Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 47
16
Diseases
1,725
Unique genes
0.119
Avg. similarity score
Autoimmune disease
Most-connected disease (7 links)
Disease
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Autoimmune disease
Common variable immunodeficiency
Diabetes mellitus type 1
Hypothyroidism
Systemic lupus erythematosus
Autoimmune thyroid disease
Celiac disease
Rheumatoid arthritis
Sarcoidosis
isolated sulfite oxidase deficiency
immunodeficiency, common variable, 6
immunodeficiency, common variable, 7
Autoinflammation with pulmonary and cutaneous vasculitis
Autoinflammatory-pancytopenia syndrome
Midline facial cleft
immunodeficiency, common variable, 4
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Autoimmune disease | 7 | 7 | 202 |
| Common variable immunodeficiency | 7 | 7 | 75 |
| Diabetes mellitus type 1 | 7 | 7 | 477 |
| Hypothyroidism | 7 | 7 | 374 |
| Systemic lupus erythematosus | 7 | 7 | 654 |
| Autoimmune thyroid disease | 6 | 6 | 144 |
| Celiac disease | 6 | 6 | 193 |
| Rheumatoid arthritis | 4 | 4 | 662 |
| Sarcoidosis | 4 | 4 | 163 |
| isolated sulfite oxidase deficiency | 3 | 3 | 1 |
| immunodeficiency, common variable, 6 | 2 | 2 | 1 |
| immunodeficiency, common variable, 7 | 2 | 2 | 1 |
| Autoinflammation with pulmonary and cutaneous vasculitis | 1 | 1 | 1 |
| Autoinflammatory-pancytopenia syndrome | 1 | 1 | 1 |
| Midline facial cleft | 1 | 1 | 1 |
| immunodeficiency, common variable, 4 | 1 | 1 | 1 |
Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| HLA-DQB1 | 9 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 5 more |
| C1ORF141 | 8 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 4 more |
| CTLA4 | 8 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 4 more |
| ICOS | 8 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 4 more |
| IL23R | 8 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 4 more |
| IL2RA | 8 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 4 more |
| NKX2-3 | 8 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 4 more |
| PHTF1 | 8 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 4 more |
| RSBN1 | 8 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 4 more |
| SH2B3 | 8 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 4 more |
| SLC25A28 | 8 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 4 more |
| SUOX | 8 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 4 more |
| ADCY7 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| ANKRD55 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| ATG16L1 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| ATXN2 | 7 / 16 | Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 3 more |
| BACH2 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 3 more |
| BTNL2 | 7 / 16 | Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 3 more |
| CARD9 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| GSDMB | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| HLA-DQA1 | 7 / 16 | Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 3 more |
| HLA-DRA | 7 / 16 | Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 3 more |
| HLA-DRB1 | 7 / 16 | Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 3 more |
| IGF2 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| IL10 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| IRF1 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| JAK2 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| KEAP1 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| NKD1 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| PSMB9 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 3 more |
| PTPN2 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 3 more |
| STAT4 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 3 more |
| TSBP1 | 7 / 16 | Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 3 more |
| TTC33 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| TYK2 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism and 3 more |
| ZMIZ1 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| ZPBP2 | 7 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more |
| ADGRL2 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| ATXN2L | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| CD226 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism and 2 more |
| CRB1 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| CYTL1 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| DAG1 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| DCTD | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| ERAP2 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| FNBP1 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| FUT2 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| GPR35 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| HLA-B | 6 / 16 | Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 2 more |
| HLA-DMB | 6 / 16 | Autoimmune disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 2 more |
| HLA-DOA | 6 / 16 | Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 2 more |
| HLA-DOB | 6 / 16 | Celiac disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 2 more |
| HLA-DPA1 | 6 / 16 | Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 2 more |
| HLA-DPB1 | 6 / 16 | Celiac disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 2 more |
| HLA-DQB3 | 6 / 16 | Autoimmune disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 2 more |
| IL18RAP | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| IL21 | 6 / 16 | Celiac disease, Common variable immunodeficiency, Diabetes mellitus type 1, Hypothyroidism and 2 more |
| INS-IGF2 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| IRF4 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Diabetes mellitus type 1 and 2 more |
| LRRK2 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| LURAP1L | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| NOTCH4 | 6 / 16 | Celiac disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 2 more |
| NPIPB6 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| PDE4A | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| PPARG | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism and 2 more |
