IDH1 (isocitrate dehydrogenase (NADP(+)) 1)

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Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 3417
• Gene name: Isocitrate dehydrogenase (NADP(+)) 1
• Gene symbol: IDH1
• Synonyms (NCBI Gene): HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD
• Chromosome: 2
• Chromosome location: 2q34
• Summary: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs121913499	G>A,C,T	Likely-pathogenic, pathogenic	Coding sequence variant, missense variant
rs121913500	C>A,G,T	Likely-pathogenic, not-provided, pathogenic	Coding sequence variant, missense variant

miRNA Show/Hide all (414)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005125	hsa-miR-30a-5p	pSILAC	18668040
MIRT017645	hsa-miR-335-5p	Microarray	18185580
MIRT005125	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT036500	hsa-miR-1226-3p	CLASH	23622248
MIRT054822	hsa-miR-30c-5p	qRT-PCR, Western blot	24623846
MIRT1059154	hsa-miR-1253	CLIP-seq
MIRT1059155	hsa-miR-1255a	CLIP-seq
MIRT1059156	hsa-miR-1255b	CLIP-seq
MIRT1059157	hsa-miR-133a	CLIP-seq
MIRT1059158	hsa-miR-133b	CLIP-seq
MIRT1059159	hsa-miR-137	CLIP-seq
MIRT1059160	hsa-miR-144	CLIP-seq
MIRT1059161	hsa-miR-1539	CLIP-seq
MIRT1059162	hsa-miR-181a	CLIP-seq
MIRT1059163	hsa-miR-181b	CLIP-seq
MIRT1059164	hsa-miR-181c	CLIP-seq
MIRT1059165	hsa-miR-181d	CLIP-seq
MIRT1059166	hsa-miR-1911	CLIP-seq
MIRT1059167	hsa-miR-194	CLIP-seq
MIRT1059168	hsa-miR-1972	CLIP-seq
MIRT1059169	hsa-miR-1976	CLIP-seq
MIRT1059170	hsa-miR-2114	CLIP-seq
MIRT1059171	hsa-miR-219-1-3p	CLIP-seq
MIRT1059172	hsa-miR-25	CLIP-seq
MIRT1059173	hsa-miR-2682	CLIP-seq
MIRT1059174	hsa-miR-28-3p	CLIP-seq
MIRT1059175	hsa-miR-298	CLIP-seq
MIRT1059176	hsa-miR-3146	CLIP-seq
MIRT1059177	hsa-miR-3152-5p	CLIP-seq
MIRT1059178	hsa-miR-3193	CLIP-seq
MIRT1059179	hsa-miR-32	CLIP-seq
MIRT1059180	hsa-miR-323-3p	CLIP-seq
MIRT1059181	hsa-miR-34a	CLIP-seq
MIRT1059182	hsa-miR-34c-5p	CLIP-seq
MIRT1059183	hsa-miR-3609	CLIP-seq
MIRT1059184	hsa-miR-3613-3p	CLIP-seq
MIRT1059185	hsa-miR-3614-5p	CLIP-seq
MIRT1059186	hsa-miR-362-5p	CLIP-seq
MIRT1059187	hsa-miR-363	CLIP-seq
MIRT1059188	hsa-miR-3659	CLIP-seq
MIRT1059189	hsa-miR-3662	CLIP-seq
MIRT1059190	hsa-miR-367	CLIP-seq
MIRT1059191	hsa-miR-3688-5p	CLIP-seq
MIRT1059192	hsa-miR-3714	CLIP-seq
MIRT1059193	hsa-miR-374a	CLIP-seq
MIRT1059194	hsa-miR-374b	CLIP-seq
MIRT1059195	hsa-miR-384	CLIP-seq
MIRT1059196	hsa-miR-3929	CLIP-seq
MIRT1059197	hsa-miR-3978	CLIP-seq
MIRT1059198	hsa-miR-421	CLIP-seq
MIRT1059199	hsa-miR-4251	CLIP-seq
MIRT1059200	hsa-miR-4255	CLIP-seq
MIRT1059201	hsa-miR-4261	CLIP-seq
MIRT1059202	hsa-miR-4262	CLIP-seq
MIRT1059203	hsa-miR-4291	CLIP-seq
MIRT1059204	hsa-miR-4303	CLIP-seq
MIRT1059205	hsa-miR-4325	CLIP-seq
MIRT1059206	hsa-miR-4329	CLIP-seq
MIRT1059207	hsa-miR-4418	CLIP-seq
MIRT1059208	hsa-miR-4419b	CLIP-seq
MIRT1059209	hsa-miR-4433	CLIP-seq
MIRT1059210	hsa-miR-4434	CLIP-seq
MIRT1059211	hsa-miR-4459	CLIP-seq
MIRT1059212	hsa-miR-4474-5p	CLIP-seq
MIRT1059213	hsa-miR-4478	CLIP-seq
MIRT1059214	hsa-miR-449a	CLIP-seq
MIRT1059215	hsa-miR-449b	CLIP-seq
MIRT1059216	hsa-miR-449c	CLIP-seq
MIRT1059217	hsa-miR-4516	CLIP-seq
MIRT1059218	hsa-miR-4530	CLIP-seq
MIRT1059219	hsa-miR-4637	CLIP-seq
MIRT1059220	hsa-miR-4645-3p	CLIP-seq
MIRT1059221	hsa-miR-4658	CLIP-seq
MIRT1059222	hsa-miR-4659a-5p	CLIP-seq
MIRT1059223	hsa-miR-4659b-5p	CLIP-seq
MIRT1059224	hsa-miR-4662a-3p	CLIP-seq
