Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 139

9 diseases · 12 shared-gene connections
9 Diseases
1,078 Unique genes
0.111 Avg. similarity score
Ischemic heart disease Most-connected disease (5 links)
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Disease Searched: Kidney disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Ischemic heart disease 5 5 170
Kidney failure 4 4 251
Heart disease 3 3 146
Myocardial ischemia 3 3 391
Preeclampsia 3 3 98
Kidney disease 2 2 425
Large artery stroke 2 2 78
Peho-like syndrome 1 1 1
Zaki syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
FTO 6 / 9 Heart disease, Ischemic heart disease, Kidney disease, Kidney failure and 2 more
ACE 5 / 9 Ischemic heart disease, Kidney disease, Kidney failure, Myocardial ischemia and 1 more
ADAMTS7 5 / 9 Heart disease, Ischemic heart disease, Kidney disease, Kidney failure and 1 more
AGT 5 / 9 Heart disease, Kidney disease, Kidney failure, Myocardial ischemia and 1 more
EDN1 5 / 9 Ischemic heart disease, Kidney disease, Kidney failure, Myocardial ischemia and 1 more
EPO 5 / 9 Heart disease, Ischemic heart disease, Kidney disease, Kidney failure and 1 more
FURIN 5 / 9 Heart disease, Ischemic heart disease, Large artery stroke, Myocardial ischemia and 1 more
MTHFR 5 / 9 Ischemic heart disease, Kidney disease, Kidney failure, Myocardial ischemia and 1 more
NOS3 5 / 9 Heart disease, Ischemic heart disease, Kidney failure, Myocardial ischemia and 1 more
PLG 5 / 9 Heart disease, Kidney disease, Kidney failure, Large artery stroke and 1 more
VEGFA 5 / 9 Heart disease, Ischemic heart disease, Kidney disease, Kidney failure and 1 more
ABCG8 4 / 9 Heart disease, Ischemic heart disease, Large artery stroke, Myocardial ischemia
ABO 4 / 9 Heart disease, Ischemic heart disease, Large artery stroke, Myocardial ischemia
AGTR1 4 / 9 Ischemic heart disease, Kidney disease, Kidney failure, Myocardial ischemia
APOE 4 / 9 Heart disease, Ischemic heart disease, Kidney failure, Myocardial ischemia
ATXN2 4 / 9 Heart disease, Kidney disease, Large artery stroke, Myocardial ischemia
CELSR2 4 / 9 Heart disease, Ischemic heart disease, Large artery stroke, Myocardial ischemia
CRP 4 / 9 Heart disease, Ischemic heart disease, Kidney failure, Myocardial ischemia
CYBA 4 / 9 Heart disease, Ischemic heart disease, Kidney failure, Myocardial ischemia
HECTD4 4 / 9 Ischemic heart disease, Kidney disease, Kidney failure, Myocardial ischemia
HMOX1 4 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia, Preeclampsia
JCAD 4 / 9 Heart disease, Ischemic heart disease, Large artery stroke, Myocardial ischemia
KIF6 4 / 9 Ischemic heart disease, Kidney disease, Kidney failure, Myocardial ischemia
LEPR 4 / 9 Ischemic heart disease, Kidney disease, Kidney failure, Myocardial ischemia
LIPA 4 / 9 Heart disease, Ischemic heart disease, Large artery stroke, Myocardial ischemia
LPA 4 / 9 Heart disease, Kidney disease, Large artery stroke, Myocardial ischemia
MMP3 4 / 9 Ischemic heart disease, Kidney failure, Large artery stroke, Myocardial ischemia
PHACTR1 4 / 9 Heart disease, Ischemic heart disease, Large artery stroke, Myocardial ischemia
PLPP3 4 / 9 Heart disease, Ischemic heart disease, Large artery stroke, Myocardial ischemia
PPARA 4 / 9 Ischemic heart disease, Kidney disease, Kidney failure, Myocardial ischemia
PSRC1 4 / 9 Heart disease, Ischemic heart disease, Large artery stroke, Myocardial ischemia
PTGS2 4 / 9 Ischemic heart disease, Kidney disease, Kidney failure, Myocardial ischemia
SCARB1 4 / 9 Heart disease, Kidney disease, Kidney failure, Myocardial ischemia
SERPINE1 4 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia, Preeclampsia
TCF21 4 / 9 Heart disease, Ischemic heart disease, Large artery stroke, Myocardial ischemia
TGFB1 4 / 9 Heart disease, Kidney disease, Kidney failure, Myocardial ischemia
ZC3HC1 4 / 9 Heart disease, Ischemic heart disease, Large artery stroke, Myocardial ischemia
ABCA1 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
ACP1 3 / 9 Ischemic heart disease, Large artery stroke, Myocardial ischemia
ADIPOQ 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
AGER 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
AHSG 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
