOLYTIC CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANOREXIA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANXIETY DISORDERS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
AA amyloidosis AA amyloidosis BEFREE 21269584
★☆☆☆☆
Found in Text Mining only
Acute Kidney Insufficiency Acute Kidney Insufficiency CTD_human_DG 12810204
★☆☆☆☆
Found in Text Mining only
Acute leukemia Leukemia BEFREE 31628525
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 10697627, 7775254
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 21338646
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 7775254
★☆☆☆☆
Found in Text Mining only
Adult Hodgkin Lymphoma Hodgkin Lymphoma CTD_human_DG 16170182
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia CTD_human_DG 12560223, 17077332
★☆☆☆☆
Found in Text Mining only
Anemia Anemia CTD_human_DG 11981781, 12620292, 16557544, 1670585, 8886046
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Anemia Anemia BEFREE 21681410, 22570109
★★☆☆☆
Found in Text Mining + Unknown/Other Associations