MIRT1059225	hsa-miR-4668-3p	CLIP-seq
MIRT1059226	hsa-miR-4709-5p	CLIP-seq
MIRT1059227	hsa-miR-4716-5p	CLIP-seq
MIRT1059228	hsa-miR-4719	CLIP-seq
MIRT1059229	hsa-miR-4729	CLIP-seq
MIRT1059230	hsa-miR-4747-5p	CLIP-seq
MIRT1059231	hsa-miR-4758-5p	CLIP-seq
MIRT1059232	hsa-miR-4762-3p	CLIP-seq
MIRT1059233	hsa-miR-4768-3p	CLIP-seq
MIRT1059234	hsa-miR-4773	CLIP-seq
MIRT1059235	hsa-miR-4774-3p	CLIP-seq
MIRT1059236	hsa-miR-4776-3p	CLIP-seq
MIRT1059237	hsa-miR-4780	CLIP-seq
MIRT1059238	hsa-miR-483-3p	CLIP-seq
MIRT1059239	hsa-miR-491-3p	CLIP-seq
MIRT1059240	hsa-miR-494	CLIP-seq
MIRT1059241	hsa-miR-500b	CLIP-seq
MIRT1059242	hsa-miR-501-5p	CLIP-seq
MIRT1059243	hsa-miR-509-3-5p	CLIP-seq
MIRT1059244	hsa-miR-509-5p	CLIP-seq
MIRT1059245	hsa-miR-513b	CLIP-seq
MIRT1059246	hsa-miR-520d-5p	CLIP-seq
MIRT1059247	hsa-miR-524-5p	CLIP-seq
MIRT1059248	hsa-miR-539	CLIP-seq
MIRT1059249	hsa-miR-542-3p	CLIP-seq
MIRT1059250	hsa-miR-543	CLIP-seq
MIRT1059251	hsa-miR-545	CLIP-seq
MIRT1059252	hsa-miR-548ah	CLIP-seq
MIRT1059253	hsa-miR-548t	CLIP-seq
MIRT1059254	hsa-miR-571	CLIP-seq
MIRT1059255	hsa-miR-574-5p	CLIP-seq
MIRT1059256	hsa-miR-586	CLIP-seq
MIRT1059257	hsa-miR-623	CLIP-seq
MIRT1059258	hsa-miR-645	CLIP-seq
MIRT1059259	hsa-miR-889	CLIP-seq
MIRT1059260	hsa-miR-890	CLIP-seq
MIRT1059261	hsa-miR-922	CLIP-seq
MIRT1059262	hsa-miR-92a	CLIP-seq
MIRT1059263	hsa-miR-92b	CLIP-seq
MIRT1059154	hsa-miR-1253	CLIP-seq
MIRT1059155	hsa-miR-1255a	CLIP-seq
MIRT1059156	hsa-miR-1255b	CLIP-seq
MIRT1059160	hsa-miR-144	CLIP-seq
MIRT1059162	hsa-miR-181a	CLIP-seq
MIRT1059163	hsa-miR-181b	CLIP-seq
MIRT1059164	hsa-miR-181c	CLIP-seq
MIRT1059165	hsa-miR-181d	CLIP-seq
MIRT2013812	hsa-miR-1914	CLIP-seq
MIRT1059168	hsa-miR-1972	CLIP-seq
MIRT2013813	hsa-miR-23a	CLIP-seq
MIRT2013814	hsa-miR-23b	CLIP-seq
MIRT2013815	hsa-miR-23c	CLIP-seq
MIRT1059173	hsa-miR-2682	CLIP-seq
MIRT1059175	hsa-miR-298	CLIP-seq
MIRT2013816	hsa-miR-30a	CLIP-seq
MIRT2013817	hsa-miR-30b	CLIP-seq
MIRT2013818	hsa-miR-30c	CLIP-seq
MIRT2013819	hsa-miR-30d	CLIP-seq
MIRT2013820	hsa-miR-30e	CLIP-seq
MIRT1059176	hsa-miR-3146	CLIP-seq
MIRT2013821	hsa-miR-3163	CLIP-seq
MIRT2013822	hsa-miR-339-5p	CLIP-seq
MIRT1059181	hsa-miR-34a	CLIP-seq
MIRT1059182	hsa-miR-34c-5p	CLIP-seq
MIRT1059189	hsa-miR-3662	CLIP-seq
MIRT2013823	hsa-miR-3684	CLIP-seq
MIRT1059192	hsa-miR-3714	CLIP-seq
MIRT2013824	hsa-miR-3974	CLIP-seq
MIRT1059197	hsa-miR-3978	CLIP-seq
MIRT2013825	hsa-miR-410	CLIP-seq
MIRT1059198	hsa-miR-421	CLIP-seq
MIRT1059199	hsa-miR-4251	CLIP-seq
MIRT1059200	hsa-miR-4255	CLIP-seq
MIRT1059201	hsa-miR-4261	CLIP-seq
MIRT1059202	hsa-miR-4262	CLIP-seq
MIRT2013826	hsa-miR-4271	CLIP-seq
MIRT1059203	hsa-miR-4291	CLIP-seq
MIRT1059204	hsa-miR-4303	CLIP-seq
MIRT1059205	hsa-miR-4325	CLIP-seq
MIRT1059206	hsa-miR-4329	CLIP-seq
MIRT1059207	hsa-miR-4418	CLIP-seq
MIRT1059209	hsa-miR-4433	CLIP-seq
MIRT1059210	hsa-miR-4434	CLIP-seq
MIRT1059211	hsa-miR-4459	CLIP-seq
MIRT1059212	hsa-miR-4474-5p	CLIP-seq
MIRT2013827	hsa-miR-4495	CLIP-seq
MIRT1059214	hsa-miR-449a	CLIP-seq
MIRT1059215	hsa-miR-449b	CLIP-seq
MIRT1059216	hsa-miR-449c	CLIP-seq
MIRT1059217	hsa-miR-4516	CLIP-seq
MIRT2013828	hsa-miR-4520a-3p	CLIP-seq
MIRT1059218	hsa-miR-4530	CLIP-seq
MIRT1059224	hsa-miR-4662a-3p	CLIP-seq
MIRT1059225	hsa-miR-4668-3p	CLIP-seq
MIRT1059226	hsa-miR-4709-5p	CLIP-seq
MIRT2013829	hsa-miR-4725-3p	CLIP-seq
MIRT1059229	hsa-miR-4729	CLIP-seq
MIRT1059230	hsa-miR-4747-5p	CLIP-seq