ALB 3 / 9 Heart disease, Kidney disease, Kidney failure
ALOX5AP 3 / 9 Ischemic heart disease, Kidney disease, Myocardial ischemia
ANGPTL4 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
APOA1 3 / 9 Ischemic heart disease, Kidney disease, Myocardial ischemia
APOC3 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
ATP2B1 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
B2M 3 / 9 Heart disease, Kidney disease, Kidney failure
CCL2 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
CLCN6 3 / 9 Ischemic heart disease, Myocardial ischemia, Preeclampsia
CNNM2 3 / 9 Kidney disease, Large artery stroke, Myocardial ischemia
CUBN 3 / 9 Ischemic heart disease, Kidney disease, Myocardial ischemia
DDAH2 3 / 9 Ischemic heart disease, Myocardial ischemia, Preeclampsia
EDNRA 3 / 9 Heart disease, Large artery stroke, Myocardial ischemia
EPHX2 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
F2 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
FABP2 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
FGB 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
FGF5 3 / 9 Kidney disease, Kidney failure, Preeclampsia
GATM 3 / 9 Kidney disease, Kidney failure, Myocardial ischemia
GPX1 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
GSTM1 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
GSTP1 3 / 9 Kidney disease, Kidney failure, Myocardial ischemia
GSTT1 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
HBB 3 / 9 Heart disease, Kidney disease, Kidney failure
HDAC9 3 / 9 Heart disease, Large artery stroke, Myocardial ischemia
HHIPL1 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
HMGCR 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
ICA1L 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
IGF1 3 / 9 Kidney disease, Kidney failure, Myocardial ischemia
IL10 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
IL6R 3 / 9 Heart disease, Large artery stroke, Myocardial ischemia
KCNE2 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
KL 3 / 9 Ischemic heart disease, Kidney disease, Myocardial ischemia
LDLR 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
LIPC 3 / 9 Ischemic heart disease, Kidney disease, Myocardial ischemia
LPL 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
MIA3 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
MLXIPL 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
MMP1 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
MMP12 3 / 9 Ischemic heart disease, Large artery stroke, Myocardial ischemia
MRPS6 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
NAA25 3 / 9 Kidney disease, Kidney failure, Myocardial ischemia
NPPA 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
NPPB 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
NYAP2 3 / 9 Heart disease, Kidney disease, Myocardial ischemia
OGG1 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
POMC 3 / 9 Kidney disease, Kidney failure, Myocardial ischemia
PON1 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
PRDM8 3 / 9 Kidney disease, Kidney failure, Preeclampsia
PROCR 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
RBP4 3 / 9 Ischemic heart disease, Kidney disease, Myocardial ischemia
SERPINA1 3 / 9 Kidney failure, Large artery stroke, Myocardial ischemia
SH2B3 3 / 9 Ischemic heart disease, Large artery stroke, Myocardial ischemia
SMARCA4 3 / 9 Heart disease, Large artery stroke, Myocardial ischemia
SOD3 3 / 9 Heart disease, Ischemic heart disease, Myocardial ischemia
SPP1 3 / 9 Heart disease, Kidney disease, Kidney failure
SREBF1 3 / 9 Ischemic heart disease, Kidney failure, Myocardial ischemia
TCF7L2 3 / 9 Kidney disease, Kidney failure, Myocardial ischemia
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
AGE-RAGE signaling pathway in diabetic complications
AGER, AGTR1, CCL2, EDN1, NOS3, SELE, SERPINE1, TNF, VEGFA, CXCL8, NFATC1, PLCB1
 KEGG 44 / 101 4.9× 2.18e-20 1.64e-17 ✓ sig.
Lipid and atherosclerosis
ABCA1, AGER, APOA1, APOB, CCL2, CD40LG, CYBA, HSPD1, IRAK1, LDLR, MMP1, MMP3
 KEGG 62 / 216 3.2× 3.35e-17 1.60e-14 ✓ sig.
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
AHSG, APOA1, APOA5, APOB, APOE, F2, MIA3, MMP1, PAPPA, APOL1, CST3, PLG
 Reactome 44 / 125 3.9× 3.64e-16 1.44e-13 ✓ sig.