| PTPN22 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism and 2 more |
| RASGRP1 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism and 2 more |
| SBK1 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| SLC9A4 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| SMAD3 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| STMN3 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| TAGAP | 6 / 16 | Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 2 more |
| TAP1 | 6 / 16 | Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 2 more |
| TAP2 | 6 / 16 | Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 2 more |
| TENM3 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| TNFSF15 | 6 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more |
| UBASH3A | 6 / 16 | Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Hypothyroidism and 2 more |
| AFF3 | 5 / 16 | Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Rheumatoid arthritis and 1 more |
| ARID5B | 5 / 16 | Autoimmune disease, Autoimmune thyroid disease, Hypothyroidism, Rheumatoid arthritis and 1 more |
| BCL2L15 | 5 / 16 | Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 1 more |
| C1QTNF6 | 5 / 16 | Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism and 1 more |
| C2 | 5 / 16 | Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more |
| CBLB | 5 / 16 | Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism and 1 more |
| CCDC88B | 5 / 16 | Autoimmune disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 1 more |
| CD28 | 5 / 16 | Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Rheumatoid arthritis and 1 more |
| ELMO1 | 5 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Hypothyroidism and 1 more |
| ERBB3 | 5 / 16 | Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism and 1 more |
| ETS1 | 5 / 16 | Celiac disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 1 more |
| FAM76B | 5 / 16 | Autoimmune disease, Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism and 1 more |
| FASLG | 5 / 16 | Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Rheumatoid arthritis and 1 more |
| HLA-DRB5 | 5 / 16 | Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis, Sarcoidosis and 1 more |
| IKZF1 | 5 / 16 | Autoimmune disease, Common variable immunodeficiency, Diabetes mellitus type 1, Rheumatoid arthritis and 1 more |
| IL6 | 5 / 16 | Autoimmune disease, Celiac disease, Diabetes mellitus type 1, Rheumatoid arthritis and 1 more |
| INPP5B | 5 / 16 | Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 1 more |
| LPP | 5 / 16 | Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Hypothyroidism and 1 more |
| MACIR | 5 / 16 | Autoimmune disease, Autoimmune thyroid disease, Hypothyroidism, Rheumatoid arthritis and 1 more |
| MAGI3 | 5 / 16 | Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 1 more |
| MSH5 | 5 / 16 | Common variable immunodeficiency, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 1 more |
| NCR3 | 5 / 16 | Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 1 more |
| RAD51B | 5 / 16 | Autoimmune thyroid disease, Diabetes mellitus type 1, Hypothyroidism, Rheumatoid arthritis and 1 more |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Inflammatory bowel disease | KEGG | 50 / 66 | 5.3× | 3.17e-29 | 8.33e-26 ✓ sig. |
| Cytokine-cytokine receptor interaction | KEGG | 112 / 298 | 2.6× | 7.14e-24 | 1.13e-20 ✓ sig. |
| Leishmaniasis | KEGG | 50 / 78 | 4.5× | 7.68e-24 | 1.20e-20 ✓ sig. |
| Type I diabetes mellitus | KEGG | 36 / 44 | 5.7× | 1.82e-23 | 2.54e-20 ✓ sig. |
| Th17 cell differentiation | KEGG | 59 / 109 | 3.8× | 1.71e-22 | 2.20e-19 ✓ sig. |
| Allograft rejection | KEGG | 32 / 39 | 5.7× | 4.60e-21 | 4.35e-18 ✓ sig. |
| Viral protein interaction with cytokine and cytokine receptor | KEGG | 53 / 100 | 3.7× | 8.81e-20 | 6.71e-17 ✓ sig. |
| Herpes simplex virus 1 infection | KEGG | 75 / 182 | 2.9× | 4.86e-19 | 3.40e-16 ✓ sig. |
| Intestinal immune network for IgA production | KEGG | 35 / 50 | 4.9× | 5.83e-19 | 4.05e-16 ✓ sig. |
| Toxoplasmosis | KEGG | 55 / 112 | 3.4× | 1.79e-18 | 1.14e-15 ✓ sig. |
| Th1 and Th2 cell differentiation | KEGG | 49 / 93 | 3.7× | 3.02e-18 | 1.83e-15 ✓ sig. |
| Autoimmune thyroid disease | KEGG | 35 / 54 | 4.5× | 2.64e-17 | 1.31e-14 ✓ sig. |
| Interleukin-10 signaling | Reactome | 32 / 47 | 4.7× | 6.92e-17 | 3.23e-14 ✓ sig. |
| Rheumatoid arthritis | KEGG | 47 / 95 | 3.4× | 3.82e-16 | 1.59e-13 ✓ sig. |
| Epstein-Barr virus infection | KEGG | 75 / 204 | 2.6× | 9.35e-16 | 3.64e-13 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| immune response | GO:0006955 | 155 / 543 | 3.1× | 2.72e-39 | 2.79e-35 ✓ sig. |
| inflammatory response | GO:0006954 | 131 / 467 | 3.0× | 2.03e-32 | 1.27e-28 ✓ sig. |
| positive regulation of type II interferon production | GO:0032729 | 39 / 77 | 5.5× | 1.22e-20 | 2.18e-17 ✓ sig. |
| immune system process | GO:0002376 | 175 / 943 | 2.0× | 5.25e-20 | 8.59e-17 ✓ sig. |
| positive regulation of transcription by RNA polymerase II | GO:0045944 | 207 / 1,208 | 1.9× | 2.49e-19 | 3.64e-16 ✓ sig. |
| positive regulation of T cell proliferation | GO:0042102 | 34 / 67 | 5.5× | 3.33e-18 | 4.10e-15 ✓ sig. |
| positive regulation of MAPK cascade | GO:0043410 | 65 / 224 | 3.1× | 1.83e-17 | 2.05e-14 ✓ sig. |
| positive regulation of tumor necrosis factor production | GO:0032760 | 43 / 113 | 4.1× | 9.57e-17 | 9.30e-14 ✓ sig. |
| cell surface receptor signaling pathway via JAK-STAT | GO:0007259 | 32 / 67 | 5.2× | 3.18e-16 | 2.75e-13 ✓ sig. |
| positive regulation of T cell activation | GO:0050870 | 26 / 45 | 6.3× | 4.49e-16 | 3.77e-13 ✓ sig. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | GO:0051897 | 61 / 217 | 3.0× | 9.34e-16 | 7.29e-13 ✓ sig. |
| cytokine-mediated signaling pathway | GO:0019221 | 48 / 145 | 3.6× | 1.03e-15 | 7.91e-13 ✓ sig. |
| positive regulation of smooth muscle cell proliferation | GO:0048661 | 27 / 52 | 5.6× | 4.61e-15 | 3.20e-12 ✓ sig. |
| positive regulation of cell population proliferation | GO:0008284 | 107 / 532 | 2.2× | 5.68e-15 | 3.86e-12 ✓ sig. |
| positive regulation of canonical NF-kappaB signal transduction | GO:0043123 | 62 / 232 | 2.9× | 7.30e-15 | 4.82e-12 ✓ sig. |