MIRT1059232	hsa-miR-4762-3p	CLIP-seq
MIRT1059233	hsa-miR-4768-3p	CLIP-seq
MIRT2013830	hsa-miR-4775	CLIP-seq
MIRT2013831	hsa-miR-4779	CLIP-seq
MIRT2013832	hsa-miR-490-5p	CLIP-seq
MIRT1059240	hsa-miR-494	CLIP-seq
MIRT1059243	hsa-miR-509-3-5p	CLIP-seq
MIRT1059244	hsa-miR-509-5p	CLIP-seq
MIRT1059246	hsa-miR-520d-5p	CLIP-seq
MIRT1059247	hsa-miR-524-5p	CLIP-seq
MIRT1059248	hsa-miR-539	CLIP-seq
MIRT1059250	hsa-miR-543	CLIP-seq
MIRT1059251	hsa-miR-545	CLIP-seq
MIRT2013833	hsa-miR-590-3p	CLIP-seq
MIRT2013834	hsa-miR-649	CLIP-seq
MIRT2013835	hsa-miR-670	CLIP-seq
MIRT1059259	hsa-miR-889	CLIP-seq
MIRT1059261	hsa-miR-922	CLIP-seq
MIRT1059155	hsa-miR-1255a	CLIP-seq
MIRT1059156	hsa-miR-1255b	CLIP-seq
MIRT2245975	hsa-miR-1303	CLIP-seq
MIRT1059157	hsa-miR-133a	CLIP-seq
MIRT1059158	hsa-miR-133b	CLIP-seq
MIRT1059159	hsa-miR-137	CLIP-seq
MIRT2245976	hsa-miR-145	CLIP-seq
MIRT2245977	hsa-miR-155	CLIP-seq
MIRT2245978	hsa-miR-185	CLIP-seq
MIRT1059166	hsa-miR-1911	CLIP-seq
MIRT2013812	hsa-miR-1914	CLIP-seq
MIRT1059167	hsa-miR-194	CLIP-seq
MIRT2245979	hsa-miR-196a	CLIP-seq
MIRT2245980	hsa-miR-196b	CLIP-seq
MIRT2245981	hsa-miR-19a	CLIP-seq
MIRT2245982	hsa-miR-19b	CLIP-seq
MIRT1059171	hsa-miR-219-1-3p	CLIP-seq
MIRT1059172	hsa-miR-25	CLIP-seq
MIRT1059173	hsa-miR-2682	CLIP-seq
MIRT1059175	hsa-miR-298	CLIP-seq
MIRT2013816	hsa-miR-30a	CLIP-seq
MIRT2013817	hsa-miR-30b	CLIP-seq
MIRT2013818	hsa-miR-30c	CLIP-seq
MIRT2013819	hsa-miR-30d	CLIP-seq
MIRT2013820	hsa-miR-30e	CLIP-seq
MIRT1059176	hsa-miR-3146	CLIP-seq
MIRT2013821	hsa-miR-3163	CLIP-seq
MIRT1059179	hsa-miR-32	CLIP-seq
MIRT1059180	hsa-miR-323-3p	CLIP-seq
MIRT2013822	hsa-miR-339-5p	CLIP-seq
MIRT1059181	hsa-miR-34a	CLIP-seq
MIRT1059182	hsa-miR-34c-5p	CLIP-seq
MIRT2245983	hsa-miR-3607-5p	CLIP-seq
MIRT1059183	hsa-miR-3609	CLIP-seq
MIRT1059184	hsa-miR-3613-3p	CLIP-seq
MIRT1059185	hsa-miR-3614-5p	CLIP-seq
MIRT1059186	hsa-miR-362-5p	CLIP-seq
MIRT1059187	hsa-miR-363	CLIP-seq
MIRT1059188	hsa-miR-3659	CLIP-seq
MIRT1059190	hsa-miR-367	CLIP-seq
MIRT1059191	hsa-miR-3688-5p	CLIP-seq
MIRT2245984	hsa-miR-369-3p	CLIP-seq
MIRT1059192	hsa-miR-3714	CLIP-seq
MIRT1059193	hsa-miR-374a	CLIP-seq
MIRT1059194	hsa-miR-374b	CLIP-seq
MIRT2013824	hsa-miR-3974	CLIP-seq
MIRT2013825	hsa-miR-410	CLIP-seq
MIRT2245985	hsa-miR-425	CLIP-seq
MIRT2013826	hsa-miR-4271	CLIP-seq
MIRT2245986	hsa-miR-4306	CLIP-seq
MIRT1059205	hsa-miR-4325	CLIP-seq
MIRT1059211	hsa-miR-4459	CLIP-seq
MIRT2013827	hsa-miR-4495	CLIP-seq
MIRT1059214	hsa-miR-449a	CLIP-seq
MIRT1059215	hsa-miR-449b	CLIP-seq
MIRT1059216	hsa-miR-449c	CLIP-seq
MIRT2013828	hsa-miR-4520a-3p	CLIP-seq
MIRT1059218	hsa-miR-4530	CLIP-seq
MIRT1059219	hsa-miR-4637	CLIP-seq
MIRT2245987	hsa-miR-4644	CLIP-seq
MIRT1059220	hsa-miR-4645-3p	CLIP-seq
MIRT1059221	hsa-miR-4658	CLIP-seq
MIRT1059222	hsa-miR-4659a-5p	CLIP-seq
MIRT1059223	hsa-miR-4659b-5p	CLIP-seq
MIRT2245988	hsa-miR-4694-3p	CLIP-seq
MIRT1059227	hsa-miR-4716-5p	CLIP-seq
MIRT1059228	hsa-miR-4719	CLIP-seq
MIRT2013829	hsa-miR-4725-3p	CLIP-seq
MIRT1059229	hsa-miR-4729	CLIP-seq
MIRT1059230	hsa-miR-4747-5p	CLIP-seq
MIRT1059231	hsa-miR-4758-5p	CLIP-seq
MIRT2245989	hsa-miR-4777-3p	CLIP-seq
MIRT2013831	hsa-miR-4779	CLIP-seq
MIRT1059238	hsa-miR-483-3p	CLIP-seq
MIRT2013832	hsa-miR-490-5p	CLIP-seq
MIRT1059241	hsa-miR-500b	CLIP-seq
MIRT1059242	hsa-miR-501-5p	CLIP-seq
MIRT1059246	hsa-miR-520d-5p	CLIP-seq
MIRT1059247	hsa-miR-524-5p	CLIP-seq