Complement and coagulation cascades
F2, F7, FGB, PROCR, SERPINE1, PLG, CFH, CFHR1, CFHR5, F11, F5, FGA
 KEGG 35 / 88 4.4× 5.29e-15 1.71e-12 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
CCL2, HMOX1, IL10, MMP1, MMP3, MMP9, PTGS2, TNF, TP53, TWIST1, VEGFA, CXCL8
 Reactome 39 / 108 4.0× 6.65e-15 2.13e-12 ✓ sig.
Platelet degranulation
AHSG, APOA1, FGB, PECAM1, SERPINE1, VEGFA, CALM2, PLG, ACTN4, FN1, ACTN2, F5
 Reactome 41 / 123 3.7× 3.19e-14 8.94e-12 ✓ sig.
Post-translational protein phosphorylation
AHSG, APOA1, APOA5, APOB, APOE, MIA3, APOL1, CST3, SCG2, FN1, F5, FGA
 Reactome 38 / 108 3.9× 3.90e-14 1.07e-11 ✓ sig.
Pathways in cancer
AGTR1, CDKN2B, CXCL12, EDN1, EPO, ESR1, ESR2, F2, GNB3, GSTM1, GSTT1, HMOX1
 KEGG 102 / 533 2.1× 6.36e-14 1.65e-11 ✓ sig.
Malaria
CCL2, CD40LG, IL10, PECAM1, SELE, TLR4, TNF, CXCL8, HBB, TGFB1, CSF3, IFNG
 KEGG 23 / 50 5.1× 6.74e-12 1.26e-9 ✓ sig.
Cholesterol metabolism
ABCA1, ABCG5, ABCG8, ANGPTL4, APOA1, APOB, APOC3, APOE, LDLR, LIPA, LIPC, LIPG
 KEGG 23 / 51 5.0× 1.12e-11 2.01e-9 ✓ sig.
HIF-1 signaling pathway
EDN1, EPO, HMOX1, NOS3, NPPA, SERPINE1, TLR4, VEGFA, MKNK1, IL6R, PLCG2, TIMP1
 KEGG 34 / 110 3.4× 5.39e-11 8.32e-9 ✓ sig.
Chagas disease
ACE, CCL2, IL10, IRAK1, SERPINE1, TLR4, TNF, TRAF6, CXCL8, PLCB1, PLCB2, TGFB1
 KEGG 32 / 103 3.5× 1.71e-10 2.40e-8 ✓ sig.
African trypanosomiasis
APOA1, IL10, NPPA, SELE, TNF, APOL1, HBB, PLCB1, PLCB2, FAS, IFNG, IL6
 KEGG 18 / 37 5.4× 4.23e-10 5.37e-8 ✓ sig.
Fluid shear stress and atherosclerosis
CCL2, CYBA, EDN1, GSTM1, GSTT1, HMOX1, MMP9, NOS3, PECAM1, SELE, TNF, TP53
 KEGG 36 / 141 2.8× 5.21e-9 5.19e-7 ✓ sig.
Leishmaniasis
CYBA, FCGR2A, FCGR3A, IL10, IRAK1, PTGS2, TLR4, TNF, TRAF6, TGFB1, NCF4, CYBB
 KEGG 25 / 78 3.6× 8.33e-9 7.83e-7 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of gene expression
ADTRP, APOB, CCL2, CRP, EPHX2, LDLR, MMP12, NOS3, PTPN22, TLR4, TNF, TP53
 GO:0010628 95 / 504 3.3× 3.29e-25 1.06e-21 ✓ sig.
response to xenobiotic stimulus
ABCA1, ABCC6, ABCG5, ABCG8, ADIPOQ, BCHE, CYBA, EDN1, GPX1, IL10, LIPA, LRP8
 GO:0009410 59 / 248 4.1× 3.58e-21 6.63e-18 ✓ sig.
regulation of blood pressure
ACE, ATP2B1, EDN1, GNB3, GUCY1A1, NOS3, NPPA, NPPB, PTGS2, HBB, KCNQ1, UMOD
 GO:0008217 33 / 83 6.9× 7.47e-20 1.13e-16 ✓ sig.
kidney development
ACE, AGTR1, TCF21, VEGFA, BICC1, HAS2, LRP2, OVOL1, SLC34A1, SOX11, UMOD, GATA3
 GO:0001822 41 / 146 4.9× 7.12e-18 8.17e-15 ✓ sig.
