HLA-DQB3 (major histocompatibility complex, class II, DQ beta 3)

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Gene Gene information from NCBI Gene database.
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Entrez ID 3121
Gene name Major histocompatibility complex, class II, DQ beta 3
Gene symbol HLA-DQB3
Synonyms (NCBI Gene)
D6S205D6S205EDQB3DVBDVbetaHLA-DVB
Chromosome 6
Chromosome location 6p21.3
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
HGNC 4946 N/A
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
42
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (42)
Phenotype Name Clinical Significance Source Reference Evidence Score
ALZHEIMER DISEASE — GWAS catalog 34743297, 35851147, 39998322
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANTI-NEUTROPHIL ANTIBODY ASSOCIATED VASCULITIS — GWAS catalog 28029757
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA — GWAS catalog 21804548, 30657218, 31361310, 31669095
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATOPIC ASTHMA — GWAS catalog 31669095
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER — GWAS catalog 23453885
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Rheumatoid Arthritis Rheumatoid arthritis GWASDB_DG 21156761
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
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CCDC88B 7 shared diseasesAutoimmune disease, Skin neoplasms, Iga nephropathy, Non-melanoma skin carcinoma, Sarcoidosis, Sclerosing cholangitis, Skin cancer 8 shared evidence sourcesGWAS catalog (Autoimmune disease), GWAS catalog (Basal cell carcinoma), GWAS catalog (Skin neoplasms), GWAS catalog (Iga nephropathy), GWAS catalog (Non-melanoma skin carcinoma), GWAS catalog (Sarcoidosis), GWAS catalog (Sclerosing cholangitis), GWAS catalog (Skin cancer) Related via 7 shared diseases including Autoimmune disease, Skin neoplasms — evidence mostly GWAS catalog. PRDX5 5 shared diseasesSkin neoplasms, Iga nephropathy, Non-melanoma skin carcinoma, Sarcoidosis, Skin cancer 6 shared evidence sourcesGWAS catalog (Basal cell carcinoma), GWAS catalog (Skin neoplasms), GWAS catalog (Iga nephropathy), GWAS catalog (Non-melanoma skin carcinoma), GWAS catalog (Sarcoidosis), GWAS catalog (Skin cancer) Related via 5 shared diseases including Skin neoplasms, Iga nephropathy — evidence mostly GWAS catalog. HLA-DRA 10 shared diseasesCervical cancer, Interstitial cystitis, Gastroesophageal reflux disease, Henoch schoenlein purpura, Iga nephropathy, Non-hodgkins lymphoma, Pemphigus vulgaris, Peptic ulcer disease, Sarcoidosis, Sclerosing cholangitis 12 shared evidence sourcesGWAS catalog (Basal cell carcinoma), GWAS catalog (Cervical cancer), GWAS catalog (Interstitial cystitis), GWAS catalog (Gastroesophageal reflux disease), GWAS catalog (Henoch schoenlein purpura), GWAS catalog (Hepatocellular carcinoma), GWAS catalog (Iga nephropathy), GWAS catalog (Non-hodgkins lymphoma), GWAS catalog (Pemphigus vulgaris), GWAS catalog (Peptic ulcer disease), GWAS catalog (Sarcoidosis), GWAS catalog (Sclerosing cholangitis) Related via 10 shared diseases including Cervical cancer, Interstitial cystitis — evidence mostly GWAS catalog. TGM3 6 shared diseasesSkin neoplasms, Cervical cancer, Non-hodgkins lymphoma, Non-melanoma skin carcinoma, Sarcoidosis, Skin cancer 8 shared evidence sourcesGWAS catalog (Basal cell carcinoma), GWAS catalog (Skin neoplasms), GWAS catalog (Cervical cancer), GWAS catalog (Hepatocellular carcinoma), GWAS catalog (Non-hodgkins lymphoma), GWAS catalog (Non-melanoma skin carcinoma), GWAS catalog (Sarcoidosis), GWAS catalog (Skin cancer) Related via 6 shared diseases including Skin neoplasms, Cervical cancer — evidence mostly GWAS catalog. RGS22 5 shared diseasesSkin neoplasms, Cervical cancer, Non-hodgkins lymphoma, Non-melanoma skin carcinoma, Skin cancer 7 shared evidence sourcesGWAS catalog (Basal cell carcinoma), GWAS catalog (Skin neoplasms), GWAS catalog (Cervical cancer), GWAS catalog (Hepatocellular carcinoma), GWAS catalog (Non-hodgkins lymphoma), GWAS catalog (Non-melanoma skin carcinoma), GWAS catalog (Skin cancer) Related via 5 shared diseases including Skin neoplasms, Cervical cancer — evidence mostly GWAS catalog.
Keratinocyte carcinoma Linked via 3 of 5 related genesCCDC88B, TGM3, RGS22 Biliary cholangitis Linked via 3 of 5 related genesCCDC88B, PRDX5, HLA-DRA Ulcerative colitis Linked via 3 of 5 related genesCCDC88B, PRDX5, HLA-DRA Biliary tract cancer Linked via 3 of 5 related genesHLA-DRA, TGM3, RGS22 Breast cancer Linked via 3 of 5 related genesHLA-DRA, TGM3, RGS22