MIRT1059248	hsa-miR-539	CLIP-seq
MIRT1059249	hsa-miR-542-3p	CLIP-seq
MIRT1059252	hsa-miR-548ah	CLIP-seq
MIRT1059253	hsa-miR-548t	CLIP-seq
MIRT1059254	hsa-miR-571	CLIP-seq
MIRT1059255	hsa-miR-574-5p	CLIP-seq
MIRT2013834	hsa-miR-649	CLIP-seq
MIRT2013835	hsa-miR-670	CLIP-seq
MIRT1059260	hsa-miR-890	CLIP-seq
MIRT1059261	hsa-miR-922	CLIP-seq
MIRT1059262	hsa-miR-92a	CLIP-seq
MIRT1059263	hsa-miR-92b	CLIP-seq
MIRT1059159	hsa-miR-137	CLIP-seq
MIRT2013812	hsa-miR-1914	CLIP-seq
MIRT1059171	hsa-miR-219-1-3p	CLIP-seq
MIRT1059180	hsa-miR-323-3p	CLIP-seq
MIRT2013822	hsa-miR-339-5p	CLIP-seq
MIRT2013824	hsa-miR-3974	CLIP-seq
MIRT1059198	hsa-miR-421	CLIP-seq
MIRT1059205	hsa-miR-4325	CLIP-seq
MIRT1059238	hsa-miR-483-3p	CLIP-seq
MIRT2013832	hsa-miR-490-5p	CLIP-seq
MIRT1059254	hsa-miR-571	CLIP-seq
MIRT2013835	hsa-miR-670	CLIP-seq
MIRT2245976	hsa-miR-145	CLIP-seq
MIRT2245977	hsa-miR-155	CLIP-seq
MIRT2245981	hsa-miR-19a	CLIP-seq
MIRT2245982	hsa-miR-19b	CLIP-seq
MIRT2245983	hsa-miR-3607-5p	CLIP-seq
MIRT2013832	hsa-miR-490-5p	CLIP-seq
MIRT2549058	hsa-miR-1321	CLIP-seq
MIRT1059157	hsa-miR-133a	CLIP-seq
MIRT1059158	hsa-miR-133b	CLIP-seq
MIRT2245976	hsa-miR-145	CLIP-seq
MIRT2245977	hsa-miR-155	CLIP-seq
MIRT2013812	hsa-miR-1914	CLIP-seq
MIRT2245981	hsa-miR-19a	CLIP-seq
MIRT2245982	hsa-miR-19b	CLIP-seq
MIRT2549059	hsa-miR-200b	CLIP-seq
MIRT2549060	hsa-miR-200c	CLIP-seq
MIRT1059173	hsa-miR-2682	CLIP-seq
MIRT2549061	hsa-miR-2909	CLIP-seq
MIRT2549062	hsa-miR-3162-5p	CLIP-seq
MIRT2013822	hsa-miR-339-5p	CLIP-seq
MIRT1059181	hsa-miR-34a	CLIP-seq
MIRT1059182	hsa-miR-34c-5p	CLIP-seq
MIRT2245983	hsa-miR-3607-5p	CLIP-seq
MIRT1059192	hsa-miR-3714	CLIP-seq
MIRT1059193	hsa-miR-374a	CLIP-seq
MIRT1059194	hsa-miR-374b	CLIP-seq
MIRT1059195	hsa-miR-384	CLIP-seq
MIRT1059196	hsa-miR-3929	CLIP-seq
MIRT2549063	hsa-miR-3942-5p	CLIP-seq
MIRT2013824	hsa-miR-3974	CLIP-seq
MIRT1059198	hsa-miR-421	CLIP-seq
MIRT2013826	hsa-miR-4271	CLIP-seq
MIRT2549064	hsa-miR-429	CLIP-seq
MIRT1059203	hsa-miR-4291	CLIP-seq
MIRT2549065	hsa-miR-4318	CLIP-seq
MIRT1059207	hsa-miR-4418	CLIP-seq
MIRT1059208	hsa-miR-4419b	CLIP-seq
MIRT1059211	hsa-miR-4459	CLIP-seq
MIRT2549066	hsa-miR-4474-3p	CLIP-seq
MIRT1059213	hsa-miR-4478	CLIP-seq
MIRT2549067	hsa-miR-448	CLIP-seq
MIRT1059214	hsa-miR-449a	CLIP-seq
MIRT1059215	hsa-miR-449b	CLIP-seq
MIRT1059216	hsa-miR-449c	CLIP-seq
MIRT2013828	hsa-miR-4520a-3p	CLIP-seq
MIRT2549068	hsa-miR-4693-5p	CLIP-seq
MIRT2549069	hsa-miR-4703-5p	CLIP-seq
MIRT1059228	hsa-miR-4719	CLIP-seq
MIRT2013829	hsa-miR-4725-3p	CLIP-seq
MIRT1059229	hsa-miR-4729	CLIP-seq
MIRT2549070	hsa-miR-4739	CLIP-seq
MIRT1059230	hsa-miR-4747-5p	CLIP-seq
MIRT2549071	hsa-miR-4756-5p	CLIP-seq
MIRT1059234	hsa-miR-4773	CLIP-seq
MIRT2245989	hsa-miR-4777-3p	CLIP-seq
MIRT2013831	hsa-miR-4779	CLIP-seq
MIRT2013832	hsa-miR-490-5p	CLIP-seq
MIRT1059239	hsa-miR-491-3p	CLIP-seq
MIRT1059243	hsa-miR-509-3-5p	CLIP-seq
MIRT1059244	hsa-miR-509-5p	CLIP-seq
MIRT1059248	hsa-miR-539	CLIP-seq
MIRT1059251	hsa-miR-545	CLIP-seq
MIRT1059256	hsa-miR-586	CLIP-seq
MIRT1059258	hsa-miR-645	CLIP-seq
MIRT2013835	hsa-miR-670	CLIP-seq
MIRT2549072	hsa-miR-892a	CLIP-seq
MIRT2549058	hsa-miR-1321	CLIP-seq
MIRT1059157	hsa-miR-133a	CLIP-seq
MIRT1059158	hsa-miR-133b	CLIP-seq
MIRT2245976	hsa-miR-145	CLIP-seq
MIRT2245977	hsa-miR-155	CLIP-seq
MIRT2013812	hsa-miR-1914	CLIP-seq
MIRT2245981	hsa-miR-19a	CLIP-seq
MIRT2245982	hsa-miR-19b	CLIP-seq