response to nutrient
ABCA1, ABCG5, ABCG8, ADIPOQ, BCHE, EPO, LIPG, LTA, NOD2, PPARA, SREBF1, AGL
 GO:0007584 27 / 63 7.4× 1.71e-17 1.84e-14 ✓ sig.
positive regulation of transcription by RNA polymerase II
CARF, DAB2IP, EDN1, ESR1, ESR2, HNF1A, IL10, LUM, MLXIPL, MMP12, NOD2, NR3C1
 GO:0045944 143 / 1,208 2.1× 5.06e-17 5.00e-14 ✓ sig.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
ADTRP, F2, GDF15, GPX1, IRS1, PDGFD, PECAM1, TNF, VEGFA, TCF7L2, GATA3, FN1
 GO:0051897 48 / 217 3.8× 4.13e-16 3.57e-13 ✓ sig.
inflammatory response
AGER, AGTR1, CCL2, CCR2, CD40LG, CRP, CYBA, DAB2IP, IL1RL1, LIPA, OLR1, SELE
 GO:0006954 75 / 467 2.8× 4.95e-16 4.22e-13 ✓ sig.
response to lipopolysaccharide
EDN1, EPO, GPX1, IL10, IRAK1, LTA, NOS3, PTPN22, SELE, TLR4, TNF, TRIB1
 GO:0032496 40 / 161 4.3× 1.85e-15 1.41e-12 ✓ sig.
positive regulation of ERK1 and ERK2 cascade
AGER, APOE, EPO, FGB, NOD2, PDGFD, PTPN22, TLR4, TNF, VEGFA, NRG1, DSTYK
 GO:0070374 45 / 201 3.9× 2.16e-15 1.62e-12 ✓ sig.
cellular response to lipopolysaccharide
ABCA1, CCL2, DAB2IP, IL10, IRAK1, MMP3, MMP9, NOD2, SERPINE1, TLR4, TNF, TRAF6
 GO:0071222 43 / 187 4.0× 3.29e-15 2.39e-12 ✓ sig.
response to hypoxia
ADIPOQ, AGER, ANGPTL4, CXCL12, CYBA, EDN1, EPO, ERCC2, F7, LTA, MTHFR, NPPA
 GO:0001666 41 / 176 4.0× 9.01e-15 6.03e-12 ✓ sig.
positive regulation of miRNA transcription
IL10, NR3C1, SREBF1, TERT, TNF, TP53, ETS1, SPI1, GATA3, WT1, SMAD3, SMARCA4
 GO:1902895 23 / 56 7.1× 1.29e-14 8.37e-12 ✓ sig.
acute-phase response
AHSG, APCS, CRP, EPO, F2, APOL2, FN1, IL6R, IL1RN, INS, LCN2, HP
 GO:0006953 19 / 37 8.9× 1.62e-14 1.03e-11 ✓ sig.
lipid metabolic process
ABCA1, ACAT2, ADTRP, ANGPTL4, APOA1, APOB, APOC3, APOE, CUBN, CYP2R1, EPHX2, GPX1
 GO:0006629 105 / 840 2.2× 3.37e-14 2.02e-11 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Ischemic heart disease Myocardial ischemia 0.434 170 1.83e-290 1.81e-287 ✓ sig.
Kidney disease Kidney failure 0.175 101 6.97e-93 6.57e-91 ✓ sig.
Heart disease Myocardial ischemia 0.137 65 3.63e-65 2.44e-63 ✓ sig.
Kidney failure Myocardial ischemia 0.101 59 2.17e-40 9.16e-39 ✓ sig.
Ischemic heart disease Kidney failure 0.108 41 1.28e-36 4.94e-35 ✓ sig.
Heart disease Ischemic heart disease 0.120 34 6.64e-36 2.49e-34 ✓ sig.
Heart disease Large artery stroke 0.092 19 4.56e-22 9.46e-21 ✓ sig.
Ischemic heart disease Large artery stroke 0.073 17 8.36e-18 1.42e-16 ✓ sig.
Kidney failure Preeclampsia 0.036 12 6.36e-8 4.62e-7 ✓ sig.
Ischemic heart disease Preeclampsia 0.039 10 1.25e-7 8.69e-7 ✓ sig.
Preeclampsia Zaki syndrome 0.010 1 6.36e-3 7.63e-3 ✓ sig.
Kidney disease Peho-like syndrome 0.002 1 2.76e-2 2.94e-2 ✓ sig.