MIRT2549059	hsa-miR-200b	CLIP-seq
MIRT2549060	hsa-miR-200c	CLIP-seq
MIRT1059173	hsa-miR-2682	CLIP-seq
MIRT2549061	hsa-miR-2909	CLIP-seq
MIRT2549062	hsa-miR-3162-5p	CLIP-seq
MIRT2013822	hsa-miR-339-5p	CLIP-seq
MIRT1059181	hsa-miR-34a	CLIP-seq
MIRT1059182	hsa-miR-34c-5p	CLIP-seq
MIRT2245983	hsa-miR-3607-5p	CLIP-seq
MIRT1059192	hsa-miR-3714	CLIP-seq
MIRT1059193	hsa-miR-374a	CLIP-seq
MIRT1059194	hsa-miR-374b	CLIP-seq
MIRT2549063	hsa-miR-3942-5p	CLIP-seq
MIRT2013824	hsa-miR-3974	CLIP-seq
MIRT1059198	hsa-miR-421	CLIP-seq
MIRT2013826	hsa-miR-4271	CLIP-seq
MIRT2549064	hsa-miR-429	CLIP-seq
MIRT2549065	hsa-miR-4318	CLIP-seq
MIRT1059207	hsa-miR-4418	CLIP-seq
MIRT1059211	hsa-miR-4459	CLIP-seq
MIRT2549066	hsa-miR-4474-3p	CLIP-seq
MIRT2549067	hsa-miR-448	CLIP-seq
MIRT1059214	hsa-miR-449a	CLIP-seq
MIRT1059215	hsa-miR-449b	CLIP-seq
MIRT1059216	hsa-miR-449c	CLIP-seq
MIRT2013828	hsa-miR-4520a-3p	CLIP-seq
MIRT2549068	hsa-miR-4693-5p	CLIP-seq
MIRT2549069	hsa-miR-4703-5p	CLIP-seq
MIRT1059228	hsa-miR-4719	CLIP-seq
MIRT2013829	hsa-miR-4725-3p	CLIP-seq
MIRT1059229	hsa-miR-4729	CLIP-seq
MIRT2549070	hsa-miR-4739	CLIP-seq
MIRT1059230	hsa-miR-4747-5p	CLIP-seq
MIRT2549071	hsa-miR-4756-5p	CLIP-seq
MIRT1059234	hsa-miR-4773	CLIP-seq
MIRT2245989	hsa-miR-4777-3p	CLIP-seq
MIRT2013831	hsa-miR-4779	CLIP-seq
MIRT2013832	hsa-miR-490-5p	CLIP-seq
MIRT1059239	hsa-miR-491-3p	CLIP-seq
MIRT1059243	hsa-miR-509-3-5p	CLIP-seq
MIRT1059244	hsa-miR-509-5p	CLIP-seq
MIRT1059248	hsa-miR-539	CLIP-seq
MIRT1059256	hsa-miR-586	CLIP-seq
MIRT2013835	hsa-miR-670	CLIP-seq
MIRT2549072	hsa-miR-892a	CLIP-seq

Gene ontology (GO) Show/Hide all (47)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IDA	19935646
GO:0000287	Function	Magnesium ion binding	IEA
GO:0004450	Function	Isocitrate dehydrogenase (NADP+) activity	IBA
GO:0004450	Function	Isocitrate dehydrogenase (NADP+) activity	IDA	10521434, 19935646, 20171178
GO:0004450	Function	Isocitrate dehydrogenase (NADP+) activity	IEA
GO:0005515	Function	Protein binding	IPI	31983428, 32814053, 35512704
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005777	Component	Peroxisome	IBA
GO:0005777	Component	Peroxisome	IDA	10521434
GO:0005777	Component	Peroxisome	IEA
GO:0005782	Component	Peroxisomal matrix	IEA
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	10521434
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006097	Process	Glyoxylate cycle	IEA
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006102	Process	Isocitrate metabolic process	IBA
GO:0006102	Process	Isocitrate metabolic process	IDA	10521434, 19935646, 20171178
GO:0006102	Process	Isocitrate metabolic process	IEA
GO:0006103	Process	2-oxoglutarate metabolic process	IDA	19935646
GO:0006103	Process	2-oxoglutarate metabolic process	IEA
GO:0006739	Process	NADP+ metabolic process	IBA
GO:0006740	Process	NADPH regeneration	IEA
GO:0006749	Process	Glutathione metabolic process	IEA
GO:0006979	Process	Response to oxidative stress	IEA
GO:0008585	Process	Female gonad development	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0042802	Function	Identical protein binding	IPI	19935646, 21516116, 26436839
GO:0042803	Function	Protein homodimerization activity	IPI	19935646
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0046872	Function	Metal ion binding	IEA
GO:0048545	Process	Response to steroid hormone	IEA
GO:0050661	Function	NADP binding	IEA
GO:0051287	Function	NAD binding	IEA
GO:0060696	Process	Regulation of phospholipid catabolic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0071071	Process	Regulation of phospholipid biosynthetic process	IEA
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 147700
• HGNC: 5382
• e!Ensembl: ENSG00000138413

Protein

• UniProt ID: O75874
• Protein name: Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)
• Protein function: Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays
• PDB: 1T09 , 1T0L , 3INM , 3MAP , 3MAR , 3MAS , 4I3K , 4I3L , 4KZO , 4L03 , 4L04 , 4L06 , 4UMX , 4UMY , 4XRX , 4XS3 , 5DE1 , 5GIR , 5K10 , 5K11 , 5L57 , 5L58 , 5LGE , 5SUN , 5SVF , 5TQH , 5YFM , 5YFN , 6ADG , 6B0Z , 6BKX , 6BKY , 6BKZ , 6BL0 , 6BL1 , 6BL2 , 6IO0 , 6O2Y , 6O2Z , 6PAY , 6Q6F , 6U4J , 6VEI , 6VG0 , 7PJM , 7PJN , 8BAY , 8HB9 , 8T7D , 8T7N , 8T7O
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00180	Iso_dh	9 → 401	Isocitrate/isopropylmalate dehydrogenase	Domain

• Sequence:

  MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
  AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
  VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
  GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
  AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
  KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
  EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL

• Sequence length: 414

Pathways

KEGG Pathway	Reactome Pathway
Citrate cycle (TCA cycle)	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
Glutathione metabolism	NADPH regeneration
Metabolic pathways	Neutrophil degranulation
Carbon metabolism	Peroxisomal protein import
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids
Peroxisome
Central carbon metabolism in cancer

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal Show/Hide Causal Diseases (17)
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Acute myeloid leukemia	Likely pathogenic; Pathogenic	rs121913499	RCV000445302 RCV005900719	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Acute myeloid leukemia with NPM1 somatic mutations	Likely pathogenic; Pathogenic	rs121913500	RCV006253824	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Astrocytoma IDH-mutant	Likely pathogenic; Pathogenic	rs121913500	RCV006253823 RCV006253949	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Cholangiocarcinoma	Pathogenic	rs121913499	RCV005900721	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Enchondromatosis	Likely pathogenic; Pathogenic	rs62193615, rs121913500, rs121913499	RCV002467575 RCV002227447 RCV002227473	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Glioblastoma multiforme, somatic	Likely pathogenic; Pathogenic	rs121913500	RCV000144504	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Glioma susceptibility 1	Likely pathogenic; Pathogenic	rs121913500, rs121913499	RCV001542733 RCV003323531	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hepatocellular carcinoma	Pathogenic	rs121913499	RCV005900720	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Juvenile type testicular granulosa cell tumor	Likely pathogenic; Pathogenic	rs121913499	RCV006253951	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Maffucci syndrome	Likely pathogenic; Pathogenic	rs121913499	RCV002291276	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Medulloblastoma	Likely pathogenic; Pathogenic	rs121913499	RCV006253950	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Medulloblastoma SHH activated	Pathogenic	rs121913499	RCV006253952	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Metaphyseal chondromatosis	Likely pathogenic; Pathogenic	rs121913500	RCV003387509	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria	Likely pathogenic; Pathogenic	rs121913500	RCV000853347	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neoplasm	Likely pathogenic; Pathogenic	rs121913500, rs121913499	RCV004668802 RCV004668920 RCV004668921 RCV005230284	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Oligodendroglioma	Likely pathogenic; Pathogenic	rs121913500	RCV006253822	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Paroxysmal extreme pain disorder	Likely pathogenic	rs2124849065	RCV001647346	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (23)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Adrenocortical carcinoma, hereditary	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANKYLOSING SPONDYLITIS AND OTHER INFLAMMATORY SPONDYLOPATHIES	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	21472284	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHONDROMA	—	CTD	22057234, 25895133	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	-	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DESBUQUOIS SYNDROME	—	CTD	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diffuse midline glioma, H3 K27-altered	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	not provided	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GIANT CELL GLIOBLASTOMA	—	Orphanet	18772396	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	CTD	19901110, 25391653, 25848751, 26618343, 28122345	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOSARCOMA	—	Orphanet	18772396	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IDH1-related disorder	Likely benign; Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKEMIA, MYELOID, ACUTE	—	CTD	25324972, 27992414	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEUKEMIA, PROMYELOCYTIC, ACUTE	—	CTD	26285909	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER FAILURE, ACUTE	—	CTD, Disgenet CTD, Disgenet	35172013	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METAPHYSEAL ENCHONDROMATOSIS WITH D-2-HYDROXYGLUTARIC ACIDURIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	29610475	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (416)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute leukemia	Leukemia	BEFREE	21647154		★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	20538800, 21647154, 22809434, 28544751		★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	20171147, 20376086, 21647152, 21647154, 21873548, 22020636, 22488406, 23365461, 23954893, 25022553, 25651001, 26016821, 26466372, 29439493, 30692099, 31145495, 31348835, 31586149		★☆☆☆☆ Found in Text Mining only
Acute Myeloid Leukemia (AML-M2)	Leukemia	CTD_human_DG	25324972, 27992414		★☆☆☆☆ Found in Text Mining only
Acute Myeloid Leukemia, M1	Myeloid Leukemia	BEFREE	20805365, 21647152		★☆☆☆☆ Found in Text Mining only
Acute Myeloid Leukemia, M1	Myeloid Leukemia	CTD_human_DG	25324972, 27992414		★☆☆☆☆ Found in Text Mining only
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	BEFREE	22397365		★☆☆☆☆ Found in Text Mining only
Acute Promyelocytic Leukemia	Promyelocytic Leukemia	CTD_human_DG	26285909		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	22064513, 25029120		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	CLINVAR_DG	26619011		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

IDH2 5 shared diseasesMyeloid leukemia, Cholangiocarcinoma, Chordoma, Promyelocytic leukemia, Maffucci syndrome 7 shared pathwaysCitrate cycle (TCA cycle), Glutathione metabolism, Carbon metabolism, 2-Oxocarboxylic acid metabolism, Biosynthesis of amino acids, Peroxisome, Central carbon metabolism in cancer 7 shared evidence sourcesCTD (Cholangiocarcinoma), CTD (Chordoma), CTD (Myeloid leukemia), CTD (Promyelocytic leukemia), Disgenet (Maffucci syndrome), Orphanet (Maffucci syndrome), CTD (Oligodendroglioma) Related via 7 shared pathways including Citrate cycle (TCA cycle), Glutathione metabolism — evidence mostly CTD. SEPTIN14 2 shared diseasesGiant cell glioblastoma, Gliosarcoma 2 shared evidence sourcesOrphanet (Giant cell glioblastoma), Orphanet (Gliosarcoma) Related via 2 shared diseases including Giant cell glioblastoma, Gliosarcoma — evidence mostly Orphanet. TACC1 2 shared diseasesGiant cell glioblastoma, Gliosarcoma 2 shared evidence sourcesOrphanet (Giant cell glioblastoma), Orphanet (Gliosarcoma) Related via 2 shared diseases including Giant cell glioblastoma, Gliosarcoma — evidence mostly Orphanet. ROS1 2 shared diseasesCholangiocarcinoma, Giant cell glioblastoma 2 shared evidence sourcesOrphanet (Giant cell glioblastoma), CTD (Glioma) Related via 2 shared diseases including Cholangiocarcinoma, Giant cell glioblastoma — evidence mostly Orphanet. AQP9 2 shared diseasesMyeloid leukemia, Promyelocytic leukemia 2 shared evidence sourcesCTD (Myeloid leukemia), CTD (Promyelocytic leukemia) Related via 2 shared diseases including Myeloid leukemia, Promyelocytic leukemia — evidence mostly CTD.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
IDH2	5	["Myeloid leukemia","Cholangiocarcinoma","Chordoma","Promyelocytic leukemia","Maffucci syndrome"]	7	["Citrate cycle (TCA cycle)","Glutathione metabolism","Carbon metabolism","2-Oxocarboxylic acid metabolism","Biosynthesis of amino acids","Peroxisome","Central carbon metabolism in cancer"]	7	["CTD (Cholangiocarcinoma)","CTD (Chordoma)","CTD (Myeloid leukemia)","CTD (Promyelocytic leukemia)","Disgenet (Maffucci syndrome)","Orphanet (Maffucci syndrome)","CTD (Oligodendroglioma)"]
SEPTIN14	2	["Giant cell glioblastoma","Gliosarcoma"]	0	[]	2	["Orphanet (Giant cell glioblastoma)","Orphanet (Gliosarcoma)"]
TACC1	2	["Giant cell glioblastoma","Gliosarcoma"]	0	[]	2	["Orphanet (Giant cell glioblastoma)","Orphanet (Gliosarcoma)"]
ROS1	2	["Cholangiocarcinoma","Giant cell glioblastoma"]	0	[]	2	["Orphanet (Giant cell glioblastoma)","CTD (Glioma)"]
AQP9	2	["Myeloid leukemia","Promyelocytic leukemia"]	0	[]	2	["CTD (Myeloid leukemia)","CTD (Promyelocytic leukemia)"]

Diseases Linked via Similar Genes

Anaplastic astrocytoma Linked via 1 of 5 related genesIDH2 Anaplastic oligoastrocytoma Linked via 1 of 5 related genesIDH2 Anaplastic oligodendroglioma Linked via 1 of 5 related genesIDH2 Cardiomegaly Linked via 1 of 5 related genesIDH2 Cardiomyopathy Linked via 1 of 5 related genesIDH2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Anaplastic astrocytoma	1	["IDH2"]
Anaplastic oligoastrocytoma	1	["IDH2"]
Anaplastic oligodendroglioma	1	["IDH2"]
Cardiomegaly	1	["IDH2"]
Cardiomyopathy	1	["IDH2"]